MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1) - Rat Genome Database

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Gene: MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1) Homo sapiens
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Symbol: MAPK8IP1
Name: mitogen-activated protein kinase 8 interacting protein 1
RGD ID: 733615
HGNC Page HGNC:6882
Description: Enables MAP-kinase scaffold activity and kinesin binding activity. Predicted to be involved in several processes, including JNK cascade; regulation of CD8-positive, alpha-beta T cell proliferation; and regulation of JNK cascade. Predicted to act upstream of or within JUN phosphorylation; negative regulation of intrinsic apoptotic signaling pathway; and regulation of DNA-templated transcription. Located in cytoplasm and plasma membrane. Implicated in type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-Jun-amino-terminal kinase-interacting protein 1; IB-1; IB1; islet-brain 1; JIP-1; JIP1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; mitogen-activated protein kinase 8-interacting protein 1; PRKM8 interacting protein; PRKM8IP
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: MAPK8IP1P1   MAPK8IP1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,885,651 - 45,906,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,885,651 - 45,906,465 (+)EnsemblGRCh38hg38GRCh38
GRCh371145,907,202 - 45,928,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,863,778 - 45,884,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 341145,863,777 - 45,884,591NCBI
Celera1146,054,811 - 46,075,621 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1145,613,904 - 45,634,868 (+)NCBIHuRef
CHM1_11145,904,472 - 45,925,436 (+)NCBICHM1_1
T2T-CHM13v2.01146,041,587 - 46,062,395 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
MAPK8IP1Humancongenital disorder of glycosylation type IIc  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Rambam Hasharon syndromeClinVarPMID:16455955 more ...
MAPK8IP1Humancongenital disorder of glycosylation type IIc  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Rambam Hasharon syndromeClinVarPMID:28492532
MAPK8IP1Humaninfantile Refsum disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: ADRENOLEUKODYSTROPHY and AUTOSOMAL NEONATALClinVarPMID:11890679 more ...
MAPK8IP1Humaninfantile Refsum disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: ADRENOLEUKODYSTROPHY and AUTOSOMAL NEONATALClinVarPMID:28492532
MAPK8IP1Humanintellectual disability  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
MAPK8IP1Humanmaturity-onset diabetes of the young type 1  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVar 
MAPK8IP1Humantype 2 diabetes mellitus  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVar 
MAPK8IP1Humantype 2 diabetes mellitus  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Diabetes mellitus type 2 and susceptibility toClinVarPMID:10700186
MAPK8IP1HumanZellweger syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorders and Zellweger syndrome spectrumClinVarPMID:11890679 more ...
MAPK8IP1HumanZellweger syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorders and Zellweger syndrome spectrumClinVarPMID:28492532
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MAPK8IP1Humantype 2 diabetes mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
MAPK8IP1Humantype 2 diabetes mellitus  IAGP 7240710 OMIM 

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Original Reference(s)
MAPK8IP1Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOMapk8ip1 (Rattus norvegicus)6480464o more ...CTDPMID:22937105
MAPK8IP1Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of MAPK8IP1 mRNACTDPMID:30165855
MAPK8IP1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMapk8ip1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin affects the expression of MAPK8IP1 mRNACTDPMID:22298810
MAPK8IP1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMapk8ip1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MAPK8IP1 mRNACTDPMID:24680724
MAPK8IP1Human2-methoxyethanol increases expressionISOMapk8ip1 (Rattus norvegicus)6480464methyl cellosolve results in increased expression of MAPK8IP1 mRNACTDPMID:19643169
