ACTR3 (actin related protein 3) - Rat Genome Database

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Gene: ACTR3 (actin related protein 3) Homo sapiens
Analyze
Symbol: ACTR3
Name: actin related protein 3
RGD ID: 736322
HGNC Page HGNC:170
Description: A structural constituent of cytoskeleton. Contributes to actin filament binding activity. Involved in several processes, including Arp2/3 complex-mediated actin nucleation; cilium assembly; and positive regulation of lamellipodium assembly. Located in cytoplasm; lamellipodium; and nucleus. Part of Arp2/3 protein complex. Implicated in opisthorchiasis. Biomarker of colorectal carcinoma; gallbladder carcinoma; glioblastoma; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: actin-like protein 3; actin-related protein 3; actin-related protein 3 homolog (yeast); ARP3; ARP3 actin related protein 3 homolog; ARP3 actin-related protein 3 homolog; ARP3 actin-related protein 3 homolog (yeast)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: ACTR3P1   ACTR3P2   ACTR3P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,889,934 - 113,962,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,890,063 - 113,962,596 (+)EnsemblGRCh38hg38GRCh38
GRCh372114,647,511 - 114,720,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,364,007 - 114,432,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342114,363,766 - 114,432,397NCBI
Celera2107,963,979 - 108,036,693 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBIHuRef
CHM1_12114,651,066 - 114,722,668 (+)NCBICHM1_1
T2T-CHM13v2.02114,314,590 - 114,387,240 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
aniline  (ISO)
aristolochic acid  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (EXP)
benzatropine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butyric acid  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
cisplatin  (EXP)
clozapine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
gentamycin  (ISO)
heparin  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (EXP)
ivermectin  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
theophylline  (EXP)
thioacetamide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
warfarin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization-dependent cell motility  (TAS)
Arp2/3 complex-mediated actin nucleation  (IBA,IDA,IEA)
astrocyte differentiation  (ISO)
asymmetric cell division  (IEA,ISO)
cell projection organization  (IEA)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to pyrimidine ribonucleotide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to triterpenoid  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (IEA,ISO)
cilium assembly  (IMP)
establishment or maintenance of cell polarity  (IEA,ISO)
meiotic cell cycle  (IEA,ISO)
meiotic chromosome movement towards spindle pole  (IEA,ISO)
meiotic cytokinesis  (IEA,ISO)
negative regulation of axon extension  (ISO)
negative regulation of bleb assembly  (ISO)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of lamellipodium assembly  (IDA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
postsynapse organization  (ISO)
postsynaptic actin cytoskeleton organization  (ISO)
regulation of myosin II filament organization  (ISO)
response to estradiol  (ISO)
response to heparin  (ISO)
Sertoli cell barrier remodeling  (ISO)
spermatogenesis  (ISO)
spindle localization  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Akiyama K, et al., Mamm Genome. 2008 Jan;19(1):41-50. Epub 2007 Dec 7.
2. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
3. A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Clark D, etal., Mol Psychiatry. 2006 May;11(5):459-70, 423.
4. Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics. Detsika MG, etal., Am J Nephrol. 2016;43(6):441-50. doi: 10.1159/000446859. Epub 2016 Jun 2.
5. RasGRP3 regulates the migration of glioma cells via interaction with Arp3. Lee HK, etal., Oncotarget. 2015 Jan 30;6(3):1850-64.
6. Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. Otsubo T, etal., Mod Pathol. 2004 Apr;17(4):461-7.
7. Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment. Ottis P, etal., PLoS One. 2013 Sep 19;8(9):e75112. doi: 10.1371/journal.pone.0075112. eCollection 2013.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Plasma IgG autoantibody against actin-related protein 3 in liver fluke Opisthorchis viverrini infection. Rucksaken R, etal., Parasite Immunol. 2015 Jul;37(7):340-8. doi: 10.1111/pim.12188.
12. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. Welch MD, etal., J Cell Biol 1997 Jul 28;138(2):375-84.
13. A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology. Wesseling H, etal., Neuropsychopharmacology. 2013 Nov;38(12):2532-44. doi: 10.1038/npp.2013.160. Epub 2013 Jul 3.
14. CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder. Yang ZL, etal., Cancer Invest. 2013 Feb;31(2):132-9. doi: 10.3109/07357907.2012.756113. Epub 2013 Jan 15.
Additional References at PubMed
PMID:9000076   PMID:9210376   PMID:9359840   PMID:9860974   PMID:9889097   PMID:10381382   PMID:10421578   PMID:10524632   PMID:10563804   PMID:10781580   PMID:10806390   PMID:11018051  
PMID:11052943   PMID:11146629   PMID:11231575   PMID:11721045   PMID:11741539   PMID:11790298   PMID:11882288   PMID:12036877   PMID:12176354   PMID:12176742   PMID:12200375   PMID:12429845  
PMID:12464680   PMID:12473693   PMID:12477932   PMID:12534372   PMID:12672817   PMID:12732638   PMID:12791263   PMID:12829704   PMID:12872157   PMID:15242766   PMID:15247266   PMID:15279900  
PMID:15385624   PMID:15469433   PMID:15489334   PMID:15592455   PMID:15635413   PMID:15741236   PMID:16004967   PMID:16253999   PMID:16403731   PMID:16767080   PMID:17085436   PMID:17220302  
PMID:17353931   PMID:17501982   PMID:17524364   PMID:17576929   PMID:18516090   PMID:19056867   PMID:19262673   PMID:19286135   PMID:19738201   PMID:19913427   PMID:19946888   PMID:20195357  
PMID:20308691   PMID:20360068   PMID:20393563   PMID:20404198   PMID:20458337   PMID:20585556   PMID:20603326   PMID:20876399   PMID:20974812   PMID:21108927   PMID:21182205   PMID:21280222  
PMID:21423176   PMID:21873635   PMID:22100162   PMID:22145905   PMID:22261722   PMID:22586326   PMID:22658674   PMID:22863883   PMID:22939629   PMID:23051739   PMID:23166591   PMID:23376485  
PMID:23533145   PMID:24058526   PMID:24344184   PMID:24415754   PMID:24469447   PMID:24711643   PMID:24872192   PMID:24981860   PMID:25264243   PMID:25665578   PMID:25737280   PMID:25921289  
PMID:25959826   PMID:25963833   PMID:25982273   PMID:26018170   PMID:26028144   PMID:26186194   PMID:26209609   PMID:26344197   PMID:26370503   PMID:26496610   PMID:26506232   PMID:26618866  
PMID:26638075   PMID:26655834   PMID:26673895   PMID:26760575   PMID:26848712   PMID:26991540   PMID:26997484   PMID:27052944   PMID:27173435   PMID:27181356   PMID:27342126   PMID:27377895  
PMID:27559607   PMID:27684187   PMID:27872092   PMID:27880917   PMID:28170369   PMID:28302793   PMID:28514442   PMID:28718761   PMID:28775156   PMID:28883622   PMID:28902428   PMID:29053956  
PMID:29058690   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29568061   PMID:29636431   PMID:29911972   PMID:29955894   PMID:30049513   PMID:30344098   PMID:30425250   PMID:30462309  
PMID:30463901   PMID:30489239   PMID:30575818   PMID:30792969   PMID:30809309   PMID:30833792   PMID:30890647   PMID:30948266   PMID:31091453   PMID:31470122   PMID:31478661   PMID:31586073  
PMID:31698518   PMID:31722399   PMID:31980649   PMID:32041737   PMID:32169900   PMID:32176628   PMID:32269044   PMID:32665550   PMID:32780723   PMID:32814053   PMID:32814769   PMID:32994395  
PMID:33106477   PMID:33144569   PMID:33194618   PMID:33536335   PMID:33644029   PMID:33684176   PMID:33731348   PMID:33947818   PMID:33961781   PMID:34079125   PMID:34373451   PMID:34428256  
PMID:34709727   PMID:35013218   PMID:35013556   PMID:35032548   PMID:35140242   PMID:35256949   PMID:35271311   PMID:35446349   PMID:35509820   PMID:35676659   PMID:35776542   PMID:35831314  


Genomics

Comparative Map Data
ACTR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,889,934 - 113,962,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,890,063 - 113,962,596 (+)EnsemblGRCh38hg38GRCh38
GRCh372114,647,511 - 114,720,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,364,007 - 114,432,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342114,363,766 - 114,432,397NCBI
Celera2107,963,979 - 108,036,693 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBIHuRef
CHM1_12114,651,066 - 114,722,668 (+)NCBICHM1_1
T2T-CHM13v2.02114,314,590 - 114,387,240 (+)NCBIT2T-CHM13v2.0
Actr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391125,320,642 - 125,363,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1125,320,642 - 125,363,464 (-)EnsemblGRCm39 Ensembl
GRCm381125,392,905 - 125,435,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1125,392,905 - 125,435,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv371127,289,483 - 127,332,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361127,220,452 - 127,263,036 (-)NCBIMGSCv36mm8
Celera1128,040,526 - 128,085,756 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
Actr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21336,800,739 - 36,843,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1336,800,093 - 36,844,124 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1339,401,982 - 39,443,515 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01340,689,982 - 40,731,516 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01337,949,578 - 37,992,708 (-)NCBIRnor_WKY
Rnor_6.01341,695,520 - 41,738,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01346,808,187 - 46,850,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41337,861,558 - 37,904,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11337,876,286 - 37,879,398 (-)NCBI
Celera1336,607,886 - 36,650,420 (-)NCBICelera
Cytogenetic Map13q12NCBI
Actr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545915,216,914 - 15,284,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545915,216,914 - 15,284,013 (-)NCBIChiLan1.0ChiLan1.0
ACTR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B114,373,392 - 114,445,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B114,373,392 - 114,445,729 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B827,184 - 900,424 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACTR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11935,097,968 - 35,133,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1935,098,639 - 35,169,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1935,329,635 - 35,387,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01936,533,033 - 36,590,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1936,533,040 - 36,591,315 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11935,181,031 - 35,238,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01935,342,002 - 35,399,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01936,561,512 - 36,619,469 (-)NCBIUU_Cfam_GSD_1.0
Actr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530385,918,173 - 85,977,081 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646955,639,068 - 55,699,640 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493646955,639,345 - 55,699,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1520,104,812 - 20,167,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11520,104,808 - 20,171,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21522,725,584 - 22,786,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11016,296,350 - 16,369,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1016,297,502 - 16,369,220 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660616,176,980 - 6,250,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473231,361,147 - 31,427,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473231,360,804 - 31,427,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACTR3
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2300
Count of miRNA genes:991
Interacting mature miRNAs:1187
Transcripts:ENST00000263238, ENST00000415792, ENST00000443297, ENST00000446821, ENST00000478928, ENST00000484165, ENST00000489779, ENST00000535589, ENST00000536059
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D2S2582  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372114,715,644 - 114,715,822UniSTSGRCh37
Build 362114,432,114 - 114,432,292RGDNCBI36
Celera2108,036,170 - 108,036,348RGD
Cytogenetic Map2q14.1UniSTS
Cytogenetic MapXp22.2-p22.1UniSTS
HuRef2107,036,166 - 107,036,344UniSTS
GeneMap99-G3 RH Map25754.0UniSTS
WI-20350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372114,715,583 - 114,715,809UniSTSGRCh37
Build 362114,432,053 - 114,432,279RGDNCBI36
Celera2108,036,109 - 108,036,335RGD
Cytogenetic Map2q14.1UniSTS
Cytogenetic MapXp22.2-p22.1UniSTS
HuRef2107,036,105 - 107,036,331UniSTS
GeneMap99-GB4 RH Map2416.12UniSTS
Whitehead-RH Map2585.9UniSTS
WI-12604  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372114,652,403 - 114,652,508UniSTSGRCh37
Build 362114,368,873 - 114,368,978RGDNCBI36
Celera2107,968,846 - 107,968,951RGD
Cytogenetic Map2q14.1UniSTS
HuRef2106,968,999 - 106,969,104UniSTS
GeneMap99-GB4 RH Map2412.88UniSTS
Whitehead-RH Map2651.4UniSTS
RH68378  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372114,716,679 - 114,716,883UniSTSGRCh37
Build 362114,433,149 - 114,433,353RGDNCBI36
Celera2108,037,205 - 108,037,409RGD
Cytogenetic Map2q14.1UniSTS
HuRef2107,037,200 - 107,037,404UniSTS
GeneMap99-GB4 RH Map2422.11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2434 2741 1589 491 1929 332 4071 1729 3350 389 1457 1610 175 1 1203 2502 6 2
Low 5 250 137 133 22 133 286 468 384 30 3 3 1 286
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_102318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF006083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI521063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB453995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000263238   ⟹   ENSP00000263238
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,890,089 - 113,962,596 (+)Ensembl
RefSeq Acc Id: ENST00000415792   ⟹   ENSP00000407912
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,890,093 - 113,940,143 (+)Ensembl
RefSeq Acc Id: ENST00000443297   ⟹   ENSP00000403125
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,890,063 - 113,931,369 (+)Ensembl
RefSeq Acc Id: ENST00000446821   ⟹   ENSP00000394213
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,890,098 - 113,942,262 (+)Ensembl
RefSeq Acc Id: ENST00000478928
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,950,824 - 113,958,589 (+)Ensembl
RefSeq Acc Id: ENST00000484165
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,933,856 - 113,940,103 (+)Ensembl
RefSeq Acc Id: ENST00000489779
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,927,369 - 113,934,640 (+)Ensembl
RefSeq Acc Id: ENST00000535589   ⟹   ENSP00000444987
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2113,890,598 - 113,957,591 (+)Ensembl
RefSeq Acc Id: NM_001277140   ⟹   NP_001264069
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,890,598 - 113,961,554 (+)NCBI
GRCh372114,647,511 - 114,719,131 (+)NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBI
CHM1_12114,651,730 - 114,722,668 (+)NCBI
T2T-CHM13v2.02114,315,254 - 114,386,198 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005721   ⟹   NP_005712
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,890,089 - 113,962,596 (+)NCBI
GRCh372114,647,511 - 114,719,131 (+)NCBI
Build 362114,364,007 - 114,432,637 (+)NCBI Archive
HuRef2106,964,108 - 107,039,652 (+)NCBI
CHM1_12114,651,066 - 114,722,668 (+)NCBI
T2T-CHM13v2.02114,314,745 - 114,387,240 (+)NCBI
Sequence:
RefSeq Acc Id: NR_102318
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,889,934 - 113,961,554 (+)NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBI
CHM1_12114,651,066 - 114,722,668 (+)NCBI
T2T-CHM13v2.02114,314,590 - 114,386,198 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005712   ⟸   NM_005721
- Peptide Label: isoform 1
- UniProtKB: Q53QM2 (UniProtKB/Swiss-Prot),   P61158 (UniProtKB/Swiss-Prot),   A0A024RAI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264069   ⟸   NM_001277140
- Peptide Label: isoform 2
- UniProtKB: B4DXW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000407912   ⟸   ENST00000415792
RefSeq Acc Id: ENSP00000444987   ⟸   ENST00000535589
RefSeq Acc Id: ENSP00000403125   ⟸   ENST00000443297
RefSeq Acc Id: ENSP00000394213   ⟸   ENST00000446821
RefSeq Acc Id: ENSP00000263238   ⟸   ENST00000263238

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61158-F1-model_v2 AlphaFold P61158 1-418 view protein structure

Promoters
RGD ID:6861406
Promoter ID:EPDNEW_H3868
Type:initiation region
Name:ACTR3_2
Description:ARP3 actin related protein 3 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3869  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,889,960 - 113,890,020EPDNEW
RGD ID:6861408
Promoter ID:EPDNEW_H3869
Type:initiation region
Name:ACTR3_1
Description:ARP3 actin related protein 3 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3868  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382113,890,131 - 113,890,191EPDNEW
RGD ID:6796731
Promoter ID:HG_KWN:34659
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000331366,   OTTHUMT00000331425,   OTTHUMT00000331499,   OTTHUMT00000331500
Position:
Human AssemblyChrPosition (strand)Source
Build 362114,363,696 - 114,364,227 (+)MPROMDB
RGD ID:6851006
Promoter ID:EP73299
Type:initiation region
Name:HS_ACTR3
Description:ARP3 actin-related protein 3 homolog (yeast).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 362114,364,144 - 114,364,204EPD
RGD ID:6796732
Promoter ID:HG_KWN:34660
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000331501
Position:
Human AssemblyChrPosition (strand)Source
Build 362114,400,504 - 114,401,004 (+)MPROMDB
RGD ID:6796730
Promoter ID:HG_KWN:34662
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000331367
Position:
Human AssemblyChrPosition (strand)Source
Build 362114,424,156 - 114,425,312 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_005721.4(ACTR3):c.1234C>T (p.Pro412Ser) single nucleotide variant Malignant melanoma [RCV000060304] Chr2:113957432 [GRCh38]
Chr2:114715009 [GRCh37]
Chr2:114431479 [NCBI36]
Chr2:2q14.1
not provided
GRCh37/hg19 2q12.2-14.1(chr2:106423310-115054828)x1 copy number loss See cases [RCV000240053] Chr2:106423310..115054828 [GRCh37]
Chr2:2q12.2-14.1
pathogenic
GRCh37/hg19 2q12.3-14.3(chr2:109798247-125658380)x1 copy number loss See cases [RCV000240485] Chr2:109798247..125658380 [GRCh37]
Chr2:2q12.3-14.3
pathogenic
GRCh37/hg19 2q12.3-14.1(chr2:109556627-117570152)x1 copy number loss See cases [RCV000240490] Chr2:109556627..117570152 [GRCh37]
Chr2:2q12.3-14.1
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q13-14.3(chr2:114056441-123673800)x1 copy number loss See cases [RCV000511150] Chr2:114056441..123673800 [GRCh37]
Chr2:2q13-14.3
pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
GRCh37/hg19 2q14.1-14.3(chr2:114707932-124328692)x1 copy number loss not provided [RCV000682164] Chr2:114707932..124328692 [GRCh37]
Chr2:2q14.1-14.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q14.1(chr2:114646847-114715533)x3 copy number gain not provided [RCV000753093] Chr2:114646847..114715533 [GRCh37]
Chr2:2q14.1
benign
NM_005721.5(ACTR3):c.858+12dup duplication not provided [RCV000964872] Chr2:113942363..113942364 [GRCh38]
Chr2:114699940..114699941 [GRCh37]
Chr2:2q14.1
benign
GRCh37/hg19 2q13-14.1(chr2:113609489-115817535)x3 copy number gain not provided [RCV001833062] Chr2:113609489..115817535 [GRCh37]
Chr2:2q13-14.1
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q13-14.3(chr2:113188197-128144700) copy number loss not specified [RCV002053220] Chr2:113188197..128144700 [GRCh37]
Chr2:2q13-14.3
pathogenic
GRCh37/hg19 2q13-22.3(chr2:111484468-146333604)x3 copy number gain not provided [RCV001832896] Chr2:111484468..146333604 [GRCh37]
Chr2:2q13-22.3
pathogenic
GRCh37/hg19 2q13-22.3(chr2:112475655-145691999)x3 copy number gain 2q13q22.3 microduplication syndrome [RCV002226436] Chr2:112475655..145691999 [GRCh37]
Chr2:2q13-22.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:170 AgrOrtholog
COSMIC ACTR3 COSMIC
Ensembl Genes ENSG00000115091 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000263238 ENTREZGENE
  ENSP00000263238.2 UniProtKB/Swiss-Prot
  ENSP00000394213.1 UniProtKB/TrEMBL
  ENSP00000403125.2 UniProtKB/TrEMBL
  ENSP00000407912.1 UniProtKB/TrEMBL
  ENSP00000444987 ENTREZGENE
  ENSP00000444987.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000263238 ENTREZGENE
  ENST00000263238.7 UniProtKB/Swiss-Prot
  ENST00000415792.5 UniProtKB/TrEMBL
  ENST00000443297.5 UniProtKB/TrEMBL
  ENST00000446821.5 UniProtKB/TrEMBL
  ENST00000535589 ENTREZGENE
  ENST00000535589.3 UniProtKB/TrEMBL
GTEx ENSG00000115091 GTEx
HGNC ID HGNC:170 ENTREZGENE
Human Proteome Map ACTR3 Human Proteome Map
InterPro Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arp3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 10096 ENTREZGENE
OMIM 604222 OMIM
PANTHER PTHR11937 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11937:SF175 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24489 PharmGKB
PROSITE ACTINS_ACT_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RAI1 ENTREZGENE, UniProtKB/TrEMBL
  ARP3_HUMAN UniProtKB/Swiss-Prot
  B4DXW1 ENTREZGENE, UniProtKB/TrEMBL
  F8WDR7_HUMAN UniProtKB/TrEMBL
  F8WE84_HUMAN UniProtKB/TrEMBL
  F8WEW2_HUMAN UniProtKB/TrEMBL
  P61158 ENTREZGENE
  Q53QM2 ENTREZGENE
UniProt Secondary P32391 UniProtKB/Swiss-Prot
  Q53QM2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 ACTR3  actin related protein 3    ARP3 actin related protein 3 homolog  Symbol and/or name change 5135510 APPROVED
2016-07-19 ACTR3  ARP3 actin related protein 3 homolog    ARP3 actin-related protein 3 homolog (yeast)  Symbol and/or name change 5135510 APPROVED
2011-08-16 ACTR3  ARP3 actin-related protein 3 homolog (yeast)  ACTR3  ARP3 actin-related protein 3 homolog (yeast)  Symbol and/or name change 5135510 APPROVED