Gene: Sirt5 (sirtuin 5) Rattus norvegicus

Analyze

Symbol:

Sirt5

Name:

sirtuin 5

RGD ID:

1303285

Description:

Predicted to enable several functions, including NAD+ binding activity; NAD-dependent protein lysine deacylase activity; and protein-malonyllysine demalonylase activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be active in cytosol; mitochondrial matrix; and nucleus. Orthologous to human SIRT5 (sirtuin 5); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC93823; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; regulatory protein SIR2 homolog 5; SIR2-like protein 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIRT5 (sirtuin 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sirt5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sirt5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIRT5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIRT5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sirt5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIRT5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIRT5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sirt5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sirt5 (sirtuin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SIRT5 (sirtuin 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sirt5 (sirtuin 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sirt5 (sirtuin 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sirt5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	21,515,982 - 21,543,529 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	21,515,985 - 21,537,442 (-)	Ensembl				GRCr8
mRatBN7.2	17	21,310,028 - 21,337,137 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	21,310,028 - 21,337,101 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	21,198,845 - 21,226,111 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	22,802,514 - 22,829,782 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	21,125,948 - 21,153,215 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	17	21,369,084 - 21,396,349 (-)	NCBI
Lyon_Normotensive	17	21,351,179 - 21,378,444 (-)	NCBI
Lyon_Hypertensive	17	21,362,316 - 21,389,581 (-)	NCBI
F344_StmMcwi	17	21,431,404 - 21,458,672 (-)	NCBI
Rnor_6.0	17	23,986,710 - 24,013,854 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	23,986,758 - 24,013,881 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	17	25,936,391 - 25,963,434 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	27,135,610 - 27,162,715 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	21,007,452 - 21,034,513 (-)	NCBI		Celera
RGSC_v3.1	17	27,138,453 - 27,165,556 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anxiety disorder (ISO)

Breast Cancer, Familial (ISO)

cervical cancer (ISO)

cholangiocarcinoma (ISO)

clear cell renal cell carcinoma (ISO)

Cognitive Dysfunction (ISO)

depressive disorder (ISO)

epilepsy (ISO)

esophageal cancer (ISO)

Familial Prostate Cancer (ISO)

Hereditary Adrenocortical Carcinoma (ISO)

hyperopia (ISO)

lung cancer (ISO)

melanoma (ISO)

Memory Disorders (ISO)

Muscle Hypotonia (ISO)

myopia (ISO)

ovarian serous cystadenocarcinoma (ISO)

sarcoma (ISO)

stomach cancer (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uterine carcinosarcoma (ISO)

uterine corpus endometrial carcinoma (ISO)

uveal melanoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

butanal (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

cyclophosphamide (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diisononyl phthalate (ISO)

doxorubicin (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

mercury atom (ISO)

mercury(0) (ISO)

metformin (ISO)

methamphetamine (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

pentanal (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

negative regulation of cardiac muscle cell apoptotic process (IMP)

negative regulation of reactive oxygen species metabolic process (IEA,ISO)

peptidyl-lysine demalonylation (ISO,ISS)

peptidyl-lysine desuccinylation (ISO,ISS)

protein deacetylation (ISO,ISS)

protein deglutarylation (ISO)

protein demalonylation (ISO,ISS)

protein desuccinylation (ISO,ISS)

regulation of ketone biosynthetic process (IEA,ISO,ISS)

response to ischemia (ISO)

response to nutrient levels (IEP)

Cellular Component

cytosol (IBA,IEA,ISO,ISS)

mitochondrial inner membrane (IEA,ISO)

mitochondrial intermembrane space (IEA,ISO,ISS)

mitochondrial matrix (IBA,IEA,ISO,ISS)

mitochondrion (IBA,IEA,ISO,ISS)

nucleus (IBA,IEA)

Molecular Function

histone deacetylase activity, NAD-dependent (IBA)

NAD+ binding (IEA,ISO,ISS)

NAD-dependent protein lysine deacetylase activity (IEA)

protein-glutaryllysine deglutarylase activity (IBA,IEA,ISO)

protein-malonyllysine demalonylase activity (IBA,IEA,ISO,ISS)

protein-succinyllysine desuccinylase activity (IBA,IEA,ISO,ISS)

zinc ion binding (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

Sirtuin mediated pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction.	Geng YQ, etal., J Cell Biochem. 2011 Dec;112(12):3755-61. doi: 10.1002/jcb.23315.
3.	SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes.	Liu B, etal., Cell Physiol Biochem. 2013;32(4):1050-9. doi: 10.1159/000354505. Epub 2013 Oct 31.
4.	Physical and functional HAT/HDAC interplay regulates protein acetylation balance.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	NAD(+) in aging, metabolism, and neurodegeneration.	Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.

Additional References at PubMed

PMID:15489334	PMID:16079181	PMID:17923681	PMID:18054327	PMID:18555008	PMID:18614015	PMID:18680753	PMID:21908771	PMID:22076378	PMID:23806337	PMID:24140062	PMID:24315375
PMID:24703693	PMID:26388266	PMID:26767982	PMID:29180469	PMID:30098330	PMID:32099074	PMID:33191606	PMID:36653443	PMID:38170384

Genomics

Comparative Map Data

Sirt5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	21,515,982 - 21,543,529 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	21,515,985 - 21,537,442 (-)	Ensembl				GRCr8
mRatBN7.2	17	21,310,028 - 21,337,137 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	21,310,028 - 21,337,101 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	21,198,845 - 21,226,111 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	22,802,514 - 22,829,782 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	21,125,948 - 21,153,215 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	17	21,369,084 - 21,396,349 (-)	NCBI
Lyon_Normotensive	17	21,351,179 - 21,378,444 (-)	NCBI
Lyon_Hypertensive	17	21,362,316 - 21,389,581 (-)	NCBI
F344_StmMcwi	17	21,431,404 - 21,458,672 (-)	NCBI
Rnor_6.0	17	23,986,710 - 24,013,854 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	23,986,758 - 24,013,881 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	17	25,936,391 - 25,963,434 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	27,135,610 - 27,162,715 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	21,007,452 - 21,034,513 (-)	NCBI		Celera
RGSC_v3.1	17	27,138,453 - 27,165,556 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

SIRT5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	13,574,274 - 13,615,158 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	13,512,411 - 13,615,158 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	6	13,574,506 - 13,615,390 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	13,682,812 - 13,720,500 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	13,682,811 - 13,713,947	NCBI
Celera	6	14,814,287 - 14,854,285 (+)	NCBI		Celera
Cytogenetic Map	6	p23	NCBI
HuRef	6	13,519,134 - 13,559,766 (+)	NCBI		HuRef
CHM1_1	6	13,577,139 - 13,617,757 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	13,447,831 - 13,488,715 (+)	NCBI		T2T-CHM13v2.0

Sirt5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	43,518,849 - 43,549,073 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	43,518,856 - 43,550,487 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	43,365,389 - 43,395,203 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	43,365,496 - 43,395,203 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	13	43,460,904 - 43,490,572 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	43,376,507 - 43,406,175 (+)	NCBI		MGSCv36	mm8
Celera	13	44,444,248 - 44,473,768 (+)	NCBI		Celera
Cytogenetic Map	13	A4	NCBI
cM Map	13	21.6	NCBI

Sirt5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	1,129,217 - 1,167,604 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955465	1,129,217 - 1,167,604 (-)	NCBI	ChiLan1.0	ChiLan1.0

SIRT5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	28,228,262 - 28,266,098 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	24,218,286 - 24,256,255 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	13,419,242 - 13,457,200 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	13,790,576 - 13,828,464 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	13,791,112 - 13,828,464 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

SIRT5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	13,017,397 - 13,055,655 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	13,017,397 - 13,063,022 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	12,966,806 - 13,004,993 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	13,115,780 - 13,154,165 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	13,115,780 - 13,179,805 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	12,941,308 - 12,979,591 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	12,994,546 - 13,031,107 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	14,317,852 - 14,356,107 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sirt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	8	145,569,168 - 145,591,077 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404946	11,516,904 - 11,539,107 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936552	192,226 - 214,030 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936552	192,182 - 214,037 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIRT5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	9,951,030 - 9,968,448 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	7	9,951,024 - 9,968,004 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	10,327,724 - 10,330,511 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIRT5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	17	13,546,523 - 13,584,567 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666044	13,624,450 - 13,664,862 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	17	58,535,645 - 58,573,769 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	58,532,650 - 58,563,818 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Sirt5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624756	12,678,866 - 12,705,862 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624756	12,678,877 - 12,706,604 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	9	11,487,279 - 11,508,278 (+)	Ensembl

Sirt5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	62,375,274 - 62,402,861 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in Sirt5
288 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	293
Count of miRNA genes:	197
Interacting mature miRNAs:	225
Transcripts:	ENSRNOT00000024066
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9266755	40968173	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
8552966	Pigfal18	Plasma insulin-like growth factor 1 level QTL 18	8.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	12860942	57860942	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9206505	23859062	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
9589151	Insul30	Insulin level QTL 30	8.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	12860942	57860942	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21498994	50592236	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
9589057	Scfw6	Subcutaneous fat weight QTL 6	8.62	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	17	12860942	57860942	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9206505	23859062	Rat
9590154	Scort9	Serum corticosterone level QTL 9	23.57	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	12860942	57860942	Rat
9590088	Insglur7	Insulin/glucose ratio QTL 7	20.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	17	12860942	57860942	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
1331720	Rf43	Renal function QTL 43	2.881		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	17	15537025	28637951	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	10604694	55604694	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15537025	60531414	Rat
7411666	Foco31	Food consumption QTL 31	11.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	17	12860942	57860942	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9206505	23859062	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Markers in Region

RH142048

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	17	21,516,006 - 21,516,205 (+)	Marker Load Pipeline
mRatBN7.2	17	21,310,052 - 21,310,251 (-)	MAPPER	mRatBN7.2
Rnor_6.0	17	24,013,631 - 24,013,829	NCBI	Rnor6.0
Rnor_5.0	17	25,963,211 - 25,963,409	UniSTS	Rnor5.0
RGSC_v3.4	17	27,135,635 - 27,135,833	UniSTS	RGSC3.4
Celera	17	21,007,477 - 21,007,675	UniSTS
RH 3.4 Map	17	267.9	UniSTS
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
277	156	729	1591	4062	1011	1727	133	874	492	856	156	5391	2593	448	3975	38	1391	741	908	160	158

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001440136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001440137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001440138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001440139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001440140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024066 ⟹ ENSRNOP00000024067

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	21,515,985 - 21,537,442 (-)	Ensembl
mRatBN7.2 Ensembl	17	21,310,028 - 21,337,101 (-)	Ensembl
Rnor_6.0 Ensembl	17	23,986,758 - 24,013,881 (+)	Ensembl

RefSeq Acc Id:

NM_001004256 ⟹ NP_001004256

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,515,982 - 21,543,056 (-)	NCBI
mRatBN7.2	17	21,310,028 - 21,337,103 (-)	NCBI
Dahl_SR_JrHsd	17	21,369,084 - 21,396,349 (-)	NCBI
Lyon_Normotensive	17	21,351,179 - 21,378,444 (-)	NCBI
Lyon_Hypertensive	17	21,362,316 - 21,389,581 (-)	NCBI
F344_StmMcwi	17	21,431,404 - 21,458,672 (-)	NCBI
Rnor_6.0	17	23,986,796 - 24,013,854 (+)	NCBI
Rnor_5.0	17	25,936,391 - 25,963,434 (+)	NCBI
RGSC_v3.4	17	27,135,610 - 27,162,715 (-)	RGD
Celera	17	21,007,452 - 21,034,513 (-)	RGD

Sequence:

show sequence

CCGCCTTTTGCAGCCTGCCCAGGGAAGTAATCCTTCAACAAAAACCTATGCGACCGCTCCCGGT
CGCTCCCGGACGTCTCTTCTCCCAGCTGTGTTGTGGACCGAAGCCTTCAGCCTCCCCACAGAGC
AAGATCTGCCTCACCATGGCTCGTCCAAGTTCCAATATGGCAGATTTTCGGAAGTGTTTTGCGA
ACGCAAAGCACATAGTCATCATCTCGGGGGCTGGTGTTAGTGCGGAGAGTGGGGTTCCAACATT
CAGAGGAACCGGAGGCTATTGGAGAAAATGGCAAGCTCAGCACCTGGCGACTCCTCTGGCCTTT
GCTCACAACCCCTCACAGGTGTGGGAGTTTTACCACTACCGGAGGGAGGTCATGCGGAACAAGG
AACCCAACCCTGGGCACCTGGCCATTGCCCAATGTGAAGCCCGGCTGCGTGACCAGGGCAGACG
GGTTGTGGTCATCACCCAGAACATTGATGAGTTACATCGAAAGGCTGGCACCAAGAACCTGCTG
GAAATCCACGGAACCTTATTTAAAACTCGGTGTACCTCGTGTGGCAATGTTGCTGAGAACTACA
AGAGTCCGATTTGTCCAGCCTTATTGGGAAAAGGGGCCCCAGAACCAGATACTCAAGAGTCCAG
AATCCCAGTCCACAAACTTCCCCGGTGCGAGGAGGCAGGATGTGGAGGCTTGCTGCGACCTCAC
GTGGTGTGGTTTGGAGAAAACCTGGATCCTGCCATTCTGAAAGAGGTGGACAGAGAGCTCGCCC
GCTGTGACCTGTGTCTAGTGGTGGGAACGTCCTCTGTGGTCTACCCAGCTGCCATGTTTGCCCC
TCAGGTGGCTTCCAGGGGGGTCCCGGTGGCCGAGTTTAACATGGAAACCACCCCAGCCACCAAC
AGATTCAGGTTTCATTTTCCCGGACCCTGTGGAGTAACTCTTCCTGAAGCCCTTGCTCCCCATG
AAACTGAAAGGATTTCTTAATTGCCCCATGGAAAGAGGAGAAGATCCTGGAGCACAGATGCAGG
GCACTGACAGGAGAAGTGGTTTTGTGGATGGTGAGCTGAACTTCGGAAAAAATCTAAAGATACC
CTCCGAGCCTCTAGCAGACAGTCGGCTAAGTGACGGTTTCAGGATCACAACAGCAAATGTGTTT
TATCTGGAAGAAGCTGTCAAGGTCTTCCATGTTATTTGATTTGACCTGAAATATGAGTATTTTG
GATCTGATATTTTGGTTAGTTACTGGAAAGGAAAAAACTGTAATCAAATTGTTTGAAAAGATGG
GAATTATCCCGATCGTACCTTTGCATCTTGGGAAAGACGGAAATAGAGAATTTAAATCCCAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006253801 ⟹ XP_006253863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,515,982 - 21,543,529 (-)	NCBI
mRatBN7.2	17	21,310,028 - 21,337,101 (-)	NCBI
Rnor_6.0	17	23,986,808 - 24,013,854 (+)	NCBI
Rnor_5.0	17	25,936,391 - 25,963,434 (+)	NCBI

Sequence:

show sequence

GGTTCGTCTCGGGCCCTGTTCGGGCTCCCAGCTTTGTCAAGGCTCCGCGCGCCGCATCCCGCGC
ATGCGCGCCTGGGTGCGGGTGGGTACCGCAGCGACCTTGTGGGCGGCTGGATGGGCTACGCGTA
GGAGAGAAACCCAAGAGAGCAGCTGGGCCCGGGAAGGCAGTGACCGGAAGGAAGGGCACTTTGG
CTAAGCCTGCCCAGGGAAGTAATCCTTCAACAAAAACCTATGCGACCGCTCCCGGTCGCTCCCG
GACGTCTCTTCTCCCAGCTGTGTTGTGGACCGAAGCCTTCAGCCTCCCCACAGAGCAAGATCTG
CCTCACCATGGCTCGTCCAAGTTCCAATATGGCAGATTTTCGGAAGTGTTTTGCGAACGCAAAG
CACATAGTCATCATCTCGGGGGCTGGTGTTAGTGCGGAGAGTGGGGTTCCAACATTCAGAGGAA
CCGGAGGCTATTGGAGAAAATGGCAAGCTCAGCACCTGGCGACTCCTCTGGCCTTTGCTCACAA
CCCCTCACAGGTGTGGGAGTTTTACCACTACCGGAGGGAGGTCATGCGGAACAAGGAACCCAAC
CCTGGGCACCTGGCCATTGCCCAATGTGAAGCCCGGCTGCGTGACCAGGGCAGACGGGTTGTGG
TCATCACCCAGAACATTGATGAGTTACATCGAAAGGCTGGCACCAAGAACCTGCTGGAAATCCA
CGGAACCTTATTTAAAACTCGGTGTACCTCGTGTGGCAATGTTGCTGAGAACTACAAGAGTCCG
ATTTGTCCAGCCTTATTGGGAAAAGGGGCCCCAGAACCAGATACTCAAGAGTCCAGAATCCCAG
TCCACAAACTTCCCCGGTGCGAGGAGGCAGGATGTGGAGGCTTGCTGCGACCTCACGTGGTGTG
GTTTGGAGAAAACCTGGATCCTGCCATTCTGAAAGAGGTGGACAGAGAGCTCGCCCGCTGTGAC
CTGTGTCTAGTGGTGGGAACGTCCTCTGTGGTCTACCCAGCTGCCATGTTTGCCCCTCAGGTGG
CTTCCAGGGGGGTCCCGGTGGCCGAGTTTAACATGGAAACCACCCCAGCCACCAACAGATTCAG
GTTTCATTTTCCCGGACCCTGTGGAGTAACTCTTCCTGAAGCCCTTGCTCCCCATGAAACTGAA
AGGATTTCTTAATTGCCCCATGGAAAGAGGAGAAGATCCTGGAGCACAGATGCAGGGCACTGAC
AGGAGAAGTGGTTTTGTGGATGGTGAGCTGAACTTCGGAAAAAATCTAAAGATACCCTCCGAGC
CTCTAGCAGACAGTCGGCTAAGTGACGGTTTCAGGATCACAACAGCAAATGTGTTTTATCTGGA
AGAAGCTGTCAAGGTCTTCCATGTTATTTGATTTGACCTGAAATATGAGTATTTTGGATCTGAT
ATTTTGGTTAGTTACTGGAAAGGAAAAAACTGTAATCAAATTGTTTGAAAAGATGGGAATTATC
CCGATCGTACCTTTGCATCTTGGGAAAGACGGAAATAGAGAATTTAAATCCCAAA

hide sequence

RefSeq Acc Id:

XM_006253802 ⟹ XP_006253864

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,515,982 - 21,543,090 (-)	NCBI
mRatBN7.2	17	21,310,028 - 21,337,137 (-)	NCBI
Rnor_6.0	17	23,986,710 - 24,013,854 (+)	NCBI
Rnor_5.0	17	25,936,391 - 25,963,434 (+)	NCBI

Sequence:

show sequence

TCTCCGGCAGGGGCCGCTGCAGCCGGGGTGCGACACCAGGAGTCGGTGCGCTCCTCCCCAGACC
TCTCGTGCCTGCACCGTCCCCACCGCCTTTTGCAGGTTCGTCTCGGGCCCTGTTCGGGCTCCCA
GCTTTGTCAAGGCTCCGCGCGCCGCATCCCGCGCATGCGCGCCTGGGTGCGGCCTGCCCAGGGA
AGTAATCCTTCAACAAAAACCTATGCGACCGCTCCCGGTCGCTCCCGGACGTCTCTTCTCCCAG
CTGTGTTGTGGACCGAAGCCTTCAGCCTCCCCACAGAGCAAGATCTGCCTCACCATGGCTCGTC
CAAGTTCCAATATGGCAGATTTTCGGAAGTGTTTTGCGAACGCAAAGCACATAGTCATCATCTC
GGGGGCTGGTGTTAGTGCGGAGAGTGGGGTTCCAACATTCAGAGGAACCGGAGGCTATTGGAGA
AAATGGCAAGCTCAGCACCTGGCGACTCCTCTGGCCTTTGCTCACAACCCCTCACAGGTGTGGG
AGTTTTACCACTACCGGAGGGAGGTCATGCGGAACAAGGAACCCAACCCTGGGCACCTGGCCAT
TGCCCAATGTGAAGCCCGGCTGCGTGACCAGGGCAGACGGGTTGTGGTCATCACCCAGAACATT
GATGAGTTACATCGAAAGGCTGGCACCAAGAACCTGCTGGAAATCCACGGAACCTTATTTAAAA
CTCGGTGTACCTCGTGTGGCAATGTTGCTGAGAACTACAAGAGTCCGATTTGTCCAGCCTTATT
GGGAAAAGGGGCCCCAGAACCAGATACTCAAGAGTCCAGAATCCCAGTCCACAAACTTCCCCGG
TGCGAGGAGGCAGGATGTGGAGGCTTGCTGCGACCTCACGTGGTGTGGTTTGGAGAAAACCTGG
ATCCTGCCATTCTGAAAGAGGTGGACAGAGAGCTCGCCCGCTGTGACCTGTGTCTAGTGGTGGG
AACGTCCTCTGTGGTCTACCCAGCTGCCATGTTTGCCCCTCAGGTGGCTTCCAGGGGGGTCCCG
GTGGCCGAGTTTAACATGGAAACCACCCCAGCCACCAACAGATTCAGGTTTCATTTTCCCGGAC
CCTGTGGAGTAACTCTTCCTGAAGCCCTTGCTCCCCATGAAACTGAAAGGATTTCTTAATTGCC
CCATGGAAAGAGGAGAAGATCCTGGAGCACAGATGCAGGGCACTGACAGGAGAAGTGGTTTTGT
GGATGGTGAGCTGAACTTCGGAAAAAATCTAAAGATACCCTCCGAGCCTCTAGCAGACAGTCGG
CTAAGTGACGGTTTCAGGATCACAACAGCAAATGTGTTTTATCTGGAAGAAGCTGTCAAGGTCT
TCCATGTTATTTGATTTGACCTGAAATATGAGTATTTTGGATCTGATATTTTGGTTAGTTACTG
GAAAGGAAAAAACTGTAATCAAATTGTTTGAAAAGATGGGAATTATCCCGATCGTACCTTTGCA
TCTTGGGAAAGACGGAAATAGAGAATTTAAATCCCAAA

hide sequence

RefSeq Acc Id:

XM_006253803 ⟹ XP_006253865

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,515,982 - 21,542,870 (-)	NCBI
mRatBN7.2	17	21,310,028 - 21,336,871 (-)	NCBI
Rnor_6.0	17	23,986,994 - 24,013,854 (+)	NCBI
Rnor_5.0	17	25,936,391 - 25,963,434 (+)	NCBI

Sequence:

show sequence

CTTTGGCTAAGGTGACAAGGGCCGGTTGTAGTAGTGGGTGTGGGAGTGCAGAAAGGGTAGGATC
GCGACACAGCCTGAAGCCTGCCCAGGGAAGTAATCCTTCAACAAAAACCTATGCGACCGCTCCC
GGTCGCTCCCGGACGTCTCTTCTCCCAGCTGTGTTGTGGACCGAAGCCTTCAGCCTCCCCACAG
AGCAAGATCTGCCTCACCATGGCTCGTCCAAGTTCCAATATGGCAGATTTTCGGAAGTGTTTTG
CGAACGCAAAGCACATAGTCATCATCTCGGGGGCTGGTGTTAGTGCGGAGAGTGGGGTTCCAAC
ATTCAGAGGAACCGGAGGCTATTGGAGAAAATGGCAAGCTCAGCACCTGGCGACTCCTCTGGCC
TTTGCTCACAACCCCTCACAGGTGTGGGAGTTTTACCACTACCGGAGGGAGGTCATGCGGAACA
AGGAACCCAACCCTGGGCACCTGGCCATTGCCCAATGTGAAGCCCGGCTGCGTGACCAGGGCAG
ACGGGTTGTGGTCATCACCCAGAACATTGATGAGTTACATCGAAAGGCTGGCACCAAGAACCTG
CTGGAAATCCACGGAACCTTATTTAAAACTCGGTGTACCTCGTGTGGCAATGTTGCTGAGAACT
ACAAGAGTCCGATTTGTCCAGCCTTATTGGGAAAAGGGGCCCCAGAACCAGATACTCAAGAGTC
CAGAATCCCAGTCCACAAACTTCCCCGGTGCGAGGAGGCAGGATGTGGAGGCTTGCTGCGACCT
CACGTGGTGTGGTTTGGAGAAAACCTGGATCCTGCCATTCTGAAAGAGGTGGACAGAGAGCTCG
CCCGCTGTGACCTGTGTCTAGTGGTGGGAACGTCCTCTGTGGTCTACCCAGCTGCCATGTTTGC
CCCTCAGGTGGCTTCCAGGGGGGTCCCGGTGGCCGAGTTTAACATGGAAACCACCCCAGCCACC
AACAGATTCAGGTTTCATTTTCCCGGACCCTGTGGAGTAACTCTTCCTGAAGCCCTTGCTCCCC
ATGAAACTGAAAGGATTTCTTAATTGCCCCATGGAAAGAGGAGAAGATCCTGGAGCACAGATGC
AGGGCACTGACAGGAGAAGTGGTTTTGTGGATGGTGAGCTGAACTTCGGAAAAAATCTAAAGAT
ACCCTCCGAGCCTCTAGCAGACAGTCGGCTAAGTGACGGTTTCAGGATCACAACAGCAAATGTG
TTTTATCTGGAAGAAGCTGTCAAGGTCTTCCATGTTATTTGATTTGACCTGAAATATGAGTATT
TTGGATCTGATATTTTGGTTAGTTACTGGAAAGGAAAAAACTGTAATCAAATTGTTTGAAAAGA
TGGGAATTATCCCGATCGTACCTTTGCATCTTGGGAAAGACGGAAATAGAGAATTTAAATCCCA
AA

hide sequence

RefSeq Acc Id:

XM_006253804 ⟹ XP_006253866

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,515,982 - 21,542,858 (-)	NCBI
mRatBN7.2	17	21,310,028 - 21,336,695 (-)	NCBI
Rnor_6.0	17	23,987,199 - 24,013,854 (+)	NCBI
Rnor_5.0	17	25,936,391 - 25,963,434 (+)	NCBI

Sequence:

show sequence

TTCCAGATGGGAGATAGGAGCGAGCCTGCCCAGGGAAGTAATCCTTCAACAAAAACCTATGCGA
CCGCTCCCGGTCGCTCCCGGACGTCTCTTCTCCCAGCTGTGTTGTGGACCGAAGCCTTCAGCCT
CCCCACAGAGCAAGATCTGCCTCACCATGGCTCGTCCAAGTTCCAATATGGCAGATTTTCGGAA
GTGTTTTGCGAACGCAAAGCACATAGTCATCATCTCGGGGGCTGGTGTTAGTGCGGAGAGTGGG
GTTCCAACATTCAGAGGAACCGGAGGCTATTGGAGAAAATGGCAAGCTCAGCACCTGGCGACTC
CTCTGGCCTTTGCTCACAACCCCTCACAGGTGTGGGAGTTTTACCACTACCGGAGGGAGGTCAT
GCGGAACAAGGAACCCAACCCTGGGCACCTGGCCATTGCCCAATGTGAAGCCCGGCTGCGTGAC
CAGGGCAGACGGGTTGTGGTCATCACCCAGAACATTGATGAGTTACATCGAAAGGCTGGCACCA
AGAACCTGCTGGAAATCCACGGAACCTTATTTAAAACTCGGTGTACCTCGTGTGGCAATGTTGC
TGAGAACTACAAGAGTCCGATTTGTCCAGCCTTATTGGGAAAAGGGGCCCCAGAACCAGATACT
CAAGAGTCCAGAATCCCAGTCCACAAACTTCCCCGGTGCGAGGAGGCAGGATGTGGAGGCTTGC
TGCGACCTCACGTGGTGTGGTTTGGAGAAAACCTGGATCCTGCCATTCTGAAAGAGGTGGACAG
AGAGCTCGCCCGCTGTGACCTGTGTCTAGTGGTGGGAACGTCCTCTGTGGTCTACCCAGCTGCC
ATGTTTGCCCCTCAGGTGGCTTCCAGGGGGGTCCCGGTGGCCGAGTTTAACATGGAAACCACCC
CAGCCACCAACAGATTCAGGTTTCATTTTCCCGGACCCTGTGGAGTAACTCTTCCTGAAGCCCT
TGCTCCCCATGAAACTGAAAGGATTTCTTAATTGCCCCATGGAAAGAGGAGAAGATCCTGGAGC
ACAGATGCAGGGCACTGACAGGAGAAGTGGTTTTGTGGATGGTGAGCTGAACTTCGGAAAAAAT
CTAAAGATACCCTCCGAGCCTCTAGCAGACAGTCGGCTAAGTGACGGTTTCAGGATCACAACAG
CAAATGTGTTTTATCTGGAAGAAGCTGTCAAGGTCTTCCATGTTATTTGATTTGACCTGAAATA
TGAGTATTTTGGATCTGATATTTTGGTTAGTTACTGGAAAGGAAAAAACTGTAATCAAATTGTT
TGAAAAGATGGGAATTATCCCGATCGTACCTTTGCATCTTGGGAAAGACGGAAATAGAGAATTT
AAATCCCAAA

hide sequence

RefSeq Acc Id:

XM_039095673 ⟹ XP_038951601

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,515,982 - 21,543,023 (-)	NCBI
mRatBN7.2	17	21,310,028 - 21,336,996 (-)	NCBI

RefSeq Acc Id:

XM_063276376 ⟹ XP_063132446

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,522,862 - 21,543,529 (-)	NCBI

RefSeq Acc Id:

XM_063276377 ⟹ XP_063132447

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,522,862 - 21,543,176 (-)	NCBI

RefSeq Acc Id:

XM_063276378 ⟹ XP_063132448

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,522,862 - 21,543,090 (-)	NCBI

RefSeq Acc Id:

XM_063276379 ⟹ XP_063132449

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	21,522,862 - 21,542,931 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004256	(Get FASTA)	NCBI Sequence Viewer
	NP_001427065	(Get FASTA)	NCBI Sequence Viewer
	NP_001427066	(Get FASTA)	NCBI Sequence Viewer
	NP_001427067	(Get FASTA)	NCBI Sequence Viewer
	NP_001427068	(Get FASTA)	NCBI Sequence Viewer
	NP_001427069	(Get FASTA)	NCBI Sequence Viewer
	XP_006253863	(Get FASTA)	NCBI Sequence Viewer
	XP_006253864	(Get FASTA)	NCBI Sequence Viewer
	XP_006253865	(Get FASTA)	NCBI Sequence Viewer
	XP_006253866	(Get FASTA)	NCBI Sequence Viewer
	XP_038951601	(Get FASTA)	NCBI Sequence Viewer
	XP_063132446	(Get FASTA)	NCBI Sequence Viewer
	XP_063132447	(Get FASTA)	NCBI Sequence Viewer
	XP_063132448	(Get FASTA)	NCBI Sequence Viewer
	XP_063132449	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78958	(Get FASTA)	NCBI Sequence Viewer
	EDL98199	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024067
	ENSRNOP00000024067.4
	ENSRNOP00055010336
	ENSRNOP00060013005
	ENSRNOP00065009555
GenBank Protein	Q68FX9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001004256 ⟸ NM_001004256

- UniProtKB:

Q68FX9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MRPLPVAPGRLFSQLCCGPKPSASPQSKICLTMARPSSNMADFRKCFANAKHIVIISGAGVSAE
SGVPTFRGTGGYWRKWQAQHLATPLAFAHNPSQVWEFYHYRREVMRNKEPNPGHLAIAQCEARL
RDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGNVAENYKSPICPALLGKGAPEP
DTQESRIPVHKLPRCEEAGCGGLLRPHVVWFGENLDPAILKEVDRELARCDLCLVVGTSSVVYP
AAMFAPQVASRGVPVAEFNMETTPATNRFRFHFPGPCGVTLPEALAPHETERIS

hide sequence

RefSeq Acc Id:

XP_006253863 ⟸ XM_006253801

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRPLPVAPGRLFSQLCCGPKPSASPQSKICLTMARPSSNMADFRKCFANAKHIVIISGAGVSAE
SGVPTFRGTGGYWRKWQAQHLATPLAFAHNPSQVWEFYHYRREVMRNKEPNPGHLAIAQCEARL
RDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGNVAENYKSPICPALLGKGAPEP
DTQESRIPVHKLPRCEEAGCGGLLRPHVVWFGENLDPAILKEVDRELARCDLCLVVGTSSVVYP
AAMFAPQVASRGVPVAEFNMETTPATNRFRFHFPGPCGVTLPEALAPHETERIS

hide sequence

RefSeq Acc Id:

XP_006253864 ⟸ XM_006253802

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRPLPVAPGRLFSQLCCGPKPSASPQSKICLTMARPSSNMADFRKCFANAKHIVIISGAGVSAE
SGVPTFRGTGGYWRKWQAQHLATPLAFAHNPSQVWEFYHYRREVMRNKEPNPGHLAIAQCEARL
RDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGNVAENYKSPICPALLGKGAPEP
DTQESRIPVHKLPRCEEAGCGGLLRPHVVWFGENLDPAILKEVDRELARCDLCLVVGTSSVVYP
AAMFAPQVASRGVPVAEFNMETTPATNRFRFHFPGPCGVTLPEALAPHETERIS

hide sequence

RefSeq Acc Id:

XP_006253865 ⟸ XM_006253803

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRPLPVAPGRLFSQLCCGPKPSASPQSKICLTMARPSSNMADFRKCFANAKHIVIISGAGVSAE
SGVPTFRGTGGYWRKWQAQHLATPLAFAHNPSQVWEFYHYRREVMRNKEPNPGHLAIAQCEARL
RDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGNVAENYKSPICPALLGKGAPEP
DTQESRIPVHKLPRCEEAGCGGLLRPHVVWFGENLDPAILKEVDRELARCDLCLVVGTSSVVYP
AAMFAPQVASRGVPVAEFNMETTPATNRFRFHFPGPCGVTLPEALAPHETERIS

hide sequence

RefSeq Acc Id:

XP_006253866 ⟸ XM_006253804

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRPLPVAPGRLFSQLCCGPKPSASPQSKICLTMARPSSNMADFRKCFANAKHIVIISGAGVSAE
SGVPTFRGTGGYWRKWQAQHLATPLAFAHNPSQVWEFYHYRREVMRNKEPNPGHLAIAQCEARL
RDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGNVAENYKSPICPALLGKGAPEP
DTQESRIPVHKLPRCEEAGCGGLLRPHVVWFGENLDPAILKEVDRELARCDLCLVVGTSSVVYP
AAMFAPQVASRGVPVAEFNMETTPATNRFRFHFPGPCGVTLPEALAPHETERIS

hide sequence

Ensembl Acc Id:

ENSRNOP00000024067 ⟸ ENSRNOT00000024066

RefSeq Acc Id:	XP_038951601 ⟸ XM_039095673
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063132446 ⟸ XM_063276376
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063132447 ⟸ XM_063276377
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063132448 ⟸ XM_063276378
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063132449 ⟸ XM_063276379
- Peptide Label:	isoform X2

Protein Domains

Deacetylase sirtuin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FX9-F1-model_v2	AlphaFold	Q68FX9	1-310	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700385

Promoter ID:

EPDNEW_R10909

Type:

initiation region

Name:

Sirt5_1

Description:

sirtuin 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	23,986,769 - 23,986,829	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303285	AgrOrtholog
BioCyc Gene	G2FUF-9799	BioCyc
Ensembl Genes	ENSRNOG00000017866	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055007740	UniProtKB/Swiss-Prot
	ENSRNOG00060009860	UniProtKB/Swiss-Prot
	ENSRNOG00065008193	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000024066	ENTREZGENE
	ENSRNOT00000024066.7	UniProtKB/Swiss-Prot
	ENSRNOT00055012952	UniProtKB/Swiss-Prot
	ENSRNOT00060016644	UniProtKB/Swiss-Prot
	ENSRNOT00065012973	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.1600.10	UniProtKB/Swiss-Prot
	TPP-binding domain	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7110841	IMAGE-MGC_LOAD
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/Swiss-Prot
	NAD-dep_sirtuin_deacylases	UniProtKB/Swiss-Prot
	Sirtuin	UniProtKB/Swiss-Prot
	Sirtuin_cat_small_dom_sf	UniProtKB/Swiss-Prot
	Sirtuin_class_III	UniProtKB/Swiss-Prot
	Ssirtuin_cat_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:306840	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93823	IMAGE-MGC_LOAD
NCBI Gene	306840	ENTREZGENE
PANTHER	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	UniProtKB/Swiss-Prot
	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	UniProtKB/Swiss-Prot
Pfam	SIR2	UniProtKB/Swiss-Prot
PhenoGen	Sirt5	PhenoGen
PROSITE	SIRTUIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017866	RatGTEx
	ENSRNOG00055007740	RatGTEx
	ENSRNOG00060009860	RatGTEx
	ENSRNOG00065008193	RatGTEx
Superfamily-SCOP	SSF52467	UniProtKB/Swiss-Prot
UniProt	Q68FX9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Sirt5	sirtuin 5	Sirt5	sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Sirt5	sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)	Sirt5	sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Sirt5	sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)		sirtuin 5	Name updated	1299863	APPROVED
2005-09-30	Sirt5				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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