MAPK8IP1Human3,4-methylenedioxymethamphetamine increases expressionISOMapk8ip1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of MAPK8IP1 mRNACTDPMID:20188158
MAPK8IP1Human4,4'-sulfonyldiphenol affects methylationISOMapk8ip1 (Mus musculus)6480464bisphenol S affects the methylation of MAPK8IP1 geneCTDPMID:31683443
MAPK8IP1Human4,4'-sulfonyldiphenol multiple interactionsISOMapk8ip1 (Rattus norvegicus)6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of MAPK8IP1 mRNACTDPMID:36041667
MAPK8IP1Human4-vinylcyclohexene dioxide affects expressionISOMapk8ip1 (Mus musculus)64804644-vinyl-1-cyclohexene dioxide affects the expression of MAPK8IP1 mRNACTDPMID:20829426
MAPK8IP1Humanacetamide decreases expressionISOMapk8ip1 (Rattus norvegicus)6480464acetamide results in decreased expression of MAPK8IP1 mRNACTDPMID:31881176
MAPK8IP1Humanacetylleucyl-leucyl-norleucinal increases expressionISOMapk8ip1 (Mus musculus)6480464acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 proteinCTDPMID:15618349
MAPK8IP1Humanacetylleucyl-leucyl-norleucinal increases expressionISOMapk8ip1 (Rattus norvegicus)6480464acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 proteinCTDPMID:15618349
MAPK8IP1Humanaflatoxin B1 increases methylationEXP 6480464Aflatoxin B1 results in increased methylation of MAPK8IP1 intronCTDPMID:30157460
MAPK8IP1Humanaflatoxin B1 decreases expressionEXP 6480464Aflatoxin B1 results in decreased expression of MAPK8IP1 mRNACTDPMID:32234424
MAPK8IP1Humanamitrole decreases expressionISOMapk8ip1 (Rattus norvegicus)6480464Amitrole results in decreased expression of MAPK8IP1 mRNACTDPMID:38685447
MAPK8IP1Humanammonium chloride affects expressionISOMapk8ip1 (Rattus norvegicus)6480464Ammonium Chloride affects the expression of MAPK8IP1 mRNACTDPMID:16483693
MAPK8IP1Humanaristolochic acid A increases expressionEXP 6480464aristolochic acid I results in increased expression of MAPK8IP1 mRNACTDPMID:33212167
MAPK8IP1Humanarsenous acid multiple interactionsEXP 6480464Arsenic Trioxide inhibits the reaction [AKT1 protein binds to MAPK8IP1 protein]CTDPMID:18566239
MAPK8IP1Humanarsenous acid increases expressionEXP 6480464Arsenic Trioxide results in increased expression of MAPK8IP1 proteinCTDPMID:18566239
MAPK8IP1Humanbenzo[a]pyrene increases methylationEXP 6480464Benzo(a)pyrene results in increased methylation of MAPK8IP1 promoterCTDPMID:27901495

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Biological Process
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MAPK8IP1HumanJNK cascade involved_inIBAMGI:1309464 more ...150520179 GO_CentralGO_REF:0000033
MAPK8IP1HumanJUN phosphorylation acts_upstream_of_or_withinISOMapk8ip1 (Mus musculus)9068941 PMID:9235893MGIPMID:9235893
MAPK8IP1Humannegative regulation of apoptotic process  ISOMapk8ip1 (Rattus norvegicus)9068941 RGDPMID:10098834 and REF_RGD_ID:70789
MAPK8IP1Humannegative regulation of apoptotic process involved_inIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1Humannegative regulation of intrinsic apoptotic signaling pathway acts_upstream_of_or_withinIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humannegative regulation of JNK cascade  ISOMapk8ip1 (Rattus norvegicus)9068941 RGDPMID:12064607 and REF_RGD_ID:1299562
MAPK8IP1Humannegative regulation of JNK cascade involved_inIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1Humannegative regulation of JUN kinase activity  ISOMapk8ip1 (Rattus norvegicus)9068941 RGDPMID:12064607 and REF_RGD_ID:1299562
MAPK8IP1Humannegative regulation of JUN kinase activity involved_inISSUniProtKB:Q9R237150520179 UniProtGO_REF:0000024
MAPK8IP1Humanpositive regulation of JNK cascade involved_inISSUniProtKB:Q9WVI9150520179 UniProtGO_REF:0000024
MAPK8IP1Humanpositive regulation of JNK cascade involved_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanregulation of CD8-positive, alpha-beta T cell proliferation involved_inISSUniProtKB:Q9WVI9150520179 UniProtGO_REF:0000024
MAPK8IP1Humanregulation of CD8-positive, alpha-beta T cell proliferation involved_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanregulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanregulation of JNK cascade involved_inISSUniProtKB:Q9WVI9150520179 UniProtGO_REF:0000024
