Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | CPD | Human | 1,1,1-trichloroethane | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:25270620 | CPD | Human | 1,1-dichloroethene | increases expression | ISO | Cpd (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of CPD mRNA | CTD | PMID:26682919 | CPD | Human | 1,2-dichloroethane | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of CPD mRNA | CTD | PMID:28189721 and PMID:28960355 | CPD | Human | 1,2-dimethylhydrazine | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of CPD mRNA | CTD | PMID:22206623 | CPD | Human | 17alpha-ethynylestradiol | increases expression | ISO | Cpd (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of CPD mRNA | CTD | PMID:17942748 | CPD | Human | 17alpha-ethynylestradiol | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of CPD mRNA | CTD | PMID:29097150 | CPD | Human | 17alpha-ethynylestradiol | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPD mRNA | CTD | PMID:17942748 | CPD | Human | 17beta-estradiol | multiple interactions | ISO | Cpd (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of CPD mRNA and [Estradiol co-treated with Testosterone] results in increased expression of CPD mRNA | CTD | PMID:11375906 and PMID:26496021 | CPD | Human | 17beta-estradiol | affects expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Estradiol affects the expression of CPD mRNA | CTD | PMID:32145629 | CPD | Human | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPD mRNA | CTD | PMID:17942748 | CPD | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CPD mRNA | CTD | PMID:34747641 | CPD | Human | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CPD mRNA | CTD | PMID:32109520 | CPD | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CPD mRNA | CTD | PMID:16054898 and PMID:33387578 | CPD | Human | 2-hydroxypropanoic acid | increases expression | EXP | | 6480464 | Lactic Acid results in increased expression of CPD mRNA | CTD | PMID:30851411 | CPD | Human | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of CPD mRNA | CTD | PMID:30071829 | CPD | Human | 4,4'-sulfonyldiphenol | affects expression | EXP | | 6480464 | bisphenol S affects the expression of CPD protein | CTD | PMID:31945527 | CPD | Human | 5-fluorouracil | affects response to substance | EXP | | 6480464 | CPD protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | CPD | Human | 5-fluorouracil | multiple interactions | EXP | | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of CPD mRNA] | CTD | PMID:15016801 | CPD | Human | 6-propyl-2-thiouracil | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of CPD mRNA | CTD | PMID:24780913 | CPD | Human | aflatoxin B1 | affects expression | EXP | | 6480464 | Aflatoxin B1 affects the expression of CPD protein | CTD | PMID:20106945 | CPD | Human | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of CPD gene | CTD | PMID:27153756 | CPD | Human | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of CPD mRNA | CTD | PMID:33167477 | CPD | Human | ammonium chloride | affects expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of CPD mRNA | CTD | PMID:16483693 | CPD | Human | amphotericin B | decreases expression | EXP | | 6480464 | Amphotericin B analog results in decreased expression of CPD mRNA | CTD | PMID:28534445 | CPD | Human | benzo[a]pyrene | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CPD mRNA | CTD | PMID:22228805 | CPD | Human | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of CPD promoter | CTD | PMID:27901495 | CPD | Human | bilirubin IXalpha | decreases expression | EXP | | 6480464 | Bilirubin results in decreased expression of CPD mRNA | CTD | PMID:20196124 | CPD | Human | bisphenol A | multiple interactions | ISO | Cpd (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of CPD mRNA | CTD | PMID:26496021 | CPD | Human | bisphenol A | affects expression | ISO | Cpd (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of CPD mRNA | CTD | PMID:32145629 | CPD | Human | bisphenol A | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of CPD mRNA | CTD | PMID:30816183 and PMID:34947998 | CPD | Human | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CPD mRNA | CTD | PMID:29275510 and PMID:36232920 | CPD | Human | bisphenol A | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of CPD mRNA | CTD | PMID:25181051 and PMID:29097150 | CPD | Human | butan-1-ol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of CPD mRNA | CTD | PMID:29432896 | CPD | Human | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of CPD mRNA | CTD | PMID:26079696 | CPD | Human | caffeine | affects phosphorylation | EXP | | 6480464 | Caffeine affects the phosphorylation of CPD protein | CTD | PMID:35688186 | CPD | Human | calcitriol | increases expression | EXP | | 6480464 | Calcitriol results in increased expression of CPD mRNA | CTD | PMID:16002434 | CPD | Human | cannabidiol | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [lipopolysaccharide and E coli O55-B5 co-treated with Cannabidiol] results in decreased expression of CPD mRNA | CTD | PMID:30742662 | CPD | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CPD gene] | CTD | PMID:28238834 | CPD | Human | chloropicrin | increases expression | EXP | | 6480464 | chloropicrin results in increased expression of