Rapsn (receptor-associated protein of the synapse) - Rat Genome Database

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Gene: Rapsn (receptor-associated protein of the synapse) Rattus norvegicus
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Symbol: Rapsn
Name: receptor-associated protein of the synapse
RGD ID: 1311592
Description: Enables ionotropic glutamate receptor binding activity. Involved in establishment of protein localization to postsynaptic membrane; positive regulation of neuromuscular synaptic transmission; and regulation of postsynaptic membrane organization. Located in neuromuscular junction. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 11 and fetal akinesia deformation sequence syndrome 2. Orthologous to human RAPSN (receptor associated protein of the synapse); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH atrazine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 43 kDa receptor-associated protein of the synapse; LOC362161; rapsyn; receptor-associated protein of the synapse, 43 kDa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,470,891 - 97,480,196 (+)NCBIGRCr8
mRatBN7.2377,015,073 - 77,024,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,983,471 - 77,024,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,493,612 - 80,502,907 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,092,627 - 89,101,922 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,943,726 - 86,953,069 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,859,815 - 79,869,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,860,179 - 79,869,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,568,568 - 86,578,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,396,836 - 75,406,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,293,208 - 75,302,485 (+)NCBI
Celera376,223,882 - 76,233,161 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
RapsnRatExperimental Autoimmune Myasthenia Gravis  IEP 8549750protein:decreased expression:neuromuscular junctionRGD 
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Original Reference(s)
RapsnRatcongenital disorder of glycosylation type IIc  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Rambam Hasharon syndromeClinVarPMID:16455955 more ...
RapsnRatcongenital myasthenic syndrome  ISORAPSN (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11791205 more ...
RapsnRatcongenital myasthenic syndrome 11  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital myasthenic syndrome 11ClinVarPMID:11791205 more ...
RapsnRatcongenital myasthenic syndrome 4C  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital myasthenic syndrome 4CClinVarPMID:11791205 more ...
RapsnRatDevelopmental Disabilities  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:16931511 more ...
RapsnRatfetal akinesia deformation sequence syndrome  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Pena Shokeir syndrome and type 1ClinVarPMID:12651869 more ...
RapsnRatfetal akinesia deformation sequence syndrome 1  ISORAPSN (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11791205 more ...
RapsnRatfetal akinesia deformation sequence syndrome 1  ISORAPSN (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11791205 more ...
RapsnRatfetal akinesia deformation sequence syndrome 2  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Fetal akinesia deformation sequence 2ClinVarPMID:11791205 more ...
RapsnRatgenetic disease  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11791205 more ...
RapsnRatHydrops Fetalis  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Hydrops fetalisClinVarPMID:10449659 more ...
RapsnRathypertrophic cardiomyopathy  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:28492532
RapsnRatintellectual disability  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
RapsnRatmyopathy  ISORAPSN (Homo sapiens)8554872ClinVar Annotator: match by term: MyopathyClinVarPMID:11791205 more ...
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Original Reference(s)
RapsnRatautoimmune disease  ISORAPSN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9668287
RapsnRatCongenital Myasthenic Syndrome, with Facial Dysmorphism, associated with Acetylcholine Receptor Deficiency  ISORAPSN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
RapsnRatmuscular disease  ISORAPSN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9668287
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Original Reference(s)
RapsnRatcongenital myasthenic syndrome 11  ISSRapsn (Mus musculus)13592920OMIM:616326MouseDO 
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Original Reference(s)
RapsnRatcongenital myasthenic syndrome 11  ISORAPSN (Homo sapiens)7240710 OMIM 
RapsnRatfetal akinesia deformation sequence syndrome 2  ISORAPSN (Homo sapiens)7240710 OMIM 

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Original Reference(s)
RapsnRat17alpha-ethynylestradiol affects expressionISORapsn (Mus musculus)6480464Ethinyl Estradiol affects the expression of RAPSN mRNACTDPMID:17555576
RapsnRat17beta-estradiol decreases expressionISORAPSN (Homo sapiens)6480464Estradiol results in decreased expression of RAPSN mRNACTDPMID:31614463
RapsnRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORapsn (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of RAPSN mRNACTDPMID:21570461
RapsnRataristolochic acid A increases expressionISORAPSN (Homo sapiens)6480464aristolochic acid I results in increased expression of RAPSN mRNACTDPMID:33212167
RapsnRatatrazine decreases expressionEXP 6480464Atrazine results in decreased expression of RAPSN mRNACTDPMID:36841081
RapsnRatbenzo[a]pyrene decreases expressionISORapsn (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of RAPSN mRNACTDPMID:22228805
RapsnRatbenzo[a]pyrene decreases methylationISORAPSN (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of RAPSN promoterCTDPMID:27901495
RapsnRatbenzo[a]pyrene affects methylationISORAPSN (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of RAPSN exonCTDPMID:27901495
RapsnRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of RAPSN mRNACTDPMID:25181051
RapsnRatcadmium dichloride increases expressionEXP 6480464Cadmium Chloride results in increased expression of RAPSN mRNACTDPMID:21297351
RapsnRatcyclophosphamide increases expressionEXP 6480464Cyclophosphamide results in increased expression of RAPSN mRNACTDPMID:27281708
RapsnRatendosulfan increases expressionEXP 6480464Endosulfan results in increased expression of RAPSN mRNACTDPMID:29391264
RapsnRatfenvalerate increases expressionEXP 6480464fenvalerate results in increased expression of RAPSN mRNACTDPMID:30307764
RapsnRatfolic acid decreases expressionISORapsn (Mus musculus)6480464Folic Acid results in decreased expression of RAPSN mRNACTDPMID:25629700
RapsnRatfuran increases methylationEXP 6480464furan results in increased methylation of RAPSN geneCTDPMID:22079235
RapsnRatgentamycin decreases expressionEXP 6480464Gentamicins results in decreased expression of RAPSN mRNACTDPMID:22061828
RapsnRatgentamycin increases expressionEXP 6480464Gentamicins results in increased expression of RAPSN mRNACTDPMID:33387578
RapsnRatozone multiple interactionsISORAPSN (Homo sapiens)6480464[Air Pollutants results in increased abundance of Ozone] which affects the expression of RAPSN mRNACTDPMID:35430440
RapsnRatperfluorohexanesulfonic acid increases expressionISORapsn (Mus musculus)6480464perfluorohexanesulfonic acid results in increased expression of RAPSN mRNACTDPMID:37995155
RapsnRatphenylephrine decreases expressionEXP 6480464Phenylephrine results in decreased expression of RAPSN mRNACTDPMID:18158353

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Biological Process
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Original Reference(s)
RapsnRatestablishment of protein localization to postsynaptic membrane  IMP 8549750 RGD 
RapsnRatmaintenance of postsynaptic specialization structure involved_inIEAGO:00988791600115GO_REF:0000108GOCGO_REF:0000108
RapsnRatmotor neuron apoptotic process acts_upstream_ofISORapsn (Mus musculus)1624291MGI:2148091 PMID:11312299RGDPMID:11312299
RapsnRatneuromuscular junction development involved_inISORapsn (Mus musculus)1624291MGI:1929066 PMID:14622576 and PMID:8653787RGDPMID:14622576 and PMID:8653787
RapsnRatneurotransmitter receptor localization to postsynaptic specialization membrane involved_inISORapsn (Mus musculus)1624291MGI:1929066 PMID:14622576 more ...RGDPMID:14622576 more ...
RapsnRatpositive regulation of motor neuron apoptotic process acts_upstream_of_or_withinISORapsn (Mus musculus)1624291MGI:2148091 PMID:11312299RGDPMID:11312299
RapsnRatpositive regulation of neuromuscular synaptic transmission  IMP 8549750 RGD 
RapsnRatpositive regulation of neuromuscular synaptic transmission involved_inIBAPANTHER:PTN001297256 and Rapsn (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
RapsnRatregulation of postsynaptic membrane organization  IMP 8549750 RGD 
RapsnRatskeletal muscle acetylcholine-gated channel clustering involved_inISORapsn (Mus musculus)1624291 PMID:18420419RGDPMID:18420419
RapsnRatsynaptic transmission, cholinergic acts_upstream_of_or_withinISORAPSN (Homo sapiens)1624291UniProtKB:Q9GZZ6 and PMID:18420419RGDPMID:18420419
RapsnRatsynaptic transmission, cholinergic involved_inIBAPANTHER:PTN001297256 and UniProtKB:Q137021600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
RapsnRatcentrosome located_inIEAUniProtKB:Q13702 and ensembl:ENSP000002988541600115GO_REF:0000107EnsemblGO_REF:0000107
RapsnRatcentrosome located_inISORAPSN (Homo sapiens) and UniProtKB:Q13702-11624291 RGDGO_REF:0000052
RapsnRatcentrosome located_inIEAUniProtKB:A0A0S2Z4F8 and ensembl:ENSP000002988541600115GO_REF:0000107EnsemblGO_REF:0000107
RapsnRatcytosol located_inISORAPSN (Homo sapiens) and UniProtKB:Q13702-11624291 RGDGO_REF:0000052
RapsnRatcytosol located_inIEAUniProtKB:Q13702 and ensembl:ENSP000002988541600115GO_REF:0000107EnsemblGO_REF:0000107
RapsnRatcytosol located_inIEAUniProtKB:A0A0S2Z4F8 and ensembl:ENSP000002988541600115GO_REF:0000107EnsemblGO_REF:0000107
RapsnRatGolgi apparatus located_inISORapsn (Mus musculus)1624291 PMID:12388596RGDPMID:12388596
RapsnRatmembrane located_inISORapsn (Mus musculus)1624291 PMID:20053883RGDPMID:20053883
RapsnRatneuromuscular junction  IDA 8549750 RGD 
RapsnRatneuromuscular junction is_active_inISORapsn (Mus musculus)1624291 PMID:27225759 more ...RGDPMID:27225759 more ...
RapsnRatneuromuscular junction located_inISORapsn (Mus musculus)1624291 PMID:17119023 more ...RGDPMID:17119023 more ...
RapsnRatneuromuscular junction is_active_inIBAMGI:99422 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RapsnRatplasma membrane located_inISORAPSN (Homo sapiens) and UniProtKB:Q13702-11624291 RGDGO_REF:0000052
RapsnRatplasma membrane located_inISORapsn (Mus musculus)1624291 PMID:12388596RGDPMID:12388596
RapsnRatplasma membrane is_active_inIBAMGI:99422 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RapsnRatpostsynaptic membrane is_active_inISORapsn (Mus musculus)1624291 PMID:14622576RGDPMID:14622576
RapsnRatpostsynaptic specialization membrane is_active_inISORapsn (Mus musculus)1624291 PMID:27225759 and PMID:9136771RGDPMID:27225759 and PMID:9136771
RapsnRatsynapse located_inISORapsn (Mus musculus)1624291 PMID:20053883RGDPMID:20053883
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RGD Manual Annotations


  
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Original Reference(s)
RapsnRatacetylcholine signaling pathway via nicotinic acetylcholine receptor   ISORapsn (Mus musculus)8549508 RGD 

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#
Reference Title
Reference Citation
1. Glutamatergic reinnervation and assembly of glutamatergic synapses in adult rat skeletal muscle occurs at cholinergic endplates. Francolini M, etal., J Neuropathol Exp Neurol. 2009 Oct;68(10):1103-15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding. Martinez-Martinez P, etal., Neurobiol Dis. 2009 Jul;35(1):14-23. doi: 10.1016/j.nbd.2009.03.008. Epub 2009 Apr 1.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
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PMID:8416841   PMID:11312299   PMID:12388596   PMID:12486121   PMID:17119023   PMID:18420419   PMID:20053883   PMID:27225759  



Rapsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,470,891 - 97,480,196 (+)NCBIGRCr8
mRatBN7.2377,015,073 - 77,024,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,983,471 - 77,024,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,493,612 - 80,502,907 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,092,627 - 89,101,922 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,943,726 - 86,953,069 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,859,815 - 79,869,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,860,179 - 79,869,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,568,568 - 86,578,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,396,836 - 75,406,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,293,208 - 75,302,485 (+)NCBI
Celera376,223,882 - 76,233,161 (+)NCBICelera
Cytogenetic Map3q24NCBI
RAPSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,437,764 - 47,449,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,437,764 - 47,449,143 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,459,315 - 47,470,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,415,891 - 47,427,306 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,415,890 - 47,427,306NCBI
Celera1147,601,051 - 47,612,463 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,159,075 - 47,170,494 (-)NCBIHuRef
CHM1_11147,458,570 - 47,469,991 (-)NCBICHM1_1
T2T-CHM13v2.01147,597,603 - 47,608,976 (-)NCBIT2T-CHM13v2.0
Rapsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,864,594 - 90,876,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,865,965 - 90,876,074 (+)EnsemblGRCm39 Ensembl
GRCm38291,035,472 - 91,045,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,035,620 - 91,045,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,875,784 - 90,885,886 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,836,478 - 90,846,568 (+)NCBIMGSCv36mm8
Celera292,420,152 - 92,430,248 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Rapsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422826,727 - 834,289 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422826,556 - 834,483 (+)NCBIChiLan1.0ChiLan1.0
RAPSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,642,069 - 49,656,586 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,661,853 - 49,676,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,387,324 - 47,398,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,940,530 - 47,951,667 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,940,530 - 47,951,667 (-)Ensemblpanpan1.1panPan2
RAPSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,199,160 - 42,210,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,199,412 - 42,210,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,930,029 - 40,941,208 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,855,197 - 42,866,378 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,855,420 - 42,866,216 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,341,801 - 42,352,980 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,896,689 - 41,907,866 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,626,215 - 42,637,394 (+)NCBIUU_Cfam_GSD_1.0
Rapsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,680,416 - 19,692,511 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,795,905 - 1,804,181 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,796,087 - 1,804,153 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,166,306 - 15,193,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,166,968 - 15,181,011 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,382,739 - 16,387,663 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAPSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,867,721 - 17,887,162 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,868,888 - 17,887,164 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,165,684 - 115,176,850 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,351,370 - 1,358,187 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,350,820 - 1,358,107 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Rapsn
41 total Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
3 75397933 75397934 G A snv SS/JrHsdMcwi (MCW) View more Information
3 75397954 75397955 G A snv SS/JrHsdMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:65
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000068444
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat

1 to 10 of 38 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 88 87 56 25 56 6 215 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000068444   ⟹   ENSRNOP00000060958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,015,094 - 77,024,373 (+)Ensembl
Rnor_6.0 Ensembl379,860,207 - 79,869,486 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081160   ⟹   ENSRNOP00000075166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl376,983,471 - 77,024,369 (+)Ensembl
Rnor_6.0 Ensembl379,860,179 - 79,869,524 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103028   ⟹   ENSRNOP00000092830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl376,983,471 - 77,024,369 (+)Ensembl
RefSeq Acc Id: NM_001108584   ⟹   NP_001102054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,470,891 - 97,480,196 (+)NCBI
mRatBN7.2377,015,073 - 77,024,378 (+)NCBI
Rnor_6.0379,860,207 - 79,869,486 (+)NCBI
Rnor_5.0386,568,568 - 86,578,239 (+)NCBI
RGSC_v3.4375,396,836 - 75,406,115 (+)RGD
Celera376,223,882 - 76,233,161 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399728   ⟹   NP_001386657
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,470,891 - 97,480,196 (+)NCBI
mRatBN7.2377,015,073 - 77,024,378 (+)NCBI
RefSeq Acc Id: XM_039105428   ⟹   XP_038961356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,471,248 - 97,480,189 (+)NCBI
mRatBN7.2377,015,427 - 77,024,371 (+)NCBI
Protein RefSeqs NP_001102054 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386657 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961356 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79499 (Get FASTA)   NCBI Sequence Viewer  
  EDL79500 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060958.1
  ENSRNOP00000075166.1
  ENSRNOP00000092830.1
RefSeq Acc Id: NP_001102054   ⟸   NM_001108584
- Peptide Label: isoform 2
- UniProtKB: D3ZPG2 (UniProtKB/TrEMBL),   A6HN99 (UniProtKB/TrEMBL),   A0A8I6AIQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060958   ⟸   ENSRNOT00000068444
Ensembl Acc Id: ENSRNOP00000075166   ⟸   ENSRNOT00000081160
RefSeq Acc Id: XP_038961356   ⟸   XM_039105428
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000092830   ⟸   ENSRNOT00000103028
RING-type

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9X2-F1-model_v2 AlphaFold A0A0G2K9X2 1-412 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692203
Promoter ID:EPDNEW_R2728
Type:single initiation site
Name:Rapsn_1
Description:receptor-associated protein of the synapse
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0379,860,208 - 79,860,268EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-48754 BioCyc
Ensembl Genes ENSRNOG00000011208 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068444.2 UniProtKB/TrEMBL
  ENSRNOT00000081160.2 UniProtKB/TrEMBL
  ENSRNOT00000103028.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro Postsynaptic UniProtKB/TrEMBL
  Postsynaptic_CS UniProtKB/TrEMBL
  RAPsyn UniProtKB/TrEMBL
  Rapsyn_myristoylation/link_N UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:362161 UniProtKB/TrEMBL
NCBI Gene 362161 ENTREZGENE
PANTHER 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE UniProtKB/TrEMBL
  43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE UniProtKB/TrEMBL
Pfam Rapsyn_N UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
  TPR_MalT UniProtKB/TrEMBL
  zf-RING_2 UniProtKB/TrEMBL
PhenoGen Rapsn PhenoGen
PRINTS POSTSYNAPTIC UniProtKB/TrEMBL
PROSITE 43_KD_POSTSYNAPTIC UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011208 RatGTEx
SMART RING UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A0G2K9X2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIQ1 ENTREZGENE, UniProtKB/TrEMBL
  A6HN98 ENTREZGENE, UniProtKB/TrEMBL
  A6HN99 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPG2 ENTREZGENE, UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Rapsn  receptor-associated protein of the synapse   Rapsn_predicted  receptor-associated protein of the synapse (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rapsn_predicted  receptor-associated protein of the synapse (predicted)      Symbol and Name status set to approved 70820 APPROVED