Tomm22 (translocase of outer mitochondrial membrane 22) - Rat Genome Database

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Gene: Tomm22 (translocase of outer mitochondrial membrane 22) Mus musculus
Analyze
Symbol: Tomm22
Name: translocase of outer mitochondrial membrane 22
RGD ID: 1623801
MGI Page MGI
Description: Predicted to enable protein transmembrane transporter activity. Predicted to be involved in positive regulation of apoptotic process; protein insertion into mitochondrial membrane; and protein insertion into mitochondrial outer membrane. Predicted to act upstream of or within protein transport. Located in mitochondrial inner membrane. Is expressed in genitourinary system. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2310047D01; mitochondrial import receptor subunit TOM22 homolog; Tom2; Tom22; translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog; translocase of outer mitochondrial membrane 22 homolog (yeast)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12906  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,555,069 - 79,557,063 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,555,062 - 79,557,601 (+)EnsemblGRCm39 Ensembl
GRCm381579,670,868 - 79,672,862 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,670,861 - 79,673,400 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,501,298 - 79,503,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,498,123 - 79,500,117 (+)NCBIMGSCv36mm8
Celera1581,796,265 - 81,798,069 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
2. Assembly of beta-barrel proteins in the mitochondrial outer membrane. Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
6. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12865426   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18287559   PMID:18614015   PMID:18614564   PMID:19578372   PMID:20497468   PMID:21267068   PMID:23665500   PMID:24457600   PMID:26787839   PMID:29165030   PMID:30550785  
PMID:32968282   PMID:36417873  


Genomics

Comparative Map Data
Tomm22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,555,069 - 79,557,063 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,555,062 - 79,557,601 (+)EnsemblGRCm39 Ensembl
GRCm381579,670,868 - 79,672,862 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,670,861 - 79,673,400 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,501,298 - 79,503,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,498,123 - 79,500,117 (+)NCBIMGSCv36mm8
Celera1581,796,265 - 81,798,069 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
TOMM22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,681,957 - 38,685,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,681,957 - 38,685,421 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,077,962 - 39,081,426 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,407,900 - 37,410,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 342237,402,453 - 37,405,263NCBI
Celera2222,884,631 - 22,887,442 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,044,164 - 22,046,979 (+)NCBIHuRef
CHM1_12239,036,846 - 39,039,661 (+)NCBICHM1_1
T2T-CHM13v2.02239,152,160 - 39,155,628 (+)NCBIT2T-CHM13v2.0
Tomm22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,103,863 - 113,109,056 (+)NCBIGRCr8
mRatBN7.27111,223,508 - 111,228,671 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,216,571 - 111,246,799 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,974,658 - 112,976,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,198,199 - 115,199,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,167,574 - 115,169,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,901,934 - 120,903,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,901,934 - 120,903,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,888,909 - 120,894,057 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,913,211 - 117,914,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,947,453 - 117,948,603 (+)NCBI
Celera7107,557,387 - 107,559,137 (+)NCBICelera
Cytogenetic Map7q34NCBI
Tomm22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541324,799,735 - 24,801,820 (+)NCBIChiLan1.0ChiLan1.0
TOMM22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,537,569 - 48,540,122 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,228,944 - 51,231,496 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02219,596,941 - 19,599,499 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,414,704 - 37,417,229 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,414,704 - 37,417,229 (+)Ensemblpanpan1.1panPan2
TOMM22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,116,635 - 26,118,692 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,072,167 - 26,074,221 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,907,763 - 26,909,817 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,907,769 - 26,909,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,629,429 - 26,631,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,940,542 - 26,942,596 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,117,431 - 27,119,486 (-)NCBIUU_Cfam_GSD_1.0
Tomm22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,660,052 - 9,662,052 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,671,076 - 2,672,446 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,670,734 - 2,672,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,336,130 - 9,350,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,336,114 - 9,339,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,579,626 - 6,581,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,344,846 - 21,347,709 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,344,865 - 21,347,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045104,411,154 - 104,414,022 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,464,412 - 9,466,874 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,464,412 - 9,466,896 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tomm22
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:259
Interacting mature miRNAs:290
Transcripts:ENSMUST00000023062, ENSMUST00000127292
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157237245979899178Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse

Markers in Region
RH124535  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15E1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023062   ⟹   ENSMUSP00000023062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,555,062 - 79,557,601 (+)Ensembl
GRCm38.p6 Ensembl1579,670,861 - 79,673,400 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127292   ⟹   ENSMUSP00000155226
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,555,292 - 79,556,881 (+)Ensembl
GRCm38.p6 Ensembl1579,671,091 - 79,672,680 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229502   ⟹   ENSMUSP00000155148
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,555,082 - 79,556,766 (+)Ensembl
GRCm38.p6 Ensembl1579,670,881 - 79,672,565 (+)Ensembl
RefSeq Acc Id: NM_172609   ⟹   NP_766197
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,555,069 - 79,557,063 (+)NCBI
GRCm381579,670,868 - 79,672,862 (+)ENTREZGENE
MGSCv371579,501,298 - 79,503,292 (+)RGD
Celera1581,796,265 - 81,798,069 (+)RGD
cM Map15 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_766197   ⟸   NM_172609
- UniProtKB: Q543M4 (UniProtKB/Swiss-Prot),   Q9D8D3 (UniProtKB/Swiss-Prot),   Q9CPQ3 (UniProtKB/Swiss-Prot),   Q3UBW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000155226   ⟸   ENSMUST00000127292
RefSeq Acc Id: ENSMUSP00000023062   ⟸   ENSMUST00000023062
RefSeq Acc Id: ENSMUSP00000155148   ⟸   ENSMUST00000229502

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CPQ3-F1-model_v2 AlphaFold Q9CPQ3 1-142 view protein structure

Promoters
RGD ID:6826557
Promoter ID:MM_KWN:19077
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000057293,   OTTMUST00000057294
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361579,501,006 - 79,501,506 (+)MPROMDB
RGD ID:8684362
Promoter ID:EPDNEW_M20212
Type:multiple initiation site
Name:Tomm22_1
Description:Mus musculus translocase of outer mitochondrial membrane 22 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381579,670,881 - 79,670,941EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2450248 AgrOrtholog
Ensembl Genes ENSMUSG00000022427 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023062 ENTREZGENE
  ENSMUST00000023062.5 UniProtKB/Swiss-Prot
  ENSMUST00000127292.2 UniProtKB/TrEMBL
  ENSMUST00000229502.2 UniProtKB/TrEMBL
InterPro Tom22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:223696 UniProtKB/Swiss-Prot
MGD MGI:2450248 ENTREZGENE
NCBI Gene 223696 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12504 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tom22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tomm22 PhenoGen
UniProt A0A2R8VHJ4_MOUSE UniProtKB/TrEMBL
  A0A2R8VHM4_MOUSE UniProtKB/TrEMBL
  Q3UBW3 ENTREZGENE, UniProtKB/TrEMBL
  Q543M4 ENTREZGENE
  Q9CPQ3 ENTREZGENE
  Q9D8D3 ENTREZGENE
  TOM22_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q543M4 UniProtKB/Swiss-Prot
  Q9D8D3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-27 Tomm22  translocase of outer mitochondrial membrane 22    translocase of outer mitochondrial membrane 22 homolog (yeast)  Symbol and/or name change 5135510 APPROVED