P3h2 (prolyl 3-hydroxylase 2) - Rat Genome Database

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Gene: P3h2 (prolyl 3-hydroxylase 2) Rattus norvegicus
Analyze
Symbol: P3h2
Name: prolyl 3-hydroxylase 2
RGD ID: 1304568
Description: Enables procollagen-proline 3-dioxygenase activity. Involved in collagen metabolic process and peptidyl-proline hydroxylation. Predicted to be located in several cellular components, including Golgi apparatus; basement membrane; and nucleoplasm. Predicted to be active in endoplasmic reticulum. Orthologous to human P3H2 (prolyl 3-hydroxylase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leprecan-like 1; leprecan-like protein 1; Leprel1; LOC102554639; LOC288016; MGC116247; prolyl 3-hydroxylase 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81188,139,086 - 88,280,221 (+)NCBIGRCr8
mRatBN7.21174,634,267 - 74,775,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,634,267 - 74,775,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,443,019 - 83,584,372 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01176,078,068 - 76,219,425 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,139,871 - 75,281,175 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,028,885 - 78,169,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,029,038 - 78,169,648 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,549,554 - 82,690,068 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,687,437 - 76,828,785 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,745,025 - 76,886,374 (+)NCBI
Celera1173,544,026 - 73,685,131 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
P3h2Ratgenetic disease  ISOP3H2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
P3h2RatHigh Myopia with Cataract and Vitreoretinal Degeneration  ISOP3H2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21885030 more ...
P3h2Ratmyopia  ISOP3H2 (Homo sapiens)8554872ClinVar Annotator: match by term: MyopiaClinVarPMID:25741868
P3h2RatMyopia 23, Autosomal Recessive  ISOP3H2 (Homo sapiens)8554872ClinVar Annotator: match by term: Rare isolated myopiaClinVarPMID:24172257 more ...
P3h2Ratretinitis pigmentosa  ISOP3H2 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:24172257 more ...
P3h2Ratschizophrenia  ISOP3H2 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Object Symbol
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Original Reference(s)
P3h2Ratintestinal disease  ISOP3H2 (Canis lupus familiaris)9068941Lundehund syndromeOMIAPMID:25860808 more ...
Object Symbol
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Original Reference(s)
P3h2RatHigh Myopia with Cataract and Vitreoretinal Degeneration  ISOP3H2 (Homo sapiens)7240710 OMIM 

1 to 20 of 80 rows

  
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Original Reference(s)
P3h2Rat1,1-dichloroethene decreases expressionISOP3h2 (Mus musculus)6480464vinylidene chloride results in decreased expression of P3H2 mRNACTDPMID:26682919
P3h2Rat17alpha-ethynylestradiol decreases expressionISOP3H2 (Homo sapiens)6480464Ethinyl Estradiol results in decreased expression of P3H2 mRNACTDPMID:18936297
P3h2Rat17beta-estradiol multiple interactionsISOP3H2 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in increased expression of P3H2 mRNACTDPMID:20660070
P3h2Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of P3H2 mRNACTDPMID:26496021
P3h2Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOP3H2 (Homo sapiens)64804642 more ...CTDPMID:23146750
P3h2Rat2,2',5,5'-tetrachlorobiphenyl increases expressionISOP3H2 (Homo sapiens)64804642 more ...CTDPMID:36804509
P3h2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOP3h2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of P3H2 mRNACTDPMID:19933214
P3h2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of P3H2 mRNACTDPMID:32109520
P3h2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOP3h2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of P3H2 mRNACTDPMID:21354282
P3h2Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionISOP3H2 (Homo sapiens)64804643 more ...CTDPMID:23146750
P3h2Rat4,4'-sulfonyldiphenol increases expressionISOP3h2 (Mus musculus)6480464bisphenol S results in increased expression of P3H2 mRNACTDPMID:30951980
P3h2Rat4,4'-sulfonyldiphenol affects expressionISOP3H2 (Homo sapiens)6480464bisphenol S affects the expression of P3H2 proteinCTDPMID:31945527
P3h2Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of P3H2 mRNACTDPMID:31881176
P3h2Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of P3H2 mRNACTDPMID:28959563
P3h2Rataflatoxin B1 increases expressionISOP3H2 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of P3H2 mRNACTDPMID:27153756
P3h2Rataflatoxin B1 increases methylationISOP3H2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of P3H2 geneCTDPMID:27153756
P3h2Ratall-trans-retinoic acid increases expressionISOP3H2 (Homo sapiens)6480464Tretinoin results in increased expression of P3H2 mRNACTDPMID:21934132
P3h2Ratantirheumatic drug increases expressionISOP3H2 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of P3H2 mRNACTDPMID:24449571
P3h2Ratarsane decreases expressionISOP3H2 (Homo sapiens)6480464Arsenic results in decreased expression of P3H2 mRNACTDPMID:36861143
P3h2Ratarsenic atom decreases expressionISOP3H2 (Homo sapiens)6480464Arsenic results in decreased expression of P3H2 mRNACTDPMID:36861143

