Tmem238l (transmembrane protein 238 like) - Rat Genome Database

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Gene: Tmem238l (transmembrane protein 238 like) Rattus norvegicus
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Symbol: Tmem238l
Name: transmembrane protein 238 like
RGD ID: 7617190
Description: Predicted to be involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human TMEM238L (transmembrane protein 238 like); INTERACTS WITH 2-hydroxypropanoic acid (ortholog); Aflatoxin B2 alpha (ortholog); all-trans-retinoic acid (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102554819; putative transmembrane protein LOC100289255 homolog; transmembrane protein 238-like; uncharacterized LOC102554819
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81052,148,188 - 52,161,234 (+)NCBIGRCr8
mRatBN7.21051,647,871 - 51,662,206 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1056,306,303 - 56,306,669 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01055,796,271 - 55,796,637 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01051,305,852 - 51,306,218 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01053,501,858 - 53,513,002 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01053,254,128 - 53,266,880 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1050,821,932 - 50,842,279 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem238lRatColorectal Neoplasms  ISOTMEM238L (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30510241


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem238lRat2-hydroxypropanoic acid decreases expressionISOTMEM238L (Homo sapiens)6480464Lactic Acid results in decreased expression of TMEM238L mRNACTDPMID:30851411
Tmem238lRatAflatoxin B2 alpha increases methylationISOTMEM238L (Homo sapiens)6480464aflatoxin B2 results in increased methylation of TMEM238L intronCTDPMID:30157460
Tmem238lRatall-trans-retinoic acid increases expressionISOTMEM238L (Homo sapiens)6480464Tretinoin results in increased expression of TMEM238L mRNACTDPMID:23830798
Tmem238lRatbenzo[a]pyrene affects methylationISOTMEM238L (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of TMEM238L intronCTDPMID:30157460
Tmem238lRatbenzo[e]pyrene increases methylationISOTMEM238L (Homo sapiens)6480464benzo(e)pyrene results in increased methylation of TMEM238L intronCTDPMID:30157460
Tmem238lRatmethapyrilene increases methylationISOTMEM238L (Homo sapiens)6480464Methapyrilene results in increased methylation of TMEM238L intronCTDPMID:30157460
Tmem238lRatrac-lactic acid decreases expressionISOTMEM238L (Homo sapiens)6480464Lactic Acid results in decreased expression of TMEM238L mRNACTDPMID:30851411


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem238lRatintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress involved_inISOTMEM238L (Homo sapiens)1624291 PMID:33112233RGDPMID:33112233

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem238lRatendoplasmic reticulum membrane located_inISOTMEM238L (Homo sapiens)1624291 PMID:33112233RGDPMID:33112233

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem238lRatprotein binding enablesISOTMEM238L (Homo sapiens)1624291UniProtKB:Q8WY22 and PMID:33112233RGDPMID:33112233



Tmem238l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81052,148,188 - 52,161,234 (+)NCBIGRCr8
mRatBN7.21051,647,871 - 51,662,206 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1056,306,303 - 56,306,669 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01055,796,271 - 55,796,637 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01051,305,852 - 51,306,218 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01053,501,858 - 53,513,002 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01053,254,128 - 53,266,880 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1050,821,932 - 50,842,279 (+)NCBICelera
Cytogenetic Map10q24NCBI
TMEM238L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381710,794,908 - 10,804,099 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1710,794,908 - 10,804,099 (-)EnsemblGRCh38hg38GRCh38
GRCh371710,698,225 - 10,707,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1710,729,077 - 10,738,263 (-)NCBICelera
Cytogenetic Map17p13.1-p12NCBI
HuRef1710,598,735 - 10,607,917 (-)NCBIHuRef
CHM1_11710,708,110 - 10,717,296 (-)NCBICHM1_1
T2T-CHM13v2.01710,702,820 - 10,712,007 (-)NCBIT2T-CHM13v2.0
Tmem238l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391166,847,368 - 66,855,842 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1166,847,464 - 66,855,842 (+)EnsemblGRCm39 Ensembl
GRCm381166,955,092 - 66,965,016 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1166,956,638 - 66,965,016 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,770,046 - 66,778,246 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361166,772,739 - 66,780,939 (+)NCBIMGSCv36mm8
Celera1173,895,900 - 73,904,290 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.59NCBI
TMEM238L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21962,944,667 - 62,947,106 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11767,754,172 - 67,765,595 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1745,597,330 - 45,597,569 (+)Ensemblpanpan1.1panPan2
TMEM238L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha535,197,228 - 35,204,945 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0535,165,981 - 35,173,701 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl535,173,231 - 35,173,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1535,131,418 - 35,139,125 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0535,087,935 - 35,095,649 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0535,270,031 - 35,277,752 (-)NCBIUU_Cfam_GSD_1.0
Tmem238l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560250,171,334 - 50,172,027 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365953,645,712 - 3,645,951 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
LOC110259862
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.137,584,024 - 7,623,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMEM238L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605911,194,932 - 11,195,941 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Tmem238l
121 total Variants

1 to 10 of 69 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat

1 to 10 of 69 rows






RefSeq Acc Id: NM_001399455   ⟹   NP_001386384
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81052,149,396 - 52,149,762 (+)NCBI
mRatBN7.21051,650,364 - 51,650,730 (+)NCBI
RefSeq Acc Id: XM_039087304   ⟹   XP_038943232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81052,148,188 - 52,161,234 (+)NCBI
mRatBN7.21051,647,871 - 51,662,206 (+)NCBI
Protein RefSeqs NP_001386384 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943232 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000102244
RefSeq Acc Id: XP_038943232   ⟸   XM_039087304
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001386384   ⟸   NM_001399455


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24677 BioCyc
Ensembl Genes ENSRNOG00000069550 ENTREZGENE
Ensembl Transcript ENSRNOT00000114280 ENTREZGENE
NCBI Gene LOC102554819 ENTREZGENE
PhenoGen Tmem238l PhenoGen
RatGTEx ENSRNOG00000069550 RatGTEx
RNAcentral URS0000CCFA27 RNACentral


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-28 Tmem238l  transmembrane protein 238 like  LOC102554819  uncharacterized LOC102554819  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102554819  uncharacterized LOC102554819      Symbol and Name status set to provisional 70820 PROVISIONAL