Phox2b (paired-like homeobox 2b) - Rat Genome Database

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Gene: Phox2b (paired-like homeobox 2b) Mus musculus
Symbol: Phox2b
Name: paired-like homeobox 2b
RGD ID: 1557466
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and regulation of respiratory gaseous exchange by nervous system process. Acts upstream of or within several processes, including nervous system development; regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; epibranchial placode; genitourinary system; and nervous system. Used to study congenital central hypoventilation syndrome. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome and neuroblastoma. Orthologous to human PHOX2B (paired like homeobox 2B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Di; dilated pupils 1; Dilp1; GENA 269; NBP; NBPhox; neuroblastoma Phox; paired mesoderm homeobox 2b; paired mesoderm homeobox protein 2B; Phox; PHOX2B homeodomain protein; Pmx2; Pmx2b; Px2; Px2b
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39567,251,740 - 67,256,469 (-)NCBIGRCm39mm39
GRCm39 Ensembl567,251,742 - 67,256,644 (-)Ensembl
GRCm38567,094,397 - 67,099,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl567,094,399 - 67,099,301 (-)EnsemblGRCm38mm10GRCm38
MGSCv37567,485,636 - 67,490,365 (-)NCBIGRCm37mm9NCBIm37
MGSCv36567,373,532 - 67,378,261 (-)NCBImm8
Celera564,399,184 - 64,403,936 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autonomic nervous system development  (ISO)
brainstem development  (ISO)
cell development  (IMP)
cell differentiation in hindbrain  (IMP)
cell population proliferation  (IMP)
cellular response to BMP stimulus  (IDA)
cellular response to carbon dioxide  (ISO)
dopaminergic neuron differentiation  (IMP)
efferent axon development in a lateral line nerve  (IMP)
enteric nervous system development  (IBA,IMP)
glial cell differentiation  (IMP)
hindbrain tangential cell migration  (IMP)
inner ear development  (IMP)
medullary reticular formation development  (IEP)
membrane depolarization  (ISO)
motor neuron migration  (IMP)
negative regulation of neuron differentiation  (IGI)
negative regulation of type B pancreatic cell proliferation  (IMP)
neural crest cell migration involved in autonomic nervous system development  (IMP)
neuron differentiation  (IGI,IMP)
noradrenergic neuron development  (IMP)
noradrenergic neuron differentiation  (IMP)
parasympathetic nervous system development  (IMP)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of neuron differentiation  (IGI)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
regulation of gene expression  (IMP)
regulation of respiratory gaseous exchange by nervous system process  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
regulation of transcription, DNA-templated  (IEA)
respiratory system development  (IMP)
response to activity  (ISO)
retrotrapezoid nucleus neuron differentiation  (IMP)
skeletal muscle cell differentiation  (IMP)
sympathetic ganglion development  (IMP)
sympathetic nervous system development  (IMP)
type B pancreatic cell proliferation  (IMP)

Cellular Component
chromatin  (ISO)
cytoplasm  (ISO)
nucleoplasm  (ISO)
nucleus  (IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal area postrema morphology  (IAGP)
abnormal autonomic nervous system morphology  (IAGP)
abnormal autonomic nervous system physiology  (IAGP)
abnormal axon extension  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal carotid body morphology  (IAGP)
abnormal ciliary ganglion morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal enteric ganglia morphology  (IAGP)
abnormal enteric nervous system morphology  (IAGP)
abnormal enteric neural crest cell migration  (IAGP)
abnormal eye morphology  (IAGP)
abnormal geniculate ganglion morphology  (IAGP)
abnormal glial cell morphology  (IAGP)
abnormal glossopharyngeal ganglion morphology  (IAGP)
abnormal locus ceruleus morphology  (IAGP)
abnormal lung volume  (IAGP)
abnormal medulla oblongata morphology  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal nodose ganglion morphology  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal parasympathetic ganglion morphology  (IAGP)
abnormal petrosal ganglion morphology  (IAGP)
abnormal pterygopalatine ganglion morphology  (IAGP)
abnormal pulmonary ventilation  (IAGP)
abnormal respiration  (IAGP)
abnormal respiratory function  (IAGP)
abnormal retrotrapezoid nucleus morphology  (IAGP)
abnormal sympathetic ganglion morphology  (IAGP)
abnormal vagus ganglion morphology  (IAGP)
abnormal vagus nerve morphology  (IAGP)
absent facial nerve  (IAGP)
absent petrosal ganglion  (IAGP)
absent trigeminal nerve  (IAGP)
alkalemia  (IAGP)
apnea  (IAGP)
blood vessel congestion  (IAGP)
cyanosis  (IAGP)
decreased body size  (IAGP)
decreased enteric neural crest cell number  (IAGP)
decreased enteric neural crest cell proliferation  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased pulmonary ventilation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
hypoventilation  (IAGP)
impaired neuron differentiation  (IAGP)
impaired pupillary reflex  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
mydriasis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
respiratory failure  (IAGP)
small facial motor nucleus  (IAGP)
small trigeminal ganglion  (IAGP)

References - curated
# Reference Title Reference Citation
1. Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome. Amiel J, etal., Nat Genet. 2003 Apr;33(4):459-61. Epub 2003 Mar 17.