1 to 20 of 80 rows

Biological Process
1 to 12 of 12 rows

  
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Original Reference(s)
P3h2Ratcollagen metabolic process involved_inIEAInterPro:IPR0395751600115GO_REF:0000002InterProGO_REF:0000002
P3h2Ratcollagen metabolic process involved_inIBAMGI:1315208 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P3h2Ratcollagen metabolic process involved_inISOP3H2 (Homo sapiens)1624291 PMID:18487197RGDPMID:18487197
P3h2Ratcollagen metabolic process involved_inISSUniProtKB:Q8IVL51600115GO_REF:0000024UniProtGO_REF:0000024
P3h2Ratcollagen metabolic process involved_inIDA 8553392PMID:21757687UniProt 
P3h2Ratcollagen metabolic process involved_inIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2Ratnegative regulation of cell population proliferation involved_inIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2Ratnegative regulation of cell population proliferation involved_inISSUniProtKB:Q8IVL51600115GO_REF:0000024UniProtGO_REF:0000024
P3h2Ratnegative regulation of cell population proliferation involved_inISOP3H2 (Homo sapiens)1624291 PMID:19436308RGDPMID:19436308
P3h2Ratpeptidyl-proline hydroxylation involved_inIDA 8553392PMID:21757687UniProt 
P3h2Ratpeptidyl-proline hydroxylation involved_inISOP3H2 (Homo sapiens)1624291 PMID:18487197RGDPMID:18487197
P3h2Ratpeptidyl-proline hydroxylation involved_inISSUniProtKB:Q8IVL51600115GO_REF:0000024UniProtGO_REF:0000024
1 to 12 of 12 rows

Cellular Component
1 to 20 of 23 rows

  
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Original Reference(s)
P3h2Ratbasement membrane located_inIEAUniProtKB:Q8CG71 and ensembl:ENSMUSP000000380561600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2Ratbasement membrane located_inISOP3h2 (Mus musculus)1624291 PMID:18487197RGDPMID:18487197
P3h2Ratbasement membrane located_inISSUniProtKB:Q8CG711600115GO_REF:0000024UniProtGO_REF:0000024
P3h2Ratcytosol located_inISOP3H2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
P3h2Ratcytosol located_inIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2Ratendoplasmic reticulum located_inISOP3H2 (Homo sapiens)1624291 PMID:15063763RGDPMID:15063763
P3h2Ratendoplasmic reticulum is_active_inIBAPANTHER:PTN001422087 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P3h2Ratendoplasmic reticulum located_inIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
P3h2Ratendoplasmic reticulum located_inISSUniProtKB:Q8IVL51600115GO_REF:0000024UniProtGO_REF:0000024
P3h2Ratendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-00951600115GO_REF:0000044UniProtGO_REF:0000044
P3h2RatGolgi apparatus located_inISOP3H2 (Homo sapiens)1624291 PMID:15063763RGDPMID:15063763
P3h2RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
P3h2RatGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01321600115GO_REF:0000044UniProtGO_REF:0000044
P3h2RatGolgi apparatus located_inISSUniProtKB:Q8IVL51600115GO_REF:0000024UniProtGO_REF:0000024
P3h2RatGolgi apparatus located_inIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2RatGolgi apparatus located_inISOP3H2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
P3h2Ratintracellular membrane-bounded organelle located_inISOP3H2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
P3h2Ratintracellular membrane-bounded organelle located_inIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2Ratnucleoplasm located_inIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 23 rows

