MS4A2 (membrane spanning 4-domains A2) - Rat Genome Database

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Gene: MS4A2 (membrane spanning 4-domains A2) Sus scrofa
Analyze
Symbol: MS4A2
Name: membrane spanning 4-domains A2
RGD ID: 13921190
Description: ENCODES a protein that exhibits IgE binding (ortholog); phosphoprotein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); cytokine production (ortholog); positive regulation of mast cell degranulation (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH aspirin-induced respiratory disease (ortholog); asthma (ortholog); atopic dermatitis (ortholog); FOUND IN endosome (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FcR beta chain; high affinity immunoglobulin epsilon receptor subunit beta; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for, beta polypeptide)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl211,400,420 - 11,420,298 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1211,400,415 - 11,420,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,959,657 - 10,979,571 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
MS4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl211,400,420 - 11,420,298 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1211,400,415 - 11,420,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,959,657 - 10,979,571 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MS4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,088,259 - 60,098,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,088,261 - 60,098,467 (+)EnsemblGRCh38hg38GRCh38
GRCh371159,856,137 - 59,865,940 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,612,713 - 59,622,593 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,612,712 - 59,622,593NCBI
Celera1157,220,517 - 57,230,320 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1156,203,291 - 56,213,094 (+)NCBIHuRef
CHM1_11159,722,124 - 59,731,922 (+)NCBICHM1_1
T2T-CHM13v2.01160,039,540 - 60,049,747 (+)NCBIT2T-CHM13v2.0
Ms4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,592,881 - 11,601,154 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,592,887 - 11,601,083 (-)EnsemblGRCm39 Ensembl
GRCm381911,615,517 - 11,623,790 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,615,523 - 11,623,719 (-)EnsemblGRCm38mm10GRCm38
MGSCv371911,691,683 - 11,698,133 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,684,238 - 11,690,688 (-)NCBIMGSCv36mm8
Celera1912,289,076 - 12,295,526 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.46NCBI
Ms4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,864,855 - 217,873,934 (-)NCBIGRCr8
mRatBN7.21208,440,179 - 208,448,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1208,440,361 - 208,448,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,815,093 - 216,823,042 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,833,935 - 223,841,752 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,569,529 - 216,577,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01227,957,363 - 227,965,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1227,957,302 - 227,965,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01235,019,784 - 235,027,733 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,011,050 - 214,018,999 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,169,479 - 214,177,429 (+)NCBI
Celera1205,916,298 - 205,924,247 (-)NCBICelera
RH 3.4 Map11501.5RGD
Cytogenetic Map1q43NCBI
Ms4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555114,380,502 - 4,400,852 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555114,377,894 - 4,400,797 (+)NCBIChiLan1.0ChiLan1.0
MS4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2961,224,616 - 61,234,384 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11162,268,298 - 62,278,085 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,318,843 - 55,326,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,764,911 - 58,772,567 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,764,911 - 58,772,567 (+)Ensemblpanpan1.1panPan2
MS4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12150,439,133 - 50,456,785 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2150,450,024 - 50,456,785 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,890,835 - 49,897,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02151,612,389 - 51,629,878 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2151,623,124 - 51,629,878 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12150,670,449 - 50,677,218 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02150,767,877 - 50,774,639 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02151,392,625 - 51,399,386 (+)NCBIUU_Cfam_GSD_1.0
Ms4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494712,629,201 - 12,638,145 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,744,881 - 2,751,925 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,743,133 - 2,751,925 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MS4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,657,842 - 13,666,314 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,654,696 - 13,665,925 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,993,186 - 111,001,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ms4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624864807,253 - 813,381 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624864804,950 - 813,419 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MS4A2
931 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000047778   ⟹   ENSSSCP00000034836
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl211,400,420 - 11,420,153 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000065915   ⟹   ENSSSCP00000049169
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl211,403,105 - 11,420,200 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000070884   ⟹   ENSSSCP00000063861
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl211,401,497 - 11,420,298 (-)Ensembl
RefSeq Acc Id: NM_214092   ⟹   NP_999257
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1211,400,476 - 11,420,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005660844   ⟹   XP_005660901
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1211,400,415 - 11,420,314 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005660901   ⟸   XM_005660844
- Peptide Label: isoform X1
- UniProtKB: A0A5G2QIW8 (UniProtKB/TrEMBL),   A0A8D0NQM9 (UniProtKB/TrEMBL),   A0A8D0KBU3 (UniProtKB/TrEMBL),   A0A8D1IHT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999257   ⟸   NM_214092
- UniProtKB: A0A8D1YFJ9 (UniProtKB/TrEMBL),   A0A4X1VMM5 (UniProtKB/TrEMBL),   A0A8D1WPC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000049169   ⟸   ENSSSCT00000065915
Ensembl Acc Id: ENSSSCP00000063861   ⟸   ENSSSCT00000070884
Ensembl Acc Id: ENSSSCP00000034836   ⟸   ENSSSCT00000047778


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034506 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005041164 UniProtKB/TrEMBL
  ENSSSCG00015041869 UniProtKB/TrEMBL
  ENSSSCG00025035643 UniProtKB/TrEMBL
  ENSSSCG00030073852 UniProtKB/TrEMBL
  ENSSSCG00035062696 UniProtKB/TrEMBL
  ENSSSCG00040043012 UniProtKB/TrEMBL
  ENSSSCG00045029800 UniProtKB/TrEMBL
  ENSSSCG00055022734 UniProtKB/TrEMBL
  ENSSSCG00060070072 UniProtKB/TrEMBL
  ENSSSCG00065030277 UniProtKB/TrEMBL
  ENSSSCG00070025494 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000047778 ENTREZGENE
  ENSSSCT00000047778.2 UniProtKB/TrEMBL
  ENSSSCT00000065915.2 UniProtKB/TrEMBL
  ENSSSCT00000070884 ENTREZGENE
  ENSSSCT00000070884.2 UniProtKB/TrEMBL
  ENSSSCT00005066002.1 UniProtKB/TrEMBL
  ENSSSCT00015056320.1 UniProtKB/TrEMBL
  ENSSSCT00025048603.1 UniProtKB/TrEMBL
  ENSSSCT00025048645.1 UniProtKB/TrEMBL
  ENSSSCT00030103467.1 UniProtKB/TrEMBL
  ENSSSCT00030103476.1 UniProtKB/TrEMBL
  ENSSSCT00035084280.1 UniProtKB/TrEMBL
  ENSSSCT00035084291.1 UniProtKB/TrEMBL
  ENSSSCT00040057765.1 UniProtKB/TrEMBL
  ENSSSCT00045050798.1 UniProtKB/TrEMBL
  ENSSSCT00045050905.1 UniProtKB/TrEMBL
  ENSSSCT00045050993.1 UniProtKB/TrEMBL
  ENSSSCT00045051088.1 UniProtKB/TrEMBL
  ENSSSCT00055044687.1 UniProtKB/TrEMBL
  ENSSSCT00055044796.1 UniProtKB/TrEMBL
  ENSSSCT00060095638.1 UniProtKB/TrEMBL
  ENSSSCT00060095661.1 UniProtKB/TrEMBL
  ENSSSCT00065040889.1 UniProtKB/TrEMBL
  ENSSSCT00065040892.1 UniProtKB/TrEMBL
  ENSSSCT00070050960.1 UniProtKB/TrEMBL
  ENSSSCT00070050961.1 UniProtKB/TrEMBL
InterPro CD20-like UniProtKB/TrEMBL
  MS4A UniProtKB/TrEMBL
KEGG Report ssc:397166 UniProtKB/TrEMBL
NCBI Gene MS4A2 ENTREZGENE
PANTHER PTHR23320 UniProtKB/TrEMBL
  PTHR23320:SF66 UniProtKB/TrEMBL
Pfam CD20 UniProtKB/TrEMBL
UniProt A0A286ZTE2_PIG UniProtKB/TrEMBL
  A0A287AYE0_PIG UniProtKB/TrEMBL
  A0A4X1VMM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VPT8_PIG UniProtKB/TrEMBL
  A0A5G2QIW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0KBU3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NQM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IHT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ILZ8_PIG UniProtKB/TrEMBL
  A0A8D1L5A8_PIG UniProtKB/TrEMBL
  A0A8D1WPC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1YFJ9 ENTREZGENE, UniProtKB/TrEMBL
  Q8MJ38_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90411 ENTREZGENE