Nsd3 (nuclear receptor binding SET domain protein 3) - Rat Genome Database

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Gene: Nsd3 (nuclear receptor binding SET domain protein 3) Rattus norvegicus
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Symbol: Nsd3
Name: nuclear receptor binding SET domain protein 3
RGD ID: 1308980
Description: Predicted to enable protein-lysine N-methyltransferase activity and transcription regulator activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin remodeling and negative regulation of DNA-templated transcription. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-lysine N-methyltransferase NSD3; LOC290831; Whsc1l1; Wolf-Hirschhorn syndrome candidate 1-like 1; Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,056,748 - 73,170,082 (-)NCBIGRCr8
mRatBN7.21666,354,030 - 66,466,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,358,973 - 66,465,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,637,714 - 71,744,185 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,044,021 - 75,150,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,283,886 - 70,390,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,126,276 - 71,237,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,130,668 - 71,237,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,786,828 - 70,897,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,733,902 - 70,839,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,734,444 - 70,806,495 (-)NCBI
Celera1664,268,667 - 64,374,056 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Rosati R, etal., Blood. 2002 May 15;99(10):3857-60.
Additional References at PubMed
PMID:12477932   PMID:16682010   PMID:21555454  


Genomics

Comparative Map Data
Nsd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,056,748 - 73,170,082 (-)NCBIGRCr8
mRatBN7.21666,354,030 - 66,466,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,358,973 - 66,465,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,637,714 - 71,744,185 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,044,021 - 75,150,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,283,886 - 70,390,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,126,276 - 71,237,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,130,668 - 71,237,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,786,828 - 70,897,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,733,902 - 70,839,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,734,444 - 70,806,495 (-)NCBI
Celera1664,268,667 - 64,374,056 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
NSD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,269,704 - 38,382,271 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,269,704 - 38,382,272 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,127,222 - 38,239,789 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,251,717 - 38,358,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 34838,251,716 - 38,358,947NCBI
Celera837,085,612 - 37,192,859 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,666,622 - 36,774,003 (-)NCBIHuRef
CHM1_1838,334,565 - 38,441,681 (-)NCBICHM1_1
T2T-CHM13v2.0838,546,659 - 38,659,240 (-)NCBIT2T-CHM13v2.0
Nsd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,091,617 - 26,209,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,091,617 - 26,209,694 (+)EnsemblGRCm39 Ensembl
GRCm38825,601,601 - 25,719,667 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,601,601 - 25,719,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,712,778 - 26,830,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,067,146 - 27,185,212 (+)NCBIMGSCv36mm8
Celera827,070,741 - 27,187,953 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Nsd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,869,610 - 13,946,830 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,864,294 - 13,985,995 (-)NCBIChiLan1.0ChiLan1.0
NSD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,833,190 - 56,946,563 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,550,256 - 32,662,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,571,831 - 37,684,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,748,409 - 34,860,766 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,754,353 - 34,860,766 (-)Ensemblpanpan1.1panPan2
NSD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,106,348 - 27,225,049 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,151,222 - 27,219,907 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,619,192 - 27,742,909 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,000,367 - 29,124,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,004,852 - 29,120,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,223,565 - 27,347,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,800,625 - 27,924,334 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,839,601 - 27,963,573 (+)NCBIUU_Cfam_GSD_1.0
Nsd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,728,386 - 49,835,860 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,631,234 - 1,732,827 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,629,178 - 1,732,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,136,363 - 48,241,815 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,119,132 - 48,245,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,298,067 - 55,405,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,288,997 - 36,398,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,291,104 - 36,398,246 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,590,913 - 5,700,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,241,537 - 5,363,325 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,241,556 - 5,367,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nsd3
261 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:186
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000066974
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.