Tnk2 (tyrosine kinase, non-receptor, 2) - Rat Genome Database

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Gene: Tnk2 (tyrosine kinase, non-receptor, 2) Rattus norvegicus
Analyze
Symbol: Tnk2
Name: tyrosine kinase, non-receptor, 2
RGD ID: 1305957
Description: Enables protein tyrosine kinase activity. Predicted to be involved in positive regulation of peptidyl-tyrosine phosphorylation; regulation of clathrin-dependent endocytosis; and spermatid development. Predicted to be located in several cellular components, including clathrin-coated pit; cytoophidium; and cytoplasmic vesicle. Predicted to be part of Grb2-EGFR complex. Predicted to be active in plasma membrane; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human TNK2 (tyrosine kinase non receptor 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ACK-1; activated CDC42 kinase 1; activated p21cdc42Hs kinase; LOC303882; MGC94214; tyrosine kinase non-receptor protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,619,795 - 81,659,074 (-)NCBIGRCr8
mRatBN7.21168,114,725 - 68,154,254 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,114,726 - 68,154,009 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,951,794 - 76,991,071 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,615,223 - 69,654,368 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,640,896 - 68,680,174 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,348,726 - 71,388,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,348,717 - 71,387,992 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,431,230 - 74,470,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,927,509 - 69,966,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,985,098 - 70,024,443 (-)NCBI
Celera1167,547,447 - 67,587,473 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. Urena JM, etal., J Comp Neurol. 2005 Sep 19;490(2):119-32.
8. Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase. Yokoyama N, etal., J Biol Chem. 2005 Dec 23;280(51):42219-26. Epub 2005 Oct 28.
Additional References at PubMed
PMID:10587647   PMID:10618719   PMID:12477932   PMID:16472662   PMID:17182860   PMID:18262180   PMID:18993068   PMID:19946888   PMID:20086093   PMID:20333297   PMID:20979614   PMID:21169560  
PMID:23562806   PMID:23686771   PMID:25223282   PMID:25416956  


Genomics

Comparative Map Data
Tnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,619,795 - 81,659,074 (-)NCBIGRCr8
mRatBN7.21168,114,725 - 68,154,254 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,114,726 - 68,154,009 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,951,794 - 76,991,071 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,615,223 - 69,654,368 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,640,896 - 68,680,174 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,348,726 - 71,388,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,348,717 - 71,387,992 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,431,230 - 74,470,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,927,509 - 69,966,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,985,098 - 70,024,443 (-)NCBI
Celera1167,547,447 - 67,587,473 (-)NCBICelera
Cytogenetic Map11q22NCBI
TNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383195,863,364 - 195,908,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3195,863,364 - 195,911,945 (-)EnsemblGRCh38hg38GRCh38
GRCh373195,590,235 - 195,635,422 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,074,633 - 197,120,277 (-)NCBINCBI36Build 36hg18NCBI36
Build 343197,078,545 - 197,124,190NCBI
Celera3194,132,138 - 194,176,550 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3192,870,965 - 192,916,101 (-)NCBIHuRef
CHM1_13195,555,272 - 195,606,419 (-)NCBICHM1_1
T2T-CHM13v2.03198,449,491 - 198,494,501 (+)NCBIT2T-CHM13v2.0
Tnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,462,699 - 32,502,311 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,462,692 - 32,502,311 (+)EnsemblGRCm39 Ensembl
GRCm381632,644,099 - 32,683,493 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,643,874 - 32,683,493 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,644,729 - 32,683,579 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,564,608 - 32,603,240 (+)NCBIMGSCv36mm8
Celera1633,124,376 - 33,163,447 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.16NCBI
Tnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,300,572 - 12,338,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,302,463 - 12,337,976 (-)NCBIChiLan1.0ChiLan1.0
TNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22193,777,761 - 193,826,414 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13193,782,481 - 193,831,288 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,254,017 - 193,302,863 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,219,978 - 203,254,498 (-)NCBIpanpan1.1PanPan1.1panPan2
TNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,153,636 - 29,177,568 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,152,851 - 29,179,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,178,360 - 29,220,811 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,386,486 - 29,428,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,386,488 - 29,412,066 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,171,866 - 29,196,006 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,227,984 - 29,270,384 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,848,891 - 29,891,309 (-)NCBIUU_Cfam_GSD_1.0
Tnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,200,392 - 125,249,164 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784636,139 - 685,210 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936784636,105 - 685,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13134,101,377 - 134,124,824 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113134,082,266 - 134,124,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,624,416 - 143,666,696 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,187,702 - 91,232,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1591,201,008 - 91,232,399 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604165,037,963 - 65,084,349 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,236,983 - 61,273,166 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnk2
206 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:74
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000002411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
AF037260  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,114,939 - 68,115,055 (+)MAPPERmRatBN7.2
Rnor_6.01171,348,941 - 71,349,056NCBIRnor6.0
Rnor_5.01174,431,445 - 74,431,560UniSTSRnor5.0
RGSC_v3.41169,927,724 - 69,927,839UniSTSRGSC3.4
Celera1167,547,662 - 67,547,777UniSTS
Cytogenetic Map11q22UniSTS
RH134491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,114,811 - 68,115,000 (+)MAPPERmRatBN7.2
Rnor_6.01171,348,813 - 71,349,001NCBIRnor6.0
Rnor_5.01174,431,317 - 74,431,505UniSTSRnor5.0
RGSC_v3.41169,927,596 - 69,927,784UniSTSRGSC3.4
Celera1167,547,534 - 67,547,722UniSTS
RH 3.4 Map11393.0UniSTS
Cytogenetic Map11q22UniSTS
RH143928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,115,257 - 68,115,412 (+)MAPPERmRatBN7.2
Rnor_6.01171,349,259 - 71,349,413NCBIRnor6.0
Rnor_5.01174,431,763 - 74,431,917UniSTSRnor5.0
RGSC_v3.41169,928,042 - 69,928,196UniSTSRGSC3.4
Celera1167,547,980 - 67,548,134UniSTS
RH 3.4 Map11403.5UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 30 22 13 22 3 74 27 34 3
Low 11 27 19 6 19 8 8 8 7 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002411   ⟹   ENSRNOP00000002411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,114,726 - 68,154,009 (-)Ensembl
Rnor_6.0 Ensembl1171,348,727 - 71,387,992 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084768   ⟹   ENSRNOP00000070836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,114,726 - 68,139,370 (-)Ensembl
Rnor_6.0 Ensembl1171,348,717 - 71,368,456 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085568   ⟹   ENSRNOP00000072336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,114,726 - 68,136,982 (-)Ensembl
Rnor_6.0 Ensembl1171,350,817 - 71,368,440 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111788   ⟹   ENSRNOP00000084054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,114,726 - 68,154,009 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116648   ⟹   ENSRNOP00000085601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,114,726 - 68,154,009 (-)Ensembl
RefSeq Acc Id: NM_001008336   ⟹   NP_001008337
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,659,074 (-)NCBI
mRatBN7.21168,114,725 - 68,154,009 (-)NCBI
Rnor_6.01171,348,726 - 71,387,992 (-)NCBI
Rnor_5.01174,431,230 - 74,470,437 (-)NCBI
RGSC_v3.41169,927,509 - 69,966,854 (-)RGD
Celera1167,547,447 - 67,587,473 (-)RGD
Sequence:
RefSeq Acc Id: XM_017597980   ⟹   XP_017453469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,273 (-)NCBI
mRatBN7.21168,114,725 - 68,137,206 (-)NCBI
Rnor_6.01171,348,726 - 71,371,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597981   ⟹   XP_017453470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,642,273 (-)NCBI
mRatBN7.21168,116,856 - 68,137,207 (-)NCBI
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597983   ⟹   XP_017453472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,644,660 (-)NCBI
mRatBN7.21168,116,856 - 68,139,599 (-)NCBI
Rnor_6.01171,348,726 - 71,374,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597984   ⟹   XP_017453473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,273 (-)NCBI
mRatBN7.21168,114,725 - 68,137,206 (-)NCBI
Rnor_6.01171,348,726 - 71,371,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597985   ⟹   XP_017453474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,642,273 (-)NCBI
mRatBN7.21168,116,856 - 68,137,207 (-)NCBI
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597987   ⟹   XP_017453476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,642,274 (-)NCBI
mRatBN7.21168,116,856 - 68,137,207 (-)NCBI
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597990   ⟹   XP_017453479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,642,274 (-)NCBI
