RGD Reference Report - SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction. - Rat Genome Database

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SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction.

Authors: Geng, YQ  Li, TT  Liu, XY  Li, ZH  Fu, YC 
Citation: Geng YQ, etal., J Cell Biochem. 2011 Dec;112(12):3755-61. doi: 10.1002/jcb.23315.
RGD ID: 9586056
Pubmed: PMID:21826711   (View Abstract at PubMed)
DOI: DOI:10.1002/jcb.23315   (Journal Full-text)

To investigate the effects of calorie restriction (CR) on behavioral performance and expression of SIRT1 and SIRT5 in rat cerebral tissues. Beginning at 18 months of age, 60 rats were randomly divided into a CR group (n = 30) and a group that remained fed ad libitum (AL; n = 30). CR rats were restricted to a diet of 60% of their daily food consumption. After 6 months of CR, CR rats displayed a maximum 50% reduction in escape latency (AL 20 +/- 0.3 s vs. CR 10 +/- 0.2 s) and a 3.2 s decrease in time and distance to target when evaluated in Morris water maze tests. The levels of SIRT1 and SIRT5 protein in cerebral tissues of CR rats were elevated compared to AL rats (P < 0.05). CR retarded declines in cognitive ability and enhanced the expression of both SIRT1 and SIRT5 proteins in the cerebral tissue of CR rats compared with AL rats.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient levels  IEP 9586056 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sirt5  (sirtuin 5)


Additional Information