Symbol:
Il27ra
Name:
interleukin 27 receptor subunit alpha
RGD ID:
1305029
Description:
Predicted to enable interleukin-27 receptor activity. Predicted to be involved in several processes, including negative regulation of T cell extravasation; negative regulation of T-helper 17 type immune response; and negative regulation of cytokine production. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of type II interferon production; and regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Predicted to be located in plasma membrane. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha); PARTICIPATES IN interleukin-27 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; alpha-Zearalanol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; LOC288905
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
IL27RA (interleukin 27 receptor subunit alpha) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Il27ra (interleukin 27 receptor, alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Il27ra (interleukin 27 receptor subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
IL27RA (interleukin 27 receptor subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
IL27RA (interleukin 27 receptor subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Il27ra (interleukin 27 receptor subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
IL27RA (interleukin 27 receptor subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
IL27RA (interleukin 27 receptor subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Il27ra (interleukin 27 receptor subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
IL27RA (interleukin 27 receptor subunit alpha)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Il27ra (interleukin 27 receptor, alpha)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 19 41,014,730 - 41,026,740 (+) NCBI GRCr8 mRatBN7.2 19 24,109,963 - 24,121,977 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 19 24,109,972 - 24,121,938 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 19 30,931,218 - 30,943,116 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 19 31,585,624 - 31,597,522 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 19 33,808,352 - 33,820,238 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 19 25,151,835 - 25,163,995 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 25,149,897 - 25,164,086 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 36,128,834 - 36,140,875 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 25,795,355 - 25,807,317 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 19 25,802,500 - 25,806,104 (+) NCBI Celera 19 23,657,895 - 23,669,746 (+) NCBI Celera Cytogenetic Map 19 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Il27ra Rat (-)-epigallocatechin 3-gallate decreases expression ISO RGD:1312815 6480464 epigallocatechin gallate results in decreased expression of IL27RA mRNA CTD PMID:16084531 Il27ra Rat (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1312815 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IL27RA mRNA CTD PMID:22079256 Il27ra Rat 1,2-dimethylhydrazine increases expression ISO RGD:1312816 6480464 1,2-Dimethylhydrazine results in increased expression of IL27RA mRNA CTD PMID:22206623 Il27ra Rat 17beta-estradiol multiple interactions ISO RGD:1312815 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL27RA mRNA CTD PMID:19619570 Il27ra Rat 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IL27RA mRNA CTD PMID:32741896 Il27ra Rat 17beta-estradiol increases expression ISO RGD:1312815 6480464 Estradiol results in increased expression of IL27RA mRNA CTD PMID:19619570|PMID:21185374|PMID:31614463 Il27ra Rat 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IL27RA mRNA CTD PMID:32741896 Il27ra Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1312815 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL27RA mRNA CTD PMID:19619570 Il27ra Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312816 6480464 Tetrachlorodibenzodioxin affects the expression of IL27RA mRNA CTD PMID:21570461|PMID:26377647 Il27ra Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1312815 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL27RA mRNA CTD PMID:19619570 Il27ra Rat 5-aza-2'-deoxycytidine affects expression ISO RGD:1312815 6480464 Decitabine affects the expression of IL27RA mRNA CTD PMID:23300844 Il27ra Rat 5-fluorouracil affects response to substance ISO RGD:1312815 