2. PHOX2B mutation-confirmed congenital central hypoventilation syndrome in a Chinese family: presentation from newborn to adulthood. Lee P, etal., Chest. 2009 Feb;135(2):537-544. doi: 10.1378/chest.08-1664.
3. A novel PITX2 mutation in a Chinese family with Axenfeld-Rieger syndrome. Li D, etal., Mol Vis. 2008;14:2205-10. Epub 2008 Dec 5.
4. Identification of novel DNA methylation markers in colorectal cancer using MIRA-based microarrays. Li H, etal., Oncol Rep. 2012 Jul;28(1):99-104. doi: 10.3892/or.2012.1779. Epub 2012 Apr 23.
5. A case of congenital central hypoventilation syndrome in a three-generation family with non-polyalanine repeat PHOX2B mutation. Low KJ, etal., Pediatr Pulmonol. 2014 Oct;49(10):E140-3. doi: 10.1002/ppul.23051. Epub 2014 May 5.
6. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Lu QR, etal., Cell 2002 Apr 5;109(1):75-86.
7. MGDs mouse GO annotations MGD data from the GO Consortium
9. PHOX2B is a suppressor of neuroblastoma metastasis. Naftali O, etal., Oncotarget. 2016 Mar 1;7(9):10627-37. doi: 10.18632/oncotarget.7056.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Molecular analysis of congenital central hypoventilation syndrome. Sasaki A, etal., Hum Genet. 2003 Dec;114(1):22-6. Epub 2003 Oct 18.
Additional References at PubMed
PMID:200898   PMID:9374403   PMID:9435281   PMID:9539123   PMID:9758704   PMID:10217145   PMID:10230789   PMID:10349636   PMID:10360575   PMID:10395784   PMID:10395798   PMID:10536054  
PMID:10655590   PMID:10704382   PMID:10736201   PMID:10873389   PMID:11034547   PMID:11042159   PMID:11044402   PMID:11060244   PMID:11076752   PMID:11076756   PMID:11076861   PMID:11217851  
PMID:11466434   PMID:11500373   PMID:11562352   PMID:11578867   PMID:11581159   PMID:11641220   PMID:11825874   PMID:11880356   PMID:11929848   PMID:12019323   PMID:12023301   PMID:12160745  
PMID:12361965   PMID:12412013   PMID:12466851   PMID:12477932   PMID:12508309   PMID:12571110   PMID:12651891   PMID:12798298   PMID:12874134   PMID:12885554   PMID:12897786   PMID:12954718  
PMID:14513037   PMID:14522873   PMID:14534138   PMID:14627646   PMID:14627719   PMID:14659090   PMID:14681479   PMID:14960494   PMID:15034141   PMID:15133515   PMID:15150159   PMID:15240886  
PMID:15242795   PMID:15289435   PMID:15329349   PMID:15489334   PMID:15496442   PMID:15545635   PMID:15618518   PMID:15691760   PMID:15703280   PMID:15733675   PMID:15741322   PMID:15843399  
PMID:15860752   PMID:15976074   PMID:16129397   PMID:16133146   PMID:16141072   PMID:16141073   PMID:16145670   PMID:16176945   PMID:16227613   PMID:16319924   PMID:16402914   PMID:16410396  
PMID:16508307   PMID:16602821   PMID:16628617   PMID:16632597   PMID:16650841   PMID:16677628   PMID:16790476   PMID:16854219   PMID:16943277   PMID:17017126   PMID:17026983   PMID:17103416  
PMID:17119020   PMID:17122055   PMID:17131407   PMID:17151600   PMID:17208219   PMID:17355878   PMID:17475798   PMID:17507395   PMID:17531968   PMID:17676639   PMID:17699610   PMID:17715184  
PMID:17922007   PMID:18031722   PMID:18094025   PMID:18198276   PMID:18275850   PMID:18287559   PMID:18351668   PMID:18356247   PMID:18424435   PMID:18501887   PMID:18506029   PMID:18547144  
PMID:18551627   PMID:18565209   PMID:18570257   PMID:18675942   PMID:18771734   PMID:18804103   PMID:18829970   PMID:19088088   PMID:19235728   PMID:19542360   PMID:19545628   PMID:19578380  
PMID:19793887   PMID:19914183   PMID:19940179   PMID:20059953   PMID:20080794   PMID:20133851   PMID:20133877   PMID:20144603   PMID:20147379   PMID:20171203   PMID:20206242   PMID:20235227  
PMID:20457670   PMID:20631175   PMID:20680010   PMID:20702712   PMID:20739296   PMID:20875861   PMID:21048147   PMID:21068058   PMID:21122108   PMID:21320481   PMID:21325504   PMID:21453680  
