RGD Reference Report - Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. - Rat Genome Database

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Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation.

Authors: Barkauskaite, E  Jankevicius, G  Ahel, I 
Citation: Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
RGD ID: 11100038
Pubmed: PMID:26091342   (View Abstract at PubMed)
DOI: DOI:10.1016/j.molcel.2015.05.007   (Journal Full-text)

The poly(ADP-ribose) polymerases (PARPs) are a major family of enzymes capable of modifying proteins by ADP-ribosylation. Due to the large size and diversity of this family, PARPs affect almost every aspect of cellular life and have fundamental roles in DNA repair, transcription, heat shock and cytoplasmic stress responses, cell division, protein degradation, and much more. In the past decade, our understanding of the PARP enzymatic mechanism and activation, as well as regulation of ADP-ribosylation signals by the readers and erasers of protein ADP-ribosylation, has been significantly advanced by the emergence of new structural data, reviewed herein, which allow for better understanding of the biological roles of this widespread post-translational modification.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APLFHumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
AplfRatADP-ribosylation pathway, mono and poly-ribosylation  ISOAPLF (Homo sapiens) RGD 
AplfMouseADP-ribosylation pathway, mono and poly-ribosylation  ISOAPLF (Homo sapiens) RGD 
CHFRHumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
ChfrRatADP-ribosylation pathway, mono and poly-ribosylation  ISOCHFR (Homo sapiens) RGD 
ChfrMouseADP-ribosylation pathway, mono and poly-ribosylation  ISOCHFR (Homo sapiens) RGD 
MACROD1HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
MACROD2HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
Macrod1RatADP-ribosylation pathway, mono and poly-ribosylation  ISOMACROD1 (Homo sapiens) RGD 
Macrod1MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOMACROD1 (Homo sapiens) RGD 
Macrod2RatADP-ribosylation pathway, mono and poly-ribosylation  ISOMACROD2 (Homo sapiens) RGD 
Macrod2MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOMACROD2 (Homo sapiens) RGD 
OARD1HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
Oard1RatADP-ribosylation pathway, mono and poly-ribosylation  ISOOARD1 (Homo sapiens) RGD 
Oard1MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOOARD1 (Homo sapiens) RGD 
PARGHumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP1HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP10HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP11HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP12HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP14HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP15HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP16HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP2HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP3HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP4HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP6HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP8HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PARP9HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
PargRatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARG (Homo sapiens) RGD 
PargMouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARG (Homo sapiens) RGD 
Parp1RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP1 (Homo sapiens) RGD 
Parp1MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP1 (Homo sapiens) RGD 
Parp10MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP10 (Homo sapiens) RGD 
Parp10RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP10 (Homo sapiens) RGD 
Parp11MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP11 (Homo sapiens) RGD 
Parp11RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP11 (Homo sapiens) RGD 
Parp12RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP12 (Homo sapiens) RGD 
Parp12MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP12 (Homo sapiens) RGD 
Parp14RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP14 (Homo sapiens) RGD 
Parp14MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP14 (Homo sapiens) RGD 
Parp16RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP16 (Homo sapiens) RGD 
Parp16MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP16 (Homo sapiens) RGD 
Parp2RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP2 (Homo sapiens) RGD 
Parp2MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP2 (Homo sapiens) RGD 
Parp3RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP3 (Homo sapiens) RGD 
Parp3MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP3 (Homo sapiens) RGD 
Parp4RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP4 (Homo sapiens) RGD 
Parp4MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP4 (Homo sapiens) RGD 
Parp6RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP6 (Homo sapiens) RGD 
Parp6MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP6 (Homo sapiens) RGD 
Parp8MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP8 (Homo sapiens) RGD 
Parp8RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP8 (Homo sapiens) RGD 
Parp9RatADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP9 (Homo sapiens) RGD 
Parp9MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOPARP9 (Homo sapiens) RGD 
RNF146HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
Rnf146RatADP-ribosylation pathway, mono and poly-ribosylation  ISORNF146 (Homo sapiens) RGD 
Rnf146MouseADP-ribosylation pathway, mono and poly-ribosylation  ISORNF146 (Homo sapiens) RGD 
TIPARPHumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
TNKSHumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
TNKS2HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
TiparpRatADP-ribosylation pathway, mono and poly-ribosylation  ISOTIPARP (Homo sapiens) RGD 
TiparpMouseADP-ribosylation pathway, mono and poly-ribosylation  ISOTIPARP (Homo sapiens) RGD 
TnksRatADP-ribosylation pathway, mono and poly-ribosylation  ISOTNKS (Homo sapiens) RGD 
TnksMouseADP-ribosylation pathway, mono and poly-ribosylation  ISOTNKS (Homo sapiens) RGD 
Tnks2RatADP-ribosylation pathway, mono and poly-ribosylation  ISOTNKS2 (Homo sapiens) RGD 
Tnks2MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOTNKS2 (Homo sapiens) RGD 
ZC3HAV1HumanADP-ribosylation pathway, mono and poly-ribosylation  TAS  RGD 
Zc3hav1RatADP-ribosylation pathway, mono and poly-ribosylation  ISOZC3HAV1 (Homo sapiens) RGD 
Zc3hav1MouseADP-ribosylation pathway, mono and poly-ribosylation  ISOZC3HAV1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Aplf  (aprataxin and PNKP like factor)
Chfr  (checkpoint with forkhead and ring finger domains)
Macrod1  (mono-ADP ribosylhydrolase 1)
Macrod2  (mono-ADP ribosylhydrolase 2)
Oard1  (O-acyl-ADP-ribose deacylase 1)
Parg  (poly (ADP-ribose) glycohydrolase)
Parp1  (poly (ADP-ribose) polymerase 1)
Parp10  (poly (ADP-ribose) polymerase family, member 10)
Parp11  (poly (ADP-ribose) polymerase family, member 11)
Parp12  (poly (ADP-ribose) polymerase family, member 12)
Parp14  (poly (ADP-ribose) polymerase family, member 14)
Parp16  (poly (ADP-ribose) polymerase family, member 16)
Parp2  (poly (ADP-ribose) polymerase 2)
Parp3  (poly (ADP-ribose) polymerase family, member 3)
Parp4  (poly (ADP-ribose) polymerase family, member 4)
Parp6  (poly (ADP-ribose) polymerase family, member 6)
Parp8  (poly (ADP-ribose) polymerase family, member 8)
Parp9  (poly (ADP-ribose) polymerase family, member 9)
Rnf146  (ring finger protein 146)
Tiparp  (TCDD-inducible poly(ADP-ribose) polymerase)
Tnks  (tankyrase)
Tnks2  (tankyrase 2)
Zc3hav1  (zinc finger CCCH-type containing, antiviral 1)

