PPIA (peptidylprolyl isomerase A) - Rat Genome Database

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Gene: PPIA (peptidylprolyl isomerase A) Homo sapiens
Analyze
Symbol: PPIA
Name: peptidylprolyl isomerase A
RGD ID: 731273
HGNC Page HGNC
Description: Enables cyclosporin A binding activity; heparan sulfate binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including cell adhesion molecule production; regulation of intracellular signal transduction; and regulation of protein modification process. Located in cytoplasm; extracellular region; and nucleus. Part of protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cyclophilin; cyclophilin A; cyclosporin A-binding protein; CYPA; CYPH; epididymis secretory sperm binding protein Li 69p; HEL-S-69p; MGC117158; MGC12404; MGC23397; peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIase A; rotamase A; T cell cyclophilin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC110596867   PPIAP1   PPIAP10   PPIAP11   PPIAP13   PPIAP14   PPIAP15   PPIAP16   PPIAP17   PPIAP18   PPIAP19   PPIAP2   PPIAP20   PPIAP21   PPIAP22   PPIAP23   PPIAP24   PPIAP25   PPIAP26   PPIAP27   PPIAP28   PPIAP29   PPIAP3   PPIAP30   PPIAP31   PPIAP35   PPIAP36   PPIAP37   PPIAP38   PPIAP39   PPIAP4   PPIAP41   PPIAP42   PPIAP43   PPIAP44   PPIAP45   PPIAP46   PPIAP47   PPIAP48   PPIAP49   PPIAP5   PPIAP50   PPIAP51   PPIAP52   PPIAP53   PPIAP54   PPIAP55   PPIAP57   PPIAP58   PPIAP6   PPIAP61   PPIAP63   PPIAP65   PPIAP66   PPIAP67   PPIAP68   PPIAP69   PPIAP7   PPIAP70   PPIAP72   PPIAP73   PPIAP74   PPIAP75   PPIAP76   PPIAP77   PPIAP78   PPIAP79   PPIAP8   PPIAP80   PPIAP82   PPIAP83   PPIAP84   PPIAP85   PPIAP86   PPIAP87   PPIAP88   PPIAP89   PPIAP9   PPIAP90   PPIAP91   PPIAP93  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl744,796,680 - 44,824,564 (+)EnsemblGRCh38hg38GRCh38
GRCh38744,795,960 - 44,803,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37744,836,280 - 44,842,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,802,766 - 44,809,241 (+)NCBINCBI36hg18NCBI36
Build 34744,609,504 - 44,615,343NCBI
Celera744,935,095 - 44,941,571 (+)NCBI
Cytogenetic Map7p13NCBI
HuRef744,721,292 - 44,727,768 (+)NCBIHuRef
CHM1_1744,840,586 - 44,847,069 (+)NCBICHM1_1
CRA_TCAGchr7v2744,875,748 - 44,882,224 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
5-aza-2'-deoxycytidine  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
alprazolam  (EXP)
ammonium chloride  (ISO)
arsenous acid  (EXP)
Bandrowski's base  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bucladesine  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
cyclosporin A  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dihydroartemisinin  (EXP)
disulfiram  (EXP)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
indometacin  (EXP)
iodide salt  (ISO)
iron(III) nitrilotriacetate  (ISO)
ivermectin  (EXP)
L-glutamic acid  (ISO)
limonene  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
medroxyprogesterone acetate  (EXP)
megestrol acetate  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (EXP)
okadaic acid  (EXP)
paracetamol  (ISO)
picoxystrobin  (EXP)
potassium dichromate  (ISO)
Propiverine  (ISO)
quercetin  (EXP)
Rebamipide  (ISO)
rotenone  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thimerosal  (EXP)
torcetrapib  (EXP)
trichostatin A  (EXP)
uranium atom  (EXP)
valproic acid  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:1560526   PMID:1602151   PMID:1715516   PMID:1896075   PMID:1946361   PMID:1989998   PMID:2001362   PMID:2179953   PMID:2197089   PMID:2644542   PMID:3297675   PMID:7541038  
PMID:7543589   PMID:7572395   PMID:7590732   PMID:7657784   PMID:7821789   PMID:7829860   PMID:7884893   PMID:7969494   PMID:7969495   PMID:8263916   PMID:8421500   PMID:8421501  