PMID:21539825   PMID:21624811   PMID:21674689   PMID:21677750   PMID:21731673   PMID:21752929   PMID:21806979   PMID:21873635   PMID:21900566   PMID:21925604   PMID:21945624   PMID:21977017  
PMID:21989918   PMID:22040872   PMID:22102600   PMID:22128334   PMID:22147266   PMID:22363567   PMID:22399681   PMID:22485187   PMID:22534286   PMID:22586713   PMID:22718343   PMID:22723422  
PMID:22771245   PMID:22922260   PMID:22958821   PMID:22988430   PMID:23103168   PMID:23251691   PMID:23408898   PMID:23454479   PMID:23462468   PMID:23554478   PMID:23555309   PMID:23592597  
PMID:23637167   PMID:23648511   PMID:23692929   PMID:23804090   PMID:23903190   PMID:23961995   PMID:23988578   PMID:24574009   PMID:24656932   PMID:24925909   PMID:24925912   PMID:24952961  
PMID:25138596   PMID:25467979   PMID:25530182   PMID:25582512   PMID:25661788   PMID:25794678   PMID:25840610   PMID:25866925   PMID:25919494   PMID:25997579   PMID:26156498   PMID:26156989  
PMID:26356988   PMID:26658318   PMID:26857994   PMID:26937009   PMID:26988119   PMID:27052164   PMID:27226447   PMID:27370713   PMID:27819291   PMID:27856909   PMID:27923395   PMID:28583412  
PMID:28623666   PMID:28637693   PMID:28684471   PMID:28698373   PMID:28807939   PMID:28850031   PMID:28856690   PMID:29031500   PMID:29078343   PMID:29103954   PMID:29192291   PMID:29196262  
PMID:29282324   PMID:29445148   PMID:29688375   PMID:30169530   PMID:30457570   PMID:30487221   PMID:30626698   PMID:30691513   PMID:30884088   PMID:31171666   PMID:31218818   PMID:32094113  
PMID:32468398   PMID:32690615   PMID:32938678   PMID:33293111   PMID:33328840   PMID:33340715   PMID:33863785   PMID:33958373   PMID:34272903   PMID:34321664   PMID:34644112   PMID:34645823  
PMID:34728601   PMID:34767545   PMID:34782793   PMID:34803597   PMID:35399523  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39567,251,740 - 67,256,469 (-)NCBIGRCm39mm39
GRCm39 Ensembl567,251,742 - 67,256,644 (-)Ensembl
GRCm38567,094,397 - 67,099,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl567,094,399 - 67,099,301 (-)EnsemblGRCm38mm10GRCm38
MGSCv37567,485,636 - 67,490,365 (-)NCBIGRCm37mm9NCBIm37
MGSCv36567,373,532 - 67,378,261 (-)NCBImm8
Celera564,399,184 - 64,403,936 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38441,744,082 - 41,748,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl441,744,082 - 41,748,725 (-)EnsemblGRCh38hg38GRCh38
GRCh37441,746,099 - 41,750,742 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36441,440,857 - 41,445,744 (-)NCBINCBI36hg18NCBI36
Build 34441,587,027 - 41,591,915NCBI
Celera442,190,119 - 42,195,007 (-)NCBI
Cytogenetic Map4p13NCBI
HuRef441,068,497 - 41,073,385 (-)NCBIHuRef
CHM1_1441,746,637 - 41,751,525 (-)NCBICHM1_1
T2T-CHM13v2.0441,717,855 - 41,722,498 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21441,066,012 - 41,069,202 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1441,066,264 - 41,068,978 (+)Ensembl
Rnor_6.01442,711,169 - 42,718,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1442,714,315 - 42,717,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,510,540 - 42,514,526 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41443,675,180 - 43,677,970 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1440,218,744 - 40,226,258 (+)NCBICelera
Cytogenetic Map14p11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554435,935,975 - 5,938,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554435,935,975 - 5,938,747 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1441,918,047 - 41,922,449 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl441,919,742 - 41,922,449 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0436,070,924 - 36,074,532 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11338,865,963 - 38,869,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,865,995 - 38,869,854 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,841,873 - 38,845,270 (-)NCBI
ROS_Cfam_1.01339,356,028 - 39,359,380 (-)NCBI
UMICH_Zoey_3.11339,045,848 - 39,049,183 (-)NCBI
UNSW_CanFamBas_1.01339,156,421 - 39,159,820 (-)NCBI
UU_Cfam_GSD_1.01339,631,094 - 39,634,496 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440528537,322,562 - 37,326,296 (+)NCBI
SpeTri2.0NW_0049364828,972,433 - 8,975,284 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl832,841,396 - 32,846,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1832,841,425 - 32,846,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1278,602,764 - 8,608,052 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl278,603,484 - 8,606,299 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604754,920,668 - 54,926,074 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476125,234,372 - 25,237,102 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476125,234,048 - 25,238,725 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38567,096,582 - 67,097,745UniSTSGRCm38
MGSCv37567,487,821 - 67,488,984UniSTSGRCm37
Celera564,401,369 - 64,402,555UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map5 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38567,098,833 - 67,099,322UniSTSGRCm38
MGSCv37567,490,072 - 67,490,561UniSTSGRCm37
Celera564,403,643 - 64,404,132UniSTS
Cytogenetic Map5C3.1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38567,097,709 - 67,098,960UniSTSGRCm38
Celera564,402,519 - 64,403,770UniSTS
Cytogenetic Map5C3.1UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:899
Count of miRNA genes:476
Interacting mature miRNAs:587
Transcripts:ENSMUST00000012664, ENSMUST00000174251
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000012664   ⟹   ENSMUSP00000012664
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl567,251,742 - 67,256,644 (-)Ensembl
GRCm38.p6 Ensembl567,094,399 - 67,099,301 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174251   ⟹   ENSMUSP00000134216
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl567,254,387 - 67,256,400 (-)Ensembl
GRCm38.p6 Ensembl567,097,044 - 67,099,057 (-)Ensembl
RefSeq Acc Id: NM_008888   ⟹   NP_032914
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39567,251,740 - 67,256,469 (-)NCBI
GRCm38567,094,397 - 67,099,126 (-)ENTREZGENE
MGSCv37567,485,636 - 67,490,365 (-)RGD
Celera564,399,184 - 64,403,936 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_032914   ⟸   NM_008888
- UniProtKB: O35690 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000012664   ⟸   ENSMUST00000012664
RefSeq Acc Id: ENSMUSP00000134216   ⟸   ENSMUST00000174251
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35690-F1-model_v2 AlphaFold O35690 1-314 view protein structure

RGD ID:6886822
Promoter ID:EPDNEW_M6858
Type:initiation region
Description:Mus musculus paired-like homeobox 2b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38567,099,056 - 67,099,116EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1100882 AgrOrtholog
Ensembl Genes ENSMUSG00000012520 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000012664 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134216.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000012664 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000174251.2 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18935 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phox2b PhenoGen
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O35690 ENTREZGENE, UniProtKB/Swiss-Prot