6480464 IL27RA protein affects the susceptibility to Fluorouracil CTD PMID:16217747 Il27ra Rat 8-Br-cAMP increases expression ISO RGD:1312815 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL27RA mRNA CTD PMID:22079614 Il27ra Rat actinomycin D increases expression ISO RGD:1312815 6480464 Dactinomycin results in increased expression of IL27RA mRNA CTD PMID:21527772 Il27ra Rat aflatoxin B1 increases methylation ISO RGD:1312815 6480464 Aflatoxin B1 results in increased methylation of IL27RA intron CTD PMID:30157460 Il27ra Rat all-trans-retinoic acid increases expression ISO RGD:1312816 6480464 Tretinoin results in increased expression of IL27RA mRNA CTD PMID:36189433 Il27ra Rat all-trans-retinoic acid multiple interactions ISO RGD:1312816 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of IL27RA mRNA CTD PMID:36189433 Il27ra Rat alpha-Zearalanol increases expression EXP 6480464 Zeranol results in increased expression of IL27RA mRNA CTD PMID:35163327 Il27ra Rat amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of IL27RA mRNA CTD PMID:30779732 Il27ra Rat antirheumatic drug decreases expression ISO RGD:1312815 6480464 Antirheumatic Agents results in decreased expression of IL27RA mRNA CTD PMID:24449571 Il27ra Rat arsane multiple interactions ISO RGD:1312815 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Il27ra Rat arsenic atom multiple interactions ISO RGD:1312815 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Il27ra Rat arsenous acid decreases expression ISO RGD:1312815 6480464 Arsenic Trioxide results in decreased expression of IL27RA mRNA CTD PMID:19128835 Il27ra Rat atrazine increases expression ISO RGD:1312815 6480464 Atrazine results in increased expression of IL27RA mRNA CTD PMID:22378314 Il27ra Rat benzo[a]pyrene affects methylation ISO RGD:1312815 6480464 Benzo(a)pyrene affects the methylation of IL27RA 3' UTR CTD PMID:27901495 Il27ra Rat benzo[a]pyrene increases expression ISO RGD:1312815 6480464 Benzo(a)pyrene results in increased expression of IL27RA mRNA CTD PMID:32234424 Il27ra Rat benzo[a]pyrene decreases methylation ISO RGD:1312815 6480464 Benzo(a)pyrene results in decreased methylation of IL27RA promoter CTD PMID:27901495 Il27ra Rat bis(2-ethylhexyl) phthalate increases expression ISO RGD:1312816 6480464 Diethylhexyl Phthalate results in increased expression of IL27RA mRNA CTD PMID:35550907 Il27ra Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IL27RA mRNA CTD PMID:25181051 Il27ra Rat bisphenol A increases expression ISO RGD:1312816 6480464 bisphenol A results in increased expression of IL27RA mRNA CTD PMID:38701888 Il27ra Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of IL27RA mRNA CTD PMID:30816183|PMID:32528016 Il27ra Rat buta-1,3-diene decreases expression ISO RGD:1312816 6480464 1,3-butadiene results in decreased expression of IL27RA mRNA CTD PMID:29038090 Il27ra Rat cadmium atom decreases expression ISO RGD:1312815 6480464 Cadmium results in decreased expression of IL27RA mRNA CTD PMID:21120746 Il27ra Rat cadmium dichloride decreases expression ISO RGD:1312815 6480464 Cadmium Chloride results in decreased expression of IL27RA mRNA CTD PMID:38568856 Il27ra Rat carbamazepine affects expression ISO RGD:1312815 6480464 Carbamazepine affects the expression of IL27RA mRNA CTD PMID:25979313 Il27ra Rat cisplatin increases expression ISO RGD:1312815 6480464 Cisplatin results in increased expression of IL27RA mRNA CTD PMID:27594783 Il27ra Rat cisplatin affects expression ISO RGD:1312815 6480464 Cisplatin affects the expression of IL27RA mRNA CTD PMID:23300844 Il27ra Rat copper(II) chloride increases expression ISO RGD:1312815 6480464 cupric chloride results in increased expression of IL27RA mRNA CTD PMID:38568856 Il27ra Rat copper(II) sulfate increases expression ISO RGD:1312815 6480464 Copper Sulfate results in increased expression of IL27RA mRNA CTD PMID:19549813 Il27ra Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of IL27RA mRNA CTD PMID:27523638 Il27ra Rat cyclosporin A increases expression ISO RGD:1312815 6480464 Cyclosporine results in increased expression of IL27RA mRNA CTD PMID:22147139 Il27ra Rat cyclosporin A decreases expression ISO RGD:1312815 6480464 Cyclosporine results in decreased expression of IL27RA mRNA CTD PMID:27989131 Il27ra Rat dextran sulfate decreases response to substance ISO RGD:1312816 6480464 IL27RA protein results in decreased susceptibility to Dextran Sulfate CTD PMID:16306766 