PMID:8513493   PMID:8648687   PMID:8648689   PMID:8652511   PMID:8659916   PMID:8662505   PMID:8676442   PMID:8676452   PMID:8709190   PMID:8764025   PMID:8806510   PMID:8830660  
PMID:8976380   PMID:8980222   PMID:8980234   PMID:9016720   PMID:9032343   PMID:9129655   PMID:9223641   PMID:9261419   PMID:9261445   PMID:9299338   PMID:9305737   PMID:9337866  
PMID:9380739   PMID:9385632   PMID:9420228   PMID:9546659   PMID:9557731   PMID:9573245   PMID:9636359   PMID:9658084   PMID:9769216   PMID:9875332   PMID:10026140   PMID:10096576  
PMID:10208938   PMID:10208939   PMID:10581250   PMID:10704338   PMID:10794694   PMID:11058892   PMID:11250896   PMID:11312344   PMID:11337467   PMID:11353871   PMID:11379967   PMID:11581426  
PMID:11790298   PMID:11830645   PMID:11836403   PMID:11859194   PMID:11929983   PMID:11943775   PMID:12009870   PMID:12032547   PMID:12091904   PMID:12167617   PMID:12181673   PMID:12207006  
PMID:12208976   PMID:12210402   PMID:12210730   PMID:12218175   PMID:12357034   PMID:12477877   PMID:12477932   PMID:12547912   PMID:12634401   PMID:12665801   PMID:12668872   PMID:12707923  
PMID:12730686   PMID:12767222   PMID:12788626   PMID:12810862   PMID:12859974   PMID:12881522   PMID:12881523   PMID:12897779   PMID:12932580   PMID:14505569   PMID:14526201   PMID:14630798  
PMID:14716299   PMID:14993672   PMID:15028279   PMID:15098018   PMID:15111303   PMID:15130913   PMID:15147195   PMID:15229879   PMID:15311922   PMID:15358143   PMID:15388255   PMID:15489334  
PMID:15596813   PMID:15680395   PMID:15688292   PMID:15772070   PMID:15782160   PMID:15845542   PMID:15952740   PMID:16027165   PMID:16049941   PMID:16097034   PMID:16120388   PMID:16169070  
PMID:16189514   PMID:16199531   PMID:16203999   PMID:16273344   PMID:16275650   PMID:16291214   PMID:16501094   PMID:16502470   PMID:16527992   PMID:16571786   PMID:16584201   PMID:16643975  
PMID:16703398   PMID:16780588   PMID:16785541   PMID:16815734   PMID:16901758   PMID:16916647   PMID:17038183   PMID:17170453   PMID:17267487   PMID:17449029   PMID:17520256   PMID:17522232  
PMID:17565686   PMID:17609268   PMID:17620599   PMID:17678621   PMID:17715216   PMID:17804494   PMID:17897064   PMID:17919644   PMID:17927958   PMID:17967060   PMID:17991743   PMID:18191978  
PMID:18212100   PMID:18321308   PMID:18367226   PMID:18385230   PMID:18417509   PMID:18421009   PMID:18514189   PMID:18673375   PMID:18678385   PMID:18704644   PMID:18789977   PMID:18829531  
PMID:18829762   PMID:18991615   PMID:19020832   PMID:19056509   PMID:19056867   PMID:19073742   PMID:19092998   PMID:19185003   PMID:19190083   PMID:19199708   PMID:19205352   PMID:19207730  
PMID:19254360   PMID:19262010   PMID:19275580   PMID:19282959   PMID:19297321   PMID:19322201   PMID:19328002   PMID:19338310   PMID:19380579   PMID:19386705   PMID:19457995   PMID:19503092  
PMID:19584157   PMID:19625401   PMID:19639585   PMID:19656870   PMID:19680534   PMID:19694548   PMID:19738201   PMID:19741300   PMID:19758589   PMID:19789967   PMID:19825046   PMID:19857522  
PMID:19865066   PMID:19932913   PMID:19946888   PMID:19956261   PMID:20000738   PMID:20012523   PMID:20012529   PMID:20070121   PMID:20107018   PMID:20139366   PMID:20147391   PMID:20219923  
PMID:20351267   PMID:20360068   PMID:20364129   PMID:20381070   PMID:20454998   PMID:20458337   PMID:20471030   PMID:20553309   PMID:20676357   PMID:20702630   PMID:20708627   PMID:20721640  
PMID:20796224   PMID:20849852   PMID:20862313   PMID:20920334   PMID:20946244   PMID:20956011   PMID:20962083   PMID:21081666   PMID:21145461   PMID:21151833   PMID:21169362   PMID:21245143  
