Fxr1 (FMR1 autosomal homolog 1) - Rat Genome Database

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Gene: Fxr1 (FMR1 autosomal homolog 1) Rattus norvegicus
Analyze
Symbol: Fxr1
Name: FMR1 autosomal homolog 1
RGD ID: 1311733
Description: Predicted to enable several functions, including RNA binding activity; molecular condensate scaffold activity; and protein dimerization activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; nucleus organization; and regulation of gene expression. Predicted to be located in several cellular components, including costamere; dendritic spine; and ribosome. Predicted to be active in several cellular components, including cytoplasmic stress granule; glutamatergic synapse; and nuclear envelope. Human ortholog(s) of this gene implicated in congenital myopathy 9A and congenital myopathy 9B. Orthologous to human FXR1 (FMR1 autosomal homolog 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fragile X mental retardation gene 1, autosomal homolog; fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; Fxr1h; LOC100366044; LOC361927; rCG41429-like; RNA-binding protein FXR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Fxr1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82118,812,287 - 118,865,813 (+)NCBIGRCr8
mRatBN7.22116,884,167 - 116,937,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2123,473,867 - 123,526,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02121,586,534 - 121,638,784 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02116,215,601 - 116,266,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02120,529,716 - 120,570,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2120,512,899 - 120,570,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02140,165,289 - 140,213,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42120,330,045 - 120,378,482 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12120,275,008 - 120,323,418 (+)NCBI
Celera2111,923,546 - 111,975,799 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Fxr1Rat3-methylglutaconic aciduria type 5  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-methylglutaconic aciduria type 5ClinVarPMID:16055927 more ...
Fxr1Ratcongenital myopathy  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital myopathyClinVarPMID:25741868
Fxr1Ratcongenital myopathy 1B  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Multiminicore myopathyClinVarPMID:25741868 and PMID:30770808
Fxr1Ratcongenital myopathy 9A  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Myopathy more ...ClinVarPMID:25741868 more ...
Fxr1Ratcongenital myopathy 9B  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Myopathy more ...ClinVarPMID:25741868 more ...
Fxr1RatCurrarino syndrome  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Currarino triadClinVarPMID:21681106 and PMID:27549440
Fxr1Ratintellectual disability  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:30167849
Fxr1Ratscoliosis  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: ScoliosisClinVarPMID:25741868
Fxr1Ratsyndromic microphthalmia 3  ISOFXR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Anophthalmia/microphthalmia-esophageal atresia syndromeClinVarPMID:16543359
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Original Reference(s)
Fxr1Ratcongenital myopathy 9A  ISOFXR1 (Homo sapiens)7240710 OMIM 
Fxr1Ratcongenital myopathy 9B  ISOFXR1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Fxr1Rat1,2-dichloroethane decreases expressionISOFxr1 (Mus musculus)6480464ethylene dichloride results in decreased expression of FXR1 mRNACTDPMID:28960355
Fxr1Rat1,2-dimethylhydrazine multiple interactionsISOFxr1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FXR1 mRNACTDPMID:22206623
Fxr1Rat1,2-dimethylhydrazine decreases expressionISOFxr1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of FXR1 mRNACTDPMID:22206623
Fxr1Rat17alpha-ethynylestradiol increases expressionISOFxr1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of FXR1 mRNACTDPMID:17942748
Fxr1Rat17alpha-ethynylestradiol multiple interactionsISOFxr1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXR1 mRNACTDPMID:17942748
Fxr1Rat17beta-estradiol increases expressionISOFxr1 (Mus musculus)6480464Estradiol results in increased expression of FXR1 mRNACTDPMID:39298647
Fxr1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOFXR1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of FXR1 mRNACTDPMID:17101203
Fxr1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOFxr1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXR1 mRNACTDPMID:17942748
Fxr1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Fxr1Rat2,4,6-tribromophenol decreases expressionISOFXR1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Fxr1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of FXR1 mRNACTDPMID:21346803
Fxr1Rat2-hydroxypropanoic acid increases expressionISOFXR1 (Homo sapiens)6480464Lactic Acid results in increased expression of FXR1 mRNACTDPMID:30851411
Fxr1Rat2-methylcholine affects expressionISOFXR1 (Homo sapiens)6480464beta-methylcholine affects the expression of FXR1 mRNACTDPMID:21179406
Fxr1Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOFXR1 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of FXR1 proteinCTDPMID:31675489
Fxr1Rat4,4'-sulfonyldiphenol increases expressionISOFxr1 (Mus musculus)6480464bisphenol S results in increased expression of FXR1 mRNACTDPMID:39298647
Fxr1Rat4,4'-sulfonyldiphenol increases methylationISOFXR1 (Homo sapiens)6480464bisphenol S results in increased methylation of FXR1 geneCTDPMID:31601247
Fxr1Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of FXR1 mRNACTDPMID:28959563
Fxr1Ratacrylamide increases expressionISOFXR1 (Homo sapiens)6480464Acrylamide results in increased expression of FXR1 mRNACTDPMID:32763439
Fxr1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of FXR1 mRNACTDPMID:35163327
Fxr1Ratamphotericin B decreases expressionISOFXR1 (Homo sapiens)6480464Amphotericin B analog results in decreased expression of FXR1 mRNACTDPMID:28534445

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Biological Process
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Original Reference(s)
Fxr1Ratanimal organ development involved_inIBAFB:FBgn0028734 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fxr1Ratcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
Fxr1Ratdentate gyrus development involved_inISSUniProtKB:Q615841600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratdentate gyrus development involved_inISOFxr1 (Mus musculus)1624291 PMID:28204491RGDPMID:28204491
Fxr1Ratmembraneless organelle assembly acts_upstream_of_or_withinISOFxr1 (Mus musculus)1624291 PMID:35951695RGDPMID:35951695
Fxr1Ratmembraneless organelle assembly involved_inISOFxr1 (Mus musculus)1624291 PMID:35951695RGDPMID:35951695
Fxr1Ratmembraneless organelle assembly involved_inISSUniProtKB:Q615841600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratmembraneless organelle assembly involved_inISOFXR1 (Homo sapiens)1624291 PMID:39106863RGDPMID:39106863
Fxr1RatmRNA destabilization involved_inISOFXR1 (Homo sapiens)1624291 PMID:30067974RGDPMID:30067974
Fxr1RatmRNA destabilization involved_inISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1RatmRNA transport involved_inIBAFB:FBgn0028734 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fxr1Ratmuscle organ development involved_inISOFxr1 (Mus musculus)1624291 PMID:30770808 and PMID:32328638RGDPMID:30770808 and PMID:32328638
Fxr1Ratmuscle organ development acts_upstream_of_or_withinISOFxr1 (Mus musculus)1624291MGI:3046846 PMID:15128702RGDPMID:15128702
Fxr1Ratmuscle organ development involved_inISOFXR1 (Homo sapiens)1624291 PMID:30770808RGDPMID:30770808
Fxr1Ratmuscle organ development involved_inIEAUniProtKB-KW:KW-05171600115GO_REF:0000043UniProtGO_REF:0000043
Fxr1Ratmuscle organ development involved_inISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratmuscle structure development involved_inIEAARBA:ARBA000436251600115GO_REF:0000117UniProtGO_REF:0000117
Fxr1Ratnegative regulation of inflammatory response involved_inISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratnegative regulation of inflammatory response involved_inISOFXR1 (Homo sapiens)1624291 PMID:30067974RGDPMID:30067974
Fxr1Ratnegative regulation of long-term synaptic potentiation involved_inISOFxr1 (Mus musculus)1624291 PMID:25456134RGDPMID:25456134
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Cellular Component
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Original Reference(s)
Fxr1Rataxon located_inISOFxr1 (Mus musculus)1624291 PMID:22022532RGDPMID:22022532
Fxr1Rataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
Fxr1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Fxr1Ratcostamere located_inISOFxr1 (Mus musculus)1624291 PMID:15128702RGDPMID:15128702
Fxr1Ratcytoplasm is_active_inISOFXR1 (Homo sapiens)1624291 PMID:9259278RGDPMID:9259278
Fxr1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Fxr1Ratcytoplasm is_active_inISOFxr1 (Mus musculus)1624291 PMID:35951695RGDPMID:35951695
Fxr1Ratcytoplasm located_inISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Fxr1Ratcytoplasm located_inISOFXR1 (Homo sapiens)1624291 PMID:30770808RGDPMID:30770808
Fxr1Ratcytoplasmic ribonucleoprotein granule located_inIEAUniProtKB-SubCell:SL-04951600115GO_REF:0000044UniProtGO_REF:0000044
Fxr1Ratcytoplasmic ribonucleoprotein granule is_active_inISOFXR1 (Homo sapiens)1624291 PMID:32706158RGDPMID:32706158
Fxr1Ratcytoplasmic ribonucleoprotein granule is_active_inISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratcytoplasmic stress granule is_active_inISOFXR1 (Homo sapiens)1624291 PMID:12417522 and PMID:20417602RGDPMID:12417522 and PMID:20417602
Fxr1Ratcytoplasmic stress granule located_inIEAUniProtKB-SubCell:SL-04961600115GO_REF:0000044UniProtGO_REF:0000044
Fxr1Ratcytoplasmic stress granule is_active_inIBAFB:FBgn0028734 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fxr1Ratcytosol located_inISOFXR1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Fxr1Ratcytosol located_inISOFxr1 (Mus musculus)1624291 PMID:30770808RGDPMID:30770808
Fxr1Ratcytosol located_inISOFXR1 (Homo sapiens)1624291 PMID:30770808RGDPMID:30770808
Fxr1Ratdendrite located_inISOFxr1 (Mus musculus)1624291 PMID:22022532RGDPMID:22022532
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Molecular Function
1 to 20 of 27 rows

  
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Original Reference(s)
Fxr1Ratmolecular condensate scaffold activity enablesISOFXR1 (Homo sapiens)1624291 PMID:39106863RGDPMID:39106863
Fxr1Ratmolecular condensate scaffold activity enablesISOFxr1 (Mus musculus)1624291 PMID:32328638 and PMID:35951695RGDPMID:32328638 and PMID:35951695
Fxr1Ratmolecular condensate scaffold activity enablesISSUniProtKB:Q615841600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1RatmRNA 3'-UTR AU-rich region binding enablesISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1RatmRNA 3'-UTR AU-rich region binding enablesISOFxr1 (Mus musculus)1624291 PMID:15548538 and PMID:25456134RGDPMID:15548538 and PMID:25456134
Fxr1RatmRNA 3'-UTR AU-rich region binding enablesISOFXR1 (Homo sapiens)1624291 PMID:17382880 more ...RGDPMID:17382880 more ...
Fxr1RatmRNA 3'-UTR binding enablesISOFXR1 (Homo sapiens)1624291 PMID:34731628RGDPMID:34731628
Fxr1RatmRNA 3'-UTR binding enablesIBAMGI:104860 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fxr1RatmRNA binding enablesIEAInterPro:IPR0401481600115GO_REF:0000002InterProGO_REF:0000002
Fxr1RatmRNA binding enablesISSUniProtKB:Q615841600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1RatmRNA binding enablesISOFxr1 (Mus musculus)1624291 PMID:28204491 more ...RGDPMID:28204491 more ...
Fxr1Ratnucleic acid binding enablesIEAInterPro:IPR0040871600115GO_REF:0000002InterProGO_REF:0000002
Fxr1Ratprotein binding enablesISOFXR1 (Homo sapiens) and UniProtKB:P51114-21624291UniProtKB:O00311 more ...RGDPMID:32296183
Fxr1Ratprotein binding enablesISOFxr1 (Mus musculus)1624291UniProtKB:P35922 more ...RGDPMID:10567518 and PMID:11438699
Fxr1Ratprotein binding enablesISOFXR1 (Homo sapiens)1624291UniProtKB:O00423 more ...RGDPMID:11157796 more ...
Fxr1Ratprotein heterodimerization activity enablesISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratprotein heterodimerization activity enablesISOFXR1 (Homo sapiens)1624291 PMID:7489725RGDPMID:7489725
Fxr1Ratprotein homodimerization activity enablesISSUniProtKB:P511141600115GO_REF:0000024UniProtGO_REF:0000024
Fxr1Ratprotein homodimerization activity enablesISOFXR1 (Homo sapiens)1624291 PMID:7489725RGDPMID:7489725
Fxr1Ratribonucleoprotein complex binding enablesISOFxr1 (Mus musculus)1624291 PMID:11178106RGDPMID:11178106
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:7489725   PMID:11178106   PMID:12477932   PMID:15128702   PMID:15489334   PMID:15548538   PMID:17057366   PMID:17170008   PMID:19946888   PMID:22022532   PMID:22658674   PMID:22681889  
PMID:27770568   PMID:29101288   PMID:29476059   PMID:30361391   PMID:31831836   PMID:32333305  



Fxr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82118,812,287 - 118,865,813 (+)NCBIGRCr8
mRatBN7.22116,884,167 - 116,937,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2123,473,867 - 123,526,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02121,586,534 - 121,638,784 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02116,215,601 - 116,266,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02120,529,716 - 120,570,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2120,512,899 - 120,570,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02140,165,289 - 140,213,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42120,330,045 - 120,378,482 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12120,275,008 - 120,323,418 (+)NCBI
Celera2111,923,546 - 111,975,799 (+)NCBICelera
Cytogenetic Map2q24NCBI
FXR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383180,912,670 - 180,982,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3180,868,141 - 180,982,753 (+)EnsemblGRCh38hg38GRCh38
GRCh373180,630,458 - 180,700,541 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363182,113,146 - 182,177,644 (+)NCBINCBI36Build 36hg18NCBI36
Build 343182,113,163 - 182,177,036NCBI
Celera3179,062,664 - 179,132,978 (+)NCBICelera
Cytogenetic Map3q26.33NCBI
HuRef3178,034,321 - 178,104,537 (+)NCBIHuRef
CHM1_13180,593,505 - 180,663,825 (+)NCBICHM1_1
T2T-CHM13v2.03183,714,436 - 183,784,535 (+)NCBIT2T-CHM13v2.0
Fxr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39334,074,133 - 34,124,129 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl334,074,092 - 34,124,471 (+)EnsemblGRCm39 Ensembl
GRCm38334,020,058 - 34,069,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl334,019,943 - 34,070,322 (+)EnsemblGRCm38mm10GRCm38
MGSCv37333,919,001 - 33,968,267 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36334,211,657 - 34,260,887 (+)NCBIMGSCv36mm8
Celera333,916,172 - 33,965,473 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map316.41NCBI
Fxr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554209,903,736 - 9,966,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554209,903,736 - 9,966,100 (+)NCBIChiLan1.0ChiLan1.0
FXR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22178,783,206 - 178,848,482 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13178,787,916 - 178,853,817 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03177,948,040 - 178,012,705 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13186,119,331 - 186,187,126 (+)NCBIpanpan1.1PanPan1.1panPan2
FXR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13414,129,978 - 14,192,016 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3414,130,017 - 14,191,370 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3418,212,277 - 18,274,019 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03414,031,339 - 14,093,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3414,031,378 - 14,093,391 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13414,077,460 - 14,139,011 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03414,059,493 - 14,121,524 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03414,303,530 - 14,365,583 (+)NCBIUU_Cfam_GSD_1.0