Il27ra Rat diarsenic trioxide decreases expression ISO RGD:1312815 6480464 Arsenic Trioxide results in decreased expression of IL27RA mRNA CTD PMID:19128835 Il27ra Rat Dibutyl phosphate affects expression ISO RGD:1312815 6480464 di-n-butylphosphoric acid affects the expression of IL27RA mRNA CTD PMID:37042841 Il27ra Rat dimethylarsinic acid multiple interactions ISO RGD:1312816 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... CTD PMID:34876320 Il27ra Rat dorsomorphin multiple interactions ISO RGD:1312815 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Il27ra Rat doxorubicin decreases expression ISO RGD:1312815 6480464 Doxorubicin results in decreased expression of IL27RA mRNA CTD PMID:29803840 Il27ra Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of IL27RA mRNA CTD PMID:29391264 Il27ra Rat entinostat increases expression ISO RGD:1312815 6480464 entinostat results in increased expression of IL27RA mRNA CTD PMID:26272509|PMID:27188386 Il27ra Rat entinostat multiple interactions ISO RGD:1312815 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Il27ra Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of IL27RA mRNA CTD PMID:22061828 Il27ra Rat GSK-J4 decreases expression ISO RGD:1312815 6480464 GSK-J4 results in decreased expression of IL27RA mRNA CTD PMID:29301935 Il27ra Rat isoflavones affects expression ISO RGD:1312815 6480464 Isoflavones affects the expression of IL27RA mRNA CTD PMID:16365062 Il27ra Rat lamivudine multiple interactions ISO RGD:1312815 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA CTD PMID:15784690 Il27ra Rat manganese atom multiple interactions ISO RGD:1312815 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Il27ra Rat manganese(0) multiple interactions ISO RGD:1312815 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Il27ra Rat manganese(II) chloride multiple interactions ISO RGD:1312815 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Il27ra Rat methylarsonic acid multiple interactions ISO RGD:1312816 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... CTD PMID:34876320 Il27ra Rat mono(2-ethylhexyl) phthalate decreases expression ISO RGD:1312816 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of IL27RA mRNA CTD PMID:22401849 Il27ra Rat mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:1312816 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of IL27RA mRNA CTD PMID:36189433 Il27ra Rat N-acetyl-L-cysteine decreases expression ISO RGD:1312815 6480464 Acetylcysteine results in decreased expression of IL27RA mRNA CTD PMID:16084531 Il27ra Rat N-Nitrosopyrrolidine increases expression ISO RGD:1312815 6480464 N-Nitrosopyrrolidine results in increased expression of IL27RA mRNA CTD PMID:32234424 Il27ra Rat nickel atom increases expression ISO RGD:1312815 6480464 Nickel results in increased expression of IL27RA mRNA CTD PMID:25583101 Il27ra Rat panobinostat increases expression ISO RGD:1312815 6480464 panobinostat results in increased expression of IL27RA mRNA CTD PMID:26272509 Il27ra Rat panobinostat multiple interactions ISO RGD:1312815 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Il27ra Rat perfluorooctanoic acid multiple interactions ISO RGD:1312815 6480464 [Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] more ... CTD PMID:33325755 Il27ra Rat phytoestrogen multiple interactions ISO RGD:1312815 6480464 [Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] more ... CTD PMID:33325755 Il27ra Rat potassium chromate increases expression ISO RGD:1312815 6480464 potassium chromate(VI) results in increased expression of IL27RA mRNA CTD PMID:22079256 Il27ra Rat potassium chromate multiple interactions ISO RGD:1312815 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IL27RA mRNA CTD PMID:22079256 Il27ra Rat resveratrol multiple interactions ISO RGD:1312815 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of IL27RA mRNA CTD PMID:23557933 Il27ra Rat sarin increases expression ISO RGD:1312815 6480464 Sarin results in increased expression of IL27RA mRNA CTD PMID:19522546 Il27ra Rat SB 431542 multiple interactions ISO RGD:1312815 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Il27ra Rat silicon dioxide increases expression ISO RGD:1312816 6480464 Silicon Dioxide results in increased expression of IL27RA mRNA CTD PMID:29341224 Il27ra Rat sodium arsenate multiple interactions ISO RGD:1312816 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... CTD PMID:34876320 Il27ra Rat sodium arsenite decreases expression ISO RGD:1312815 6480464 sodium arsenite results in decreased expression of IL27RA mRNA CTD PMID:38568856 Il27ra Rat sodium arsenite increases expression ISO RGD:1312816 6480464 sodium arsenite results in increased expression of IL27RA mRNA CTD PMID:37682722 Il27ra Rat sodium arsenite multiple interactions ISO RGD:1312816 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... CTD PMID:34876320 Il27ra Rat sodium arsenite multiple interactions ISO RGD:1312815 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Il27ra Rat sodium arsenite affects expression ISO RGD:1312815 6480464 sodium arsenite affects the expression of IL27RA mRNA CTD PMID:34032870 Il27ra Rat sunitinib decreases expression ISO RGD:1312815 6480464 Sunitinib results in decreased expression of IL27RA mRNA CTD PMID:31533062 Il27ra Rat temozolomide increases expression ISO RGD:1312815 6480464 Temozolomide results in increased expression of IL27RA mRNA CTD PMID:31758290 Il27ra Rat testosterone multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IL27RA mRNA CTD PMID:32741896 Il27ra Rat thimerosal decreases expression ISO RGD:1312815 6480464 Thimerosal results in decreased expression of IL27RA mRNA CTD PMID:27188386 Il27ra Rat thiram decreases expression ISO RGD:1312815 6480464 Thiram results in decreased expression of IL27RA mRNA CTD PMID:38568856 Il27ra Rat titanium dioxide decreases methylation ISO RGD:1312816 6480464 titanium dioxide results in decreased methylation of IL27RA gene CTD PMID:35295148 Il27ra Rat trichostatin A increases expression ISO RGD:1312815 6480464 trichostatin A results in increased expression of IL27RA mRNA CTD PMID:24935251|PMID:26272509 Il27ra Rat trichostatin A multiple interactions ISO RGD:1312815 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Il27ra Rat triclosan decreases expression ISO RGD:1312815 6480464 Triclosan results in decreased expression of IL27RA mRNA CTD PMID:30510588 Il27ra Rat triphenyl phosphate affects expression ISO RGD:1312815 6480464 triphenyl phosphate affects the expression of IL27RA mRNA CTD PMID:37042841 Il27ra Rat triptonide decreases expression ISO RGD:1312816 6480464 triptonide results in decreased expression of IL27RA mRNA CTD PMID:33045310 Il27ra Rat valproic acid decreases expression ISO RGD:1312815 6480464 Valproic Acid results in decreased expression of IL27RA mRNA CTD PMID:29154799 Il27ra Rat valproic acid affects expression ISO RGD:1312815 6480464 Valproic Acid affects the expression of IL27RA mRNA CTD PMID:25979313 Il27ra Rat valproic acid affects expression ISO RGD:1312816 6480464 Valproic Acid affects the expression of IL27RA mRNA CTD PMID:17292431 Il27ra Rat zidovudine multiple interactions ISO RGD:1312815 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA CTD PMID:15784690
Imported Annotations - PID (archival)
Biological Process
biological_process (ND) defense response to Gram-positive bacterium (IEA,ISO) interleukin-27-mediated signaling pathway (IEA) negative regulation of cellular extravasation (IEA,ISO) negative regulation of interleukin-17 production (IEA,ISO) negative regulation of interleukin-6 production (IEA,ISO) negative regulation of neuron apoptotic process (IEA,ISO) negative regulation of T cell extravasation (IEA,ISO) negative regulation of T-helper 17 type immune response (IEA,ISO) negative regulation of tumor necrosis factor production (IEA,ISO) negative regulation of type 2 immune response (IEA,ISO) positive regulation of T-helper 1 type immune response (IEA,ISO) positive regulation of type II interferon production (IEA,ISO) regulation of isotype switching to IgG isotypes (IEA,ISO)
1.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.
The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis.
Holscher C, etal., J Immunol. 2005 Mar 15;174(6):3534-44.
3.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
4.
Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice.
Miyazaki Y, etal., J Immunol. 2005 Aug 15;175(4):2401-7.
5.
PID Annotation Import Pipeline
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
8.
Comprehensive gene review and curation
RGD comprehensive gene curation
9.
Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling.
Shimanoe Y, etal., Ann Allergy Asthma Immunol. 2009 Mar;102(3):223-32.
10.
Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation.
Yoshizaki A, etal., Ann Rheum Dis. 2011 Jan;70(1):194-200. Epub 2010 Aug 12.
Il27ra Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 19 41,014,730 - 41,026,740 (+) NCBI GRCr8 mRatBN7.2 19 24,109,963 - 24,121,977 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 19 24,109,972 - 24,121,938 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 19 30,931,218 - 30,943,116 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 19 31,585,624 - 31,597,522 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 19 33,808,352 - 33,820,238 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 19 25,151,835 - 25,163,995 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 25,149,897 - 25,164,086 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 36,128,834 - 36,140,875 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 25,795,355 - 25,807,317 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 19 25,802,500 - 25,806,104 (+) NCBI Celera 19 23,657,895 - 23,669,746 (+) NCBI Celera Cytogenetic Map 19 q11 NCBI
IL27RA Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 19 14,031,762 - 14,053,218 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 19 14,031,762 - 14,053,218 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 19 14,142,574 - 14,164,030 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 19 14,003,262 - 14,025,026 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 19 14,003,261 - 14,025,026 NCBI Celera 19 14,036,058 - 14,057,825 (+) NCBI Celera Cytogenetic Map 19 p13.12 NCBI HuRef 19 13,714,538 - 13,735,786 (+) NCBI HuRef CHM1_1 19 14,143,096 - 14,164,322 (+) NCBI CHM1_1 T2T-CHM13v2.0 19 14,158,051 - 14,179,508 (+) NCBI T2T-CHM13v2.0
Il27ra Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 8 84,756,915 - 84,769,250 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 8 84,756,923 - 84,769,218 (-) Ensembl GRCm39 Ensembl GRCm38 8 84,030,286 - 84,042,600 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 8 84,030,294 - 84,042,589 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 8 86,554,185 - 86,566,474 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 8 86,920,423 - 86,932,680 (-) NCBI MGSCv36 mm8 Celera 8 88,323,361 - 88,337,096 (-) NCBI Celera Cytogenetic Map 8 C2 NCBI cM Map 8 40.26 NCBI
Il27ra Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955415 32,749,094 - 32,761,882 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955415 32,749,682 - 32,762,532 (+) NCBI ChiLan1.0 ChiLan1.0
IL27RA Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 20 18,960,949 - 18,982,615 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 19 17,961,963 - 17,983,593 (+) NCBI NHGRI_mPanPan1 PanPan1.1 19 14,323,618 - 14,343,636 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 19 14,323,618 - 14,343,627 (+) Ensembl panpan1.1 panPan2
IL27RA Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 20 48,456,766 - 48,475,414 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 20 48,457,134 - 48,472,450 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 20 48,330,953 - 48,346,665 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 20 48,974,444 - 48,990,172 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 20 48,974,445 - 48,990,429 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 20 48,185,368 - 48,201,224 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 20 48,612,194 - 48,627,913 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 20 48,854,767 - 48,870,725 (-) NCBI UU_Cfam_GSD_1.0
Il27ra Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405118 207,634,220 - 207,649,537 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936659 2,705,985 - 2,722,748 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936659 2,706,037 - 2,720,486 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
IL27RA Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 2 65,127,287 - 65,149,740 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 2 65,127,278 - 65,149,665 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 2 65,401,420 - 65,423,808 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
IL27RA Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 6 12,679,270 - 12,699,254 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 6 12,686,838 - 12,701,867 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666074 6,950,555 - 6,971,183 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Il27ra
.
Predicted Target Of
Count of predictions: 87 Count of miRNA genes: 71 Interacting mature miRNAs: 81 Transcripts: ENSRNOT00000007726 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1549847 Bss8 Bone structure and strength QTL 8 4 lumbar vertebra strength trait (VT:0010574) vertebra ultimate force (CMO:0001678) 19 1 31963836 Rat 61447 Tcas1 Tongue tumor susceptibility QTL 1 6.08 tongue integrity trait (VT:0010553) squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875) 19 2316121 47316121 Rat 631681 Cm12 Cardiac mass QTL 12 3.33 0.00053 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 19 1 28982497 Rat 9590298 Uminl5 Urine mineral level QTL 5 3.59 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 19 1 36824771 Rat 1331737 Uae29 Urinary albumin excretion QTL 29 5.