Uvrag (UV radiation resistance associated) - Rat Genome Database

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Gene: Uvrag (UV radiation resistance associated) Rattus norvegicus
Analyze
Symbol: Uvrag
Name: UV radiation resistance associated
RGD ID: 1589754
Description: Predicted to enable SH3 domain binding activity and SNARE binding activity. Predicted to be involved in several processes, including SNARE complex assembly; double-strand break repair via classical nonhomologous end joining; and microtubule cytoskeleton organization. Predicted to act upstream of or within symbiont entry into host cell. Predicted to be located in several cellular components, including cytoplasmic vesicle; midbody; and vacuole. Predicted to be part of DNA-dependent protein kinase complex and phosphatidylinositol 3-kinase complex, class III. Predicted to be active in endosome and lytic vacuole. Orthologous to human UVRAG (UV radiation resistance associated); PARTICIPATES IN autophagy pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308846; similar to UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance-associated gene protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,596,514 - 162,854,348 (-)NCBIGRCr8
mRatBN7.21153,185,356 - 153,442,200 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,185,395 - 153,442,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,182,222 - 161,438,380 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,362,388 - 168,618,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,235,906 - 161,492,053 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,844,804 - 164,101,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,844,818 - 164,101,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,047,877 - 170,304,150 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,194,649 - 156,435,696 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1151,290,816 - 151,527,565 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
leflunomide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
sodium chromate  (ISO)
testosterone  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
Additional References at PubMed
PMID:12477932   PMID:15623521   PMID:17891140   PMID:19270696   PMID:20643123   PMID:22493499   PMID:22542840   PMID:24056303   PMID:24550300   PMID:28306502  


Genomics

Comparative Map Data
Uvrag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,596,514 - 162,854,348 (-)NCBIGRCr8
mRatBN7.21153,185,356 - 153,442,200 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,185,395 - 153,442,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,182,222 - 161,438,380 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,362,388 - 168,618,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,235,906 - 161,492,053 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,844,804 - 164,101,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,844,818 - 164,101,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,047,877 - 170,304,150 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,194,649 - 156,435,696 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1151,290,816 - 151,527,565 (-)NCBICelera
Cytogenetic Map1q32NCBI
UVRAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,815,210 - 76,144,232 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,815,210 - 76,144,232 (+)EnsemblGRCh38hg38GRCh38
GRCh371175,526,255 - 75,855,276 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,203,860 - 75,532,930 (+)NCBINCBI36Build 36hg18NCBI36
Build 341175,203,922 - 75,531,342NCBI
Celera1172,834,011 - 73,163,074 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1171,822,964 - 72,152,180 (+)NCBIHuRef
CHM1_11175,409,808 - 75,738,738 (+)NCBICHM1_1
T2T-CHM13v2.01175,744,934 - 76,073,948 (+)NCBIT2T-CHM13v2.0
Uvrag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,535,949 - 98,790,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,534,228 - 98,790,348 (-)EnsemblGRCm39 Ensembl
GRCm38798,886,742 - 99,141,167 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,885,021 - 99,141,141 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,035,253 - 106,289,654 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36798,761,944 - 99,016,305 (-)NCBIMGSCv36mm8
Celera799,208,465 - 99,465,675 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.92NCBI
Uvrag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541415,731,519 - 16,043,555 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541415,733,116 - 16,043,555 (-)NCBIChiLan1.0ChiLan1.0
UVRAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2976,742,134 - 77,066,961 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11177,784,598 - 78,112,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,870,341 - 71,197,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11174,172,678 - 74,496,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,172,919 - 74,496,046 (+)Ensemblpanpan1.1panPan2
UVRAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,505,968 - 22,821,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,507,162 - 22,820,824 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,272,215 - 22,586,892 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02122,710,811 - 23,024,221 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2122,709,593 - 23,024,214 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12122,485,190 - 22,823,262 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02122,704,676 - 23,019,383 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02122,623,729 - 22,937,005 (-)NCBIUU_Cfam_GSD_1.0
Uvrag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,955,789 - 63,269,496 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,555,276 - 4,870,896 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,555,325 - 4,869,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UVRAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,088,798 - 10,370,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,088,779 - 10,370,857 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,196,380 - 11,457,245 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UVRAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,032,575 - 67,353,207 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,032,436 - 67,353,166 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604358,449,006 - 58,771,147 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uvrag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624817989,362 - 1,371,096 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uvrag
1311 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:396
Count of miRNA genes:203
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000022176
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat

Markers in Region
D1Rat468  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,221,561 - 153,221,779 (+)MAPPERmRatBN7.2
Rnor_6.01163,880,997 - 163,881,214NCBIRnor6.0
Rnor_5.01170,084,070 - 170,084,287UniSTSRnor5.0
RGSC_v3.41156,212,393 - 156,212,611RGDRGSC3.4
RGSC_v3.41156,212,394 - 156,212,611UniSTSRGSC3.4
RGSC_v3.11156,290,799 - 156,291,017RGD
Celera1151,307,669 - 151,307,886UniSTS
FHH x ACI Map169.95RGD
FHH x ACI Map169.95UniSTS
Cytogenetic Map1q32UniSTS
D1Rat422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,345,474 - 153,345,631 (+)MAPPERmRatBN7.2
Rnor_6.01164,005,123 - 164,005,277NCBIRnor6.0
Rnor_5.01170,208,005 - 170,208,159UniSTSRnor5.0
RGSC_v3.41156,339,115 - 156,339,270RGDRGSC3.4
RGSC_v3.41156,339,116 - 156,339,270UniSTSRGSC3.4
RGSC_v3.11156,417,521 - 156,417,676RGD
Celera1151,431,504 - 151,431,628UniSTS
SHRSP x BN Map177.8599RGD
SHRSP x BN Map177.8599UniSTS
Cytogenetic Map1q32UniSTS
BM387130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,366,671 - 153,366,841 (+)MAPPERmRatBN7.2
Rnor_6.01164,026,316 - 164,026,485NCBIRnor6.0
Rnor_5.01170,229,198 - 170,229,367UniSTSRnor5.0
RGSC_v3.41156,360,309 - 156,360,478UniSTSRGSC3.4
Celera1151,452,662 - 151,452,831UniSTS
RH 3.4 Map11232.7UniSTS
Cytogenetic Map1q32UniSTS
BE105509  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,429,872 - 153,430,031 (+)MAPPERmRatBN7.2
Rnor_6.01164,088,916 - 164,089,074NCBIRnor6.0
Rnor_5.01170,291,498 - 170,291,656UniSTSRnor5.0
RGSC_v3.41156,423,379 - 156,423,537UniSTSRGSC3.4
Celera1151,515,211 - 151,515,369UniSTS
RH 3.4 Map11231.8UniSTS
Cytogenetic Map1q32UniSTS
AU047929  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,441,449 - 153,441,610 (+)MAPPERmRatBN7.2
Rnor_6.01164,100,828 - 164,100,990NCBIRnor6.0
Rnor_5.01170,303,410 - 170,303,572UniSTSRnor5.0
RGSC_v3.41156,434,956 - 156,435,118UniSTSRGSC3.4
Celera1151,526,823 - 151,526,987UniSTS
Cytogenetic Map1q32UniSTS
AW535888  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,204,648 - 153,204,804 (+)MAPPERmRatBN7.2
Rnor_6.01163,864,084 - 163,864,239NCBIRnor6.0
Rnor_5.01170,067,157 - 170,067,312UniSTSRnor5.0
RGSC_v3.41156,194,724 - 156,194,879UniSTSRGSC3.4
Celera1151,290,891 - 151,291,046UniSTS
RH 3.4 Map11214.5UniSTS
Cytogenetic Map1q32UniSTS
AA957656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,185,537 - 153,185,700 (+)MAPPERmRatBN7.2
Rnor_6.01163,844,986 - 163,845,148NCBIRnor6.0
Rnor_5.01170,048,059 - 170,048,221UniSTSRnor5.0
RGSC_v3.41156,173,387 - 156,173,549UniSTSRGSC3.4
Celera1151,271,725 - 151,271,887UniSTS
RH 3.4 Map11214.3UniSTS
Cytogenetic Map1q32UniSTS
AU048854  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,345,481 - 153,345,718 (+)MAPPERmRatBN7.2
Rnor_6.01164,005,130 - 164,005,364NCBIRnor6.0
Rnor_5.01170,208,012 - 170,208,246UniSTSRnor5.0
RGSC_v3.41156,339,123 - 156,339,357UniSTSRGSC3.4
Celera1151,431,511 - 151,431,715UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 57 41 19 41 74 35 39 11
Low 19 8 11 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022176   ⟹   ENSRNOP00000022176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1153,185,395 - 153,442,136 (-)Ensembl
Rnor_6.0 Ensembl1163,844,818 - 164,101,578 (-)Ensembl
RefSeq Acc Id: NM_001107536   ⟹   NP_001101006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,615,732 - 162,854,346 (-)NCBI
mRatBN7.21153,204,574 - 153,442,189 (-)NCBI
Rnor_6.01163,864,009 - 164,101,568 (-)NCBI
Rnor_5.01170,047,877 - 170,304,150 (-)NCBI
RGSC_v3.41156,194,649 - 156,435,696 (-)RGD
Celera1151,290,816 - 151,527,565 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401542   ⟹   NP_001388471
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,596,515 - 162,854,348 (-)NCBI
mRatBN7.21153,185,357 - 153,442,191 (-)NCBI
RefSeq Acc Id: XM_039113238   ⟹   XP_038969166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,599,895 - 162,854,186 (-)NCBI
mRatBN7.21153,188,737 - 153,442,200 (-)NCBI
RefSeq Acc Id: XM_039113251   ⟹   XP_038969179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,596,514 - 162,777,037 (-)NCBI
mRatBN7.21153,185,356 - 153,365,941 (-)NCBI
RefSeq Acc Id: XM_039113255   ⟹   XP_038969183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,681,501 - 162,854,186 (-)NCBI
mRatBN7.21153,273,945 - 153,442,196 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001101006   ⟸   NM_001107536
- Peptide Label: isoform 2
- UniProtKB: A6I6F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022176   ⟸   ENSRNOT00000022176
RefSeq Acc Id: XP_038969179   ⟸   XM_039113251
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038969166   ⟸   XM_039113238
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038969183   ⟸   XM_039113255
- Peptide Label: isoform X3
- UniProtKB: A6I6F6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388471   ⟸   NM_001401542
- Peptide Label: isoform 1
- UniProtKB: D3ZKE1 (UniProtKB/TrEMBL),   A6I6F4 (UniProtKB/TrEMBL)
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKE1-F1-model_v2 AlphaFold D3ZKE1 1-698 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690225
Promoter ID:EPDNEW_R748
Type:initiation region
Name:Uvrag_1
Description:UV radiation resistance associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,101,541 - 164,101,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589754 AgrOrtholog
BioCyc Gene G2FUF-58412 BioCyc
Ensembl Genes ENSRNOG00000016206 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022176 ENTREZGENE
  ENSRNOT00000022176.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  UV_resistance/autophagy_Atg14 UniProtKB/TrEMBL
  Vps38 UniProtKB/TrEMBL
KEGG Report rno:308846 UniProtKB/TrEMBL
NCBI Gene 308846 ENTREZGENE
PANTHER UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN UniProtKB/TrEMBL
  UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN UniProtKB/TrEMBL
Pfam Atg14 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  VPS38 UniProtKB/TrEMBL
PhenoGen Uvrag PhenoGen
PROSITE PS50004 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016206 RatGTEx
SMART SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
UniProt A6I6F4 ENTREZGENE, UniProtKB/TrEMBL
  A6I6F5 ENTREZGENE, UniProtKB/TrEMBL
  A6I6F6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKE1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Uvrag  UV radiation resistance associated  Uvrag  UV radiation resistance associated gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Uvrag  UV radiation resistance associated gene  LOC308846  similar to UV radiation resistance associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC308846  similar to UV radiation resistance associated      Symbol and Name status set to provisional 70820 PROVISIONAL