NSD3 (nuclear receptor binding SET domain protein 3) - Rat Genome Database

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Gene: NSD3 (nuclear receptor binding SET domain protein 3) Chlorocebus sabaeus
Analyze
Symbol: NSD3
Name: nuclear receptor binding SET domain protein 3
RGD ID: 18386729
Description: ENCODES a protein that exhibits histone H3K27 methyltransferase activity (ortholog); histone H3K4 methyltransferase activity (ortholog); INVOLVED IN chromatin remodeling (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 54 (ortholog); hypogonadotropic hypogonadism 2 with or without anosmia (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone-lysine N-methyltransferase NSD3; WHSC1L1; Wolf-Hirschhorn syndrome candidate 1-like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,288,997 - 36,398,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,291,104 - 36,398,246 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,590,913 - 5,700,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NSD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,288,997 - 36,398,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,291,104 - 36,398,246 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,590,913 - 5,700,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NSD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,269,704 - 38,382,271 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,269,704 - 38,382,272 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,127,222 - 38,239,789 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,251,717 - 38,358,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 34838,251,716 - 38,358,947NCBI
Celera837,085,612 - 37,192,859 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,666,622 - 36,774,003 (-)NCBIHuRef
CHM1_1838,334,565 - 38,441,681 (-)NCBICHM1_1
T2T-CHM13v2.0838,546,659 - 38,659,240 (-)NCBIT2T-CHM13v2.0
Nsd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,091,617 - 26,209,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,091,617 - 26,209,694 (+)EnsemblGRCm39 Ensembl
GRCm38825,601,601 - 25,719,667 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,601,601 - 25,719,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,712,778 - 26,830,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,067,146 - 27,185,212 (+)NCBIMGSCv36mm8
Celera827,070,741 - 27,187,953 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Nsd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,056,748 - 73,170,082 (-)NCBIGRCr8
mRatBN7.21666,354,030 - 66,466,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,358,973 - 66,465,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,637,714 - 71,744,185 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,044,021 - 75,150,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,283,886 - 70,390,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,126,276 - 71,237,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,130,668 - 71,237,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,786,828 - 70,897,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,733,902 - 70,839,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,734,444 - 70,806,495 (-)NCBI
Celera1664,268,667 - 64,374,056 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
Nsd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,869,610 - 13,946,830 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,864,294 - 13,985,995 (-)NCBIChiLan1.0ChiLan1.0
NSD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,833,190 - 56,946,563 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,550,256 - 32,662,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,571,831 - 37,684,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,748,409 - 34,860,766 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,754,353 - 34,860,766 (-)Ensemblpanpan1.1panPan2
NSD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,106,348 - 27,225,049 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,151,222 - 27,219,907 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,619,192 - 27,742,909 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,000,367 - 29,124,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,004,852 - 29,120,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,223,565 - 27,347,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,800,625 - 27,924,334 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,839,601 - 27,963,573 (+)NCBIUU_Cfam_GSD_1.0
Nsd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,728,386 - 49,835,860 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,631,234 - 1,732,827 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,629,178 - 1,732,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,136,363 - 48,241,815 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,119,132 - 48,245,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,298,067 - 55,405,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nsd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,241,537 - 5,363,325 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,241,556 - 5,367,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000013518   ⟹   ENSCSAP00000011515
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl836,291,104 - 36,398,246 (-)Ensembl
RefSeq Acc Id: XM_007962202   ⟹   XP_007960393
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1836,288,997 - 36,398,334 (-)NCBI
Vero_WHO_p1.0NW_0236660525,590,913 - 5,699,167 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007962205   ⟹   XP_007960396
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1836,288,997 - 36,398,032 (-)NCBI
Vero_WHO_p1.0NW_0236660525,591,237 - 5,698,820 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007962206   ⟹   XP_007960397
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1836,288,997 - 36,398,130 (-)NCBI
Vero_WHO_p1.0NW_0236660525,591,117 - 5,700,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007962207   ⟹   XP_007960398
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1836,331,989 - 36,398,334 (-)NCBI
Vero_WHO_p1.0NW_0236660525,590,913 - 5,658,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037983561   ⟹   XP_037839489
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660525,591,237 - 5,700,510 (+)NCBI
RefSeq Acc Id: XM_037983562   ⟹   XP_037839490
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660525,615,690 - 5,700,754 (+)NCBI
RefSeq Acc Id: XM_037983563   ⟹   XP_037839491
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660525,611,514 - 5,700,754 (+)NCBI
RefSeq Acc Id: XM_037983564   ⟹   XP_037839492
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660525,591,444 - 5,700,510 (+)NCBI
RefSeq Acc Id: XM_037983565   ⟹   XP_037839493
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660525,591,237 - 5,700,510 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007960393   ⟸   XM_007962202
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007960397   ⟸   XM_007962206
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007960396   ⟸   XM_007962205
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007960398   ⟸   XM_007962207
- Peptide Label: isoform X6
RefSeq Acc Id: ENSCSAP00000011515   ⟸   ENSCSAT00000013518
RefSeq Acc Id: XP_037839489   ⟸   XM_037983561
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037839493   ⟸   XM_037983565
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037839492   ⟸   XM_037983564
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037839491   ⟸   XM_037983563
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037839490   ⟸   XM_037983562
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RSC6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015427 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013518.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro AWS_dom UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  PHD2_NSD3 UniProtKB/TrEMBL
  PHD4_NSD3 UniProtKB/TrEMBL
  PHD5_NSD3 UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  PWWP_dom UniProtKB/TrEMBL
  PWWP_NSD3_rpt1 UniProtKB/TrEMBL
  PWWP_NSD3_rpt2 UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SET_NSD3 UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report csab:103215646 UniProtKB/TrEMBL
NCBI Gene NSD3 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE NSD3 UniProtKB/TrEMBL
  SET DOMAIN PROTEINS UniProtKB/TrEMBL
Pfam AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PROSITE AWS UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
SMART AWS UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP SSF57903 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A0D9RSC6 ENTREZGENE, UniProtKB/TrEMBL