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 4096155 55283277 Rat 2298478 Eau8 Experimental allergic uveoretinitis QTL 8 0.0163 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 19 17154433 57337602 Rat 1578764 Stresp19 Stress response QTL 19 3.6 0.001 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) 19 15630201 57337602 Rat 1558656 Prcs1 Prostate cancer susceptibility QTL 1 5 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) 19 15114598 34521833 Rat 9590090 Insglur8 Insulin/glucose ratio QTL 8 10.81 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 19 1 36824771 Rat 1331788 Rf45 Renal function QTL 45 2.818 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) 19 15605023 46559041 Rat 724566 Uae12 Urinary albumin excretion QTL 12 5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 2187927 56457239 Rat 724565 Tcas5 Tongue tumor susceptibility QTL 5 10.04 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 19 9977753 39654489 Rat 61407 Scl12 Serum cholesterol level QTL 12 0.001 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) 19 13926401 30303727 Rat 8552935 Pigfal10 Plasma insulin-like growth factor 1 level QTL 10 5.7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 19 1 36824771 Rat 61350 Bp32 Blood pressure QTL 32 0.012 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 19 20483575 57337602 Rat 7411549 Bw130 Body weight QTL 130 5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 19 15455860 57337602 Rat 10054132 Srcrt9 Stress Responsive Cort QTL 9 2.87 0.0017 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 19 1 27355345 Rat 724518 Uae19 Urinary albumin excretion QTL 19 5.5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 19 7457249 42983518 Rat 8694186 Bw152 Body weight QTL 152 3.34 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 19 569374 45569374 Rat 61423 Cia14 Collagen induced arthritis QTL 14 3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 19 10827970 43544039 Rat 7411590 Foco7 Food consumption QTL 7 6.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 19 1 24688055 Rat 631678 Cm9 Cardiac mass QTL 9 4.27 0.0001 aorta mass (VT:0002845) aorta weight (CMO:0000076) 19 1 28982497 Rat 9590250 Scort11 Serum corticosterone level QTL 11 23.45 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 19 1 36824771 Rat 2317848 Alcrsp21 Alcohol response QTL 21 1.899999976158142 0.05 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 19 3204777 48204777 Rat 9589102 Slep13 Serum leptin concentration QTL 13 4.63 0.001 blood leptin amount (VT:0005667) plasma leptin level (CMO:0000781) 19 569374 45569374 Rat 7247442 Uae39 Urinary albumin excretion QTL 39 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 19 2187927 46708701 Rat
D19Mgh1
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 19 41,021,013 - 41,021,123 (+) Marker Load Pipeline RGSC_v3.4 19 25,801,629 - 25,801,740 RGD RGSC3.4 RGSC_v3.4 19 25,801,630 - 25,801,740 UniSTS RGSC3.4 RGSC_v3.4 19 25,801,630 - 25,801,739 UniSTS RGSC3.4 RGSC_v3.1 19 25,806,455 - 25,806,566 RGD Celera 19 23,664,170 - 23,664,280 UniSTS Celera 19 23,664,170 - 23,664,279 UniSTS SHRSP x BN Map 19 16.9499 RGD FHH x ACI Map 19 21.16 RGD Cytogenetic Map 19 RGD
D19Mgh1
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 19 41,021,013 - 41,021,123 (+) Marker Load Pipeline Rnor_5.0 19 36,134,451 - 36,134,560 UniSTS Rnor5.0 RGSC_v3.4 19 25,801,630 - 25,801,739 UniSTS RGSC3.4 Celera 19 23,664,170 - 23,664,279 UniSTS SHRSP x BN Map 19 16.9499 UniSTS Cytogenetic Map 19 q11 UniSTS
D19Mgh1
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 19 41,021,013 - 41,021,124 (+) Marker Load Pipeline Rnor_5.0 19 36,134,450 - 36,134,560 UniSTS Rnor5.0 RGSC_v3.4 19 25,801,630 - 25,801,740 UniSTS RGSC3.4 Celera 19 23,664,170 - 23,664,280 UniSTS Cytogenetic Map 19 q11 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
5
49
107
89
89
58
25
58
6
210
94
88
45
60
31
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Ensembl Acc Id:
ENSRNOT00000007726 ⟹ ENSRNOP00000007726
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 19 24,109,972 - 24,121,938 (+) Ensembl Rnor_6.0 Ensembl 19 25,151,995 - 25,163,957 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000085630 ⟹ ENSRNOP00000069777
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source Rnor_6.0 Ensembl 19 25,149,897 - 25,164,086 (-) Ensembl
RefSeq Acc Id:
NM_001395124 ⟹ NP_001382053
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 19 41,014,730 - 41,026,740 (+) NCBI mRatBN7.2 19 24,109,963 - 24,121,977 (+) NCBI
Ensembl Acc Id:
ENSRNOP00000069777 ⟸ ENSRNOT00000085630
Ensembl Acc Id:
ENSRNOP00000007726 ⟸ ENSRNOT00000007726
RefSeq Acc Id:
NP_001382053 ⟸ NM_001395124
- Peptide Label:
precursor
- UniProtKB:
D4A6K5 (UniProtKB/TrEMBL), A6IYB4 (UniProtKB/TrEMBL)
RGD ID: 13701011 Promoter ID: EPDNEW_R11534 Type: initiation region Name: Il27ra_1 Description: interleukin 27 receptor subunit alpha SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 19 25,163,929 - 25,163,989 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2015-12-16
Il27ra
interleukin 27 receptor subunit alpha
Il27ra
interleukin 27 receptor, alpha
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-04-30
Il27ra
interleukin 27 receptor, alpha
Il27ra_predicted
interleukin 27 receptor, alpha (predicted)
'predicted' is removed
2292626 APPROVED
2005-01-12
Il27ra_predicted
interleukin 27 receptor, alpha (predicted)
Symbol and Name status set to approved
70820 APPROVED