MAPK8IP1Humanregulation of JNK cascade involved_inIEAInterPro:IPR047178150520179 InterProGO_REF:0000002
MAPK8IP1Humanregulation of JNK cascade involved_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humansignal transduction acts_upstream_of_or_withinIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanvesicle-mediated transport involved_inISSUniProtKB:P34609150520179 UniProtGO_REF:0000024
MAPK8IP1Humanvesicle-mediated transport acts_upstream_of_or_withinIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
MAPK8IP1Humanaxon located_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanaxonal growth cone located_inIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
MAPK8IP1Humancytoplasm located_inIEAUniProtKB:Q9R237 more ...150520179 EnsemblGO_REF:0000107
MAPK8IP1Humancytoplasm is_active_inIBAMGI:1309464 more ...150520179 GO_CentralGO_REF:0000033
MAPK8IP1Humancytoplasm located_inIDA 150520179 PMID:10574993UniProtPMID:10574993
MAPK8IP1Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
MAPK8IP1Humancytosol located_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humandendrite located_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humandendritic growth cone located_inIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1Humandentate gyrus mossy fiber located_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
MAPK8IP1Humanendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
MAPK8IP1Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
MAPK8IP1Humanmembrane located_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanmitochondrial membrane located_inIEAUniProtKB-SubCell:SL-0171150520179 UniProtGO_REF:0000044
MAPK8IP1Humanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
MAPK8IP1Humanneuron projection located_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanneuronal cell body located_inIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
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Molecular Function
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Original Reference(s)
MAPK8IP1Humanidentical protein binding enablesISOUniProtKB:Q9R237-39068941PMID:16456539IntActPMID:16456539 and REF_RGD_ID:8554208
MAPK8IP1HumanJUN kinase binding  ISOMapk9 (Rattus norvegicus)9068941 RGDPMID:17348686 and REF_RGD_ID:2298766
MAPK8IP1HumanJUN kinase binding enablesIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1HumanJUN kinase binding enablesIBAPANTHER:PTN000881520 and Mapk8ip1 (Rattus norvegicus)150520179 GO_CentralGO_REF:0000033
MAPK8IP1HumanJUN kinase binding  ISOMapk8 (Rattus norvegicus)9068941 RGDPMID:17348686 and REF_RGD_ID:2298766
MAPK8IP1Humankinase activity enablesIEAUniProtKB-KW:KW-0418150520179 UniProtGO_REF:0000043
MAPK8IP1Humankinesin binding enablesIEAUniProtKB:Q9WVI9 and ensembl:ENSMUSP00000050773150520179 EnsemblGO_REF:0000107
MAPK8IP1Humankinesin binding enablesIPIUniProtKB:Q07866150520179 PMID:11238452UniProtPMID:11238452
MAPK8IP1HumanMAP-kinase scaffold activity  ISOMapk8ip1 (Rattus norvegicus)9068941 RGDPMID:17348686 and REF_RGD_ID:2298766
MAPK8IP1HumanMAP-kinase scaffold activity enablesIBAPANTHER:PTN000881520 more ...150520179 GO_CentralGO_REF:0000033
MAPK8IP1HumanMAP-kinase scaffold activity enablesIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1HumanMAP-kinase scaffold activity enablesIPIUniProtKB:P45983150520179 PMID:11238452UniProtPMID:11238452
MAPK8IP1Humanmitogen-activated protein kinase kinase binding  ISOMap2k7 (Rattus norvegicus)9068941 RGDPMID:15816852 more ...
MAPK8IP1Humanmitogen-activated protein kinase kinase binding enablesIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanmitogen-activated protein kinase kinase kinase binding  ISOMap3k11 (Rattus norvegicus)9068941 RGDPMID:17348686 and REF_RGD_ID:2298766
MAPK8IP1Humanmitogen-activated protein kinase kinase kinase binding enablesIEAUniProtKB:Q9R237 and ensembl:ENSRNOP00000090670150520179 EnsemblGO_REF:0000107
MAPK8IP1Humanprotein binding enablesIPIUniProtKB:P45983150520179 PMID:33961781IntActPMID:33961781
MAPK8IP1Humanprotein binding enablesIPIUniProtKB:P05067150520179 PMID:11724784 more ...IntActPMID:11724784 more ...
MAPK8IP1Humanprotein binding enablesIPIUniProtKB:P12023150520179 PMID:11517249IntActPMID:11517249
MAPK8IP1Humanprotein binding enablesIPIUniProtKB:O43283150520179 PMID:11726277UniProtPMID:11726277
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RGD Manual Annotations


  
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Original Reference(s)
MAPK8IP1Humanc-Jun N-terminal kinases MAPK signaling pathway   TAS 2293880 RGD 
MAPK8IP1Humanc-Jun N-terminal kinases MAPK signaling pathway   ISOMapk8ip1 (Rattus norvegicus)1579811 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
MAPK8IP1Humanmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGhsa:04010
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Original Reference(s)
MAPK8IP1HumanIntellectual disability  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
MAPK8IP1HumanType II diabetes mellitus  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Type II diabetes mellitusClinVar 

#
Reference Title
Reference Citation
1. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. Bonny C, etal., J Biol Chem 1998 Jan 23;273(4):1843-6.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region. Li CH, etal., J Neurochem. 2005 Apr;93(2):290-8.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Regulatory mechanisms of mitogen-activated kinase signaling. Zhang Y and Dong C, Cell Mol Life Sci. 2007 Nov;64(21):2771-89.
PMID:8619474   PMID:9110174   PMID:9235893   PMID:9733513   PMID:9933567   PMID:10490659   PMID:10574993   PMID:10629060   PMID:10700186   PMID:10748095   PMID:10827173   PMID:10827199  
PMID:11147798   PMID:11238452   PMID:11517249   PMID:11585908   PMID:11700324   PMID:11724784   PMID:11726277   PMID:11790792   PMID:11907332   PMID:11912189   PMID:12024021   PMID:12064607  
PMID:12194869   PMID:12477932   PMID:12508107   PMID:12524447   PMID:12563035   PMID:12665528   PMID:12740599   PMID:12756254   PMID:12783873   PMID:12893827   PMID:12917434   PMID:12937412  
PMID:14507925   PMID:15138488   PMID:15868948   PMID:15894166   PMID:15911620   PMID:15998799   PMID:16169070   PMID:16273093   PMID:16301330   PMID:16343492   PMID:16456539   PMID:16533805  
PMID:16840345   PMID:17200414   PMID:17709393   PMID:17719230   PMID:18055217   PMID:18286207   PMID:18480379   PMID:18626009   PMID:19491104   PMID:19616077   PMID:20173330   PMID:20205790  
PMID:20301750   PMID:21237154   PMID:21873635   PMID:23172226   PMID:23360921   PMID:23770673   PMID:23825109   PMID:24144296   PMID:24478353   PMID:27891669   PMID:28319085   PMID:28514442  
PMID:30026235   PMID:31413325   PMID:31980649   PMID:32427938   PMID:33848645   PMID:33961781   PMID:34014261   PMID:35092815   PMID:35914814   PMID:36902422   PMID:39013462  



MAPK8IP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,885,651 - 45,906,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,885,651 - 45,906,465 (+)EnsemblGRCh38hg38GRCh38
GRCh371145,907,202 - 45,928,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,863,778 - 45,884,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 341145,863,777 - 45,884,591NCBI
Celera1146,054,811 - 46,075,621 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1145,613,904 - 45,634,868 (+)NCBIHuRef
CHM1_11145,904,472 - 45,925,436 (+)NCBICHM1_1
T2T-CHM13v2.01146,041,587 - 46,062,395 (+)NCBIT2T-CHM13v2.0
Mapk8ip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39292,214,021 - 92,231,608 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl292,214,021 - 92,231,608 (-)EnsemblGRCm39 Ensembl
GRCm38292,383,671 - 92,401,346 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl292,383,676 - 92,401,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv37292,223,837 - 92,241,420 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36292,184,519 - 92,202,102 (-)NCBIMGSCv36mm8
Celera293,776,808 - 93,794,307 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.99NCBI
Mapk8ip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,810,540 - 98,829,302 (-)NCBIGRCr8
mRatBN7.2378,355,051 - 78,372,946 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl378,355,048 - 78,372,884 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx381,830,830 - 81,839,989 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0390,429,871 - 90,439,030 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0388,280,966 - 88,290,137 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0381,295,023 - 81,304,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl381,295,024 - 81,304,181 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,998,491 - 88,016,191 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,781,504 - 76,790,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1376,677,932 - 76,687,089 (-)NCBI
Celera377,557,046 - 77,566,196 (-)NCBICelera
Cytogenetic Map3q24NCBI
Mapk8ip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554222,061,851 - 2,082,514 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554222,064,010 - 2,081,681 (-)NCBIChiLan1.0ChiLan1.0
MAPK8IP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2948,094,027 - 48,114,916 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,100,901 - 48,121,788 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,839,754 - 45,860,615 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,332,121 - 46,352,750 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,332,159 - 46,352,010 (+)Ensemblpanpan1.1panPan2
MAPK8IP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11843,517,186 - 43,522,603 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1843,517,677 - 43,526,379 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1842,245,214 - 42,263,683 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01844,173,152 - 44,191,616 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1844,173,163 - 44,192,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,657,404 - 43,675,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01843,210,353 - 43,228,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,942,641 - 43,961,111 (-)NCBIUU_Cfam_GSD_1.0
Mapk8ip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494721,001,575 - 21,011,189 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365623,109,547 - 3,122,939 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365623,113,217 - 3,122,794 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8IP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl216,564,257 - 16,584,768 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1216,562,687 - 16,584,763 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,929,057 - 17,949,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8IP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,435,593 - 19,457,073 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,432,631 - 19,442,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038116,712,446 - 116,733,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk8ip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,603,483 - 2,620,536 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247672,603,483 - 2,620,574 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in MAPK8IP1
76 total Variants

1 to 10 of 100 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_005456.4(MAPK8IP1):c.176G>A (p.Ser59Asn) single nucleotide variant Diabetes mellitus type 2, susceptibility to [RCV000005752] Chr11:45898159 [GRCh38]
Chr11:45919710 [GRCh37]
Chr11:11p11.2		 pathogenic|risk factor
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11p13-11.2(chr11:35663578-46959820)x1 copy number loss See cases [RCV000052679] Chr11:35663578..46959820 [GRCh38]
Chr11:35685126..46981371 [GRCh37]
Chr11:35641702..46937947 [NCBI36]
Chr11:11p13-11.2		 pathogenic
GRCh38/hg38 11p12-11.2(chr11:36508280-48643003)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052680]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052680]|See cases [RCV000052680] Chr11:36508280..48643003 [GRCh38]
Chr11:36529830..48664555 [GRCh37]
Chr11:36486406..48621131 [NCBI36]
Chr11:11p12-11.2		 pathogenic
GRCh38/hg38 11p11.2(chr11:44136593-46121139)x1 copy number loss See cases [RCV000052681] Chr11:44136593..46121139 [GRCh38]
Chr11:44158143..46142690 [GRCh37]
Chr11:44114719..46099266 [NCBI36]
Chr11:11p11.2		 pathogenic
NM_005456.3(MAPK8IP1):c.1395G>T (p.Met465Ile) single nucleotide variant Malignant melanoma [RCV000062218] Chr11:45903162 [GRCh38]
Chr11:45924713 [GRCh37]
Chr11:45881289 [NCBI36]
Chr11:11p11.2		 not provided
GRCh38/hg38 11p12-11.2(chr11:41118322-48643003)x1 copy number loss See cases [RCV000135405] Chr11:41118322..48643003 [GRCh38]
Chr11:41139872..48664555 [GRCh37]
Chr11:41096448..48621131 [NCBI36]
Chr11:11p12-11.2		 pathogenic
GRCh38/hg38 11p12-11.12(chr11:39179252-49135735)x1 copy number loss See cases [RCV000137391] Chr11:39179252..49135735 [GRCh38]
Chr11:39200802..49157287 [GRCh37]
Chr11:39157378..49113863 [NCBI36]
Chr11:11p12-11.12		 pathogenic
GRCh38/hg38 11p12-11.12(chr11:42727555-49135735)x3 copy number gain See cases [RCV000139422] Chr11:42727555..49135735 [GRCh38]
Chr11:42749105..49157287 [GRCh37]
Chr11:42705681..49113863 [NCBI36]
Chr11:11p12-11.12		 likely pathogenic
GRCh38/hg38 11p12-11.2(chr11:42553659-46114792)x1 copy number loss See cases [RCV000142289] Chr11:42553659..46114792 [GRCh38]
Chr11:42575209..46136343 [GRCh37]
Chr11:42531785..46092919 [NCBI36]
Chr11:11p12-11.2		 pathogenic
1 to 10 of 100 rows

Predicted Target Of
Summary Value
Count of predictions:1614
Count of miRNA genes:610
Interacting mature miRNAs:717
Transcripts:ENST00000241014, ENST00000395629, ENST00000497090
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597038660GWAS1134734_Hhigh density lipoprotein cholesterol measurement QTL GWAS1134734 (human)1e-23high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)114589205645892057Human
597066258GWAS1162332_Hhigh density lipoprotein cholesterol measurement QTL GWAS1162332 (human)3e-09high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)114589205645892057Human
597248896GWAS1344970_Hglucose measurement QTL GWAS1344970 (human)7e-10glucose measurementblood glucose level (CMO:0000046)114589046245890463Human
597099806GWAS1195880_Hprotein measurement QTL GWAS1195880 (human)6e-09protein measurement114589388045893881Human
597322179GWAS1418253_Hdrug allergy, trait in response to platinum QTL GWAS1418253 (human)0.000007drug allergy, trait in response to platinum114590489445904895Human
597143389GWAS1239463_Hhigh density lipoprotein cholesterol measurement QTL GWAS1239463 (human)1e-12high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)114589205645892057Human
406988878GWAS637854_Hmean corpuscular hemoglobin concentration QTL GWAS637854 (human)3e-10mean corpuscular hemoglobin concentrationmean corpuscular hemoglobin concentration (CMO:0000291)114589205645892057Human
597273412GWAS1369486_Hhigh density lipoprotein cholesterol measurement QTL GWAS1369486 (human)4e-21high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)114589205645892057Human
597035817GWAS1131891_Htype 2 diabetes mellitus QTL GWAS1131891 (human)4e-09type 2 diabetes mellitus114589046245890463Human
597262342GWAS1358416_Hhigh density lipoprotein cholesterol measurement QTL GWAS1358416 (human)2e-29high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)114589205645892057Human

1 to 10 of 11 rows
RH103702  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371145,928,186 - 45,928,496UniSTSGRCh37
Build 361145,884,762 - 45,885,072RGDNCBI36
Celera1146,075,791 - 46,076,101RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map11p11.2UniSTS
HuRef1145,635,038 - 45,635,348UniSTS
GeneMap99-GB4 RH Map11159.69UniSTS
D11S946E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371743,678,153 - 43,678,251UniSTSGRCh37
GRCh371145,927,257 - 45,927,354UniSTSGRCh37
Build 361145,883,833 - 45,883,930RGDNCBI36
Celera1146,074,862 - 46,074,959RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map11p11.2UniSTS
HuRef1739,343,291 - 39,343,389UniSTS
HuRef1145,634,109 - 45,634,206UniSTS
SHGC-144940  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371145,913,859 - 45,914,208UniSTSGRCh37
Build 361145,870,435 - 45,870,784RGDNCBI36
Celera1146,061,468 - 46,061,817RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map11p11.2UniSTS
HuRef1145,620,716 - 45,621,065UniSTS
TNG Radiation Hybrid Map1122198.0UniSTS
RH78669  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371145,924,447 - 45,924,613UniSTSGRCh37
Build 361145,881,023 - 45,881,189RGDNCBI36
Celera1146,072,052 - 46,072,218RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map11p11.2UniSTS
HuRef1145,631,299 - 45,631,465UniSTS
GeneMap99-GB4 RH Map11163.76UniSTS
RH64899  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map11p11.2UniSTS
GeneMap99-GB4 RH Map11168.92UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2432 2788 2245 4969 1725 2345 4 622 1927 464 2268 7262 6433 52 3734 848 1733 1612 172 1



Ensembl Acc Id: ENST00000241014   ⟹   ENSP00000241014
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1145,885,651 - 45,906,465 (+)Ensembl
Ensembl Acc Id: ENST00000395629   ⟹   ENSP00000378991
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1145,896,550 - 45,906,465 (+)Ensembl
Ensembl Acc Id: ENST00000497090
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1145,901,933 - 45,902,743 (+)Ensembl
RefSeq Acc Id: NM_005456   ⟹   NP_005447
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381145,885,651 - 45,906,465 (+)NCBI
GRCh371145,907,047 - 45,928,016 (+)ENTREZGENE
GRCh371145,907,047 - 45,928,016 (+)NCBI
Build 361145,863,778 - 45,884,592 (+)NCBI Archive
HuRef1145,613,904 - 45,634,868 (+)ENTREZGENE
CHM1_11145,904,472 - 45,925,436 (+)NCBI
T2T-CHM13v2.01146,041,587 - 46,062,395 (+)NCBI
Sequence:
1 to 12 of 12 rows
Protein RefSeqs NP_005447 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC19150 (Get FASTA)   NCBI Sequence Viewer  
  AAD20443 (Get FASTA)   NCBI Sequence Viewer  
  AAH68470 (Get FASTA)   NCBI Sequence Viewer  
  BAD92957 (Get FASTA)   NCBI Sequence Viewer  
  BAG58726 (Get FASTA)   NCBI Sequence Viewer  
  BAH11553 (Get FASTA)   NCBI Sequence Viewer  
  EAW68027 (Get FASTA)   NCBI Sequence Viewer  
  EAW68028 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000241014
  ENSP00000241014.2
GenBank Protein Q9UQF2 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_005447   ⟸   NM_005456
- UniProtKB: D3DQP4 (UniProtKB/Swiss-Prot),   O43407 (UniProtKB/Swiss-Prot),   Q9UQF2 (UniProtKB/Swiss-Prot),   Q6NUQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000241014   ⟸   ENST00000241014
Ensembl Acc Id: ENSP00000378991   ⟸   ENST00000395629
PID   SH3

Name Modeler Protein Id AA Range Protein Structure
AF-Q9UQF2-F1-model_v2 AlphaFold Q9UQF2 1-711 view protein structure

RGD ID:6789098
Promoter ID:HG_KWN:12741
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour
Transcripts:NM_005456
Position:
Human AssemblyChrPosition (strand)Source
Build 361145,863,359 - 45,863,859 (+)MPROMDB
RGD ID:6789099
Promoter ID:HG_KWN:12743
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562
Transcripts:OTTHUMT00000259406
Position:
Human AssemblyChrPosition (strand)Source
Build 361145,877,954 - 45,878,454 (+)MPROMDB
RGD ID:7220151
Promoter ID:EPDNEW_H15821
Type:initiation region
Name:MAPK8IP1_1
Description:mitogen-activated protein kinase 8 interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381145,885,642 - 45,885,702EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
COSMIC MAPK8IP1 COSMIC
Ensembl Genes ENSG00000121653 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000241014 ENTREZGENE
  ENST00000241014.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
GTEx ENSG00000121653 GTEx
HGNC ID HGNC:6882 ENTREZGENE
Human Proteome Map MAPK8IP1 Human Proteome Map
InterPro JIP1_scaffold UniProtKB/Swiss-Prot
  JIP1_SH3 UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PTB/PI_dom UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report hsa:9479 UniProtKB/Swiss-Prot
NCBI Gene 9479 ENTREZGENE
OMIM 604641 OMIM
PANTHER C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 UniProtKB/Swiss-Prot
  JNK-INTERACTING PROTEIN 1-LIKE PROTEIN UniProtKB/Swiss-Prot
Pfam PID UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PharmGKB PA30626 PharmGKB
PROSITE PID UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART PTB UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt D3DQP4 ENTREZGENE
  E9PBB9_HUMAN UniProtKB/TrEMBL
  JIP1_HUMAN UniProtKB/Swiss-Prot
  O43407 ENTREZGENE
  Q6NUQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q9UQF2 ENTREZGENE
UniProt Secondary D3DQP4 UniProtKB/Swiss-Prot
  O43407 UniProtKB/Swiss-Prot
1 to 37 of 37 rows