PMID:21319273   PMID:21423176   PMID:21441138   PMID:21464540   PMID:21489988   PMID:21516116   PMID:21568899   PMID:21585617   PMID:21593166   PMID:21667159   PMID:21711559   PMID:21718636  
PMID:21724278   PMID:21738476   PMID:21743322   PMID:21832049   PMID:21839816   PMID:21873635   PMID:21956400   PMID:22004035   PMID:22046132   PMID:22174692   PMID:22185200   PMID:22205628  
PMID:22238232   PMID:22256739   PMID:22301145   PMID:22342556   PMID:22347431   PMID:22421161   PMID:22446626   PMID:22492959   PMID:22580540   PMID:22623428   PMID:22658674   PMID:22677509  
PMID:22681889   PMID:22701176   PMID:22810585   PMID:22814107   PMID:22855686   PMID:22863883   PMID:22874433   PMID:22898364   PMID:22902549   PMID:22930659   PMID:22939629   PMID:22944661  
PMID:22944692   PMID:22990118   PMID:22996014   PMID:23022198   PMID:23031673   PMID:23041358   PMID:23087682   PMID:23097435   PMID:23138189   PMID:23152499   PMID:23180369   PMID:23266279  
PMID:23320071   PMID:23322171   PMID:23325683   PMID:23332074   PMID:23376485   PMID:23448277   PMID:23511555   PMID:23533145   PMID:23558220   PMID:23576398   PMID:23602568   PMID:23741361  
PMID:23885082   PMID:23935497   PMID:24036847   PMID:24051001   PMID:24055605   PMID:24196705   PMID:24196714   PMID:24272759   PMID:24332027   PMID:24434516   PMID:24479545   PMID:24502618  
PMID:24525292   PMID:24559861   PMID:24662981   PMID:24711643   PMID:24713575   PMID:24782340   PMID:24979782   PMID:24982184   PMID:24998431   PMID:24999758   PMID:25036886   PMID:25147182  
PMID:25192599   PMID:25225668   PMID:25229650   PMID:25270076   PMID:25296734   PMID:25324306   PMID:25339776   PMID:25356737   PMID:25416956   PMID:25420107   PMID:25445708   PMID:25550208  
PMID:25552928   PMID:25556234   PMID:25580061   PMID:25678563   PMID:25738284   PMID:25833399   PMID:25874870   PMID:25921289   PMID:25959826   PMID:25963833   PMID:26005854   PMID:26008617  
PMID:26084004   PMID:26095851   PMID:26109731   PMID:26167880   PMID:26170170   PMID:26209609   PMID:26217791   PMID:26281011   PMID:26318518   PMID:26344197   PMID:26414211   PMID:26496610  
PMID:26511606   PMID:26553990   PMID:26641092   PMID:26656091   PMID:26702934   PMID:26792730   PMID:26833980   PMID:26865710   PMID:26885983   PMID:26940118   PMID:27025967   PMID:27033630  
PMID:27071107   PMID:27088296   PMID:27342126   PMID:27397650   PMID:27432908   PMID:27465491   PMID:27468721   PMID:27516963   PMID:27533088   PMID:27576135   PMID:27609421   PMID:27676132  
PMID:27684187   PMID:28076787   PMID:28077629   PMID:28089447   PMID:28153875   PMID:28225217   PMID:28317380   PMID:28394340   PMID:28442737   PMID:28479159   PMID:28515276   PMID:28581483  
PMID:28685749   PMID:28729360   PMID:28739738   PMID:28838205   PMID:28981554   PMID:29027312   PMID:29081463   PMID:29117863   PMID:29128334   PMID:29180619   PMID:29229926   PMID:29298432  
PMID:29396555   PMID:29403273   PMID:29449217   PMID:29467282   PMID:29491746   PMID:29507755   PMID:29551599   PMID:29564676   PMID:29845934   PMID:29884859   PMID:29885319   PMID:29891613  
PMID:29911972   PMID:30021884   PMID:30194290   PMID:30196744   PMID:30198892   PMID:30328013   PMID:30455355   PMID:30463901   PMID:30572748   PMID:30575818   PMID:30825933   PMID:30844143  
PMID:30948266   PMID:31063815   PMID:31091453   PMID:31180492   PMID:31240211   PMID:31248990   PMID:31282281   PMID:31300519   PMID:31329371   PMID:31436131   PMID:31494257   PMID:31501420  
PMID:31519036   PMID:31536960   PMID:31586073   PMID:31594532   PMID:31615744   PMID:31623908   PMID:31634494   PMID:31655924   PMID:31722399   PMID:31783885   PMID:31797533   PMID:31799884  
