RGD Reference Report - NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). - Rat Genome Database

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NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).

Authors: Rosati, R  La Starza, R  Veronese, A  Aventin, A  Schwienbacher, C  Vallespi, T  Negrini, M  Martelli, MF  Mecucci, C 
Citation: Rosati R, etal., Blood. 2002 May 15;99(10):3857-60.
RGD ID: 1599847
Pubmed: PMID:11986249   (View Abstract at PubMed)

Fusion between the NUP98 and NSD3 genes in a patient with acute myeloid leukemia associated with t(8;11)(p11.2;p15), is reported for the first time. The t(8;11)(p11.2;p15) was identified by classical cytogenetics. Fluorescence in situ hybridization (FISH) analysis revealed a split signal with a mix of BAC 118H17 and 290A12, indicating the translocation disrupted NUP98. FISH restriction at 8p11-12 showed a split of BAC 350N15. Molecular investigations into candidate genes in this BAC showed the NUP98 fusion partner at 8p11.2 was the NSD3 gene. To date the NSD3 gene has never been implicated in hematologic malignancies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myeloid leukemia  IAGP 1599847 RGD 
myeloid leukemia  ISONSD3 (Homo sapiens)1599847; 1599847 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nsd3  (nuclear receptor binding SET domain protein 3)

Genes (Mus musculus)
Nsd3  (nuclear receptor binding SET domain protein 3)

Genes (Homo sapiens)
NSD3  (nuclear receptor binding SET domain protein 3)


Additional Information