Gtf2h1 (general transcription factor IIH subunit 1) - Rat Genome Database

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Gene: Gtf2h1 (general transcription factor IIH subunit 1) Rattus norvegicus
Analyze
Symbol: Gtf2h1
Name: general transcription factor IIH subunit 1
RGD ID: 1308225
Description: Enables chromatin binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human GTF2H1 (general transcription factor IIH subunit 1); PARTICIPATES IN nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: general transcription factor II H, polypeptide 1; general transcription factor IIH, polypeptide 1; LOC361580
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,457,692 - 106,485,729 (+)NCBIGRCr8
mRatBN7.2197,321,417 - 97,349,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,321,394 - 97,349,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,713,646 - 102,741,801 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,185,630 - 111,213,785 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,469,761 - 104,497,796 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,849,618 - 102,877,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,849,889 - 102,877,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,923,681 - 103,951,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,352,251 - 97,380,298 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,430,363 - 97,458,409 (+)NCBI
Celera191,568,224 - 91,596,262 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gtf2h1RatAsthenozoospermia  ISOGTF2H1 (Homo sapiens)8554872ClinVar Annotator: match by term: asthenozoospermiaClinVarPMID:25741868
Gtf2h1RatFanconi-Bickel syndrome  ISOGTF2H1 (Homo sapiens)8554872ClinVar Annotator: match by term: Glycogen storage disease XIClinVarPMID:28492532
Gtf2h1RatGlycogen Storage Disease XI  ISOGTF2H1 (Homo sapiens)8554872ClinVar Annotator: match by term: LACTATE DEHYDROGENASE A DEFICIENCYClinVarPMID:28492532
Gtf2h1Ratintellectual disability  ISOGTF2H1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Gtf2h1Ratoligospermia  ISOGTF2H1 (Homo sapiens)8554872ClinVar Annotator: match by term: OligospermiaClinVarPMID:25741868
Gtf2h1Ratprogressive myoclonus epilepsy 7  ISOGTF2H1 (Homo sapiens)8554872ClinVar Annotator: match by term: Progressive myoclonic epilepsy type 7ClinVarPMID:28492532
Gtf2h1RatTeratozoospermia  ISOGTF2H1 (Homo sapiens)8554872ClinVar Annotator: match by term: TeratozoospermiaClinVarPMID:25741868

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gtf2h1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GTF2H1 mRNA]CTDPMID:31150632
Gtf2h1Rat1,2-dichloroethane decreases expressionISOGtf2h1 (Mus musculus)6480464ethylene dichloride results in decreased expression of GTF2H1 mRNACTDPMID:28960355
Gtf2h1Rat1,2-dimethylhydrazine multiple interactionsISOGtf2h1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GTF2H1 mRNACTDPMID:22206623
Gtf2h1Rat17alpha-ethynylestradiol multiple interactionsISOGtf2h1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTF2H1 mRNACTDPMID:17942748
Gtf2h1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOGTF2H1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Gtf2h1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of GTF2H1 mRNACTDPMID:18465118
Gtf2h1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOGtf2h1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of GTF2H1 mRNACTDPMID:21570461
Gtf2h1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOGtf2h1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTF2H1 mRNACTDPMID:17942748
Gtf2h1Rat2,4,6-tribromophenol decreases expressionISOGTF2H1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Gtf2h1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of GTF2H1 mRNACTDPMID:21346803
Gtf2h1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of GTF2H1 mRNACTDPMID:21346803
Gtf2h1Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOGtf2h1 (Mus musculus)64804643 more ...CTDPMID:19467301
Gtf2h1Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOGTF2H1 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of GTF2H1 proteinCTDPMID:31675489
Gtf2h1Rat3,4-methylenedioxymethamphetamine decreases expressionISOGtf2h1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of GTF2H1 mRNACTDPMID:26251327
Gtf2h1Rat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2 and 6-dinitrotoluene affects the expression of GTF2H1 mRNACTDPMID:21346803
Gtf2h1Rat5-aza-2'-deoxycytidine multiple interactionsISOGTF2H1 (Homo sapiens)6480464[Decitabine co-treated with TNF protein] promotes the reaction [GTF2H1 protein binds to IER3 promoter]CTDPMID:19117987
Gtf2h1Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of GTF2H1 mRNACTDPMID:28959563
Gtf2h1Ratacrylamide increases expressionISOGTF2H1 (Homo sapiens)6480464Acrylamide results in increased expression of GTF2H1 mRNACTDPMID:32763439
Gtf2h1Rataflatoxin B1 decreases methylationISOGTF2H1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of GTF2H1 geneCTDPMID:27153756
Gtf2h1Rataluminium sulfate (anhydrous) decreases expressionISOGTF2H1 (Homo sapiens)6480464aluminum sulfate results in decreased expression of GTF2H1 mRNACTDPMID:15961160

