Snf8 (SNF8 subunit of ESCRT-II) - Rat Genome Database

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Gene: Snf8 (SNF8 subunit of ESCRT-II) Rattus norvegicus
Analyze
Symbol: Snf8
Name: SNF8 subunit of ESCRT-II
RGD ID: 1310144
Description: Predicted to enable channel regulator activity; lipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including endosomal transport; multivesicular body assembly; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including endosome; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of ESCRT II complex and transcription regulator complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SNF8 (SNF8 subunit of ESCRT-II); PARTICIPATES IN autophagy pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D11moh34; EAP30 subunit of ELL complex; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; LOC287645; MGC105799; RGD1310144; similar to EAP30 subunit of ELL complex; SNF8, ESCRT-II complex subunit; SNF8, ESCRT-II complex subunit, homolog; SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); vacuolar-sorting protein SNF8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,481,054 - 81,493,430 (+)NCBIGRCr8
mRatBN7.21080,984,337 - 80,996,724 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,984,363 - 80,996,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,932,673 - 85,944,874 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,430,709 - 85,442,910 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,823,176 - 80,835,608 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,856,331 - 83,868,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,856,280 - 83,868,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,661,434 - 83,673,490 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,749,033 - 84,761,230 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,763,402 - 84,775,600 (+)NCBI
Celera1079,752,499 - 79,764,696 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Snf8RatDevelopmental and Epileptic Encephalopathy 115  ISORGD:16048338554872ClinVar Annotator: match by term: SNF8-associated diseaseClinVarPMID:38423010
Snf8Rathereditary breast ovarian cancer syndrome  ISORGD:16048338554872ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 1ClinVarPMID:38922859
Snf8RatHirschsprung's disease  ISORGD:16048338554872ClinVar Annotator: match by term: Hirschsprung diseaseClinVar 
Snf8RatNEURODEVELOPMENTAL DISORDER PLUS OPTIC ATROPHY  ISORGD:16048338554872ClinVar Annotator: match by term: Neurodevelopmental disorder plus optic atrophyClinVarPMID:38423010
Snf8Rattrichodontoosseous syndrome  ISORGD:16048338554872ClinVar Annotator: match by term: Tricho-dento-osseous syndromeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Snf8RatDevelopmental and Epileptic Encephalopathy 115  ISORGD:16048337240710 OMIM 
Snf8RatNEURODEVELOPMENTAL DISORDER PLUS OPTIC ATROPHY  ISORGD:16048337240710 OMIM 

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Object Symbol
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Original Reference(s)
Snf8Rat1,2-dimethylhydrazine increases expressionISORGD:162156864804641,2-Dimethylhydrazine results in increased expression of SNF8 mRNACTDPMID:22206623
Snf8Rat14-Deoxy-11,12-didehydroandrographolide decreases expressionISORGD:1604833648046414-deoxy-11,12-didehydroandrographolide results in decreased expression of SNF8 mRNACTDPMID:22101062
Snf8Rat17alpha-ethynylestradiol affects expressionISORGD:16215686480464Ethinyl Estradiol affects the expression of SNF8 mRNACTDPMID:17555576
Snf8Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:16215686480464Tetrachlorodibenzodioxin affects the expression of SNF8 mRNACTDPMID:21570461
Snf8Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SNF8 mRNACTDPMID:33387578
Snf8Rat2,4,6-trinitrotoluene affects expressionEXP 6480464Trinitrotoluene affects the expression of SNF8 mRNACTDPMID:21346803
Snf8Rat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of SNF8 mRNACTDPMID:21346803
Snf8Rat4,4'-sulfonyldiphenol increases expressionISORGD:16215686480464bisphenol S results in increased expression of SNF8 mRNACTDPMID:39298647
Snf8Ratarsane multiple interactionsISORGD:16048336480464[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SNF8 more ...CTDPMID:39836092
Snf8Ratarsenic atom multiple interactionsISORGD:16048336480464[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SNF8 more ...CTDPMID:39836092
Snf8Ratarsenite(3-) multiple interactionsISORGD:16048336480464arsenite promotes the reaction [G3BP1 protein binds to SNF8 mRNA]CTDPMID:32406909
Snf8Ratatrazine decreases expressionISORGD:16048336480464Atrazine results in decreased expression of SNF8 mRNACTDPMID:22378314
Snf8Ratbenzo[a]pyrene increases methylationISORGD:16048336480464Benzo(a)pyrene results in increased methylation of SNF8 promoterCTDPMID:27901495
Snf8Ratbenzo[a]pyrene decreases expressionISORGD:16048336480464Benzo(a)pyrene results in decreased expression of SNF8 proteinCTDPMID:32717239
Snf8Ratbenzo[a]pyrene increases expressionISORGD:16215686480464Benzo(a)pyrene results in increased expression of SNF8 mRNACTDPMID:22228805
Snf8Ratbeta-lapachone decreases expressionISORGD:16048336480464beta-lapachone results in decreased expression of SNF8 mRNACTDPMID:38218311
Snf8Ratbeta-lapachone increases expressionISORGD:16048336480464beta-lapachone results in increased expression of SNF8 mRNACTDPMID:38218311
Snf8Ratbis(2-ethylhexyl) phthalate increases expressionISORGD:16215686480464Diethylhexyl Phthalate results in increased expression of SNF8 mRNACTDPMID:33754040
Snf8Ratbisphenol A increases expressionISORGD:16048336480464bisphenol A results in increased expression of SNF8 mRNACTDPMID:20678512
Snf8Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of SNF8 mRNACTDPMID:30816183|PMID:32528016|PMID:33296240|PMID:34947998

