Aldob (aldolase, fructose-bisphosphate B) - Rat Genome Database

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Gene: Aldob (aldolase, fructose-bisphosphate B) Rattus norvegicus
Analyze
Symbol: Aldob
Name: aldolase, fructose-bisphosphate B
RGD ID: 2090
Description: Enables fructose-bisphosphate aldolase activity and phosphatidylcholine binding activity. Involved in several processes, including cellular response to insulin stimulus; response to copper ion; and response to fructose. Located in perinuclear region of cytoplasm; rough endoplasmic reticulum membrane; and smooth endoplasmic reticulum membrane. Used to study type 2 diabetes mellitus. Biomarker of liver benign neoplasm; peritonitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B); PARTICIPATES IN forkhead class A signaling pathway; fructose and mannose metabolic pathway; fructosuria pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Aldo2; aldolase B; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B; LIV10; liver-type aldolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8568,684,541 - 68,697,582 (-)NCBIGRCr8
mRatBN7.2563,889,045 - 63,902,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl563,889,046 - 63,902,116 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx565,820,242 - 65,833,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0567,639,574 - 67,652,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0567,608,954 - 67,621,988 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,805,772 - 64,818,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,805,773 - 64,818,824 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0569,297,185 - 69,312,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4566,283,165 - 66,296,171 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1566,288,278 - 66,301,295 (-)NCBI
Celera563,706,063 - 63,718,940 (+)NCBICelera
RH 3.4 Map5428.2RGD
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-methylphenanthrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
alcohol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
chlorpyrifos  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP)
fenthion  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
folpet  (ISO)
fructose  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
inulin  (ISO)
iron(III) citrate  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
metronidazole  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
neomycin  (EXP)
niclosamide  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
tebuconazole  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Association of the widespread A149P hereditary fructose intolerance mutation with newly identified sequence polymorphisms in the aldolase B gene. Brooks CC and Tolan DR, Am J Hum Genet 1993 Apr;52(4):835-40.
2. Altered levels of mRNA encoding enzymes of hepatic glucose metabolism in septic rats. Chang CK, etal., Circ Shock. 1993 Sep;41(1):35-9.
3. Gene expression in rats with Barrett's esophagus and esophageal adenocarcinoma induced by gastroduodenoesophageal reflux. Cheng P, etal., World J Gastroenterol. 2005 Sep 7;11(33):5117-22.
4. Zinc inhibition of hepatic fructose metabolism in rats. Coyle P, etal., Biol Trace Elem Res. 2003 Apr;92(1):41-54.
5. Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population. Daimon M, etal., Biochem Biophys Res Commun. 2003 Mar 21;302(4):751-8.
6. Microstructured scaffolds for liver tissue cultures of high cell density: morphological and biochemical characterization of tissue aggregates. Eschbach E, etal., J Cell Biochem. 2005 May 15;95(2):243-55.
7. Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. Esposito G, etal., Hum Mutat. 2004 Dec;24(6):534.
8. Intracellular localization of fructose 1,6-bisphosphate aldolase. Foemmel RS, etal., J Biol Chem. 1975 Mar 10;250(5):1892-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Location of adult and fetal aldolases A, B, and C by immunoperoxidase technique in LF fast-growing rat hepatomas. Hatzfeld A, etal., Cancer Res. 1978 Jan;38(1):16-22.
12. Interleukin-6 down-regulates expressions of the aldolase B and albumin genes through a pathway involving the activation of tyrosine kinase. Huang Y, etal., Arch Biochem Biophys. 1995 Jul 10;320(2):203-9.
13. Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. Ishii Y, etal., Toxicology. 1997 Jan 15;116(1-3):193-9.
14. Hormonal regulation of aldolase B gene expression in rat primary cultured hepatocytes. Ito J, etal., Arch Biochem Biophys. 1998 Feb 15;350(2):291-7.
15. Developmental alteration of the chromatin state at promoter/replication origin region of the aldolase B locus precedes transcriptional activation in the liver. Ito K, etal., Dev Genet. 1995;17(4):312-8.
16. Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Koo HY, etal., Biochim Biophys Acta. 2008 May;1782(5):341-8. Epub 2008 Feb 29.
17. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
18. Ubiquitinated aldolase B accumulates during starvation-induced lysosomal proteolysis. Lenk SE, etal., J Cell Physiol. 1999 Jan;178(1):17-27.
19. Single step purification of rat liver aldolase using immobilized artificial membrane chromatography. Liu H, etal., J Chromatogr B Biomed Sci Appl. 1997 Dec 5;703(1-2):53-62.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Hepatic fructose-metabolizing enzymes and related metabolites: role of dietary copper and gender. Millo H and Werman MJ, J Nutr Biochem. 2000 Jul-Aug;11(7-8):374-81.
22. Binding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B origin. Minami H, etal., Mol Cell Biol. 2006 Dec;26(23):8770-80. Epub 2006 Sep 18.
23. Dietary and hormonal regulation of aldolase B gene expression. Munnich A, etal., J Clin Invest. 1985 Mar;75(3):1045-52.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways. Ndisang JF, etal., Endocrinology. 2009 May;150(5):2098-108. Epub 2008 Dec 23.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma. Parimala R and Sachdanandam P, Mol Cell Biochem. 1993 Aug 11;125(1):59-63.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Differential gene expression in rats following subacute exposure to the anticonvulsant sodium valproate. Plant N, etal., Toxicol Appl Pharmacol. 2002 Sep 1;183(2):127-34.
32. Response of rat cerebral glycolytic enzymes to hyperammonemic states. Ratnakumari L and Murthy CR, Neurosci Lett. 1993 Oct 14;161(1):37-40.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. Aldolase variants: structure and physiological significance. Rutter WJ, etal., Ann N Y Acad Sci. 1968 Jun 14;151(1):102-17.
38. Subcellular localization of aldolase B. Saez DE and Slebe JC, J Cell Biochem. 2000 Apr;78(1):62-72.
39. Microsomal glutathione transferase 1 is not S-nitrosylated in rat liver microsomes or in endotoxin challenged rats. Shi Q and Lou YJ, Pharmacol Res. 2005 Apr;51(4):303-10.
40. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Shih DQ, etal., Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.
41. Molecular cloning of cDNA for rat L-type pyruvate kinase and aldolase B. Simon MP, etal., J Biol Chem. 1983 Dec 10;258(23):14576-84.
42. Characterization of the responsive elements to hormones in the rat aldolase B gene. Takano Y, etal., Arch Biochem Biophys. 2000 May 1;377(1):58-64.
43. Nucleotide sequence of rat liver aldolase B messenger RNA. Tsutsumi K, etal., J Biol Chem 1984 Dec 10;259(23):14572-5.
44. Rat aldolase isozyme gene. Tsutsumi K, etal., J Biol Chem. 1983 May 25;258(10):6537-42.
45. Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. Wang H, etal., J Biol Chem. 2000 Nov 17;275(46):35953-9.
46. Different involvement for aldolase isoenzymes in kidney glucose metabolism: aldolase B but not aldolase A colocalizes and forms a complex with FBPase. Yanez AJ, etal., J Cell Physiol. 2005 Mar;202(3):743-53.