mRatBN7.21168,116,856 - 68,137,207 (-)NCBI
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088304   ⟹   XP_038944232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,273 (-)NCBI
mRatBN7.21168,114,725 - 68,137,207 (-)NCBI
RefSeq Acc Id: XM_039088305   ⟹   XP_038944233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,274 (-)NCBI
mRatBN7.21168,114,725 - 68,137,207 (-)NCBI
RefSeq Acc Id: XM_039088306   ⟹   XP_038944234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,644,659 (-)NCBI
mRatBN7.21168,114,725 - 68,139,599 (-)NCBI
RefSeq Acc Id: XM_039088307   ⟹   XP_038944235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,274 (-)NCBI
mRatBN7.21168,114,725 - 68,137,207 (-)NCBI
RefSeq Acc Id: XM_039088309   ⟹   XP_038944237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,274 (-)NCBI
mRatBN7.21168,114,725 - 68,137,207 (-)NCBI
RefSeq Acc Id: XM_039088311   ⟹   XP_038944239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,274 (-)NCBI
mRatBN7.21168,114,725 - 68,137,207 (-)NCBI
RefSeq Acc Id: XM_039088312   ⟹   XP_038944240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,644,659 (-)NCBI
mRatBN7.21168,116,856 - 68,139,598 (-)NCBI
RefSeq Acc Id: XM_039088314   ⟹   XP_038944242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,642,274 (-)NCBI
mRatBN7.21168,116,856 - 68,137,207 (-)NCBI
RefSeq Acc Id: XM_039088315   ⟹   XP_038944243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,274 (-)NCBI
mRatBN7.21168,114,725 - 68,137,207 (-)NCBI
RefSeq Acc Id: XM_039088316   ⟹   XP_038944244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,644,664 (-)NCBI
mRatBN7.21168,116,856 - 68,139,602 (-)NCBI
RefSeq Acc Id: XM_039088317   ⟹   XP_038944245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,621,926 - 81,644,663 (-)NCBI
mRatBN7.21168,116,856 - 68,139,601 (-)NCBI
RefSeq Acc Id: XM_039088321   ⟹   XP_038944249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,631,482 (-)NCBI
mRatBN7.21168,114,725 - 68,126,414 (-)NCBI
RefSeq Acc Id: XM_039088322   ⟹   XP_038944250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,624,466 - 81,642,274 (-)NCBI
mRatBN7.21168,119,402 - 68,137,206 (-)NCBI
RefSeq Acc Id: XM_063270499   ⟹   XP_063126569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,273 (-)NCBI
RefSeq Acc Id: XM_063270501   ⟹   XP_063126571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,273 (-)NCBI
RefSeq Acc Id: XM_063270502   ⟹   XP_063126572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,273 (-)NCBI
RefSeq Acc Id: XM_063270503   ⟹   XP_063126573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,619,795 - 81,642,273 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001008337 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453469 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453470 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453472 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453473 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453474 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453476 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453479 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944232 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944233 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944235 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944237 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944239 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944240 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944242 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944243 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944244 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944245 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944249 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944250 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126569 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126571 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126572 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126573 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85825 (Get FASTA)   NCBI Sequence Viewer  
  EDM11400 (Get FASTA)   NCBI Sequence Viewer  
  EDM11401 (Get FASTA)   NCBI Sequence Viewer  
  EDM11402 (Get FASTA)   NCBI Sequence Viewer  
  EDM11403 (Get FASTA)   NCBI Sequence Viewer  
  EDM11404 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002411
  ENSRNOP00000002411.4
  ENSRNOP00000070836
  ENSRNOP00000070836.2
  ENSRNOP00000072336
  ENSRNOP00000072336.2
  ENSRNOP00000084054.1
  ENSRNOP00000085601.1
GenBank Protein Q5U2X5 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001008337   ⟸   NM_001008336
- UniProtKB: Q5U2X5 (UniProtKB/Swiss-Prot),   F1M7W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453472   ⟸   XM_017597983
- Peptide Label: isoform X9
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453473   ⟸   XM_017597984
- Peptide Label: isoform X11
- UniProtKB: A0A0G2K2Q7 (UniProtKB/TrEMBL),   F1M7W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453469   ⟸   XM_017597980