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Biological Process
1 to 20 of 31 rows

  
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Original Reference(s)
Snf8Ratbiological_process  ND 159840702/11: no relevant rat dataRGD 
Snf8Ratearly endosome to late endosome transport involved_inISORGD:16048331624291 PMID:17714434RGDPMID:17714434
Snf8Ratearly endosome to late endosome transport involved_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratendocytic recycling involved_inISORGD:16048331624291 PMID:17714434RGDPMID:17714434
Snf8Ratendocytic recycling involved_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratmacroautophagy involved_inISSUniProtKB:Q96H201600115GO_REF:0000024UniProtGO_REF:0000024
Snf8Ratmacroautophagy involved_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratmacroautophagy involved_inISORGD:16048331624291 PMID:38423010RGDPMID:38423010
Snf8Ratmultivesicular body assembly involved_inISSUniProtKB:Q96H201600115GO_REF:0000024UniProtGO_REF:0000024
Snf8Ratmultivesicular body assembly involved_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratmultivesicular body assembly involved_inISORGD:16048331624291 PMID:38423010RGDPMID:38423010
Snf8Ratmultivesicular body sorting pathway involved_inIEAUniRule:UR0003427991600115GO_REF:0000104UniProtGO_REF:0000104
Snf8Ratmultivesicular body sorting pathway involved_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratmultivesicular body sorting pathway involved_inIEAInterPro:IPR0166891600115GO_REF:0000002InterProGO_REF:0000002
Snf8Ratmultivesicular body sorting pathway involved_inISORGD:16048331624291 PMID:38423010RGDPMID:38423010
Snf8Ratmultivesicular body sorting pathway involved_inISSUniProtKB:Q96H201600115GO_REF:0000024UniProtGO_REF:0000024
Snf8Ratpositive regulation of exosomal secretion involved_inISORGD:16048331624291 PMID:22660413RGDPMID:22660413
Snf8Ratpositive regulation of exosomal secretion involved_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratpositive regulation of gene expression involved_inISORGD:16048331624291 PMID:22978549RGDPMID:22978549
Snf8Ratpositive regulation of gene expression involved_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 20 of 36 rows

  
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Original Reference(s)
Snf8Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Snf8Ratcytoplasm located_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratcytoplasm located_inISORGD:16048331624291 PMID:22978549, PMID:23171048RGDPMID:22978549|PMID:23171048
Snf8Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Snf8Ratcytosol located_inISORGD:16048331624291 PMID:17010938RGDPMID:17010938
Snf8Ratcytosol located_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratcytosol located_inISORGD:1604833|UniProtKB:Q96H20-1|UniProtKB:Q96H20-21624291 RGDGO_REF:0000052
Snf8Ratendosome located_inIEAUniProtKB-KW:KW-09671600115GO_REF:0000043UniProtGO_REF:0000043
Snf8Ratendosome membrane located_inISORGD:16048331624291 PMID:16973552RGDPMID:16973552
Snf8Ratendosome membrane located_inIEAUniProtKB-SubCell:SL-01001600115GO_REF:0000044UniProtGO_REF:0000044
Snf8Ratendosome membrane located_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8RatESCRT II complex part_ofISORGD:16048331624291 PMID:16973552, PMID:18539118RGDPMID:16973552|PMID:18539118
Snf8RatESCRT II complex part_ofIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8RatESCRT II complex part_ofIBAPANTHER:PTN000301561|SGD:S000005923|UniProtKB:Q96H201600115GO_REF:0000033GO_CentralGO_REF:0000033
Snf8RatESCRT II complex part_ofIEAInterPro:IPR0166891600115GO_REF:0000002InterProGO_REF:0000002
Snf8RatESCRT II complex part_ofIEAUniRule:UR0003427991600115GO_REF:0000104UniProtGO_REF:0000104
Snf8Ratlate endosome membrane located_inISORGD:16048331624291 PMID:17010938RGDPMID:17010938
Snf8Ratlate endosome membrane located_inIEAUniProtKB-SubCell:SL-01511600115GO_REF:0000044UniProtGO_REF:0000044
Snf8Ratlate endosome membrane located_inIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratmembrane located_inISORGD:16048331624291 PMID:23171048RGDPMID:23171048
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Molecular Function

  
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Original Reference(s)
Snf8Ratchannel regulator activity enablesISORGD:16048331624291 PMID:23171048RGDPMID:23171048
Snf8Ratchannel regulator activity enablesIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratlipid binding enablesISORGD:16048331624291ChEBI:16038|ChEBI:49183 PMID:18539118RGDPMID:18539118
Snf8Ratlipid binding enablesIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107
Snf8Ratprotein binding enablesISORGD:16048331624291UniProtKB:O14901|UniProtKB:O60341|UniProtKB:O75190-2|UniProtKB:O75400-2|UniProtKB:O95793|UniProtKB:O95793-2|UniProtKB:P13473-2|UniProtKB:P24928|UniProtKB:P40222|UniProtKB:P49736|UniProtKB:P51687|UniProtKB:P55199|UniProtKB:P55212|UniProtKB:P62826|UniProtKB:Q08379|UniProtKB:Q08AM6|UniProtKB:Q6PJH3|UniProtKB:Q86VN1|UniProtKB:Q8IVS8|UniProtKB:Q8WUE5|UniProtKB:Q92989|UniProtKB:Q96FZ7|UniProtKB:Q96GM5|UniProtKB:Q96LA8|UniProtKB:Q96NA2|UniProtKB:Q99816|UniProtKB:Q9BRG1|UniProtKB:Q9BYV2|UniProtKB:Q9NW38|UniProtKB:Q9Y210 PMID:14505570, PMID:14519844, PMID:16189514, PMID:16973552, PMID:17010938, PMID:17959629, PMID:19819239, PMID:21516116, PMID:22978549, PMID:23171048, PMID:23455924, PMID:25416956, PMID:28514442, more ...RGDPMID:14505570|PMID:14519844|PMID:16189514|PMID:16973552|PMID:17010938|PMID:17959629|PMID:19819239|PMID:21516116|PMID:22978549|PMID:23171048|PMID:23455924|PMID:25416956|PMID:28514442|PMID:29892012|PMID:31515488|PMID:32296183|PMID:32814053|PMID:33961781|PMID:35271311
Snf8Ratprotein homodimerization activity enablesISORGD:16048331624291UniProtKB:Q96H20 PMID:14505570, PMID:14519844RGDPMID:14505570|PMID:14519844
Snf8Ratprotein homodimerization activity enablesIEAUniProtKB:Q96H20|ensembl:ENSP000004213801600115GO_REF:0000107EnsemblGO_REF:0000107

RGD Manual Annotations


  
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Original Reference(s)
Snf8Ratautophagy pathway   ISORGD:16048334892619 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Snf8Ratendocytosis pathway  IEA 6907045 KEGGrno:04144

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. How do ESCRT proteins control autophagy? Rusten TE and Stenmark H, J Cell Sci. 2009 Jul 1;122(Pt 13):2179-83.
PMID:10419521   PMID:11278625   PMID:12477932   PMID:14505570   PMID:14519844   PMID:15489334   PMID:16778019   PMID:16973552   PMID:17010938   PMID:17714434   PMID:17959629   PMID:19056867  
PMID:22660413   PMID:22978549   PMID:23171048   PMID:23376485  



Snf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,481,054 - 81,493,430 (+)NCBIGRCr8
mRatBN7.21080,984,337 - 80,996,724 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,984,363 - 80,996,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,932,673 - 85,944,874 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,430,709 - 85,442,910 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,823,176 - 80,835,608 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,856,331 - 83,868,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,856,280 - 83,868,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,661,434 - 83,673,490 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,749,033 - 84,761,230 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,763,402 - 84,775,600 (+)NCBI
Celera1079,752,499 - 79,764,696 (+)NCBICelera
Cytogenetic Map10q26NCBI
SNF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,929,316 - 48,944,842 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,929,316 - 48,944,842 (-)EnsemblGRCh38hg38GRCh38
GRCh371747,006,678 - 47,022,204 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,362,457 - 44,377,153 (-)NCBINCBI36Build 36hg18NCBI36
Celera1743,461,656 - 43,476,351 (-)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1742,375,136 - 42,389,830 (-)NCBIHuRef
CHM1_11747,073,206 - 47,087,896 (-)NCBICHM1_1
T2T-CHM13v2.01749,793,036 - 49,808,559 (-)NCBIT2T-CHM13v2.0
Snf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,925,711 - 95,938,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,925,711 - 95,938,256 (+)EnsemblGRCm39 Ensembl
GRCm381196,034,885 - 96,047,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,034,885 - 96,047,430 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,896,231 - 95,908,719 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,851,007 - 95,863,495 (+)NCBIMGSCv36mm8
Celera11105,685,354 - 105,697,707 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.24NCBI
Snf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,396,625 - 12,406,014 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,396,625 - 12,406,014 (+)NCBIChiLan1.0ChiLan1.0
SNF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,158,715 - 16,172,794 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,124,309 - 18,138,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,595,647 - 8,609,730 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,577,948 - 8,794,859 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,578,050 - 8,794,480 (+)Ensemblpanpan1.1panPan2
SNF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,151,992 - 25,162,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,152,011 - 25,162,023 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,613,162 - 24,623,187 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,947,254 - 25,957,310 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,947,273 - 25,957,217 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1924,715,090 - 24,725,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,973,356 - 24,983,364 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,102,284 - 25,112,314 (-)NCBIUU_Cfam_GSD_1.0
Snf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,554,980 - 24,567,996 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,507,116 - 12,523,674 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,507,147 - 12,520,424 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,142,813 - 25,153,016 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,142,748 - 25,152,847 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,108,502 - 25,118,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,343,260 - 69,357,843 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,339,804 - 69,357,860 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,445,605 - 40,459,909 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,318,802 - 5,328,768 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,318,803 - 5,328,542 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Snf8
39 total Variants

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:72
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000008964
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 87 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat

1 to 10 of 87 rows
RH137056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21080,996,513 - 80,996,700 (+)MAPPERmRatBN7.2
Rnor_6.01083,868,401 - 83,868,587NCBIRnor6.0
Rnor_5.01083,673,270 - 83,673,456UniSTSRnor5.0
RGSC_v3.41084,761,103 - 84,761,289UniSTSRGSC3.4
Celera1079,764,569 - 79,764,755UniSTS
RH 3.4 Map10738.2UniSTS
Cytogenetic Map10q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000008964   ⟹   ENSRNOP00000008964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1080,984,365 - 80,996,734 (+)Ensembl
Rnor_6.0 Ensembl1083,856,280 - 83,868,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110029   ⟹   ENSRNOP00000087170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1080,984,389 - 80,996,734 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114272   ⟹   ENSRNOP00000096004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1080,984,363 - 80,996,641 (+)Ensembl
RefSeq Acc Id: NM_001007804   ⟹   NP_001007805
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,481,057 - 81,493,430 (+)NCBI
mRatBN7.21080,984,350 - 80,996,724 (+)NCBI
Rnor_6.01083,856,331 - 83,868,528 (+)NCBI
Rnor_5.01083,661,434 - 83,673,490 (+)NCBI
RGSC_v3.41084,749,033 - 84,761,230 (+)RGD
Celera1079,752,499 - 79,764,696 (+)RGD
Sequence:
RefSeq Acc Id: XM_063268726   ⟹   XP_063124796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,481,510 - 81,493,430 (+)NCBI
RefSeq Acc Id: XM_063268727   ⟹   XP_063124797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,485,013 - 81,493,430 (+)NCBI
RefSeq Acc Id: XR_005489752
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,481,054 - 81,493,241 (+)NCBI
mRatBN7.21080,984,337 - 80,996,724 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_001007805 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124796 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124797 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86364 (Get FASTA)   NCBI Sequence Viewer  
  EDM05780 (Get FASTA)   NCBI Sequence Viewer  
  EDM05781 (Get FASTA)   NCBI Sequence Viewer  
  EDM05782 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008964
  ENSRNOP00000008964.2
  ENSRNOP00000087170
GenBank Protein Q5RK19 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_001007805   ⟸   NM_001007804
- UniProtKB: Q5RK19 (UniProtKB/Swiss-Prot),   A6HIC5 (UniProtKB/TrEMBL),   A0A8I6APW2 (UniProtKB/TrEMBL),   A6HIC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008964   ⟸   ENSRNOT00000008964
Ensembl Acc Id: ENSRNOP00000087170   ⟸   ENSRNOT00000110029
Ensembl Acc Id: ENSRNOP00000096004   ⟸   ENSRNOT00000114272
RefSeq Acc Id: XP_063124796   ⟸   XM_063268726
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APW2 (UniProtKB/TrEMBL),   A6HIC6 (UniProtKB/TrEMBL),   A0A8I6A7G8 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-Q5RK19-F1-model_v2 AlphaFold Q5RK19 1-258 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697625
Promoter ID:EPDNEW_R8149
Type:multiple initiation site
Name:Snf8_1
Description:SNF8, ESCRT-II complex subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01083,856,239 - 83,856,299EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23522 BioCyc
Ensembl Genes ENSRNOG00000006500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008964 ENTREZGENE
  ENSRNOT00000008964.5 UniProtKB/Swiss-Prot
  ENSRNOT00000110029 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  6.10.140.180 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7304427 IMAGE-MGC_LOAD
InterPro ESCRT-2_cplx_Snf8 UniProtKB/Swiss-Prot
  Snf8/Vps36 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:287645 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105799 IMAGE-MGC_LOAD
NCBI Gene 287645 ENTREZGENE
PANTHER PTHR12806 UniProtKB/Swiss-Prot
  VACUOLAR-SORTING PROTEIN SNF8 UniProtKB/Swiss-Prot
Pfam EAP30 UniProtKB/Swiss-Prot
PhenoGen Snf8 PhenoGen
PIRSF ESCRT2_Vps22 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006500 RatGTEx
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt A0A8I6A7G8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APW2 ENTREZGENE, UniProtKB/TrEMBL
  A6HIC5 ENTREZGENE, UniProtKB/TrEMBL
  A6HIC6 ENTREZGENE, UniProtKB/TrEMBL
  A6HIC7_RAT UniProtKB/TrEMBL
  Q5RK19 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Snf8  SNF8 subunit of ESCRT-II  Snf8  SNF8, ESCRT-II complex subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-14 Snf8  SNF8, ESCRT-II complex subunit  Snf8  SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Snf8  SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)  RGD1310144  similar to EAP30 subunit of ELL complex  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1310144  similar to EAP30 subunit of ELL complex  RGD1310144_predicted  similar to EAP30 subunit of ELL complex (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310144_predicted  similar to EAP30 subunit of ELL complex (predicted)  LOC287645_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287645_predicted  similar to EAP30 subunit of ELL complex (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL