CDCA5 (cell division cycle associated 5) - Rat Genome Database

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Gene: CDCA5 (cell division cycle associated 5) Homo sapiens
Analyze
Symbol: CDCA5
Name: cell division cycle associated 5
RGD ID: 1350338
HGNC Page HGNC
Description: Predicted to enable chromatin binding activity. Involved in double-strand break repair; mitotic sister chromatid segregation; and regulation of cell cycle process. Located in nucleoplasm; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell division cycle-associated protein 5; MGC16386; p35; sororin
RGD Orthologs
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1165,066,300 - 65,084,164 (-)EnsemblGRCh38hg38GRCh38
GRCh381165,061,009 - 65,084,129 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,844,925 - 64,851,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,601,503 - 64,608,100 (-)NCBINCBI36hg18NCBI36
Build 341164,601,502 - 64,608,100NCBI
Celera1162,171,226 - 62,177,913 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,171,560 - 61,178,247 (-)NCBIHuRef
CHM1_11164,728,627 - 64,735,313 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
5-fluorouracil  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
antimycin A  (EXP)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
folic acid  (ISO)
genistein  (EXP)
indometacin  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
menadione  (EXP)
methyl methanesulfonate  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (EXP)
ozone  (ISO)
palbociclib  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phytoestrogen  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
propanal  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sunitinib  (EXP)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISS)
chromosome  (IEA,TAS)
chromosome, centromeric region  (TAS)
cytoplasm  (ISS)
cytosol  (TAS)
nucleoplasm  (IDA,TAS)
nucleus  (IBA,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:11111111   PMID:12188893   PMID:12477932   PMID:14702039   PMID:15146197   PMID:15489334   PMID:15837422   PMID:16169070   PMID:16964243   PMID:17081983   PMID:17349791   PMID:17361102  
PMID:18029348   PMID:20360068   PMID:20379614   PMID:20551060   PMID:21111234   PMID:21115494   PMID:21873635   PMID:21987589   PMID:21988832   PMID:22833568   PMID:22885700   PMID:22939629  
PMID:23242214   PMID:23455924   PMID:23548868   PMID:24098701   PMID:24999758   PMID:25092791   PMID:25257309   PMID:25281560   PMID:25608232   PMID:26177583   PMID:26186194   PMID:26496610  
PMID:26497678   PMID:26895426   PMID:26951638   PMID:28514442   PMID:29117863   PMID:29326043   PMID:29383807   PMID:29452217   PMID:29724914   PMID:30015982   PMID:30497429   PMID:30657957  
PMID:30804502   PMID:31010829   PMID:31068217   PMID:31180492   PMID:31586073   PMID:32203420   PMID:32296183   PMID:32694239   PMID:32759885   PMID:34079125  


Genomics

Comparative Map Data
CDCA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1165,066,300 - 65,084,164 (-)EnsemblGRCh38hg38GRCh38
GRCh381165,061,009 - 65,084,129 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,844,925 - 64,851,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,601,503 - 64,608,100 (-)NCBINCBI36hg18NCBI36
Build 341164,601,502 - 64,608,100NCBI
Celera1162,171,226 - 62,177,913 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,171,560 - 61,178,247 (-)NCBIHuRef
CHM1_11164,728,627 - 64,735,313 (-)NCBICHM1_1
Cdca5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,135,127 - 6,141,803 (+)NCBIGRCm39mm39
GRCm39 Ensembl196,135,013 - 6,141,807 (+)Ensembl
GRCm38196,085,097 - 6,091,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,084,983 - 6,091,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,085,097 - 6,091,773 (+)NCBIGRCm37mm9NCBIm37
MGSCv36196,085,097 - 6,091,773 (+)NCBImm8
Celera195,957,560 - 5,964,236 (+)NCBICelera
Cytogenetic Map19ANCBI
Cdca5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21203,378,550 - 203,392,027 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1203,378,577 - 203,392,023 (+)Ensembl
Rnor_6.01221,448,661 - 221,462,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,448,661 - 221,462,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,384,097 - 228,394,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41210,247,351 - 210,247,881 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1200,912,264 - 200,925,714 (+)NCBICelera
Cytogenetic Map1q43NCBI
Cdca5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542220,114,565 - 20,129,679 (+)NCBIChiLan1.0ChiLan1.0
CDCA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,115,081 - 52,129,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,115,203 - 52,120,817 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,723,160 - 50,736,970 (+)NCBI
ROS_Cfam_1.01853,156,720 - 53,170,506 (+)NCBI
UMICH_Zoey_3.11852,251,940 - 52,258,937 (+)NCBI
UNSW_CanFamBas_1.01851,825,978 - 51,839,752 (+)NCBI
UU_Cfam_GSD_1.01852,620,789 - 52,634,766 (+)NCBI
Cdca5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,842,550 - 7,856,508 (+)NCBI
SpeTri2.0NW_0049365994,285,007 - 4,291,875 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDCA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,102,982 - 7,113,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,103,648 - 7,112,772 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,235,704 - 6,251,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDCA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,151,503 - 9,157,412 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl19,151,712 - 9,157,456 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038106,533,173 - 106,538,620 (+)NCBIVero_WHO_p1.0
Cdca5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476721,321,286 - 21,327,780 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
A002B21  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,845,024 - 64,845,130UniSTSGRCh37
Build 361164,601,600 - 64,601,706RGDNCBI36
Celera1162,171,323 - 62,171,429RGD
Cytogenetic Map11q12.1UniSTS
HuRef1161,171,657 - 61,171,763UniSTS
GeneMap99-GB4 RH Map11237.91UniSTS
NCBI RH Map11573.2UniSTS
WI-21617  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,844,931 - 64,845,193UniSTSGRCh37
Build 361164,601,507 - 64,601,769RGDNCBI36
Celera1162,171,230 - 62,171,492RGD
Cytogenetic Map11q12.1UniSTS
HuRef1161,171,564 - 61,171,826UniSTS
GeneMap99-GB4 RH Map11238.01UniSTS
Whitehead-RH Map11316.9UniSTS
NCBI RH Map11573.2UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR331hsa-miR-331-3pMirecordsexternal_info{changed}NA19996289

Predicted Target Of
Summary Value
Count of predictions:4239
Count of miRNA genes:1125
Interacting mature miRNAs:1403
Transcripts:ENST00000275517, ENST00000404147, ENST00000438878, ENST00000462902, ENST00000479032, ENST00000524733, ENST00000525464, ENST00000527430, ENST00000529290, ENST00000531401, ENST00000533015
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 271 34 90 79 763 82 304 57 123 84 667 320 10 2 5 3
Low 1680 1855 1277 319 1003 182 3147 926 2740 258 733 1213 138 1078 1932 1
Below cutoff 481 1095 356 224 181 200 904 1209 850 75 49 75 23 124 851

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005273733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005273734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB231703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN332525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000275517   ⟹   ENSP00000275517
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,077,453 - 65,084,040 (-)Ensembl
RefSeq Acc Id: ENST00000404147   ⟹   ENSP00000385711
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,079,088 - 65,084,047 (-)Ensembl
RefSeq Acc Id: ENST00000462902
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,083,250 - 65,083,896 (-)Ensembl
RefSeq Acc Id: ENST00000479032
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,079,132 - 65,084,039 (-)Ensembl
RefSeq Acc Id: ENST00000524733   ⟹   ENSP00000431888
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,078,633 - 65,083,531 (-)Ensembl
RefSeq Acc Id: ENST00000525464   ⟹   ENSP00000432342
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,066,365 - 65,079,415 (-)Ensembl
RefSeq Acc Id: ENST00000527430   ⟹   ENSP00000432621
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,079,166 - 65,083,977 (-)Ensembl
RefSeq Acc Id: ENST00000529290   ⟹   ENSP00000432183
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,066,300 - 65,079,389 (-)Ensembl
RefSeq Acc Id: ENST00000531401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,079,141 - 65,084,164 (-)Ensembl
RefSeq Acc Id: ENST00000533015
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,068,044 - 65,083,900 (-)Ensembl
RefSeq Acc Id: NM_080668   ⟹   NP_542399
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,077,453 - 65,084,040 (-)NCBI
GRCh371164,833,772 - 64,851,635 (-)NCBI
Build 361164,601,503 - 64,608,100 (-)NCBI Archive
Celera1162,171,226 - 62,177,913 (-)RGD
HuRef1161,171,560 - 61,178,247 (-)ENTREZGENE
CHM1_11164,728,627 - 64,735,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005273733   ⟹   XP_005273790
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,296 - 65,084,068 (-)NCBI
GRCh371164,833,772 - 64,851,635 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005273734   ⟹   XP_005273791
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,298 - 65,084,068 (-)NCBI
GRCh371164,833,772 - 64,851,635 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544743   ⟹   XP_011543045
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,061,009 - 65,084,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544747   ⟹   XP_011543049
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,230 - 65,084,129 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544748   ⟹   XP_011543050
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,067,661 - 65,084,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544749   ⟹   XP_011543051
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,572 - 65,084,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017158   ⟹   XP_016872647
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,065,035 - 65,084,068 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001747757
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,062,702 - 65,084,068 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001747758
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,062,702 - 65,084,068 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_542399   ⟸   NM_080668
- UniProtKB: Q96FF9 (UniProtKB/Swiss-Prot),   A0A024R5D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005273790   ⟸   XM_005273733
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005273791   ⟸   XM_005273734
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011543045   ⟸   XM_011544743
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011543049   ⟸   XM_011544747
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011543051   ⟸   XM_011544749
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_011543050   ⟸   XM_011544748
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016872647   ⟸   XM_017017158
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000385711   ⟸   ENST00000404147
RefSeq Acc Id: ENSP00000431888   ⟸   ENST00000524733
RefSeq Acc Id: ENSP00000275517   ⟸   ENST00000275517
RefSeq Acc Id: ENSP00000432342   ⟸   ENST00000525464
RefSeq Acc Id: ENSP00000432621   ⟸   ENST00000527430
RefSeq Acc Id: ENSP00000432183   ⟸   ENST00000529290

Promoters
RGD ID:6788618
Promoter ID:HG_KWN:13299
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000404147,   NM_006782,   OTTHUMT00000318028,   OTTHUMT00000318029,   OTTHUMT00000318030,   UC009YQA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361164,607,421 - 64,608,312 (-)MPROMDB
RGD ID:7220969
Promoter ID:EPDNEW_H16230
Type:initiation region
Name:CDCA5_1
Description:cell division cycle associated 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16233  EPDNEW_H16231  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,084,040 - 65,084,100EPDNEW
RGD ID:7220975
Promoter ID:EPDNEW_H16231
Type:initiation region
Name:CDCA5_3
Description:cell division cycle associated 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16230  EPDNEW_H16233  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,084,174 - 65,084,234EPDNEW
RGD ID:7220973
Promoter ID:EPDNEW_H16233
Type:initiation region
Name:CDCA5_2
Description:cell division cycle associated 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16230  EPDNEW_H16231  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,084,413 - 65,084,473EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_006782.3(ZFPL1):c.214+63C>T single nucleotide variant Malignant melanoma [RCV000069603] Chr11:65085289 [GRCh38]
Chr11:64852761 [GRCh37]
Chr11:64609337 [NCBI36]
Chr11:11q13.1
not provided
NM_006782.3(ZFPL1):c.439C>T (p.Pro147Ser) single nucleotide variant Malignant melanoma [RCV000069604] Chr11:65086750 [GRCh38]
Chr11:64854222 [GRCh37]
Chr11:64610798 [NCBI36]
Chr11:11q13.1
not provided
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_080668.4(CDCA5):c.654G>A (p.Lys218=) single nucleotide variant not provided [RCV000881471] Chr11:65079377 [GRCh38]
Chr11:64846849 [GRCh37]
Chr11:11q13.1
likely benign
NM_080668.4(CDCA5):c.360T>A (p.Pro120=) single nucleotide variant not provided [RCV000903647] Chr11:65079671 [GRCh38]
Chr11:64847143 [GRCh37]
Chr11:11q13.1
benign
NM_080668.4(CDCA5):c.367G>A (p.Glu123Lys) single nucleotide variant not provided [RCV000893617] Chr11:65079664 [GRCh38]
Chr11:64847136 [GRCh37]
Chr11:11q13.1
benign
dup(11)(q13.1q13.1) duplication Ependymoma [RCV000785872] Chr11:63533279..65429676 [GRCh37]
Chr11:11q13.1
likely pathogenic
GRCh37/hg19 11q13.1(chr11:64396501-64883447)x3 copy number gain not provided [RCV000848683] Chr11:64396501..64883447 [GRCh37]
Chr11:11q13.1
uncertain significance
NM_080668.4(CDCA5):c.243+10C>T single nucleotide variant not provided [RCV000886713] Chr11:65083354 [GRCh38]
Chr11:64850826 [GRCh37]
Chr11:11q13.1
likely benign
NM_080668.4(CDCA5):c.519G>A (p.Gly173=) single nucleotide variant not provided [RCV000974100] Chr11:65079512 [GRCh38]
Chr11:64846984 [GRCh37]
Chr11:11q13.1
benign
NM_080668.4(CDCA5):c.535G>A (p.Gly179Arg) single nucleotide variant not provided [RCV000962174] Chr11:65079496 [GRCh38]
Chr11:64846968 [GRCh37]
Chr11:11q13.1
benign
NM_080668.4(CDCA5):c.315A>G (p.Thr105=) single nucleotide variant not provided [RCV000889069] Chr11:65079716 [GRCh38]
Chr11:64847188 [GRCh37]
Chr11:11q13.1
benign
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Epilepsy, familial temporal lobe, 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14626 AgrOrtholog
COSMIC CDCA5 COSMIC
Ensembl Genes ENSG00000146670 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000275517 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385711 UniProtKB/TrEMBL
  ENSP00000431888 UniProtKB/TrEMBL
  ENSP00000432183 UniProtKB/TrEMBL
  ENSP00000432342 UniProtKB/TrEMBL
  ENSP00000432621 UniProtKB/TrEMBL
Ensembl Transcript ENST00000275517 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000404147 UniProtKB/TrEMBL
  ENST00000524733 UniProtKB/TrEMBL
  ENST00000525464 UniProtKB/TrEMBL
  ENST00000527430 UniProtKB/TrEMBL
  ENST00000529290 UniProtKB/TrEMBL
GTEx ENSG00000146670 GTEx
HGNC ID HGNC:14626 ENTREZGENE
Human Proteome Map CDCA5 Human Proteome Map
InterPro Sororin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:113130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 113130 ENTREZGENE
OMIM 609374 OMIM
PANTHER PTHR31092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sororin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26278 PharmGKB
UniProt A0A024R5D6 ENTREZGENE, UniProtKB/TrEMBL
  B5MBX0_HUMAN UniProtKB/TrEMBL
  CDCA5_HUMAN UniProtKB/Swiss-Prot
  H0YCL8_HUMAN UniProtKB/TrEMBL
  H0YCR8_HUMAN UniProtKB/TrEMBL
  H0YCT9_HUMAN UniProtKB/TrEMBL
  H0YCZ9_HUMAN UniProtKB/TrEMBL
  Q96FF9 ENTREZGENE
UniProt Secondary A8K625 UniProtKB/Swiss-Prot