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453479   ⟸   XM_017597990
- Peptide Label: isoform X21
- UniProtKB: A0A8I6A0G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453476   ⟸   XM_017597987
- Peptide Label: isoform X14
- UniProtKB: F1M7W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453474   ⟸   XM_017597985
- Peptide Label: isoform X12
- UniProtKB: F1M7W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453470   ⟸   XM_017597981
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070836   ⟸   ENSRNOT00000084768
RefSeq Acc Id: ENSRNOP00000072336   ⟸   ENSRNOT00000085568
RefSeq Acc Id: ENSRNOP00000002411   ⟸   ENSRNOT00000002411
RefSeq Acc Id: XP_038944234   ⟸   XM_039088306
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944235   ⟸   XM_039088307
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944237   ⟸   XM_039088309
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944243   ⟸   XM_039088315
- Peptide Label: isoform X19
- UniProtKB: A0A8I6A0G1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944239   ⟸   XM_039088311
- Peptide Label: isoform X10
- UniProtKB: A0A8I6A0G1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944233   ⟸   XM_039088305
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944232   ⟸   XM_039088304
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1S7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944249   ⟸   XM_039088321
- Peptide Label: isoform X23
- UniProtKB: A6IRQ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944244   ⟸   XM_039088316
- Peptide Label: isoform X20
- UniProtKB: A0A0G2JYY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944245   ⟸   XM_039088317
- Peptide Label: isoform X22
- UniProtKB: A0A0G2JYY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944240   ⟸   XM_039088312
- Peptide Label: isoform X15
- UniProtKB: F1M7W9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944242   ⟸   XM_039088314
- Peptide Label: isoform X18
- UniProtKB: A0A8I6A0G1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944250   ⟸   XM_039088322
- Peptide Label: isoform X24
RefSeq Acc Id: ENSRNOP00000085601   ⟸   ENSRNOT00000116648
RefSeq Acc Id: ENSRNOP00000084054   ⟸   ENSRNOT00000111788
RefSeq Acc Id: XP_063126573   ⟸   XM_063270503
- Peptide Label: isoform X17
RefSeq Acc Id: XP_063126571   ⟸   XM_063270501
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063126572   ⟸   XM_063270502
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063126569   ⟸   XM_063270499
- Peptide Label: isoform X7
Protein Domains
Cdc42 binding   Mig-6   Protein kinase   SH3   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2X5-F1-model_v2 AlphaFold Q5U2X5 1-1040 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305957 AgrOrtholog
BioCyc Gene G2FUF-21110 BioCyc
Ensembl Genes ENSRNOG00000001769 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002411 ENTREZGENE
  ENSRNOT00000002411.8 UniProtKB/TrEMBL
  ENSRNOT00000084768.2 UniProtKB/TrEMBL
  ENSRNOT00000085568 ENTREZGENE
  ENSRNOT00000085568.2 UniProtKB/TrEMBL
  ENSRNOT00000111788.1 UniProtKB/TrEMBL
  ENSRNOT00000116648.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.680.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130376 IMAGE-MGC_LOAD
InterPro Ack1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cdc42-bd-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cdc42_binding_dom-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mig-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNK-like_SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
KEGG Report rno:303882 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94214 IMAGE-MGC_LOAD
NCBI Gene 303882 ENTREZGENE
PANTHER GENE 33 POLYPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14254:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GTPase_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inhibitor_Mig-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnk2 PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001769 RatGTEx
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
UniProt A0A0G2JYY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K2Q7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0G1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A1S7 ENTREZGENE, UniProtKB/TrEMBL
  A6IRP7_RAT UniProtKB/TrEMBL
  A6IRP8_RAT UniProtKB/TrEMBL
  A6IRQ0 ENTREZGENE, UniProtKB/TrEMBL
  A6IRQ1_RAT UniProtKB/TrEMBL
  ACK1_RAT UniProtKB/Swiss-Prot
  F1M7W9 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2X5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tnk2  tyrosine kinase, non-receptor, 2  LOC682784  similar to tyrosine kinase, non-receptor, 2  Data merged from RGD:1595258 1643240 APPROVED
2006-11-20 LOC682784  similar to tyrosine kinase, non-receptor, 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Tnk2  tyrosine kinase, non-receptor, 2  Tnk2_predicted  tyrosine kinase, non-receptor, 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tnk2_predicted  tyrosine kinase, non-receptor, 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED