RGD Reference Report - Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. - Rat Genome Database

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Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation.

Authors: Yoshizaki, A  Yanaba, K  Iwata, Y  Komura, K  Ogawa, A  Muroi, E  Ogawa, F  Takenaka, M  Shimizu, K  Hasegawa, M  Fujimoto, M  Sato, S 
Citation: Yoshizaki A, etal., Ann Rheum Dis. 2011 Jan;70(1):194-200. Epub 2010 Aug 12.
RGD ID: 5128477
Pubmed: PMID:20705635   (View Abstract at PubMed)
DOI: DOI:10.1136/ard.2009.121053   (Journal Full-text)

OBJECTIVE: To determine serum levels of interleukin 27 (IL-27) in patients with systemic sclerosis (SSc) and relate the results to the clinical features of SSc. METHODS: Serum levels of IL-27 in 91 patients with SSc and the production of IL-27 by isolated monocytes were examined by ELISA. The expression of IL-27 receptor in the skin fibroblasts, B cells and T cells was quantified by real-time PCR. The effect of IL-27 on immunoglobulin G (IgG) production of B cells, IL-17 production of CD4 T cells and proliferation and collagen synthesis of fibroblasts was also analysed. RESULTS: Serum IL-27 levels were raised in patients with SSc compared with healthy controls and correlated positively with the extent of skin and pulmonary fibrosis and immunological abnormalities. IL-27 levels also correlated positively with serum levels of hyaluronan, recently identified as an endogenous ligand for Toll-like receptors. The retrospective longitudinal analysis showed a tendency for serum IL-27 levels to be attenuated during the follow-up period. IL-27 production by cultured monocytes was increased by hyaluronan stimulation. IL-27 receptor expression was upregulated in the affected skin fibroblasts, B cells and CD4 T cells of patients with SSc. Moreover, IL-27 stimulation increased IgG production of B cells, IL-17 production of CD4 T cells and proliferation and collagen synthesis of fibroblasts in patients with SSc compared with those in healthy controls. CONCLUSION: These results suggest that IL-27 and its signalling in B cells, T cells and fibroblasts contributes to disease development in patients with SSc.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
systemic scleroderma  IEP 5128477protein:increased expression:serumRGD 
systemic scleroderma  IEP 5128477mRNA:increased expression:skinRGD 
systemic scleroderma  ISOIL27 (Homo sapiens)5128477; 5128477protein:increased expression:serumRGD 
systemic scleroderma  ISOIL27RA (Homo sapiens)5128477; 5128477mRNA:increased expression:skinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)
Il27ra  (interleukin 27 receptor subunit alpha)

Genes (Mus musculus)
Il27  (interleukin 27)
Il27ra  (interleukin 27 receptor, alpha)

Genes (Homo sapiens)
IL27  (interleukin 27)
IL27RA  (interleukin 27 receptor subunit alpha)


Additional Information