PMID:31825469   PMID:31921057   PMID:31936351   PMID:31980649   PMID:31995728   PMID:32041737   PMID:32129710   PMID:32162654   PMID:32188574   PMID:32321766   PMID:32322062   PMID:32406527  
PMID:32457219   PMID:32507068   PMID:32513696   PMID:32529326   PMID:32539931   PMID:32631377   PMID:32708451   PMID:32727878   PMID:32747784   PMID:32774749   PMID:32775435   PMID:32807901  
PMID:32814053   PMID:32829656   PMID:32929329   PMID:33024031   PMID:33191348   PMID:33194618   PMID:33834670   PMID:33849122   PMID:34099711   PMID:34360654  


Genomics

Comparative Map Data
PPIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl744,796,680 - 44,824,564 (+)EnsemblGRCh38hg38GRCh38
GRCh38744,795,960 - 44,803,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37744,836,280 - 44,842,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,802,766 - 44,809,241 (+)NCBINCBI36hg18NCBI36
Build 34744,609,504 - 44,615,343NCBI
Celera744,935,095 - 44,941,571 (+)NCBI
Cytogenetic Map7p13NCBI
HuRef744,721,292 - 44,727,768 (+)NCBIHuRef
CHM1_1744,840,586 - 44,847,069 (+)NCBICHM1_1
CRA_TCAGchr7v2744,875,748 - 44,882,224 (+)NCBI
Ppia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,365,867 - 6,369,817 (+)NCBIGRCm39mm39
GRCm39 Ensembl116,365,443 - 6,369,817 (+)Ensembl
GRCm38116,415,867 - 6,419,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,415,443 - 6,419,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,315,873 - 6,319,813 (+)NCBIGRCm37mm9NCBIm37
MGSCv36116,315,873 - 6,319,813 (+)NCBImm8
Celera116,899,520 - 6,903,460 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.97NCBI
Ppia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21481,279,292 - 81,282,960 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1481,275,091 - 81,299,601 (+)Ensembl
Rnor_6.01486,673,775 - 86,677,443 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,673,775 - 86,677,443 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,306,923 - 80,310,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,165,998 - 87,169,995 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11487,185,142 - 87,189,140 (+)NCBI
Celera1480,161,152 - 80,164,810 (+)NCBICelera
Cytogenetic Map14q21NCBI
Ppia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554567,381,923 - 7,383,203 (-)NCBIChiLan1.0ChiLan1.0
PPIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1745,578,764 - 45,583,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,578,765 - 45,605,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0745,510,450 - 45,515,448 (+)NCBIMhudiblu_PPA_v0panPan3
LOC403581
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1780,937,433 - 80,938,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0781,027,063 - 81,027,805 (-)NCBI
UMICH_Zoey_3.1780,741,873 - 80,742,615 (-)NCBI
UNSW_CanFamBas_1.01764,379,529 - 64,380,271 (-)NCBI
UU_Cfam_GSD_1.0781,058,591 - 81,059,333 (-)NCBI
Ppia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,457,966 - 100,461,621 (+)NCBI
SpeTri2.0NW_00493647819,669,727 - 19,673,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11850,563,130 - 50,566,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,286,994 - 55,290,557 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12113,876,099 - 13,883,546 (-)NCBI
ChlSab1.1 Ensembl2113,876,099 - 13,883,462 (-)Ensembl
Vero_WHO_p1.0NW_0236660628,652,515 - 8,658,073 (+)NCBI
Ppia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247407,447,554 - 7,450,707 (-)NCBI

Position Markers
SHGC-56052  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,842,430 - 44,842,681UniSTSGRCh37
Build 36744,808,955 - 44,809,206RGDNCBI36
Celera744,941,285 - 44,941,536RGD
Cytogenetic Map7p13UniSTS
HuRef744,727,482 - 44,727,733UniSTS
CRA_TCAGchr7v2744,881,938 - 44,882,189UniSTS
GeneMap99-GB4 RH Map7208.68UniSTS
Whitehead-RH Map7159.7UniSTS