CPD mRNA | CTD | PMID:26352163 | CPD | Human | chloroprene | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Chloroprene results in increased expression of CPD mRNA | CTD | PMID:23125180 | CPD | Human | choline | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPD gene | CTD | PMID:20938992 | CPD | Human | clorgyline | increases expression | EXP | | 6480464 | Clorgyline results in increased expression of CPD mRNA | CTD | PMID:19691856 | CPD | Human | copper atom | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CPD mRNA | CTD | PMID:15467011 | CPD | Human | copper(0) | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CPD mRNA | CTD | PMID:15467011 | CPD | Human | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of CPD mRNA | CTD | PMID:25562108 | CPD | Human | Dibutyl phosphate | affects expression | EXP | | 6480464 | di-n-butylphosphoric acid affects the expression of CPD mRNA | CTD | PMID:37042841 | CPD | Human | dibutyl phthalate | increases expression | ISO | Cpd (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of CPD mRNA | CTD | PMID:21266533 | CPD | Human | dichlorine | multiple interactions | ISO | Cpd (Rattus norvegicus) | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of CPD mRNA | CTD | PMID:18636392 | CPD | Human | dimethylarsinic acid | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Cacodylic Acid results in decreased expression of CPD mRNA | CTD | PMID:17720352 | CPD | Human | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPD mRNA | CTD | PMID:27188386 | CPD | Human | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of CPD mRNA | CTD | PMID:29803840 | CPD | Human | elemental selenium | decreases expression | EXP | | 6480464 | Selenium results in decreased expression of CPD mRNA | CTD | PMID:19244175 | CPD | Human | endosulfan | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of CPD mRNA | CTD | PMID:29391264 | CPD | Human | epoxiconazole | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of CPD mRNA | CTD | PMID:35436446 | CPD | Human | ethanol | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Ethanol results in increased expression of CPD mRNA | CTD | PMID:15353170 | CPD | Human | ethanol | affects splicing | ISO | Cpd (Mus musculus) | 6480464 | Ethanol affects the splicing of CPD mRNA | CTD | PMID:30319688 | CPD | Human | ethanol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of CPD mRNA | CTD | PMID:29432896 | CPD | Human | folic acid | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPD gene | CTD | PMID:20938992 | CPD | Human | folic acid | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | Folic Acid results in decreased expression of CPD mRNA | CTD | PMID:25629700 | CPD | Human | FR900359 | affects phosphorylation | EXP | | 6480464 | FR900359 affects the phosphorylation of CPD protein | CTD | PMID:37730182 | CPD | Human | gamma-hexachlorocyclohexane | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Hexachlorocyclohexane results in increased expression of CPD mRNA | CTD | PMID:17785943 | CPD | Human | gentamycin | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of CPD mRNA | CTD | PMID:22061828 | CPD | Human | hydrogen cyanide | increases expression | ISO | Cpd (Mus musculus) | 6480464 | Hydrogen Cyanide results in increased expression of CPD mRNA | CTD | PMID:33914522 | CPD | Human | isobutanol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of CPD mRNA | CTD | PMID:29432896 | CPD | Human | isotretinoin | decreases expression | EXP | | 6480464 | Isotretinoin results in decreased expression of CPD mRNA | CTD | PMID:20436886 | CPD | Human | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of CPD protein | CTD | PMID:32959892 | CPD | Human | L-methionine | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPD gene | CTD | PMID:20938992 | CPD | Human | methapyrilene | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of CPD mRNA | CTD | PMID:30467583 | CPD | Human | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of CPD mRNA | CTD | PMID:23179753 | CPD | Human | nitric oxide | affects chemical synthesis | EXP | | 6480464 | CPD affects the chemical synthesis of Nitric Oxide | CTD | PMID:21688280 | CPD | Human | nitric oxide | multiple interactions | EXP | | 6480464 | [PRL results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide and [Testosterone results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide | CTD | PMID:21688280 | CPD | Human | ozone | multiple interactions | ISO | Cpd (Rattus norvegicus) | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of CPD mRNA | CTD | PMID:18636392 | CPD | Human | perfluorooctanoic acid | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | perfluorooctanoic acid results in decreased expression of CPD mRNA | CTD | PMID:19162173 | CPD | Human | phenobarbital | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of CPD mRNA | CTD | PMID:23091169 | CPD | Human | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPD mRNA | CTD | PMID:19710929 | CPD | Human | pirinixic acid | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of CPD mRNA | CTD | PMID:23811191 | CPD | Human | potassium cyanide | increases expression | ISO | Cpd (Mus musculus) | 6480464 | Potassium Cyanide results in increased expression of CPD mRNA | CTD | PMID:33914522 | CPD | Human | procymidone | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | procymidone results in increased expression of CPD mRNA | CTD | PMID:15686871 | CPD | Human | protein kinase inhibitor | multiple interactions | EXP | | 6480464 | Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CPD mRNA] | CTD | PMID:28003376 | CPD | Human | rac-lactic acid | increases expression | EXP | | 6480464 | Lactic Acid results in increased expression of CPD mRNA | CTD | PMID:30851411 | CPD | Human | resveratrol | multiple interactions | EXP | | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of CPD mRNA | CTD | PMID:23557933 | CPD | Human | rotenone | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Rotenone results in decreased expression of CPD protein | CTD | PMID:35544339 | CPD | Human | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPD mRNA | CTD | PMID:27188386 | CPD | Human | selenium atom | decreases expression | EXP | | 6480464 | Selenium results in decreased expression of CPD mRNA | CTD | PMID:19244175 | CPD | Human | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide analog results in decreased expression of CPD mRNA | CTD | PMID:25895662 | CPD | Human | sodium arsenate | increases expression | ISO | Cpd (Mus musculus) | 6480464 | sodium arsenate results in increased expression of CPD mRNA | CTD | PMID:21795629 | CPD | Human | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of CPD mRNA | CTD | PMID:38568856 | CPD | Human | succimer | multiple interactions | ISO | Cpd (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of CPD mRNA and [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CPD mRNA | CTD | PMID:21641980 and PMID:26378955 | CPD | Human | sulforaphane | increases expression | EXP | | 6480464 | sulforaphane results in increased expression of CPD mRNA | CTD | PMID:26833863 | CPD | Human | testosterone | multiple interactions | EXP | | 6480464 | [Testosterone results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide and SRD5A1 promotes the reaction [Testosterone results in increased expression of CPD mRNA] | CTD | PMID:21688280 | CPD | Human | testosterone | multiple interactions | ISO | Cpd (Rattus norvegicus) | 6480464 | [Estradiol co-treated with Testosterone] results in increased expression of CPD mRNA | CTD | PMID:11375906 | CPD | Human | testosterone | increases expression | EXP | | 6480464 | Testosterone results in increased expression of CPD mRNA and Testosterone results in increased expression of CPD protein | CTD | PMID:21688280 | CPD | Human | tetrachloroethene | increases expression | ISO | Cpd (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of CPD mRNA | CTD | PMID:28973375 | CPD | Human | tetrachloromethane | affects expression | ISO | Cpd (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of CPD mRNA | CTD | PMID:17484886 | CPD | Human | thioacetamide | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of CPD mRNA | CTD | PMID:34492290 | CPD | Human | titanium dioxide | decreases methylation | ISO | Cpd (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of CPD gene | CTD | PMID:35295148 | CPD | Human | trichloroethene | increases methylation | ISO | Cpd (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased methylation of CPD gene | CTD | PMID:27618143 | CPD | Human | trichostatin A | decreases expression | EXP | | 6480464 | trichostatin A results in decreased expression of CPD mRNA | CTD | PMID:26272509 | CPD | Human | trichostatin A | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPD mRNA | CTD | PMID:27188386 | CPD | Human | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of CPD mRNA | CTD | PMID:37042841 | CPD | Human | triptonide | increases expression | ISO | Cpd (Mus musculus) | 6480464 | triptonide results in increased expression of CPD mRNA | CTD | PMID:33045310 | CPD | Human | troglitazone | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | troglitazone results in decreased expression of CPD mRNA | CTD | PMID:28973697 | CPD | Human | tungsten | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | Tungsten results in decreased expression of CPD mRNA | CTD | PMID:30912803 | CPD | Human | tunicamycin | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | Tunicamycin results in decreased expression of CPD mRNA | CTD | PMID:17127020 | CPD | Human | urethane | decreases expression | ISO | Cpd (Mus musculus) | 6480464 | Urethane results in decreased expression of CPD mRNA | CTD | PMID:16289808 | CPD | Human | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of CPD mRNA | CTD | PMID:23179753 and PMID:29154799 | CPD | Human | valproic acid | affects splicing | ISO | Cpd (Rattus norvegicus) | 6480464 | Valproic Acid affects the splicing of CPD mRNA | CTD | PMID:29427782 | CPD | Human | venlafaxine hydrochloride | increases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | Venlafaxine Hydrochloride results in increased expression of CPD mRNA | CTD | PMID:25423262 | CPD | Human | vinclozolin | decreases expression | ISO | Cpd (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of CPD mRNA | CTD | PMID:23034163 | CPD | Human | zoledronic acid | increases expression | EXP | | 6480464 | zoledronic acid results in increased expression of CPD mRNA | CTD | PMID:20977926 | |
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