Molecular Function
1 to 14 of 14 rows

  
Object Symbol
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Original Reference(s)
P3h2Ratdioxygenase activity enablesIEAUniProtKB-KW:KW-02231600115GO_REF:0000043UniProtGO_REF:0000043
P3h2Ratiron ion binding enablesIEAInterPro:IPR0066201600115GO_REF:0000002InterProGO_REF:0000002
P3h2RatL-ascorbic acid binding enablesIEAUniProtKB-KW:KW-08471600115GO_REF:0000043UniProtGO_REF:0000043
P3h2RatL-ascorbic acid binding enablesIEAInterPro:IPR0066201600115GO_REF:0000002InterProGO_REF:0000002
P3h2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
P3h2Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
P3h2Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR0066201600115GO_REF:0000002InterProGO_REF:0000002
P3h2Ratprocollagen-proline 3-dioxygenase activity enablesISSUniProtKB:Q8IVL51600115GO_REF:0000024UniProtGO_REF:0000024
P3h2Ratprocollagen-proline 3-dioxygenase activity enablesIEARHEA:228721600115GO_REF:0000116RHEAGO_REF:0000116
P3h2Ratprocollagen-proline 3-dioxygenase activity enablesIBAPANTHER:PTN001422087 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P3h2Ratprocollagen-proline 3-dioxygenase activity enablesIEAUniProtKB:Q8IVL5 and ensembl:ENSP000003168811600115GO_REF:0000107EnsemblGO_REF:0000107
P3h2Ratprocollagen-proline 3-dioxygenase activity enablesISOP3H2 (Homo sapiens)1624291 PMID:18487197RGDPMID:18487197
P3h2Ratprocollagen-proline 3-dioxygenase activity enablesIEAEC:1.14.11.71600115GO_REF:0000003UniProtGO_REF:0000003
P3h2Ratprocollagen-proline 3-dioxygenase activity enablesIDA 8553392PMID:21757687UniProt 
1 to 14 of 14 rows


#
Reference Title
Reference Citation
1. A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens. Fernandes RJ, etal., J Biol Chem. 2011 Sep 2;286(35):30662-9. doi: 10.1074/jbc.M111.267906. Epub 2011 Jul 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:15063763   PMID:15489334   PMID:18487197   PMID:19436308  



P3h2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81188,139,086 - 88,280,221 (+)NCBIGRCr8
mRatBN7.21174,634,267 - 74,775,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,634,267 - 74,775,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,443,019 - 83,584,372 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01176,078,068 - 76,219,425 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,139,871 - 75,281,175 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,028,885 - 78,169,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,029,038 - 78,169,648 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,549,554 - 82,690,068 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,687,437 - 76,828,785 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,745,025 - 76,886,374 (+)NCBI
Celera1173,544,026 - 73,685,131 (+)NCBICelera
Cytogenetic Map11q22NCBI
P3H2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383189,956,728 - 190,122,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3189,956,728 - 190,122,437 (-)EnsemblGRCh38hg38GRCh38
GRCh373189,674,517 - 189,840,067 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363191,157,316 - 191,321,412 (-)NCBINCBI36Build 36hg18NCBI36
Build 343191,157,323 - 191,321,420NCBI
Celera3188,102,461 - 188,268,906 (-)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3187,072,503 - 187,237,981 (-)NCBIHuRef
CHM1_13189,637,377 - 189,803,103 (-)NCBICHM1_1
T2T-CHM13v2.03192,773,118 - 192,938,644 (-)NCBIT2T-CHM13v2.0
P3h2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391625,778,034 - 25,924,563 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1625,778,038 - 25,924,534 (-)EnsemblGRCm39 Ensembl
GRCm381625,959,284 - 26,105,813 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1625,959,288 - 26,105,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371625,960,409 - 26,105,870 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361625,875,672 - 26,021,133 (-)NCBIMGSCv36mm8
Celera1626,503,926 - 26,649,250 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1617.63NCBI
P3h2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542017,964,153 - 18,117,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542017,964,153 - 18,118,442 (+)NCBIChiLan1.0ChiLan1.0
P3H2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22187,822,467 - 187,990,737 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13187,827,183 - 187,995,467 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03186,976,926 - 187,141,678 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13195,532,341 - 195,695,510 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3195,533,511 - 195,695,598 (-)Ensemblpanpan1.1panPan2
P3H2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13422,035,124 - 22,185,146 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3422,023,068 - 22,185,026 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3426,128,347 - 26,278,616 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03421,969,192 - 22,119,559 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3421,967,663 - 22,119,559 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13421,984,404 - 22,141,097 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03421,977,205 - 22,127,973 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03422,219,915 - 22,370,251 (-)NCBIUU_Cfam_GSD_1.0
P3h2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602114,177,035 - 114,339,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936578268,856 - 431,137 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936578268,815 - 431,123 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P3H2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13127,414,958 - 127,572,163 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113127,414,955 - 127,572,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213136,665,659 - 136,863,053 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P3H2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11584,185,288 - 84,348,186 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1584,185,299 - 84,348,011 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604157,767,198 - 57,931,651 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P3h2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473067,072,478 - 67,228,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473067,072,389 - 67,228,207 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in P3h2
1456 total Variants