G20876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,842,456 - 44,842,661UniSTSGRCh37
Build 36744,808,981 - 44,809,186RGDNCBI36
Celera744,941,311 - 44,941,516RGD
Cytogenetic Map7p13UniSTS
HuRef744,727,508 - 44,727,713UniSTS
CRA_TCAGchr7v2744,881,964 - 44,882,169UniSTS
A006J31  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,842,456 - 44,842,661UniSTSGRCh37
Build 36744,808,981 - 44,809,186RGDNCBI36
Celera744,941,311 - 44,941,516RGD
Cytogenetic Map7p13UniSTS
HuRef744,727,508 - 44,727,713UniSTS
CRA_TCAGchr7v2744,881,964 - 44,882,169UniSTS
GeneMap99-GB4 RH Map7213.91UniSTS
PPIA  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,837,639 - 44,837,749UniSTSGRCh37
Build 36744,804,164 - 44,804,274RGDNCBI36
Celera744,936,493 - 44,936,603RGD
Cytogenetic Map7p13UniSTS
HuRef744,722,690 - 44,722,800UniSTS
CRA_TCAGchr7v2744,877,146 - 44,877,256UniSTS
PMC262691P6  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map1q21.1UniSTS
PMC307696P1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7p13UniSTS
PMC112625P1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7p13UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2074
Count of miRNA genes:898
Interacting mature miRNAs:1026
Transcripts:ENST00000355968, ENST00000415933, ENST00000451562, ENST00000468812, ENST00000479021, ENST00000480603, ENST00000481437, ENST00000489459, ENST00000494484
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 39 9 8 79 8 27 6 17 17 105 68 1
Medium 2400 2983 1717 616 1870 457 4330 2184 3717 402 1355 1545 174 1 1204 2788 6 2
Low 8 2 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001300981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC013436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU100120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY739283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM806224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM909285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU786475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX347265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX408703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD014106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU794650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000355968   ⟹   ENSP00000430817
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,681 - 44,801,631 (+)Ensembl
RefSeq Acc Id: ENST00000415933   ⟹   ENSP00000394670
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,682 - 44,801,624 (+)Ensembl
RefSeq Acc Id: ENST00000451562   ⟹   ENSP00000405975
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,680 - 44,800,011 (+)Ensembl
RefSeq Acc Id: ENST00000468812   ⟹   ENSP00000419425
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,681 - 44,803,117 (+)Ensembl
RefSeq Acc Id: ENST00000479021   ⟹   ENSP00000429251
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,681 - 44,824,564 (+)Ensembl
RefSeq Acc Id: ENST00000480603
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,798,814 - 44,801,624 (+)Ensembl
RefSeq Acc Id: ENST00000481437
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,680 - 44,799,816 (+)Ensembl
RefSeq Acc Id: ENST00000489459   ⟹   ENSP00000427976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,681 - 44,801,630 (+)Ensembl
RefSeq Acc Id: ENST00000494484
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,797,973 - 44,801,647 (+)Ensembl
RefSeq Acc Id: ENST00000620047   ⟹   ENSP00000479961
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,693 - 44,801,631 (+)Ensembl
RefSeq Acc Id: ENST00000676977   ⟹   ENSP00000504621
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,681 - 44,803,115 (+)Ensembl
RefSeq Acc Id: ENST00000677022   ⟹   ENSP00000504216
