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Gene: Phox2b (paired-like homeobox 2b) Rattus norvegicus
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Symbol: Phox2b
Name: paired-like homeobox 2b
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and regulation of respiratory gaseous exchange by nervous system process. Localizes to the nucleus. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome and neuroblastoma. Orthologous to human PHOX2B (paired like homeobox 2B); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: paired mesoderm homeobox protein 2B; NBPhox; neuroblastoma Phox; paired mesoderm homeobox protein 2B
Orthologs:
Homo sapiens (human) : PHOX2B (paired like homeobox 2B)  HGNC  Alliance
Mus musculus (house mouse) : Phox2b (paired-like homeobox 2b)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phox2b (paired like homeobox 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : PHOX2B (paired like homeobox 2B)
Canis lupus familiaris (dog) : PHOX2B (paired like homeobox 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phox2b (paired like homeobox 2B)
Sus scrofa (pig) : PHOX2B (paired like homeobox 2B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01442,711,169 - 42,718,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01442,510,540 - 42,514,526 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41443,675,180 - 43,677,970 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1440,218,744 - 40,226,258 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Phox2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1560582
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.