Tomm22 (translocase of outer mitochondrial membrane 22) - Rat Genome Database

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Gene: Tomm22 (translocase of outer mitochondrial membrane 22) Rattus norvegicus
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Symbol: Tomm22
Name: translocase of outer mitochondrial membrane 22
RGD ID: 1303260
Description: Enables protein transmembrane transporter activity. Involved in positive regulation of apoptotic process; protein insertion into mitochondrial membrane; and protein targeting to mitochondrion. Part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22); PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; presequence pathway of mitochondrial protein import; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mitochondrial import receptor subunit TOM22 homolog; rTOM22; TOM22; translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog; translocase of outer mitochondrial membrane 22 homolog (yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,103,863 - 113,109,056 (+)NCBIGRCr8
mRatBN7.27111,223,508 - 111,228,671 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,216,571 - 111,246,799 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,974,658 - 112,976,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,198,199 - 115,199,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,167,574 - 115,169,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,901,934 - 120,903,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,901,934 - 120,903,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,888,909 - 120,894,057 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,913,211 - 117,914,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,947,453 - 117,948,603 (+)NCBI
Celera7107,557,387 - 107,559,137 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
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Original Reference(s)
Tomm22Ratadenylosuccinase lyase deficiency  ISOTOMM22 (Homo sapiens)8554872ClinVar Annotator: match by term: Adenylosuccinate lyase deficiencyClinVarPMID:28492532
Tomm22RatEmery-Dreifuss muscular dystrophy  ISOTOMM22 (Homo sapiens)8554872ClinVar Annotator: match by term: Emery-Dreifuss muscular dystrophyClinVarPMID:16783378 more ...
Tomm22Ratmyoclonic dystonia 26  ISOTOMM22 (Homo sapiens)8554872ClinVar Annotator: match by term: Myoclonic dystonia 26ClinVarPMID:16783378 more ...
Tomm22Ratneurodegeneration with brain iron accumulation 2A  ISOTOMM22 (Homo sapiens)8554872ClinVar Annotator: match by term: Infantile neuroaxonal dystrophyClinVarPMID:16783378 more ...

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Object Symbol
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Original Reference(s)
Tomm22Rat(1->4)-beta-D-glucan multiple interactionsISOTomm22 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TOMM22 mRNACTDPMID:36331819
Tomm22Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOTomm22 (Mus musculus)64804642 more ...CTDPMID:30294300
Tomm22Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTomm22 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TOMM22 mRNACTDPMID:21570461
Tomm22Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TOMM22 mRNACTDPMID:33387578
Tomm22Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of TOMM22 mRNACTDPMID:21346803
Tomm22Rat2-hydroxypropanoic acid decreases expressionISOTOMM22 (Homo sapiens)6480464Lactic Acid results in decreased expression of TOMM22 mRNACTDPMID:30851411
Tomm22Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of TOMM22 proteinCTDPMID:34915118
Tomm22Rat4,4'-sulfonyldiphenol increases expressionISOTomm22 (Mus musculus)6480464bisphenol S results in increased expression of TOMM22 mRNACTDPMID:39298647
Tomm22Rataconitine decreases expressionEXP 6480464Aconitine results in decreased expression of TOMM22 proteinCTDPMID:33236894
Tomm22Rataflatoxin B1 increases expressionISOTOMM22 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of TOMM22 mRNACTDPMID:27153756
Tomm22Ratall-trans-retinoic acid decreases expressionISOTOMM22 (Homo sapiens)6480464Tretinoin results in decreased expression of TOMM22 mRNACTDPMID:33167477
Tomm22Ratarsane multiple interactionsISOTOMM22 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of TOMM22 mRNACTDPMID:39836092
Tomm22Ratarsenic atom multiple interactionsISOTOMM22 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of TOMM22 mRNACTDPMID:39836092
Tomm22Ratarsenite(3-) decreases expressionISOTomm22 (Mus musculus)6480464arsenite results in decreased expression of TOMM22 mRNACTDPMID:33053406
Tomm22Ratarsenite(3-) multiple interactionsISOTOMM22 (Homo sapiens)6480464arsenite promotes the reaction [G3BP1 protein binds to TOMM22 mRNA]CTDPMID:32406909
Tomm22Ratatrazine decreases expressionISOTOMM22 (Homo sapiens)6480464Atrazine results in decreased expression of TOMM22 mRNACTDPMID:22378314
Tomm22Ratbeauvericin multiple interactionsISOTOMM22 (Homo sapiens)6480464[beauvericin co-treated with enniatins] results in decreased expression of TOMM22 proteinCTDPMID:32407736
Tomm22Ratbenzo[a]pyrene decreases expressionISOTOMM22 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of TOMM22 mRNACTDPMID:20106945
Tomm22Ratbenzo[a]pyrene decreases expressionISOTomm22 (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of TOMM22 mRNACTDPMID:27195522
Tomm22Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of TOMM22 mRNACTDPMID:25181051