Genes (Mus musculus)
Aplf  (aprataxin and PNKP like factor)
Chfr  (checkpoint with forkhead and ring finger domains)
Macrod1  (mono-ADP ribosylhydrolase 1)
Macrod2  (mono-ADP ribosylhydrolase 2)
Oard1  (O-acyl-ADP-ribose deacylase 1)
Parg  (poly (ADP-ribose) glycohydrolase)
Parp1  (poly (ADP-ribose) polymerase family, member 1)
Parp10  (poly (ADP-ribose) polymerase family, member 10)
Parp11  (poly (ADP-ribose) polymerase family, member 11)
Parp12  (poly (ADP-ribose) polymerase family, member 12)
Parp14  (poly (ADP-ribose) polymerase family, member 14)
Parp16  (poly (ADP-ribose) polymerase family, member 16)
Parp2  (poly (ADP-ribose) polymerase family, member 2)
Parp3  (poly (ADP-ribose) polymerase family, member 3)
Parp4  (poly (ADP-ribose) polymerase family, member 4)
Parp6  (poly (ADP-ribose) polymerase family, member 6)
Parp8  (poly (ADP-ribose) polymerase family, member 8)
Parp9  (poly (ADP-ribose) polymerase family, member 9)
Rnf146  (ring finger protein 146)
Tiparp  (TCDD-inducible poly(ADP-ribose) polymerase)
Tnks  (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)
Tnks2  (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)
Zc3hav1  (zinc finger CCCH type, antiviral 1)

Genes (Homo sapiens)
APLF  (aprataxin and PNKP like factor)
CHFR  (checkpoint with forkhead and ring finger domains)
MACROD1  (mono-ADP ribosylhydrolase 1)
MACROD2  (mono-ADP ribosylhydrolase 2)
OARD1  (O-acyl-ADP-ribose deacylase 1)
PARG  (poly(ADP-ribose) glycohydrolase)
PARP1  (poly(ADP-ribose) polymerase 1)
PARP10  (poly(ADP-ribose) polymerase family member 10)
PARP11  (poly(ADP-ribose) polymerase family member 11)
PARP12  (poly(ADP-ribose) polymerase family member 12)
PARP14  (poly(ADP-ribose) polymerase family member 14)
PARP15  (poly(ADP-ribose) polymerase family member 15)
PARP16  (poly(ADP-ribose) polymerase family member 16)
PARP2  (poly(ADP-ribose) polymerase 2)
PARP3  (poly(ADP-ribose) polymerase family member 3)
PARP4  (poly(ADP-ribose) polymerase family member 4)
PARP6  (poly(ADP-ribose) polymerase family member 6)
PARP8  (poly(ADP-ribose) polymerase family member 8)
PARP9  (poly(ADP-ribose) polymerase family member 9)
RNF146  (ring finger protein 146)
TIPARP  (TCDD inducible poly(ADP-ribose) polymerase)
TNKS  (tankyrase)
TNKS2  (tankyrase 2)
ZC3HAV1  (zinc finger CCCH-type containing, antiviral 1)


Additional Information