Il27ra (interleukin 27 receptor, alpha) - Rat Genome Database
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Gene: Il27ra (interleukin 27 receptor, alpha) Mus musculus
Analyze
Symbol: Il27ra
Name: interleukin 27 receptor, alpha
RGD ID: 1312816
MGI Page MGI
Description: Exhibits interleukin-27 receptor activity. Predicted to contribute to interleukin-12 receptor binding activity and interleukin-23 binding activity. Involved in several processes, including negative regulation of T cell extravasation; regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and regulation of cytokine production. Predicted to localize to external side of plasma membrane; interleukin-12 receptor complex; and interleukin-23 receptor complex. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha); PARTICIPATES IN interleukin-27 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; buta-1,3-diene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CRL1; cytokine receptor family, class 1 (WSXWS), member 1; IL-; IL-27 receptor subunit alpha; IL-27R; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; interleukin-27 receptor subunit alpha; T cell cytokine receptor; Tcc; Tccr; type I T-cell cytokine receptor; WSX-; WSX-1; Wsx1; zcytor1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,756,915 - 84,769,250 (-)NCBIGRCm39mm39
GRCm38884,030,286 - 84,042,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,030,294 - 84,042,589 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,554,185 - 86,566,474 (-)NCBIGRCm37mm9NCBIm37
MGSCv36886,920,423 - 86,932,680 (-)NCBImm8
Celera888,323,361 - 88,337,096 (-)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
colitis  (IAGP)
decreased anti-double stranded DNA antibody level  (IAGP)
decreased blood urea nitrogen level  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to experimental autoimmune uveoretinitis  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased susceptibility to systemic lupus erythematosus  (IAGP)
extended life span  (IAGP)
glomerulonephritis  (IAGP)
hepatic necrosis  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-12 level  (IAGP)
increased circulating interleukin-4 level  (IAGP)
increased circulating interleukin-5 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased lymphocyte cell number  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased T cell proliferation  (IAGP)
References

Additional References at PubMed
PMID:9600072   PMID:10349636   PMID:11042159   PMID:11057672   PMID:11076861   PMID:11217851   PMID:11672539   PMID:12121660   PMID:12477932   PMID:12646495   PMID:14610273   PMID:14657353  
PMID:14764690   PMID:15004160   PMID:15067040   PMID:15187144   PMID:15489334   PMID:15494513   PMID:15585875   PMID:15850576   PMID:15944269   PMID:16141072   PMID:16141073   PMID:16301622  
PMID:16365415   PMID:16400019   PMID:16906166   PMID:16906167   PMID:16926428   PMID:17015723   PMID:17118967   PMID:17403877   PMID:17982030   PMID:17994022   PMID:17994023   PMID:18178806  
PMID:18178832   PMID:18292493   PMID:18375937   PMID:18572017   PMID:19549909   PMID:19570826   PMID:19596985   PMID:19620301   PMID:19668220   PMID:19703422   PMID:19748991   PMID:20534530  
PMID:20554759   PMID:20631310   PMID:21057510   PMID:21098093   PMID:21233255   PMID:21267068   PMID:21281790   PMID:21873635   PMID:21925473   PMID:22116827   PMID:22205023   PMID:22306691  
PMID:22693446   PMID:22927332   PMID:22981537   PMID:23091017   PMID:23125412   PMID:23335749   PMID:23349024   PMID:23536628   PMID:23554861   PMID:23593003   PMID:23836062   PMID:23980098  
PMID:23993651   PMID:24101691   PMID:24216477   PMID:24244314   PMID:24337375   PMID:24408967   PMID:24604832   PMID:24726498   PMID:24809349   PMID:25088998   PMID:25267651   PMID:25614966  
PMID:25658840   PMID:26222157   PMID:26260044   PMID:26282876   PMID:26417004   PMID:26459508   PMID:26637970   PMID:26689285   PMID:26886799   PMID:26968425   PMID:26991425   PMID:27158906  
PMID:27259855   PMID:27488350   PMID:27881708   PMID:28129374   PMID:28132857   PMID:28239679   PMID:28439004   PMID:28536468   PMID:28584007   PMID:28666115   PMID:28738016   PMID:28758191  
PMID:28874534   PMID:29021521   PMID:29140433   PMID:29358280   PMID:29494633   PMID:29500240   PMID:29728641   PMID:29779048   PMID:29899446   PMID:30038376   PMID:30044874   PMID:30759395  
PMID:30811989   PMID:30899058   PMID:30926808   PMID:31801074   PMID:32075272   PMID:32270034   PMID:32292786  


Genomics

Comparative Map Data
Il27ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,756,915 - 84,769,250 (-)NCBIGRCm39mm39
GRCm38884,030,286 - 84,042,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,030,294 - 84,042,589 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,554,185 - 86,566,474 (-)NCBIGRCm37mm9NCBIm37
MGSCv36886,920,423 - 86,932,680 (-)NCBImm8
Celera888,323,361 - 88,337,096 (-)NCBICelera
Cytogenetic Map8C2NCBI
IL27RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,031,762 - 14,053,218 (+)EnsemblGRCh38hg38GRCh38
GRCh381914,031,762 - 14,053,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,142,552 - 14,163,731 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,003,262 - 14,025,026 (+)NCBINCBI36hg18NCBI36
Build 341914,003,261 - 14,025,026NCBI
Celera1914,036,058 - 14,057,825 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,714,538 - 13,735,786 (+)NCBIHuRef
CHM1_11914,143,096 - 14,164,322 (+)NCBICHM1_1
Il27ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,151,835 - 25,163,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,149,897 - 25,164,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,128,834 - 36,140,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,795,355 - 25,807,317 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,802,500 - 25,806,104 (+)NCBI
Celera1923,657,895 - 23,669,746 (+)NCBICelera
Cytogenetic Map19q11NCBI
Il27ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,749,094 - 32,761,882 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,749,682 - 32,762,532 (+)NCBIChiLan1.0ChiLan1.0
IL27RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,323,618 - 14,343,636 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,323,618 - 14,343,627 (+)Ensemblpanpan1.1panPan2
IL27RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2048,457,134 - 48,472,450 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12048,456,766 - 48,475,414 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il27ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,706,037 - 2,720,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL27RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,127,278 - 65,149,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,127,278 - 65,149,665 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,401,420 - 65,423,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL27RA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,679,270 - 12,699,254 (+)NCBI
ChlSab1.1 Ensembl612,686,838 - 12,701,867 (+)Ensembl
Il27ra
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,274,753 - 1,288,783 (+)NCBI

Position Markers
Il27ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
cM Map840.26UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:216
Interacting mature miRNAs:243
Transcripts:ENSMUST00000005601
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000005601   ⟹   ENSMUSP00000005601
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,030,294 - 84,042,589 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210245
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,030,352 - 84,042,569 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210790
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,041,769 - 84,042,540 (-)Ensembl
RefSeq Acc Id: NM_016671   ⟹   NP_057880
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,756,915 - 84,769,204 (-)NCBI
GRCm38884,030,286 - 84,042,575 (-)NCBI
MGSCv37886,554,185 - 86,566,474 (-)RGD
Celera888,323,361 - 88,337,096 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011248437   ⟹   XP_011246739
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,758,689 - 84,769,249 (-)NCBI
GRCm38884,032,060 - 84,042,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243668   ⟹   XP_030099528
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,756,915 - 84,769,248 (-)NCBI
GRCm38884,030,286 - 84,042,599 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154161   ⟹   XP_036010054
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,756,915 - 84,768,833 (-)NCBI
RefSeq Acc Id: XM_036154162   ⟹   XP_036010055
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,762,774 - 84,769,250 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_057880   ⟸   NM_016671
- Peptide Label: precursor
- UniProtKB: O70394 (UniProtKB/Swiss-Prot),   Q3UZN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246739   ⟸   XM_011248437
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030099528   ⟸   XM_030243668
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000005601   ⟸   ENSMUST00000005601
RefSeq Acc Id: XP_036010054   ⟸   XM_036154161
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036010055   ⟸   XM_036154162
- Peptide Label: isoform X4
Protein Domains
Fibronectin type-III

Promoters
RGD ID:8667637
Promoter ID:EPDNEW_M11850
Type:initiation region
Name:Il27ra_1
Description:Mus musculus interleukin 27 receptor, alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,042,588 - 84,042,648EPDNEW
RGD ID:6843319
Promoter ID:MM_KWN:55045
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   Spleen
Transcripts:ENSMUST00000005601
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,566,146 - 86,566,646 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1355318 AgrOrtholog
Ensembl Genes ENSMUSG00000005465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000005601 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000005601 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1355318 ENTREZGENE
NCBI Gene 50931 ENTREZGENE
PhenoGen Il27ra PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.38386 ENTREZGENE
UniProt I27RA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UZN3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9QNY4 UniProtKB/Swiss-Prot