Actr3 (actin related protein 3) - Rat Genome Database

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Gene: Actr3 (actin related protein 3) Chinchilla lanigera
Analyze
Symbol: Actr3
Name: actin related protein 3
RGD ID: 8975913
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); ATPase binding (ortholog); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); astrocyte differentiation (ortholog); asymmetric cell division (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Cognitive Dysfunction (ortholog); colorectal carcinoma (ortholog); FOUND IN actin filament (ortholog); apical ectoplasmic specialization (ortholog); apical tubulobulbar complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: actin-related protein 3; ARP3 actin related protein 3 homolog; ARP3 actin-related protein 3 homolog; ARP3 actin-related protein 3 homolog (yeast)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545915,216,914 - 15,284,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545915,216,914 - 15,284,013 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
Arp2/3 complex-mediated actin nucleation  (ISO)
astrocyte differentiation  (ISO)
asymmetric cell division  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to pyrimidine ribonucleotide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to triterpenoid  (ISO)
cellular response to tumor necrosis factor  (ISO)
cilium assembly  (ISO)
establishment or maintenance of cell polarity  (ISO)
meiotic cell cycle  (ISO)
meiotic chromosome movement towards spindle pole  (ISO)
meiotic cytokinesis  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of bleb assembly  (ISO)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
postsynaptic actin cytoskeleton organization  (ISO)
regulation of myosin II filament organization  (ISO)
response to estradiol  (ISO)
response to heparin  (ISO)
Sertoli cell barrier remodeling  (ISO)
spermatogenesis  (ISO)
spindle localization  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Actr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545915,216,914 - 15,284,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545915,216,914 - 15,284,013 (-)NCBIChiLan1.0ChiLan1.0
ACTR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,889,934 - 113,962,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,890,063 - 113,962,596 (+)EnsemblGRCh38hg38GRCh38
GRCh372114,647,511 - 114,720,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,364,007 - 114,432,637 (+)NCBINCBI36hg18NCBI36
Build 342114,363,766 - 114,432,397NCBI
Celera2107,963,979 - 108,036,693 (+)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBIHuRef
CHM1_12114,651,066 - 114,722,668 (+)NCBICHM1_1
T2T-CHM13v2.02114,314,590 - 114,387,240 (+)NCBI
Actr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391125,320,642 - 125,363,464 (-)NCBIGRCm39mm39
GRCm39 Ensembl1125,320,642 - 125,363,464 (-)Ensembl
GRCm381125,392,905 - 125,435,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1125,392,905 - 125,435,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv371127,289,483 - 127,332,067 (-)NCBIGRCm37mm9NCBIm37
MGSCv361127,220,452 - 127,263,036 (-)NCBImm8
Celera1128,040,526 - 128,085,756 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
Actr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21336,800,739 - 36,843,837 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1336,800,093 - 36,844,124 (-)Ensembl
Rnor_6.01341,695,520 - 41,738,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01346,808,187 - 46,850,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41337,861,558 - 37,904,589 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11337,876,286 - 37,879,398 (-)NCBI
Celera1336,607,886 - 36,650,420 (-)NCBICelera
Cytogenetic Map13q12NCBI
ACTR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B114,373,392 - 114,445,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B114,373,392 - 114,445,729 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B827,184 - 900,424 (+)NCBIMhudiblu_PPA_v0panPan3
ACTR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11935,097,968 - 35,133,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1935,098,639 - 35,169,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1935,329,635 - 35,387,572 (-)NCBI
ROS_Cfam_1.01936,533,033 - 36,590,987 (-)NCBI
ROS_Cfam_1.0 Ensembl1936,533,040 - 36,591,315 (-)Ensembl
UMICH_Zoey_3.11935,181,031 - 35,238,936 (-)NCBI
UNSW_CanFamBas_1.01935,342,002 - 35,399,933 (-)NCBI
UU_Cfam_GSD_1.01936,561,512 - 36,619,469 (-)NCBI
Actr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530385,918,173 - 85,977,081 (+)NCBI
SpeTri2.0NW_00493646955,639,345 - 55,699,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1520,104,846 - 20,208,186 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11520,104,808 - 20,171,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21522,725,584 - 22,786,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11016,296,350 - 16,369,561 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1016,297,502 - 16,369,220 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660616,176,980 - 6,250,598 (+)NCBIVero_WHO_p1.0
Actr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473231,361,147 - 31,427,811 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473231,360,804 - 31,427,885 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000008252   ⟹   ENSCLAP00000008126
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545915,216,914 - 15,284,013 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000008253   ⟹   ENSCLAP00000008127
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545915,242,322 - 15,283,389 (-)Ensembl
RefSeq Acc Id: XM_005397698   ⟹   XP_005397755
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545915,216,914 - 15,284,013 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005397755 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS59419 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005397755   ⟸   XM_005397698
- Sequence:
RefSeq Acc Id: ENSCLAP00000008126   ⟸   ENSCLAT00000008252
RefSeq Acc Id: ENSCLAP00000008127   ⟸   ENSCLAT00000008253


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005698 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000008126 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAP00000008127 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000008252 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAT00000008253 UniProtKB/TrEMBL
InterPro Actin UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  Arp3 UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
NCBI Gene LOC102029596 ENTREZGENE
PANTHER PTHR11937 UniProtKB/TrEMBL
  PTHR11937:SF175 UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PROSITE ACTINS_ACT_LIKE UniProtKB/TrEMBL
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8C2V0I2_CHILA UniProtKB/TrEMBL
  A0A8C2V640_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 Actr3  actin related protein 3    ARP3 actin related protein 3 homolog  Symbol and/or name change 5135510 APPROVED
2016-07-26 Actr3  ARP3 actin related protein 3 homolog    ARP3 actin-related protein 3 homolog (yeast)  Symbol and/or name change 5135510 APPROVED
2015-08-25 Actr3  ARP3 actin-related protein 3 homolog (yeast)  LOC102029596  actin-related protein 3-like  Symbol and/or name change 5135510 APPROVED