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Biological Process
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Original Reference(s)
Tomm22Ratintracellular protein transport involved_inIEAInterPro:IPR0056831600115GO_REF:0000002InterProGO_REF:0000002
Tomm22Ratnegative regulation of DNA-templated transcription involved_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratnegative regulation of Wnt signaling pathway involved_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratpositive regulation of apoptotic process  IMP 8554729 RGD 
Tomm22Ratprotein homotetramerization involved_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratprotein import into mitochondrial matrix involved_inISOTOMM22 (Homo sapiens)1624291 PMID:15644312RGDPMID:15644312
Tomm22Ratprotein insertion into mitochondrial membrane  IMP 8554729 RGD 
Tomm22Ratprotein insertion into mitochondrial outer membrane involved_inIEAUniProtKB:Q9NS69 and ensembl:ENSP000002160341600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratprotein localization involved_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratprotein targeting to mitochondrion involved_inIMP 13838795PMID:19401463UniProt 
Tomm22Ratprotein transmembrane transport involved_inIEAGO:00083201600115GO_REF:0000108GOCGO_REF:0000108
Tomm22Ratprotein transport involved_inIEAUniProtKB-KW:KW-0653 and UniProtKB-KW:KW-08111600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Object Symbol
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Original Reference(s)
Tomm22Ratcentriole located_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratcentrosome located_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratmembrane located_inISOTOMM22 (Homo sapiens)1624291 PMID:15644312RGDPMID:15644312
Tomm22Ratmembrane located_inIEAUniProtKB:Q9NS69 and ensembl:ENSP000002160341600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Tomm22Ratmitochondrial outer membrane located_inIEAUniProtKB-SubCell:SL-01721600115GO_REF:0000044UniProtGO_REF:0000044
Tomm22Ratmitochondrial outer membrane located_inIEAUniProtKB-KW:KW-10001600115GO_REF:0000043UniProtGO_REF:0000043
Tomm22Ratmitochondrial outer membrane located_inIEAInterPro:IPR0056831600115GO_REF:0000002InterProGO_REF:0000002
Tomm22Ratmitochondrial outer membrane translocase complex  IDA 1303976 RGD 
Tomm22Ratmitochondrial outer membrane translocase complex part_ofISOTOMM22 (Homo sapiens)1624291 PMID:12198123 and PMID:15644312RGDPMID:12198123 and PMID:15644312
Tomm22Ratmitochondrial outer membrane translocase complex part_ofIEAUniProtKB:Q9NS69 and ensembl:ENSP000002160341600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratmitochondrion located_inISOTOMM22 (Homo sapiens)1624291 RGDGO_REF:0000052
Tomm22Ratmitochondrion located_inIEAUniProtKB:Q9NS69 and ensembl:ENSP000002160341600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratmitochondrion located_inIEAUniProtKB:Q549C5 and ensembl:ENSP000002160341600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Tomm22Ratnucleolus located_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratnucleoplasm located_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratnucleus located_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Rattrans-Golgi network located_inIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Tomm22Ratbeta-catenin binding enablesIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratidentical protein binding enablesIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratmitochondrion targeting sequence binding enablesISOTOMM22 (Homo sapiens)1624291 PMID:35733257RGDPMID:35733257
Tomm22Ratmitochondrion targeting sequence binding enablesIEAUniProtKB:Q9NS69 and ensembl:ENSP000002160341600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratprotein binding enablesIPIUniProtKB:P36877-28554174PMID:15923182UniProt 
Tomm22Ratprotein binding enablesISOTomm22 (Mus musculus)1624291PR:O55125 PMID:20497468RGDPMID:20497468
Tomm22Ratprotein binding enablesISOTOMM22 (Homo sapiens)1624291UniProtKB:O00170 more ...RGDPMID:12198123 more ...
Tomm22Ratprotein binding  IPITomm70 (Rattus norvegicus)1303951 RGD 
Tomm22Ratprotein homodimerization activity enablesIEAUniProtKB:Q9Y3M2 and ensembl:ENSP000002160291600115GO_REF:0000107EnsemblGO_REF:0000107
Tomm22Ratprotein transmembrane transporter activity enablesIMP 8554729PMID:18687331BHF-UCL 
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RGD Manual Annotations


  

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Reference Title
Reference Citation
1. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
2. Bax inserts into the mitochondrial outer membrane by different mechanisms. Cartron PF, etal., FEBS Lett. 2008 Sep 3;582(20):3045-51. doi: 10.1016/j.febslet.2008.07.047. Epub 2008 Aug 5.
3. Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A. Dagda RK, etal., J Biol Chem. 2005 Jul 22;280(29):27375-82. Epub 2005 May 27.
4. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
5. Assembly of beta-barrel proteins in the mitochondrial outer membrane. Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
6. Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex. Nakamura Y, etal., J Biol Chem 2004 May 14;279(20):21223-32. Epub 2004 Feb 25.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
10. Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane. Suzuki H, etal., J Cell Sci 2002 May 1;115(Pt 9):1895-905.
11. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
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PMID:12198123   PMID:12477932   PMID:12865426   PMID:15644312   PMID:18614015   PMID:19946888   PMID:33526603  



Tomm22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,103,863 - 113,109,056 (+)NCBIGRCr8
mRatBN7.27111,223,508 - 111,228,671 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,216,571 - 111,246,799 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,974,658 - 112,976,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,198,199 - 115,199,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,167,574 - 115,169,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,901,934 - 120,903,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,901,934 - 120,903,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,888,909 - 120,894,057 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,913,211 - 117,914,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,947,453 - 117,948,603 (+)NCBI
Celera7107,557,387 - 107,559,137 (+)NCBICelera
Cytogenetic Map7q34NCBI
TOMM22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,681,957 - 38,685,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,681,957 - 38,685,421 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,077,962 - 39,081,426 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,407,900 - 37,410,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 342237,402,453 - 37,405,263NCBI
Celera2222,884,631 - 22,887,442 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,044,164 - 22,046,979 (+)NCBIHuRef
CHM1_12239,036,846 - 39,039,661 (+)NCBICHM1_1
T2T-CHM13v2.02239,152,160 - 39,155,628 (+)NCBIT2T-CHM13v2.0
Tomm22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,555,069 - 79,557,063 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,555,062 - 79,557,601 (+)EnsemblGRCm39 Ensembl
GRCm381579,670,868 - 79,672,862 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,670,861 - 79,673,400 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,501,298 - 79,503,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,498,123 - 79,500,117 (+)NCBIMGSCv36mm8
Celera1581,796,265 - 81,798,069 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Tomm22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,799,735 - 24,801,820 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,799,735 - 24,801,820 (+)NCBIChiLan1.0ChiLan1.0
TOMM22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,537,569 - 48,540,122 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,228,944 - 51,231,496 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02219,596,941 - 19,599,499 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,414,704 - 37,417,229 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,414,704 - 37,417,229 (+)Ensemblpanpan1.1panPan2
TOMM22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,116,635 - 26,118,692 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,072,167 - 26,074,221 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,907,763 - 26,909,817 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,907,769 - 26,909,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,629,429 - 26,631,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,940,542 - 26,942,596 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,117,431 - 27,119,486 (-)NCBIUU_Cfam_GSD_1.0
Tomm22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,660,052 - 9,662,052 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,671,076 - 2,672,446 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,670,734 - 2,672,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,336,130 - 9,350,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,336,114 - 9,339,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,579,626 - 6,581,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,344,846 - 21,347,709 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,344,865 - 21,347,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045104,411,154 - 104,414,022 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,464,412 - 9,466,874 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,464,412 - 9,466,896 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tomm22
18 total Variants

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:64
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000019323
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat

1 to 10 of 35 rows
RH141915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,226,069 - 111,226,265 (+)MAPPERmRatBN7.2
Rnor_6.07120,901,083 - 120,901,278NCBIRnor6.0
Rnor_5.07120,891,456 - 120,891,651UniSTSRnor5.0
RGSC_v3.47117,912,360 - 117,912,555UniSTSRGSC3.4
Celera7107,556,536 - 107,556,731UniSTS
Cytogenetic Map7q34UniSTS
RH127815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,228,238 - 111,228,456 (+)MAPPERmRatBN7.2
Rnor_6.07120,903,252 - 120,903,469NCBIRnor6.0
Rnor_5.07120,893,625 - 120,893,842UniSTSRnor5.0
RGSC_v3.47117,914,529 - 117,914,746UniSTSRGSC3.4
Celera7107,558,705 - 107,558,922UniSTS
RH 3.4 Map7848.8UniSTS
Cytogenetic Map7q34UniSTS
AW529762  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,228,210 - 111,228,381 (+)MAPPERmRatBN7.2
Rnor_6.07120,903,224 - 120,903,394NCBIRnor6.0
Rnor_5.07120,893,597 - 120,893,767UniSTSRnor5.0
RGSC_v3.47117,914,501 - 117,914,671UniSTSRGSC3.4
Celera7107,558,677 - 107,558,847UniSTS
Cytogenetic Map7q34UniSTS
BI281592  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87113,108,824 - 113,108,978 (+)Marker Load Pipeline
mRatBN7.27111,228,439 - 111,228,593 (+)MAPPERmRatBN7.2
Rnor_6.07120,903,453 - 120,903,606NCBIRnor6.0
Rnor_5.07120,893,826 - 120,893,979UniSTSRnor5.0
RGSC_v3.47117,914,730 - 117,914,883UniSTSRGSC3.4
Celera7107,558,906 - 107,559,059UniSTS
RH 3.4 Map7855.4UniSTS
Cytogenetic Map7q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000019323   ⟹   ENSRNOP00000019323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,216,571 - 111,228,654 (+)Ensembl
Rnor_6.0 Ensembl7120,901,934 - 120,903,684 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095761   ⟹   ENSRNOP00000080542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,226,923 - 111,246,799 (+)Ensembl
RefSeq Acc Id: NM_212514   ⟹   NP_997679
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,107,306 - 113,109,056 (+)NCBI
mRatBN7.27111,226,921 - 111,228,671 (+)NCBI
Rnor_6.07120,901,934 - 120,903,684 (+)NCBI
Rnor_5.07120,888,909 - 120,894,057 (+)NCBI
RGSC_v3.47117,913,211 - 117,914,961 (+)RGD
Celera7107,557,387 - 107,559,137 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078838   ⟹   XP_038934766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,103,863 - 113,109,056 (+)NCBI
mRatBN7.27111,223,508 - 111,228,671 (+)NCBI
Protein RefSeqs NP_997679 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934766 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98639 (Get FASTA)   NCBI Sequence Viewer  
  BAD11364 (Get FASTA)   NCBI Sequence Viewer  
  EDM15790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080542
GenBank Protein Q75Q41 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997679   ⟸   NM_212514
- UniProtKB: Q75Q41 (UniProtKB/Swiss-Prot),   A0A8I5ZQA0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019323   ⟸   ENSRNOT00000019323
RefSeq Acc Id: XP_038934766   ⟸   XM_039078838
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q9P3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080542   ⟸   ENSRNOT00000095761

Name Modeler Protein Id AA Range Protein Structure
AF-Q75Q41-F1-model_v2 AlphaFold Q75Q41 1-142 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695484
Promoter ID:EPDNEW_R6009
Type:multiple initiation site
Name:Tomm22_1
Description:translocase of outer mitochondrial membrane 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07120,901,936 - 120,901,996EPDNEW


1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-32753 BioCyc
Ensembl Genes ENSRNOG00000014058 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000095761 ENTREZGENE
IMAGE_CLONE IMAGE:7324771 IMAGE-MGC_LOAD
InterPro Tom22 UniProtKB/Swiss-Prot
KEGG Report rno:300075 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112569 IMAGE-MGC_LOAD
NCBI Gene 300075 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG UniProtKB/Swiss-Prot
  PTHR12504 UniProtKB/Swiss-Prot
Pfam Tom22 UniProtKB/Swiss-Prot
PhenoGen Tomm22 PhenoGen
RatGTEx ENSRNOG00000014058 RatGTEx
UniProt A0A8I5ZQA0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q9P3 ENTREZGENE, UniProtKB/TrEMBL
  Q75Q41 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Tomm22  translocase of outer mitochondrial membrane 22  Tomm22  translocase of outer mitochondrial membrane 22 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Tomm22  translocase of outer mitochondrial membrane 22 homolog (yeast)  TOM22  TOM22 protein  Symbol and Name updated 1299863 APPROVED
2005-07-14 TOM22  TOM22 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_physical_interaction interacts with import receptor Tom20 1303976