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,797,136 - 44,803,115 (+)Ensembl
RefSeq Acc Id: ENST00000677107   ⟹   ENSP00000504735
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,681 - 44,803,115 (+)Ensembl
RefSeq Acc Id: ENST00000677521
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,891 - 44,803,078 (+)Ensembl
RefSeq Acc Id: ENST00000678165
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,979 - 44,803,103 (+)Ensembl
RefSeq Acc Id: ENST00000678643
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,701 - 44,801,613 (+)Ensembl
RefSeq Acc Id: ENST00000678789   ⟹   ENSP00000503804
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,796,952 - 44,803,105 (+)Ensembl
RefSeq Acc Id: ENST00000678805   ⟹   ENSP00000502945
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl744,797,600 - 44,803,115 (+)Ensembl
RefSeq Acc Id: NM_001300981   ⟹   NP_001287910
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,796,681 - 44,803,117 (+)NCBI
CHM1_1744,840,580 - 44,847,075 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021130   ⟹   NP_066953
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,796,681 - 44,803,117 (+)NCBI
GRCh37744,836,241 - 44,842,716 (+)ENTREZGENE
Build 36744,802,766 - 44,809,241 (+)NCBI Archive
HuRef744,721,292 - 44,727,768 (+)ENTREZGENE
CHM1_1744,840,580 - 44,847,075 (+)NCBI
CRA_TCAGchr7v2744,875,748 - 44,882,224 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_024446808   ⟹   XP_024302576
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,796,690 - 44,801,642 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024446809   ⟹   XP_024302577
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,796,681 - 44,801,642 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002956460
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,795,960 - 44,801,642 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001287910 (Get FASTA)   NCBI Sequence Viewer  
  NP_066953 (Get FASTA)   NCBI Sequence Viewer  
  XP_024302576 (Get FASTA)   NCBI Sequence Viewer  
  XP_024302577 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH00689 (Get FASTA)   NCBI Sequence Viewer  
  AAH03026 (Get FASTA)   NCBI Sequence Viewer  
  AAH05320 (Get FASTA)   NCBI Sequence Viewer  
  AAH05982 (Get FASTA)   NCBI Sequence Viewer  
  AAH07104 (Get FASTA)   NCBI Sequence Viewer  
  AAH13915 (Get FASTA)   NCBI Sequence Viewer  
  AAH73992 (Get FASTA)   NCBI Sequence Viewer  
  AAH93076 (Get FASTA)   NCBI Sequence Viewer  
  AAI06031 (Get FASTA)   NCBI Sequence Viewer  
  AAI37058 (Get FASTA)   NCBI Sequence Viewer  
  AAI37059 (Get FASTA)   NCBI Sequence Viewer  
  AAU13906 (Get FASTA)   NCBI Sequence Viewer  
  ACJ13704 (Get FASTA)   NCBI Sequence Viewer  
  BAA05717 (Get FASTA)   NCBI Sequence Viewer  
  BAF82774 (Get FASTA)   NCBI Sequence Viewer  
  BAF83540 (Get FASTA)   NCBI Sequence Viewer  
  BAF85692 (Get FASTA)   NCBI Sequence Viewer  
  BAG38153 (Get FASTA)   NCBI Sequence Viewer  
  BAG59794 (Get FASTA)   NCBI Sequence Viewer  
  BAG70121 (Get FASTA)   NCBI Sequence Viewer  
  BAG70252 (Get FASTA)   NCBI Sequence Viewer  
  CAA37039 (Get FASTA)   NCBI Sequence Viewer  
  CAA68264 (Get FASTA)   NCBI Sequence Viewer  
  CAG32988 (Get FASTA)   NCBI Sequence Viewer  
  P62937 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_066953   ⟸   NM_021130
- Peptide Label: isoform 1
- UniProtKB: P62937 (UniProtKB/Swiss-Prot),   V9HWF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001287910   ⟸   NM_001300981
- Peptide Label: isoform 2
- UniProtKB: P62937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024302577   ⟸   XM_024446809
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024302576   ⟸   XM_024446808