Fxr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602110,795,745 - 110,866,441 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365662,354,441 - 2,425,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365662,354,301 - 2,425,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13118,839,338 - 118,900,136 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113118,839,314 - 118,899,804 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213128,089,495 - 128,175,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FXR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,420,789 - 8,486,681 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,421,654 - 8,486,384 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606317,252,536 - 17,318,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fxr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473058,680,030 - 58,743,229 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473058,679,945 - 58,743,688 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Fxr1
120 total Variants

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000074060
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 59 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat

1 to 10 of 59 rows
RH123299  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02140,184,741 - 140,185,213NCBIRnor5.0
RGSC_v3.42120,358,866 - 120,359,337UniSTSRGSC3.4
Celera2111,952,036 - 111,952,507UniSTS
Cytogenetic Map2q25UniSTS
RH132222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22116,932,491 - 116,932,685 (-)MAPPERmRatBN7.2
Rnor_6.02120,516,718 - 120,516,911NCBIRnor6.0
Rnor_5.02140,162,560 - 140,162,753UniSTSRnor5.0
RGSC_v3.42120,379,472 - 120,379,665UniSTSRGSC3.4
Celera2111,971,786 - 111,971,979UniSTS
RH 3.4 Map2683.6UniSTS
Cytogenetic Map2q25UniSTS
X90875  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02140,158,874 - 140,159,032UniSTSRnor5.0
Rnor_5.02140,165,423 - 140,165,581UniSTSRnor5.0
Celera2111,975,507 - 111,975,665UniSTS
Cytogenetic Map2q25UniSTS
RH139070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22116,924,570 - 116,924,704 (-)MAPPERmRatBN7.2
Rnor_6.02120,530,350 - 120,530,483NCBIRnor6.0
Rnor_5.02140,173,143 - 140,173,276UniSTSRnor5.0
Celera2111,963,863 - 111,963,996UniSTS
RH 3.4 Map2684.9UniSTS
Cytogenetic Map2q25UniSTS
BI274570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22116,935,372 - 116,936,240 (-)MAPPERmRatBN7.2
Rnor_6.02120,519,947 - 120,520,151NCBIRnor6.0
Rnor_6.02120,513,163 - 120,514,030NCBIRnor6.0
Rnor_5.02140,159,005 - 140,159,872UniSTSRnor5.0
Rnor_5.02140,165,554 - 140,165,758UniSTSRnor5.0
Celera2111,974,667 - 111,975,534UniSTS
RH 3.4 Map116.7UniSTS
Cytogenetic Map2q25UniSTS
BI281166  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02120,520,007 - 120,520,204NCBIRnor6.0
Rnor_5.02140,165,614 - 140,165,811UniSTSRnor5.0
RH 3.4 Map116.7UniSTS
Cytogenetic Map2q25UniSTS
UniSTS:479111  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02120,520,193 - 120,520,822NCBIRnor6.0
Rnor_5.02140,165,800 - 140,166,429UniSTSRnor5.0
Cytogenetic Map2q25UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 17 of 17 rows
RefSeq Transcripts NM_001012179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG938503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000088442   ⟹   ENSRNOP00000069834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,257 - 116,936,504 (+)Ensembl
Rnor_6.0 Ensembl2120,512,899 - 120,570,355 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101775   ⟹   ENSRNOP00000084548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102612   ⟹   ENSRNOP00000095711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,251 - 116,936,347 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103508   ⟹   ENSRNOP00000081168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117973   ⟹   ENSRNOP00000084892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,905,868 - 116,932,847 (+)Ensembl
RefSeq Acc Id: NM_001012179   ⟹   NP_001012179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
Rnor_6.02120,529,716 - 120,570,356 (-)NCBI
Rnor_5.02140,165,289 - 140,213,149 (-)NCBI
RGSC_v3.42120,330,045 - 120,378,482 (+)RGD
Celera2111,923,546 - 111,975,799 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001415068   ⟹   NP_001401997
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: NM_001415069   ⟹   NP_001401998
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: NM_001415070   ⟹   NP_001401999
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: NM_001415071   ⟹   NP_001402000
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: XM_039102584   ⟹   XP_038958512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,320 - 118,865,353 (+)NCBI
mRatBN7.22116,884,167 - 116,937,586 (+)NCBI
RefSeq Acc Id: XM_063282053   ⟹   XP_063138123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,813,263 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282054   ⟹   XP_063138124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,287 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282055   ⟹   XP_063138125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,813,263 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282057   ⟹   XP_063138127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,842,850 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282058   ⟹   XP_063138128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,320 - 118,848,436 (+)NCBI
RefSeq Acc Id: XM_063282059   ⟹   XP_063138129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,320 - 118,848,492 (+)NCBI
1 to 5 of 17 rows
1 to 5 of 17 rows
RefSeq Acc Id: NP_001012179   ⟸   NM_001012179
- Peptide Label: isoform 4
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot),   A0A3G2LW22 (UniProtKB/TrEMBL),   A0A0G2JWD2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069834   ⟸   ENSRNOT00000088442
RefSeq Acc Id: XP_038958512   ⟸   XM_039102584
- Peptide Label: isoform X2
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000084892   ⟸   ENSRNOT00000117973
Ensembl Acc Id: ENSRNOP00000081168   ⟸   ENSRNOT00000103508
Agenet-like   KH

Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI81-F1-model_v2 AlphaFold Q5XI81 1-568 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 49 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-53396 BioCyc
Ensembl Genes ENSRNOG00000051480 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000101775 ENTREZGENE
  ENSRNOT00000103508 ENTREZGENE
  ENSRNOT00000121093 ENTREZGENE
Gene3D-CATH 2.30.30.140 UniProtKB/Swiss-Prot
  3.30.1370.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109902 IMAGE-MGC_LOAD
InterPro Agenet-like_dom UniProtKB/Swiss-Prot
  FMR1 UniProtKB/Swiss-Prot
  FMRP_KH0 UniProtKB/Swiss-Prot
  FXMRP1_C_core UniProtKB/Swiss-Prot
  FXR_C1 UniProtKB/Swiss-Prot
  KH_dom UniProtKB/Swiss-Prot
  KH_dom_type_1 UniProtKB/Swiss-Prot
  KH_dom_type_1_sf UniProtKB/Swiss-Prot
  KH_I_FXR1_rpt1 UniProtKB/Swiss-Prot
  KH_I_FXR1_rpt2 UniProtKB/Swiss-Prot
  KH_I_FXR1_rpt3 UniProtKB/Swiss-Prot
  Tudor_Agenet_FXR1_rpt1 UniProtKB/Swiss-Prot
  Tudor_Agenet_FXR1_rpt2 UniProtKB/Swiss-Prot
  Tudor_FRX1 UniProtKB/Swiss-Prot
KEGG Report rno:361927 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94858 IMAGE-MGC_LOAD
NCBI Gene 361927 ENTREZGENE
PANTHER FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR10603 UniProtKB/Swiss-Prot
Pfam Agenet UniProtKB/Swiss-Prot
  FXMRP1_C_core UniProtKB/Swiss-Prot
  FXR_C1 UniProtKB/Swiss-Prot
  KH_1 UniProtKB/Swiss-Prot
  KH_9 UniProtKB/Swiss-Prot
  Tudor_FRX1 UniProtKB/Swiss-Prot
PhenoGen Fxr1 PhenoGen
PROSITE AGENET_LIKE UniProtKB/Swiss-Prot
  KH_TYPE_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051480 RatGTEx
SMART SM00322 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot
UniProt A0A0G2JWD2 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 49 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fxr1  FMR1 autosomal homolog 1  LOC100366044  rCG41429-like  Data merged from RGD:2324412 737654 PROVISIONAL
2016-02-24 Fxr1  FMR1 autosomal homolog 1  Fxr1  fragile X mental retardation, autosomal homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-09 Fxr1  fragile X mental retardation, autosomal homolog 1  Fxr1  fragile X mental retardation gene 1, autosomal homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-17 Fxr1  fragile X mental retardation gene 1, autosomal homolog  Fxr1  fragile X mental retardation, autosomal homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100366044  rCG41429-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Fxr1  fragile X mental retardation, autosomal homolog 1  Fxr1h  fragile X mental retardation gene 1, autosomal homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fxr1h  fragile X mental retardation gene 1, autosomal homolog  Fxr1h_predicted  fragile X mental retardation gene 1, autosomal homolog (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fxr1h_predicted  fragile X mental retardation gene 1, autosomal homolog (predicted)      Symbol and Name status set to approved 70820 APPROVED