1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

1 to 10 of 21 rows
D11Got65  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21174,713,769 - 74,713,884 (+)MAPPERmRatBN7.2
Rnor_6.01178,107,976 - 78,108,092NCBIRnor6.0
Rnor_5.01182,611,208 - 82,611,324UniSTSRnor5.0
RGSC_v3.41176,766,885 - 76,767,002RGDRGSC3.4
RGSC_v3.41176,766,886 - 76,767,002UniSTSRGSC3.4
RGSC_v3.11176,824,475 - 76,824,591RGD
Celera1173,623,597 - 73,623,713UniSTS
RH 3.4 Map11609.3RGD
RH 3.4 Map11609.3UniSTS
Cytogenetic Map11q22-q23UniSTS
AU048531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21174,713,764 - 74,713,885 (+)MAPPERmRatBN7.2
Rnor_6.01178,107,971 - 78,108,093NCBIRnor6.0
Rnor_5.01182,611,207 - 82,611,329UniSTSRnor5.0
RGSC_v3.41176,766,881 - 76,767,003UniSTSRGSC3.4
Celera1173,623,592 - 73,623,714UniSTS
Cytogenetic Map11q22-q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000089540   ⟹   ENSRNOP00000074673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,634,267 - 74,775,421 (+)Ensembl
Rnor_6.0 Ensembl1178,029,038 - 78,169,648 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095886   ⟹   ENSRNOP00000092914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,634,267 - 74,775,421 (+)Ensembl
RefSeq Acc Id: NM_001025627   ⟹   NP_001020798
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81188,139,086 - 88,280,221 (+)NCBI
mRatBN7.21174,634,267 - 74,775,422 (+)NCBI
Rnor_6.01178,028,885 - 78,169,746 (+)NCBI
Rnor_5.01182,549,554 - 82,690,068 (-)NCBI
RGSC_v3.41176,687,437 - 76,828,785 (+)RGD
Celera1173,544,026 - 73,685,131 (+)RGD
Sequence:
Protein RefSeqs NP_001020798 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99107 (Get FASTA)   NCBI Sequence Viewer  
  EDL78114 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074673
  ENSRNOP00000074673.2
  ENSRNOP00000092914.1
GenBank Protein Q4KLM6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020798   ⟸   NM_001025627
- Peptide Label: precursor
- UniProtKB: Q4KLM6 (UniProtKB/Swiss-Prot),   A0A0G2K8N3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074673   ⟸   ENSRNOT00000089540
Ensembl Acc Id: ENSRNOP00000092914   ⟸   ENSRNOT00000095886
Fe2OG dioxygenase

Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLM6-F1-model_v2 AlphaFold Q4KLM6 1-703 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20933 BioCyc
BioCyc Pathway PWY-7894 [procollagen hydroxylation and glycosylation] BioCyc
BioCyc Pathway Image PWY-7894 BioCyc
Ensembl Genes ENSRNOG00000055751 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089540 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000089540.2 UniProtKB/Swiss-Prot
  ENSRNOT00000095886.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  q2cbj1_9rhob like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460856 IMAGE-MGC_LOAD
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P3H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:288016 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116247 IMAGE-MGC_LOAD
NCBI Gene 288016 ENTREZGENE
PANTHER PTHR14049 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14049:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P3h2 PhenoGen
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055751 RatGTEx
SMART P4Hc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K8N3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGJ2_RAT UniProtKB/TrEMBL
  P3H2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 P3h2  prolyl 3-hydroxylase 2  LOC102554639  prolyl 3-hydroxylase 2-like  Data merged from RGD:7561514 737654 PROVISIONAL
2014-12-17 P3h2  prolyl 3-hydroxylase 2  Leprel1  leprecan-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-17 LOC102554639  prolyl 3-hydroxylase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Leprel1  leprecan-like 1  Leprel1_predicted  leprecan-like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Leprel1_predicted  leprecan-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED