Rnf146 (ring finger protein 146) - Rat Genome Database

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Pathways
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Gene: Rnf146 (ring finger protein 146) Rattus norvegicus
Analyze
Symbol: Rnf146
Name: ring finger protein 146
RGD ID: 1306482
Description: Enables enzyme binding activity. Involved in several processes, including cellular response to glucose stimulus; cellular response to hydrogen peroxide; and negative regulation of cellular response to oxidative stress. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human RNF146 (ring finger protein 146); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase RNF146; iduna; LOC308051; RING-type E3 ubiquitin transferase RNF146
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,286,680 - 30,304,367 (+)NCBIGRCr8
mRatBN7.2128,458,864 - 28,475,758 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,458,887 - 28,475,923 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,260,504 - 28,271,097 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0134,260,355 - 34,270,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,461,120 - 28,471,713 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0130,856,923 - 30,873,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl130,863,217 - 30,873,808 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0132,290,907 - 32,307,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,255,138 - 29,265,731 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,258,082 - 29,268,670 (+)NCBI
Celera127,132,709 - 27,143,302 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post-hypoxic cardiomyocytes. Gero D and Szabo C, Br J Pharmacol. 2015 Oct;172(20):4817-32. doi: 10.1111/bph.13252. Epub 2015 Oct 14.
4. Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes. Gerö D, etal., Mol Med. 2014 Jul 31;20:313-28. doi: 10.2119/molmed.2014.00102.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia. Yang X, etal., Neuroscience. 2017 Mar 27;346:74-80. doi: 10.1016/j.neuroscience.2017.01.010. Epub 2017 Jan 17.
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15489334   PMID:15813938   PMID:21478859   PMID:32326811  


Genomics

Comparative Map Data
Rnf146
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,286,680 - 30,304,367 (+)NCBIGRCr8
mRatBN7.2128,458,864 - 28,475,758 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,458,887 - 28,475,923 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,260,504 - 28,271,097 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0134,260,355 - 34,270,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,461,120 - 28,471,713 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0130,856,923 - 30,873,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl130,863,217 - 30,873,808 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0132,290,907 - 32,307,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,255,138 - 29,265,731 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,258,082 - 29,268,670 (+)NCBI
Celera127,132,709 - 27,143,302 (+)NCBICelera
Cytogenetic Map1p11NCBI
RNF146
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386127,266,682 - 127,288,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6127,266,726 - 127,288,567 (+)EnsemblGRCh38hg38GRCh38
GRCh376127,587,827 - 127,609,707 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366127,629,713 - 127,651,202 (+)NCBINCBI36Build 36hg18NCBI36
Build 346127,629,712 - 127,651,198NCBI
Celera6128,330,302 - 128,351,791 (+)NCBICelera
Cytogenetic Map6q22.33NCBI
HuRef6125,164,466 - 125,186,349 (+)NCBIHuRef
CHM1_16127,852,150 - 127,874,042 (+)NCBICHM1_1
T2T-CHM13v2.06128,455,637 - 128,477,520 (+)NCBIT2T-CHM13v2.0
Rnf146
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391029,220,172 - 29,238,438 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1029,220,172 - 29,238,438 (-)EnsemblGRCm39 Ensembl
GRCm381029,344,176 - 29,362,442 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1029,344,176 - 29,362,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv371029,063,982 - 29,082,248 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361029,035,587 - 29,051,858 (-)NCBIMGSCv36mm8
Celera1030,276,585 - 30,294,697 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1016.6NCBI
Rnf146
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554368,312,096 - 8,331,648 (+)NCBIChiLan1.0ChiLan1.0
RNF146
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25147,263,264 - 147,284,796 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16145,172,033 - 145,193,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06125,057,312 - 125,079,096 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16129,170,440 - 129,192,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6129,190,562 - 129,191,733 (+)Ensemblpanpan1.1panPan2
RNF146
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,988,600 - 66,010,873 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl165,988,656 - 66,010,881 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha166,794,457 - 66,816,710 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,191,606 - 66,213,917 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,191,010 - 66,213,917 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,121,749 - 66,143,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,906,358 - 65,928,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,548,694 - 66,570,938 (+)NCBIUU_Cfam_GSD_1.0
Rnf146
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946116,001,734 - 116,023,924 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366392,393,150 - 2,417,982 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366392,394,566 - 2,417,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF146
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl135,909,575 - 35,926,968 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1135,909,789 - 35,927,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2139,594,042 - 39,612,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RNF146
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11346,441,069 - 46,462,533 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1346,441,741 - 46,442,823 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604018,718,979 - 18,740,720 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf146
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247531,671,614 - 1,706,793 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnf146
66 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:375
Count of miRNA genes:222
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000015421
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat

Markers in Region
BF394734  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0132,299,301 - 32,299,475NCBIRnor5.0
RGSC_v3.4129,257,248 - 29,257,418UniSTSRGSC3.4
Celera127,134,819 - 27,134,989UniSTS
RH 3.4 Map1312.58UniSTS
Cytogenetic Map1p11UniSTS
RH127705  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2128,475,492 - 28,475,678 (+)MAPPERmRatBN7.2
Rnor_6.0130,873,549 - 30,873,734NCBIRnor6.0
Rnor_5.0132,307,524 - 32,307,709UniSTSRnor5.0
RGSC_v3.4129,265,466 - 29,265,651UniSTSRGSC3.4
Celera127,143,037 - 27,143,222UniSTS
Cytogenetic Map1p11UniSTS
BF389128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2128,464,987 - 28,465,143 (+)MAPPERmRatBN7.2
Rnor_6.0130,863,040 - 30,863,195NCBIRnor6.0
Rnor_5.0132,297,015 - 32,297,170UniSTSRnor5.0
RGSC_v3.4129,254,961 - 29,255,116UniSTSRGSC3.4
Celera127,132,532 - 27,132,687UniSTS
RH 3.4 Map1317.4UniSTS
Cytogenetic Map1p11UniSTS
RH139137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2128,470,809 - 28,470,932 (+)MAPPERmRatBN7.2
Rnor_6.0130,868,866 - 30,868,988NCBIRnor6.0
Rnor_5.0132,302,841 - 32,302,963UniSTSRnor5.0
RGSC_v3.4129,260,783 - 29,260,905UniSTSRGSC3.4
Celera127,138,354 - 27,138,476UniSTS
RH 3.4 Map1314.2UniSTS
Cytogenetic Map1p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 55 39 19 39 8 11 74 35 41 11 8
Low 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015421   ⟹   ENSRNOP00000015421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,458,887 - 28,475,748 (+)Ensembl
Rnor_6.0 Ensembl130,863,217 - 30,873,808 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110925   ⟹   ENSRNOP00000094151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,458,890 - 28,475,923 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119984   ⟹   ENSRNOP00000081042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,458,890 - 28,475,923 (+)Ensembl
RefSeq Acc Id: NM_001012060   ⟹   NP_001012060
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8130,293,774 - 30,304,367 (+)NCBI
mRatBN7.2128,465,165 - 28,475,758 (+)NCBI
Rnor_6.0130,863,217 - 30,873,814 (+)NCBI
Rnor_5.0132,290,907 - 32,307,789 (+)NCBI
RGSC_v3.4129,255,138 - 29,265,731 (+)RGD
Celera127,132,709 - 27,143,302 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227744   ⟹   XP_006227806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8130,286,680 - 30,304,364 (+)NCBI
mRatBN7.2128,458,864 - 28,475,755 (+)NCBI
Rnor_6.0130,856,923 - 30,873,811 (+)NCBI
Rnor_5.0132,290,907 - 32,307,789 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227745   ⟹   XP_006227807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8130,287,497 - 30,304,364 (+)NCBI
mRatBN7.2128,458,884 - 28,475,755 (+)NCBI
Rnor_6.0130,856,932 - 30,873,811 (+)NCBI
Rnor_5.0132,290,907 - 32,307,789 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001012060   ⟸   NM_001012060
- UniProtKB: Q5XIK5 (UniProtKB/Swiss-Prot),   A0A140TAB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227806   ⟸   XM_006227744
- Peptide Label: isoform X1
- UniProtKB: Q5XIK5 (UniProtKB/Swiss-Prot),   A0A140TAB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227807   ⟸   XM_006227745
- Peptide Label: isoform X1
- UniProtKB: Q5XIK5 (UniProtKB/Swiss-Prot),   A0A140TAB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015421   ⟸   ENSRNOT00000015421
RefSeq Acc Id: ENSRNOP00000081042   ⟸   ENSRNOT00000119984
RefSeq Acc Id: ENSRNOP00000094151   ⟸   ENSRNOT00000110925
Protein Domains
RING-type   WWE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIK5-F1-model_v2 AlphaFold Q5XIK5 1-352 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689548
Promoter ID:EPDNEW_R72
Type:single initiation site
Name:Rnf146_1
Description:ring finger protein 146
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0130,863,207 - 30,863,267EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306482 AgrOrtholog
BioCyc Gene G2FUF-61961 BioCyc
Ensembl Genes ENSRNOG00000011588 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003168 UniProtKB/Swiss-Prot
  ENSRNOG00060023731 UniProtKB/Swiss-Prot
  ENSRNOG00065019124 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015421.7 UniProtKB/TrEMBL
  ENSRNOT00000110925.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119984.1 UniProtKB/Swiss-Prot
  ENSRNOT00055004921 UniProtKB/Swiss-Prot
  ENSRNOT00055004929 UniProtKB/Swiss-Prot
  ENSRNOT00055004931 UniProtKB/Swiss-Prot
  ENSRNOT00060041066 UniProtKB/Swiss-Prot
  ENSRNOT00060041085 UniProtKB/Swiss-Prot
  ENSRNOT00065032146 UniProtKB/Swiss-Prot
  ENSRNOT00065032149 UniProtKB/Swiss-Prot
  ENSRNOT00065032164 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.720.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135728 IMAGE-MGC_LOAD
InterPro RING-HC_RNF146 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNF146 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WWE-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WWE-dom_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WWE_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:308051 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94520 IMAGE-MGC_LOAD
NCBI Gene 308051 ENTREZGENE
PANTHER PTHR13417:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WWE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnf146 PhenoGen
PROSITE WWE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011588 RatGTEx
  ENSRNOG00055003168 RatGTEx
  ENSRNOG00060023731 RatGTEx
  ENSRNOG00065019124 RatGTEx
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WWE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF117839 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAB2 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIK5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Rnf146  ring finger protein 146  Rnf146_predicted  ring finger protein 146 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rnf146_predicted  ring finger protein 146 (predicted)      Symbol and Name status set to approved 70820 APPROVED