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Biological Process
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gtf2h1Ratcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOGtf2h1 (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
Gtf2h1RatDNA repair involved_inIBAPANTHER:PTN000304482 and SGD:S0000027191600115GO_REF:0000033GO_CentralGO_REF:0000033
Gtf2h1RatDNA-templated transcription involved_inIEAInterPro:IPR0270791600115GO_REF:0000002InterProGO_REF:0000002
Gtf2h1Ratnucleotide-excision repair involved_inIEAInterPro:IPR0270791600115GO_REF:0000002InterProGO_REF:0000002
Gtf2h1Ratpositive regulation of DNA-templated transcription involved_inISOGTF2H1 (Homo sapiens)1624291 PMID:15625236RGDPMID:15625236
Gtf2h1Ratpositive regulation of DNA-templated transcription involved_inIEAUniProtKB:P32780 and ensembl:ENSP000002659631600115GO_REF:0000107EnsemblGO_REF:0000107
Gtf2h1Rattranscription by RNA polymerase I involved_inIBAPANTHER:PTN000304482 and SGD:S0000027191600115GO_REF:0000033GO_CentralGO_REF:0000033
Gtf2h1Rattranscription by RNA polymerase II  IDA 9590319 RGD 
Gtf2h1Rattranscription by RNA polymerase II involved_inIBAPANTHER:PTN000304482 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gtf2h1Rattranscription by RNA polymerase II involved_inISOGTF2H1 (Homo sapiens)1624291 PMID:9852112RGDPMID:9852112
Gtf2h1Rattranscription by RNA polymerase II involved_inIEAUniProtKB:P32780 and ensembl:ENSP000002659631600115GO_REF:0000107EnsemblGO_REF:0000107
Gtf2h1Rattranscription initiation at RNA polymerase II promoter involved_inISOGTF2H1 (Homo sapiens)1624291 PMID:8692841RGDPMID:8692841
Gtf2h1Rattranscription initiation at RNA polymerase II promoter involved_inIEAUniProtKB:P32780 and ensembl:ENSP000002659631600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 13 of 13 rows

Cellular Component
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gtf2h1Ratnucleoplasm located_inISOGTF2H1 (Homo sapiens) and UniProtKB:P32780-11624291 RGDGO_REF:0000052
Gtf2h1Ratnucleoplasm located_inIEAUniProtKB:A0A384MTQ8 and ensembl:ENSP000002659631600115GO_REF:0000107EnsemblGO_REF:0000107
Gtf2h1Ratnucleoplasm located_inIEAUniProtKB:P32780 and ensembl:ENSP000002659631600115GO_REF:0000107EnsemblGO_REF:0000107
Gtf2h1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Gtf2h1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Gtf2h1Ratnucleus located_inIEAARBA:ARBA000263301600115GO_REF:0000117UniProtGO_REF:0000117
Gtf2h1Ratnucleus located_inISOGtf2h1 (Mus musculus)1624291 PMID:12815074RGDPMID:12815074
Gtf2h1Rattranscription factor TFIIH core complex part_ofISOGTF2H1 (Homo sapiens)1624291 PMID:8692841RGDPMID:8692841
Gtf2h1Rattranscription factor TFIIH core complex part_ofIEAUniProtKB:P32780 and ensembl:ENSP000002659631600115GO_REF:0000107EnsemblGO_REF:0000107
Gtf2h1Rattranscription factor TFIIH core complex part_ofIBAPANTHER:PTN000304482 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gtf2h1Rattranscription factor TFIIH core complex part_ofIEAInterPro:IPR0270791600115GO_REF:0000002InterProGO_REF:0000002
Gtf2h1Rattranscription factor TFIIH holo complex  IDA 9590319 RGD 
Gtf2h1Rattranscription factor TFIIH holo complex part_ofIBAFB:FBgn0033929 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gtf2h1Rattranscription factor TFIIH holo complex part_ofIEAUniProtKB:P32780 and ensembl:ENSP000002659631600115GO_REF:0000107EnsemblGO_REF:0000107
Gtf2h1Rattranscription factor TFIIH holo complex part_ofISOGTF2H1 (Homo sapiens)1624291 PMID:9852112RGDPMID:9852112
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Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gtf2h1Ratnucleotide excision repair pathway   ISOGTF2H1 (Homo sapiens)7246920 RGD 
Gtf2h1RatRNA polymerase II transcription initiation pathway  ISOGTF2H1 (Homo sapiens)9681726 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gtf2h1Ratnucleotide excision repair pathway   IEA 6907045 KEGGrno:03420

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#
Reference Title
Reference Citation
1. TFIIH: when transcription met DNA repair. Compe E and Egly JM, Nat Rev Mol Cell Biol. 2012 May 10;13(6):343-54. doi: 10.1038/nrm3350.
2. The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding. Cowling VH and Cole MD, Mol Cell Biol. 2007 Mar;27(6):2059-73. Epub 2007 Jan 22.
3. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Ossipow V, etal., Cell. 1995 Oct 6;83(1):137-46.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tissue and cell distribution of a mammalian proteasomal ATPase, MSS1, and its complex formation with the basal transcription factors. Yanagi S, etal., Biochem Biophys Res Commun. 2000 Dec 20;279(2):568-73.
1 to 10 of 10 rows
PMID:8692841   PMID:9852112   PMID:12815074   PMID:20439489  



Gtf2h1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,457,692 - 106,485,729 (+)NCBIGRCr8
mRatBN7.2197,321,417 - 97,349,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,321,394 - 97,349,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,713,646 - 102,741,801 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,185,630 - 111,213,785 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,469,761 - 104,497,796 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,849,618 - 102,877,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,849,889 - 102,877,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,923,681 - 103,951,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,352,251 - 97,380,298 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,430,363 - 97,458,409 (+)NCBI
Celera191,568,224 - 91,596,262 (+)NCBICelera
Cytogenetic Map1q22NCBI
GTF2H1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,322,567 - 18,367,045 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,322,295 - 18,367,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371118,344,114 - 18,388,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,300,719 - 18,345,153 (+)NCBINCBI36Build 36hg18NCBI36
Build 341118,300,718 - 18,345,152NCBI
Celera1118,476,032 - 18,520,801 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,026,329 - 18,071,105 (+)NCBIHuRef
CHM1_11118,343,304 - 18,388,093 (+)NCBICHM1_1
T2T-CHM13v2.01118,418,103 - 18,462,582 (+)NCBIT2T-CHM13v2.0
Gtf2h1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,445,518 - 46,473,224 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,445,527 - 46,473,224 (+)EnsemblGRCm39 Ensembl
GRCm38746,796,094 - 46,823,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,796,103 - 46,823,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv37754,051,464 - 54,079,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,664,145 - 46,691,839 (+)NCBIMGSCv36mm8
Celera742,274,479 - 42,302,829 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.58NCBI
Gtf2h1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,028,701 - 33,063,233 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541433,028,701 - 33,063,233 (+)NCBIChiLan1.0ChiLan1.0
GTF2H1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,636,598 - 20,681,276 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,596,985 - 20,641,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,357,594 - 18,402,268 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,042,822 - 18,086,898 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,042,824 - 18,086,898 (+)Ensemblpanpan1.1panPan2
GTF2H1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,770,661 - 40,807,329 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,770,983 - 40,806,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,250,242 - 40,286,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,894,288 - 41,930,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,894,288 - 41,930,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,886,602 - 40,922,934 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,075,253 - 41,111,663 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,452,829 - 41,489,189 (+)NCBIUU_Cfam_GSD_1.0
Gtf2h1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,869,445 - 44,906,096 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528903,322 - 940,313 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936528903,429 - 940,308 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GTF2H1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,857,723 - 40,900,624 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,857,720 - 40,900,591 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,921,524 - 43,964,052 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GTF2H1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,573,907 - 46,620,443 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,573,393 - 46,609,261 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,946,538 - 143,998,018 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gtf2h1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,808,170 - 9,848,173 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,807,973 - 9,848,167 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gtf2h1
97 total Variants

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:225
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000066791
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

1 to 10 of 45 rows
BI293524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,320,737 - 97,320,957 (+)MAPPERmRatBN7.2
Rnor_6.01102,849,223 - 102,849,442NCBIRnor6.0
Rnor_5.01103,923,286 - 103,923,505UniSTSRnor5.0
RGSC_v3.4197,351,585 - 97,351,804UniSTSRGSC3.4
Celera191,567,558 - 91,567,777UniSTS
RH 3.4 Map1909.5UniSTS
Cytogenetic Map1q22UniSTS
RH127470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,349,108 - 97,349,313 (+)MAPPERmRatBN7.2
Rnor_6.01102,877,593 - 102,877,797NCBIRnor6.0
Rnor_5.01103,951,649 - 103,951,853UniSTSRnor5.0
RGSC_v3.4197,379,955 - 97,380,159UniSTSRGSC3.4
Celera191,595,919 - 91,596,123UniSTS
RH 3.4 Map1909.99UniSTS
Cytogenetic Map1q22UniSTS
RH140781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,348,568 - 97,348,747 (+)MAPPERmRatBN7.2
Rnor_6.01102,877,053 - 102,877,231NCBIRnor6.0
Rnor_5.01103,951,109 - 103,951,287UniSTSRnor5.0
RGSC_v3.4197,379,415 - 97,379,593UniSTSRGSC3.4
Celera191,595,379 - 91,595,557UniSTS
RH 3.4 Map1908.6UniSTS
Cytogenetic Map1q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000066791   ⟹   ENSRNOP00000063357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,321,404 - 97,349,452 (+)Ensembl
Rnor_6.0 Ensembl1102,849,889 - 102,877,936 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087920   ⟹   ENSRNOP00000069965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,321,394 - 97,349,455 (+)Ensembl
Rnor_6.0 Ensembl1102,857,251 - 102,877,944 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099036   ⟹   ENSRNOP00000095099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,329,696 - 97,349,450 (+)Ensembl
RefSeq Acc Id: NM_001399644   ⟹   NP_001386573
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,457,692 - 106,485,729 (+)NCBI
mRatBN7.2197,321,417 - 97,349,455 (+)NCBI
Protein RefSeqs NP_001386573 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07251 (Get FASTA)   NCBI Sequence Viewer  
  EDM07252 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063357.1
  ENSRNOP00000069965
  ENSRNOP00000069965.2
  ENSRNOP00000095099.1
Ensembl Acc Id: ENSRNOP00000069965   ⟸   ENSRNOT00000087920
Ensembl Acc Id: ENSRNOP00000063357   ⟸   ENSRNOT00000066791
Ensembl Acc Id: ENSRNOP00000095099   ⟸   ENSRNOT00000099036
RefSeq Acc Id: NP_001386573   ⟸   NM_001399644
- UniProtKB: A6JBD2 (UniProtKB/TrEMBL),   D3ZYG3 (UniProtKB/TrEMBL)
BSD

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWQ0-F1-model_v2 AlphaFold A0A0G2JWQ0 1-547 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690067
Promoter ID:EPDNEW_R591
Type:multiple initiation site
Name:Gtf2h1_1
Description:general transcription factor IIH subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,849,902 - 102,849,962EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-59612 BioCyc
Ensembl Genes ENSRNOG00000012360 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066791.3 UniProtKB/TrEMBL
  ENSRNOT00000087920 ENTREZGENE
  ENSRNOT00000087920.2 UniProtKB/TrEMBL
  ENSRNOT00000099036.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3970.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  6.10.140.1200 UniProtKB/TrEMBL
InterPro BSD UniProtKB/TrEMBL
  BSD_dom_sf UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Tfb1/p62 UniProtKB/TrEMBL
  TFIIH_BTF_p62_N UniProtKB/TrEMBL
NCBI Gene 361580 ENTREZGENE
PANTHER PTHR12856 UniProtKB/TrEMBL
Pfam BSD UniProtKB/TrEMBL
  TFIIH_BTF_p62_N UniProtKB/TrEMBL
PhenoGen Gtf2h1 PhenoGen
PROSITE BSD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012360 RatGTEx
SMART BSD UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF140383 UniProtKB/TrEMBL
UniProt A0A0G2JWQ0_RAT UniProtKB/TrEMBL
  A0A8I6AJ08_RAT UniProtKB/TrEMBL
  A6JBD2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYG3 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 Gtf2h1  general transcription factor IIH subunit 1  Gtf2h1  general transcription factor IIH, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Gtf2h1  general transcription factor IIH, polypeptide 1  Gtf2h1  general transcription factor II H, polypeptide 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gtf2h1  general transcription factor II H, polypeptide 1   Gtf2h1_predicted  general transcription factor II H, polypeptide 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gtf2h1_predicted  general transcription factor II H, polypeptide 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED