Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | RGD:1557503 | 6480464 | Nicotine results in increased expression of AK5 mRNA | CTD | PMID:21955143 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA | CTD | PMID:20823114 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557503 | 6480464 | Tetrachlorodibenzodioxin affects the expression of AK5 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1590818 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AK5 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of AK5 mRNA | CTD | PMID:22574217 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | RGD:1590818 | 6480464 | 2 more ... | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:1557503 | 6480464 | bis4-hydroxyphenylsulfone results in increased expression of AK5 mRNA | CTD | PMID:30951980 | 5-azacytidine | increases expression | EXP | | 6480464 | Azacitidine results in increased expression of AK5 mRNA | CTD | PMID:20823114 | 6-propyl-2-thiouracil | increases expression | ISO | RGD:1590818 | 6480464 | Propylthiouracil results in increased expression of AK5 mRNA | CTD | PMID:24780913 | afimoxifene | decreases response to substance | EXP | | 6480464 | AK5 results in decreased susceptibility to afimoxifene | CTD | PMID:21233418 | aflatoxin B1 | affects methylation | EXP | | 6480464 | Aflatoxin B1 affects the methylation of AK5 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of AK5 mRNA | CTD | PMID:23724009 | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of AK5 mRNA | CTD | PMID:24449571 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzoapyrene results in decreased expression of AK5 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | increases methylation | ISO | RGD:1557503 | 6480464 | Benzoapyrene results in increased methylation of AK5 exon, Benzoapyrene results in increased methylation of AK5 intron | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzoapyrene results in increased methylation of AK5 exon | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of AK5 mRNA | CTD | PMID:31163220 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1590818 | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of AK5 mRNA | CTD | PMID:31199487 | bisphenol A | increases expression | ISO | RGD:1557503 | 6480464 | bisphenol A results in increased expression of AK5 mRNA | CTD | PMID:30245210 | bisphenol F | increases expression | ISO | RGD:1557503 | 6480464 | bisphenol F results in increased expression of AK5 mRNA | CTD | PMID:30951980 | bucladesine | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA | CTD | PMID:20823114 | Butylbenzyl phthalate | multiple interactions | ISO | RGD:1590818 | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of AK5 mRNA | CTD | PMID:31199487 | calcitriol | decreases expression | EXP | | 6480464 | Calcitriol results in decreased expression of AK5 mRNA | CTD | PMID:26485663 | clobetasol | decreases expression | ISO | RGD:1557503 | 6480464 | Clobetasol results in decreased expression of AK5 mRNA | CTD | PMID:27462272 | copper atom | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of AK5 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of AK5 mRNA | CTD | PMID:20971185 | copper(II) sulfate | affects expression | EXP | | 6480464 | Copper Sulfate affects the expression of AK5 mRNA | CTD | PMID:19549813 | dibutyl phthalate | multiple interactions | ISO | RGD:1590818 | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of AK5 mRNA | CTD | PMID:31199487 | diethyl phthalate | multiple interactions | ISO | RGD:1590818 | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of AK5 mRNA | CTD | PMID:31199487 | diisobutyl phthalate | multiple interactions | ISO | RGD:1590818 | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of AK5 mRNA | CTD | PMID:31199487 | diisononyl phthalate | multiple interactions | ISO | RGD:1590818 | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of AK5 mRNA | CTD | PMID:31199487 | doramapimod | increases expression | ISO | RGD:1590818 | 6480464 | BIRB 796 results in increased expression of AK5 mRNA | CTD | PMID:24303162 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of AK5 mRNA | CTD | PMID:27188386 | ethanol | decreases expression | ISO | RGD:1557503 | 6480464 | Ethanol results in decreased expression of AK5 mRNA | CTD | PMID:21955143 | ethanol | affects splicing | ISO | RGD:1557503 | 6480464 | Ethanol affects the splicing of AK5 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | ISO | RGD:1590818 | 6480464 | fenvalerate results in increased expression of AK5 mRNA | CTD | PMID:30307764 | fonofos | increases methylation | EXP | | 6480464 | Fonofos results in increased methylation of AK5 promoter | CTD | PMID:22847954 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of AK5 mRNA | CTD | PMID:22228119 | lead(0) | affects expression | EXP | | 6480464 | Lead affects the expression of AK5 mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | EXP | | 6480464 | Lead affects the expression of AK5 mRNA | CTD | PMID:28903495 | medroxyprogesterone acetate | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA | CTD | PMID:20823114 | methamphetamine | affects response to substance | EXP | | 6480464 | AK5 gene SNP affects the susceptibility to Methamphetamine | CTD | PMID:18316681 | methylmercury chloride | decreases expression | EXP | | 6480464 | methylmercuric chloride results in decreased expression of AK5 mRNA | CTD | PMID:28001369 | morphine | decreases expression | ISO | RGD:1557503 | 6480464 | Morphine results in decreased expression of AK5 mRNA | CTD | PMID:21955143 | nicotine | increases expression | ISO | RGD:1557503 | 6480464 | Nicotine results in increased expression of AK5 mRNA | CTD | PMID:21955143 | paracetamol | multiple interactions | ISO | RGD:1557503 | 6480464 | MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of AK5 mRNA] | CTD | PMID:18700144 | parathion | increases methylation | EXP | | 6480464 | Parathion results in increased methylation of AK5 promoter | CTD | PMID:22847954 | PCB138 | increases expression | ISO | RGD:1590818 | 6480464 | 2 more ... | CTD | PMID:23829299 | phenylmercury acetate | decreases expression | EXP | | 6480464 | Phenylmercuric Acetate results in decreased expression of AK5 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of AK5 mRNA | CTD | PMID:27188386 | pirinixic acid | increases expression | ISO | RGD:1557503 | 6480464 | pirinixic acid results in increased expression of AK5 mRNA | CTD | PMID:20813756 | potassium chromate | increases expression | EXP | | 6480464 | potassium chromateVI results in increased expression of AK5 mRNA | CTD | PMID:22714537 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of AK5 mRNA | CTD | PMID:27188386 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide analog results in increased expression of AK5 mRNA | CTD | PMID:25895662 | terbufos | increases methylation | EXP | | 6480464 | terbufos results in increased methylation of AK5 promoter | CTD | PMID:22847954 | trichostatin A | decreases expression | EXP | | 6480464 | trichostatin A results in decreased expression of AK5 mRNA | CTD | PMID:24935251 | triptonide | decreases expression | ISO | RGD:1557503 | 6480464 | triptonide results in decreased expression of AK5 mRNA | CTD | PMID:33045310 | tunicamycin | increases expression | ISO | RGD:1557503 | 6480464 | Tunicamycin results in increased expression of AK5 mRNA | CTD | PMID:17127020 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of AK5 mRNA | CTD | PMID:23179753 | zoledronic acid | decreases expression | EXP | | 6480464 | zoledronic acid results in decreased expression of AK5 mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| 1. | GOA_HUMAN data from the GO Consortium |
| 2. | Noma T J Med Invest. 2005 Aug;52(3-4):127-36. |
| 3. | Pipeline to import KEGG annotations from KEGG into RGD |
| 4. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 5. | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10215863 | PMID:12477932 | PMID:14702039 | PMID:15489334 | PMID:16169070 | PMID:18029348 | PMID:18239623 | PMID:19647735 | PMID:20379614 | PMID:21873635 | PMID:23416111 | PMID:23898208 |
| PMID:27288770 | PMID:31799658 |
Genomics
