Nsd3 (nuclear receptor binding SET domain protein 3) - Rat Genome Database

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Gene: Nsd3 (nuclear receptor binding SET domain protein 3) Chinchilla lanigera
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Symbol: Nsd3
Name: nuclear receptor binding SET domain protein 3
RGD ID: 8767373
Description: ENCODES a protein that exhibits histone H3K27 dimethyltransferase activity (ortholog); histone H3K27 methyltransferase activity (ortholog); histone H3K27 trimethyltransferase activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); positive regulation of DNA-templated transcription (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH hereditary spastic paraplegia 54 (ortholog); hypogonadotropic hypogonadism 2 with or without anosmia (ortholog); myeloid leukemia (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone-lysine N-methyltransferase NSD3; Whsc1l1; Wolf-Hirschhorn syndrome candidate 1-like 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,869,610 - 13,946,830 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,864,294 - 13,985,995 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nsd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,869,610 - 13,946,830 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,864,294 - 13,985,995 (-)NCBIChiLan1.0ChiLan1.0
NSD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,269,704 - 38,382,271 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,269,704 - 38,382,272 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,127,222 - 38,239,789 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,251,717 - 38,358,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 34838,251,716 - 38,358,947NCBI
Celera837,085,612 - 37,192,859 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,666,622 - 36,774,003 (-)NCBIHuRef
CHM1_1838,334,565 - 38,441,681 (-)NCBICHM1_1
T2T-CHM13v2.0838,546,659 - 38,659,240 (-)NCBIT2T-CHM13v2.0
Nsd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,091,617 - 26,209,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,091,617 - 26,209,694 (+)EnsemblGRCm39 Ensembl
GRCm38825,601,601 - 25,719,667 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,601,601 - 25,719,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,712,778 - 26,830,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,067,146 - 27,185,212 (+)NCBIMGSCv36mm8
Celera827,070,741 - 27,187,953 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Nsd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,056,748 - 73,170,082 (-)NCBIGRCr8
mRatBN7.21666,354,030 - 66,466,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,358,973 - 66,465,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,637,714 - 71,744,185 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,044,021 - 75,150,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,283,886 - 70,390,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,126,276 - 71,237,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,130,668 - 71,237,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,786,828 - 70,897,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,733,902 - 70,839,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,734,444 - 70,806,495 (-)NCBI
Celera1664,268,667 - 64,374,056 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
NSD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,833,190 - 56,946,563 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,550,256 - 32,662,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,571,831 - 37,684,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,748,409 - 34,860,766 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,754,353 - 34,860,766 (-)Ensemblpanpan1.1panPan2
NSD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,106,348 - 27,225,049 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,151,222 - 27,219,907 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,619,192 - 27,742,909 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,000,367 - 29,124,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,004,852 - 29,120,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,223,565 - 27,347,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,800,625 - 27,924,334 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,839,601 - 27,963,573 (+)NCBIUU_Cfam_GSD_1.0
Nsd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,728,386 - 49,835,860 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,631,234 - 1,732,827 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,629,178 - 1,732,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,136,363 - 48,241,815 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,119,132 - 48,245,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,298,067 - 55,405,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,288,997 - 36,398,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,291,104 - 36,398,246 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,590,913 - 5,700,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,241,537 - 5,363,325 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,241,556 - 5,367,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000002100   ⟹   ENSCLAP00000002055
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546313,869,610 - 13,946,830 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000002101   ⟹   ENSCLAP00000002056
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546313,869,610 - 13,946,830 (-)Ensembl
RefSeq Acc Id: XM_005398440   ⟹   XP_005398497
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546313,864,294 - 13,985,995 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005398497 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000002055
  ENSCLAP00000002055.1
  ENSCLAP00000002056.1
RefSeq Acc Id: XP_005398497   ⟸   XM_005398440
- UniProtKB: A0A8C2UQX9 (UniProtKB/TrEMBL),   A0A8C2UMS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000002055   ⟸   ENSCLAT00000002100
Ensembl Acc Id: ENSCLAP00000002056   ⟸   ENSCLAT00000002101
Protein Domains
AWS   PHD-type   Post-SET   PWWP   SET


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002100 ENTREZGENE
  ENSCLAT00000002100.1 UniProtKB/TrEMBL
  ENSCLAT00000002101.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro AWS_dom UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  NSD_PHD UniProtKB/TrEMBL
  PHD2_NSD3 UniProtKB/TrEMBL
  PHD4_NSD3 UniProtKB/TrEMBL
  PHD5_NSD3 UniProtKB/TrEMBL
  PHDvar_NSD UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  PWWP_dom UniProtKB/TrEMBL
  PWWP_NSD3_rpt1 UniProtKB/TrEMBL
  PWWP_NSD3_rpt2 UniProtKB/TrEMBL
  SET2_Histone-Lys_MeTrsfase UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SET_NSD3 UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Whsc1l1 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE NSD3 UniProtKB/TrEMBL
  SET DOMAIN PROTEINS UniProtKB/TrEMBL
Pfam AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  NSD_PHD UniProtKB/TrEMBL
  PHD-1st_NSD UniProtKB/TrEMBL
  PHDvar_NSD UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PROSITE AWS UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
SMART AWS UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP SSF57903 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8C2UMS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UQX9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-22 Nsd3  nuclear receptor binding SET domain protein 3  Whsc1l1  Wolf-Hirschhorn syndrome candidate 1-like 1  Symbol and/or name change 5135510 APPROVED