Ucn (urocortin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ucn (urocortin) Heterocephalus glaber
Analyze
Symbol: Ucn
Name: urocortin
RGD ID: 18931396
Description: ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); aerobic respiration (ortholog); associative learning (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH anxiety disorder (ortholog); asthma (ortholog); Burns (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,393,329 - 9,393,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,393,004 - 9,393,966 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase A activity  (ISO)
aerobic respiration  (ISO)
associative learning  (ISO)
drinking behavior  (ISO)
feeding behavior  (ISO)
female pregnancy  (ISO)
learning or memory  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of appetite  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuron projection development  (ISO)
neuropeptide signaling pathway  (ISO)
positive regulation of behavioral fear response  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular permeability  (ISO)
prepulse inhibition  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
response to auditory stimulus  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to immobilization stress  (ISO)
response to oxidative stress  (ISO)
response to pain  (ISO)
response to starvation  (ISO)
social behavior  (ISO)
startle response  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ucn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,393,329 - 9,393,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,393,004 - 9,393,966 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
UCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,307,400 - 27,308,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,307,400 - 27,308,445 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,530,268 - 27,531,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,383,769 - 27,384,634 (-)NCBINCBI36Build 36hg18NCBI36
Build 34227,441,915 - 27,442,781NCBI
Celera227,377,369 - 27,378,234 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,272,488 - 27,273,352 (-)NCBIHuRef
CHM1_1227,460,211 - 27,461,076 (-)NCBICHM1_1
T2T-CHM13v2.0227,349,815 - 27,350,860 (-)NCBIT2T-CHM13v2.0
Ucn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,295,333 - 31,296,239 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,295,407 - 31,296,173 (-)EnsemblGRCm39 Ensembl
GRCm38531,137,989 - 31,138,895 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,138,063 - 31,138,829 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,440,362 - 31,441,268 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,414,570 - 31,415,476 (-)NCBIMGSCv36mm8
Celera528,616,898 - 28,617,804 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.11NCBI
Ucn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,958,086 - 30,958,916 (+)NCBIGRCr8
mRatBN7.2625,238,120 - 25,238,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,238,120 - 25,238,950 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,538,943 - 25,539,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,854,837 - 25,855,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,333,721 - 25,334,551 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,602,144 - 26,602,974 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,602,144 - 26,602,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,418,524 - 36,419,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,216,788 - 25,217,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,219,740 - 25,220,571 (+)NCBI
Celera624,729,244 - 24,730,074 (+)NCBICelera
Cytogenetic Map6q14NCBI
Ucn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,277,637 - 9,278,641 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,277,637 - 9,278,641 (-)NCBIChiLan1.0ChiLan1.0
UCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,203,119 - 99,205,065 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,207,076 - 99,209,033 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,309,458 - 27,311,268 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,397,175 - 27,399,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,397,295 - 27,397,669 (-)Ensemblpanpan1.1panPan2
UCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,278,512 - 21,280,404 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,278,932 - 21,279,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,170,573 - 21,171,891 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,600,051 - 21,601,369 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,600,211 - 21,600,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,286,746 - 21,288,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,296,246 - 21,297,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,344,471 - 21,345,789 (-)NCBIUU_Cfam_GSD_1.0
Ucn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,578,803 - 65,579,918 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,260,219 - 5,260,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,258,574 - 5,260,692 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,835,125 - 111,835,508 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,834,082 - 111,835,932 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,303,210 - 80,304,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,304,416 - 80,304,790 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,847,056 - 31,848,892 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004839187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01015636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000028889   ⟹   ENSHGLP00000028419
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247389,393,329 - 9,393,706 (-)Ensembl
RefSeq Acc Id: XM_004839187   ⟹   XP_004839244
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247389,393,004 - 9,393,966 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004839244 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000028419
Reference Protein Sequences
RefSeq Acc Id: XP_004839244   ⟸   XM_004839187
RefSeq Acc Id: ENSHGLP00000028419   ⟸   ENSHGLT00000028889


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000020679 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000028889 ENTREZGENE
NCBI Gene Ucn ENTREZGENE