RGD Reference Report - Plasma urocortin 1 in human heart failure. - Rat Genome Database

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Plasma urocortin 1 in human heart failure.

Authors: Wright, SP  Doughty, RN  Frampton, CM  Gamble, GD  Yandle, TG  Richards, AM 
Citation: Wright SP, etal., Circ Heart Fail. 2009 Sep;2(5):465-71. Epub 2009 Jul 8.
RGD ID: 5490589
Pubmed: PMID:19808377   (View Abstract at PubMed)
DOI: DOI:10.1161/CIRCHEARTFAILURE.108.840207   (Journal Full-text)

BACKGROUND: The urocortins are emerging as potentially important contributors to neurohumoral regulation of the circulation with recent reports attributing a powerful array of hemodynamic, renal, and neurohumoral effects to the urocortins in cardiac failure. These peptides also seem to have cardioprotective effects in the setting of ischemia-reperfusion. Little is known concerning the plasma concentrations of the urocortins in health and disease. We have investigated plasma urocortin 1 as a potential diagnostic marker of heart failure and documented its relationships to symptoms, measures of cardiac function, and concurrent levels of other circulating neurohormones. METHODS AND RESULTS: In 299 patients with recent onset dyspnea or peripheral edema presenting to primary care, plasma urocortin 1 and other vasoactive hormones were assayed, and echocardiography was performed. Heart failure was present in 74 patients (25%) according to predefined diagnostic criteria. Urocortin 1 levels were increased in patients with heart failure and were related to functional class, clinical signs of heart failure, echocardiographic indicators of left ventricular dimensions and function, plasma creatinine, and concurrent circulating levels of plasma natriuretic peptides, adrenomedullin, and endothelin 1. CONCLUSIONS: Plasma urocortin 1 is elevated in heart failure (in proportion to the degree of cardiac dysfunction) in concert with the generalized neurohormonal activation seen in this condition. Urocortin levels predict heart failure independent of age, history of previous myocardial infarction, diabetes, hypertension, fractional shortening, and N-terminal prohormone brain natriuretic peptide levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
UCNHumancongestive heart failure  IEP protein:increased secretion:plasma (human)RGD 
UcnRatcongestive heart failure  ISOUCN (Homo sapiens)protein:increased secretion:plasma (human)RGD 
UcnMousecongestive heart failure  ISOUCN (Homo sapiens)protein:increased secretion:plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ucn  (urocortin)

Genes (Mus musculus)
Ucn  (urocortin)

Genes (Homo sapiens)
UCN  (urocortin)


Additional Information