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000479961   ⟸   ENST00000620047
RefSeq Acc Id: ENSP00000429251   ⟸   ENST00000479021
RefSeq Acc Id: ENSP00000405975   ⟸   ENST00000451562
RefSeq Acc Id: ENSP00000394670   ⟸   ENST00000415933
RefSeq Acc Id: ENSP00000419425   ⟸   ENST00000468812
RefSeq Acc Id: ENSP00000430817   ⟸   ENST00000355968
RefSeq Acc Id: ENSP00000427976   ⟸   ENST00000489459
RefSeq Acc Id: ENSP00000504621   ⟸   ENST00000676977
RefSeq Acc Id: ENSP00000504735   ⟸   ENST00000677107
RefSeq Acc Id: ENSP00000504216   ⟸   ENST00000677022
RefSeq Acc Id: ENSP00000502945   ⟸   ENST00000678805
RefSeq Acc Id: ENSP00000503804   ⟸   ENST00000678789
Protein Domains
PPIase cyclophilin-type

Promoters
RGD ID:7210529
Promoter ID:EPDNEW_H11011
Type:initiation region
Name:PPIA_1
Description:peptidylprolyl isomerase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,796,681 - 44,796,741EPDNEW
RGD ID:6806052
Promoter ID:HG_KWN:57272
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_021130,   OTTHUMT00000341786,   OTTHUMT00000341787,   OTTHUMT00000341788,   OTTHUMT00000341811,   UC003TLX.1,   UC010KYL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36744,802,271 - 44,802,962 (+)MPROMDB
RGD ID:6850844
Promoter ID:EP73217
Type:single initiation site
Name:HS_PPIA
Description:Peptidylprolyl isomerase A (cyclophilin A).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36744,802,805 - 44,802,865EPD
RGD ID:6806051
Promoter ID:HG_KWN:57273
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000341785,   OTTHUMT00000341789
Position:
Human AssemblyChrPosition (strand)Source
Build 36744,803,281 - 44,805,387 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p13-12.3(chr7:44193369-46558381)x1 copy number loss See cases [RCV000052316] Chr7:44193369..46558381 [GRCh38]
Chr7:44232968..46597979 [GRCh37]
Chr7:44199493..46564504 [NCBI36]
Chr7:7p13-12.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:39814159-45749735)x1 copy number loss See cases [RCV000053132] Chr7:39814159..45749735 [GRCh38]
Chr7:39853758..45789334 [GRCh37]
Chr7:39820283..45755859 [NCBI36]
Chr7:7p14.1-12.3
pathogenic
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 copy number gain See cases [RCV000053532] Chr7:33328312..62377476 [GRCh38]
Chr7:33367924..61831899 [GRCh37]
Chr7:33334449..61469334 [NCBI36]
Chr7:7p14.3-q11.21
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p13-12.1(chr7:44571949-53699760)x1 copy number loss See cases [RCV000134973] Chr7:44571949..53699760 [GRCh38]
Chr7:44611548..53767453 [GRCh37]
Chr7:44578073..53734947 [NCBI36]
Chr7:7p13-12.1
pathogenic
GRCh38/hg38 7p14.1-11.2(chr7:40534157-56107122)x1 copy number loss See cases [RCV000136092] Chr7:40534157..56107122 [GRCh38]
Chr7:40573756..56174815 [GRCh37]
Chr7:40540281..56142309 [NCBI36]
Chr7:7p14.1-11.2
pathogenic
GRCh38/hg38 7p14.1-12.1(chr7:40020598-50543500)x1 copy number loss See cases [RCV000136904] Chr7:40020598..50543500 [GRCh38]
Chr7:40060197..50611198 [GRCh37]
Chr7:40026722..50578692 [NCBI36]
Chr7:7p14.1-12.1
pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:37303478-48660738)x1 copy number loss See cases [RCV000137139] Chr7:37303478..48660738 [GRCh38]
Chr7:37343082..48700334 [GRCh37]
Chr7:37309607..48670880 [NCBI36]
Chr7:7p14.1-12.3
pathogenic
GRCh38/hg38 7p14.1-13(chr7:39063400-45363096)x1 copy number loss See cases [RCV000137305] Chr7:39063400..45363096 [GRCh38]
Chr7:39103000..45402695 [GRCh37]
Chr7:39069525..45369220 [NCBI36]
Chr7:7p14.1-13
pathogenic
GRCh38/hg38 7p13(chr7:44345798-45076469)x3 copy number gain See cases [RCV000140230] Chr7:44345798..45076469 [GRCh38]
Chr7:44385397..45116068 [GRCh37]
Chr7:44351922..45082593 [NCBI36]
Chr7:7p13
uncertain significance
GRCh38/hg38 7p14.1-13(chr7:38177999-45304100)x1 copy number loss See cases [RCV000142297] Chr7:38177999..45304100 [GRCh38]
Chr7:38217601..45343699 [GRCh37]
Chr7:38184126..45310224 [NCBI36]
Chr7:7p14.1-13
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p14.1-12.3(chr7:40350383-47034422)x1 copy number loss See cases [RCV000446941] Chr7:40350383..47034422 [GRCh37]
Chr7:7p14.1-12.3
pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p13(chr7:44688036-45364793)x3 copy number gain See cases [RCV000511814] Chr7:44688036..45364793 [GRCh37]
Chr7:7p13
likely benign
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p13(chr7:44620163-44961185)x3 copy number gain not provided [RCV000682830] Chr7:44620163..44961185 [GRCh37]
Chr7:7p13
uncertain significance
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p14.1-12.3(chr7:41124364-47945566) copy number loss Non-syndromic syndactyly [RCV001352654] Chr7:41124364..47945566 [GRCh37]
Chr7:7p14.1-12.3
pathogenic
GRCh37/hg19 7p13-12.2(chr7:43341583-50171623) copy number loss Intracranial hemorrhage [RCV001352658] Chr7:43341583..50171623 [GRCh37]
Chr7:7p13-12.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9253 AgrOrtholog
COSMIC PPIA COSMIC
Ensembl Genes ENSG00000196262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000394670 UniProtKB/TrEMBL
  ENSP00000405975 UniProtKB/TrEMBL
  ENSP00000419425 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429251 UniProtKB/TrEMBL
  ENSP00000430817 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000479961 UniProtKB/TrEMBL
  ENSP00000502945 UniProtKB/Swiss-Prot
  ENSP00000503804 UniProtKB/Swiss-Prot
  ENSP00000504216 UniProtKB/Swiss-Prot
  ENSP00000504293 UniProtKB/TrEMBL
  ENSP00000504621 UniProtKB/TrEMBL
  ENSP00000504735 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000355968 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000415933 UniProtKB/TrEMBL
  ENST00000451562 UniProtKB/TrEMBL
  ENST00000468812 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000479021 UniProtKB/TrEMBL
  ENST00000480603 UniProtKB/TrEMBL
  ENST00000489459 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000620047 UniProtKB/TrEMBL
  ENST00000676977 UniProtKB/TrEMBL
  ENST00000677022 UniProtKB/Swiss-Prot
  ENST00000677107 UniProtKB/Swiss-Prot
  ENST00000678789 UniProtKB/Swiss-Prot
  ENST00000678805 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000196262 GTEx
HGNC ID HGNC:9253 ENTREZGENE
Human Proteome Map PPIA Human Proteome Map
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5478 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5478 ENTREZGENE
OMIM 123840 OMIM
Pfam Pro_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33574 PharmGKB
PIRSF Peptidylpro_ismrse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50891 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7I2V4V1_HUMAN UniProtKB/TrEMBL
  A0A7I2V5J5_HUMAN UniProtKB/TrEMBL
  A0A7P0S768_HUMAN UniProtKB/TrEMBL
  C9J5S7_HUMAN UniProtKB/TrEMBL
  E5RIZ5_HUMAN UniProtKB/TrEMBL
  F8WE65_HUMAN UniProtKB/TrEMBL
  P62937 ENTREZGENE, UniProtKB/Swiss-Prot
  V9HWF5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A8K220 UniProtKB/Swiss-Prot
  P05092 UniProtKB/Swiss-Prot
  Q3KQW3 UniProtKB/Swiss-Prot
  Q567Q0 UniProtKB/Swiss-Prot
  Q6IBU5 UniProtKB/Swiss-Prot
  Q96IX3 UniProtKB/Swiss-Prot
  Q9BRU4 UniProtKB/Swiss-Prot
  Q9BTY9 UniProtKB/Swiss-Prot
  Q9UC61 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 PPIA  peptidylprolyl isomerase A    peptidylprolyl isomerase A (cyclophilin A)  Symbol and/or name change 5135510 APPROVED
2011-08-16 PPIA  peptidylprolyl isomerase A (cyclophilin A)  PPIA  peptidylprolyl isomerase A (cyclophilin A)  Symbol and/or name change 5135510 APPROVED