Additional References at PubMed
PMID:604178   PMID:1834654   PMID:2580098   PMID:2649152   PMID:3383242   PMID:6696436   PMID:9244396   PMID:10625657   PMID:12477932   PMID:17576770   PMID:18000879   PMID:21890532  
PMID:23376485   PMID:23533145   PMID:25637246   PMID:26417114   PMID:27923787  


Genomics

Comparative Map Data
Aldob
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8568,684,541 - 68,697,582 (-)NCBIGRCr8
mRatBN7.2563,889,045 - 63,902,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl563,889,046 - 63,902,116 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx565,820,242 - 65,833,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0567,639,574 - 67,652,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0567,608,954 - 67,621,988 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,805,772 - 64,818,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,805,773 - 64,818,824 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0569,297,185 - 69,312,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4566,283,165 - 66,296,171 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1566,288,278 - 66,301,295 (-)NCBI
Celera563,706,063 - 63,718,940 (+)NCBICelera
RH 3.4 Map5428.2RGD
Cytogenetic Map5q22NCBI
ALDOB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389101,420,560 - 101,435,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9101,420,560 - 101,449,664 (-)EnsemblGRCh38hg38GRCh38
GRCh379104,182,842 - 104,198,056 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369103,223,479 - 103,237,926 (-)NCBINCBI36Build 36hg18NCBI36
Build 349101,263,213 - 101,277,660NCBI
Celera974,696,447 - 74,711,667 (-)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef973,782,293 - 73,797,509 (-)NCBIHuRef
CHM1_19104,329,256 - 104,344,476 (-)NCBICHM1_1
T2T-CHM13v2.09113,592,536 - 113,607,747 (-)NCBIT2T-CHM13v2.0
Aldob
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39449,535,993 - 49,549,546 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl449,535,995 - 49,549,546 (-)EnsemblGRCm39 Ensembl
GRCm38449,535,993 - 49,549,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl449,535,995 - 49,549,546 (-)EnsemblGRCm38mm10GRCm38
MGSCv37449,548,867 - 49,562,355 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36449,557,095 - 49,570,583 (-)NCBIMGSCv36mm8
Celera449,564,249 - 49,577,800 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.57NCBI
Aldob
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541924,377,427 - 24,389,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541924,377,427 - 24,389,909 (+)NCBIChiLan1.0ChiLan1.0
ALDOB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,931,727 - 37,950,064 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1937,934,099 - 37,952,436 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0972,630,064 - 72,650,918 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19100,624,151 - 100,645,030 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9100,624,151 - 100,638,597 (-)Ensemblpanpan1.1panPan2
ALDOB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11158,150,621 - 58,166,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1158,150,967 - 58,176,319 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1156,596,344 - 56,610,538 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01159,287,382 - 59,301,579 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1159,284,442 - 59,301,485 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11157,797,128 - 57,811,322 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01157,810,165 - 57,824,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01158,507,786 - 58,521,987 (-)NCBIUU_Cfam_GSD_1.0
Aldob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947173,036,560 - 173,048,699 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365249,584,140 - 9,596,276 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365249,584,302 - 9,592,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDOB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1243,110,585 - 243,141,418 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11243,127,870 - 243,141,504 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21271,728,934 - 271,735,543 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDOB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11237,993,367 - 38,021,693 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1238,007,265 - 38,021,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660354,531,807 - 4,546,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldob
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247589,868,260 - 9,880,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247589,868,223 - 9,880,205 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldob
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:135
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000009111
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598814Mcs13Mammary carcinoma susceptibility QTL 130.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)56319089069927503Rat

Markers in Region
RH94455  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2563,889,065 - 63,889,239 (+)MAPPERmRatBN7.2
Rnor_6.0564,805,793 - 64,805,966NCBIRnor6.0
Rnor_5.0569,297,206 - 69,297,379UniSTSRnor5.0
RGSC_v3.4566,283,186 - 66,283,359UniSTSRGSC3.4
Celera563,718,746 - 63,718,919UniSTS
RH 3.4 Map5428.2UniSTS
Cytogenetic Map5q22UniSTS
RH129135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2563,889,074 - 63,889,287 (+)MAPPERmRatBN7.2
Rnor_6.0564,805,802 - 64,806,014NCBIRnor6.0
Rnor_5.0569,297,215 - 69,297,427UniSTSRnor5.0
RGSC_v3.4566,283,195 - 66,283,407UniSTSRGSC3.4
Celera563,718,698 - 63,718,910UniSTS
RH 3.4 Map5428.2UniSTS
Cytogenetic Map5q22UniSTS
RH129202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2563,889,080 - 63,889,232 (+)MAPPERmRatBN7.2
Rnor_6.0564,805,808 - 64,805,959NCBIRnor6.0
Rnor_5.0569,297,221 - 69,297,372UniSTSRnor5.0
RGSC_v3.4566,283,201 - 66,283,352UniSTSRGSC3.4
Celera563,718,753 - 63,718,904UniSTS
RH 3.4 Map5425.2UniSTS
Cytogenetic Map5q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 27 27 27 23
Medium 3 16 14 14 8 5 2
Low 14 14 17 8 9 31 4 28 6 8
Below cutoff 19 1 2 31 8 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M10149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009111   ⟹   ENSRNOP00000009111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl563,890,296 - 63,902,116 (-)Ensembl
Rnor_6.0 Ensembl564,805,773 - 64,818,813 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086505   ⟹   ENSRNOP00000075134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl563,889,046 - 63,902,097 (-)Ensembl
Rnor_6.0 Ensembl564,805,773 - 64,818,824 (-)Ensembl
RefSeq Acc Id: NM_012496   ⟹   NP_036628
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8568,684,541 - 68,697,582 (-)NCBI
mRatBN7.2563,889,045 - 63,902,086 (-)NCBI
Rnor_6.0564,805,772 - 64,818,813 (-)NCBI
Rnor_5.0569,297,185 - 69,312,980 (-)NCBI
RGSC_v3.4566,283,165 - 66,296,171 (-)RGD
Celera563,706,063 - 63,718,940 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036628   ⟸   NM_012496
- UniProtKB: P70706 (UniProtKB/Swiss-Prot),   P00884 (UniProtKB/Swiss-Prot),   Q66HT1 (UniProtKB/TrEMBL),   A0A0G2K9U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009111   ⟸   ENSRNOT00000009111
RefSeq Acc Id: ENSRNOP00000075134   ⟸   ENSRNOT00000086505

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00884-F1-model_v2 AlphaFold P00884 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693735
Promoter ID:EPDNEW_R4256
Type:multiple initiation site
Name:Aldob_1
Description:aldolase, fructose-bisphosphate B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0564,818,833 - 64,818,893EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2090 AgrOrtholog
BioCyc Gene G2FUF-41326 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY66-373 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000006807 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009111.6 UniProtKB/TrEMBL
  ENSRNOT00000086505 ENTREZGENE
  ENSRNOT00000086505.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109764 IMAGE-MGC_LOAD
InterPro Aldolase_I_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FBA_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24190 UniProtKB/TrEMBL
MGC_CLONE MGC:93076 IMAGE-MGC_LOAD
NCBI Gene 24190 ENTREZGENE
PANTHER FRUCTOSE-BISPHOSPHATE ALDOLASE B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glycolytic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aldob PhenoGen
PROSITE ALDOLASE_CLASS_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006807 RatGTEx
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9U5 ENTREZGENE, UniProtKB/TrEMBL
  A6KJD9_RAT UniProtKB/TrEMBL
  A6KJE0_RAT UniProtKB/TrEMBL
  A6KJE2_RAT UniProtKB/TrEMBL
  ALDOB_RAT UniProtKB/Swiss-Prot
  F7FHU2_RAT UniProtKB/TrEMBL
  P00884 ENTREZGENE
  P70706 ENTREZGENE
  Q66HT1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P70706 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Aldob  aldolase, fructose-bisphosphate B  Aldob  aldolase B, fructose-bisphosphate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-18 Aldob  aldolase B, fructose-bisphosphate  Aldob  aldolase B fructose-bisphosphate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Aldob  aldolase B fructose-bisphosphate  Aldob  aldolase B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Aldob  aldolase B    Aldolase B, fructose-biphosphate  Name updated 625702 APPROVED
2002-06-10 Aldob  Aldolase B, fructose-biphosphate      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 632187
gene_product member of the aldolase enzyme family 632188
gene_protein encodes a protein sequence of 364 amino acid residues 632187