CDCA5 (cell division cycle associated 5) - Rat Genome Database

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Gene: CDCA5 (cell division cycle associated 5) Homo sapiens
Analyze
Symbol: CDCA5
Name: cell division cycle associated 5
RGD ID: 1350338
HGNC Page HGNC:14626
Description: Predicted to enable chromatin binding activity. Involved in chromosome organization; double-strand break repair; and positive regulation of exit from mitosis. Located in nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division cycle-associated protein 5; MGC16386; p35; sororin
RGD Orthologs
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,061,093 - 65,084,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,066,300 - 65,084,164 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,844,925 - 64,851,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,601,503 - 64,608,100 (-)NCBINCBI36Build 36hg18NCBI36
Build 341164,601,502 - 64,608,100NCBI
Celera1162,171,226 - 62,177,913 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,171,560 - 61,178,247 (-)NCBIHuRef
CHM1_11164,728,627 - 64,735,313 (-)NCBICHM1_1
T2T-CHM13v2.01165,054,375 - 65,077,318 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
CDCA5HumanCOVID-19  HEP 28912744mRNA:increased expression:peripheral blood mononuclear cell (human)RGD 
Object Symbol
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Original Reference(s)
CDCA5HumanBardet-Biedl syndrome  IAGPRGD:1517290988554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:12118255|PMID:16786513|PMID:21520335|PMID:27032803|PMID:28492532|PMID:8316268
CDCA5Humanglycogen storage disease V  IAGPRGD:1517290988554872ClinVar Annotator: match by term: Glycogen storage disease, type VClinVarPMID:12118255|PMID:16786513|PMID:21520335|PMID:27032803|PMID:28492532|PMID:8316268
CDCA5Humanintellectual disability  IAGPRGD:427234668554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
CDCA5Humanleukocyte adhesion deficiency 3  IAGPRGD:1564430298554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
Object Symbol
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Original Reference(s)
CDCA5Humanhepatocellular carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560

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Original Reference(s)
CDCA5Human1,1-dichloroethene increases expressionISORGD:16223136480464vinylidene chloride results in increased expression of CDCA5 mRNACTDPMID:26682919
CDCA5Human1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:16223136480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
CDCA5Human1,2-dimethylhydrazine increases expressionISORGD:162231364804641,2-Dimethylhydrazine results in increased expression of CDCA5 mRNACTDPMID:22206623
CDCA5Human17alpha-ethynylestradiol affects expressionISORGD:16223136480464Ethinyl Estradiol affects the expression of CDCA5 mRNACTDPMID:17555576
CDCA5Human17alpha-ethynylestradiol multiple interactionsISORGD:16223136480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDCA5 mRNACTDPMID:17942748
CDCA5Human17alpha-ethynylestradiol increases expressionISORGD:16223136480464Ethinyl Estradiol results in increased expression of CDCA5 mRNACTDPMID:17942748
CDCA5Human17beta-estradiol increases expressionISORGD:16223136480464Estradiol results in increased expression of CDCA5 mRNACTDPMID:25210133
CDCA5Human17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of CDCA5 mRNACTDPMID:19167446|PMID:20106945
CDCA5Human17beta-estradiol multiple interactionsISORGD:16223136480464ESR1 protein promotes the reaction [Estradiol results in increased expression of CDCA5 mRNA]CTDPMID:25210133
CDCA5Human2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISORGD:16223136480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
CDCA5Human2,2',5,5'-tetrachlorobiphenyl multiple interactionsISORGD:16223136480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
CDCA5Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CDCA5 mRNACTDPMID:19684285
CDCA5Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:16223136480464Tetrachlorodibenzodioxin affects the expression of CDCA5 mRNACTDPMID:21570461|PMID:23994337
CDCA5Human2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CDCA5 mRNACTDPMID:22574217
CDCA5Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:16223136480464Tetrachlorodibenzodioxin results in increased expression of CDCA5 mRNACTDPMID:15328365|PMID:16611356|PMID:19684285|PMID:19770486
CDCA5Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CDCA5 mRNACTDPMID:19684285
CDCA5Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:16223136480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDCA5 mRNACTDPMID:17942748
CDCA5Human2,4,4'-trichlorobiphenyl multiple interactionsISORGD:16223136480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
CDCA5Human2-palmitoylglycerol increases expressionEXP 64804642-palmitoylglycerol results in increased expression of CDCA5 mRNACTDPMID:37199045
CDCA5Human3,3',4,4',5-pentachlorobiphenyl affects expressionISORGD:162231364804643,4,5,3',4'-pentachlorobiphenyl affects the expression of CDCA5 mRNACTDPMID:23994337

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Biological Process
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Original Reference(s)
CDCA5Humancell division involved_inIEAUniProtKB-KW:KW-0132150520179 UniProtGO_REF:0000043
CDCA5Humandouble-strand break repair involved_inIMP 150520179 PMID:17349791UniProtPMID:17349791
CDCA5Humandouble-strand break repair involved_inIBAPANTHER:PTN002828026|UniProtKB:Q96FF9150520179 GO_CentralGO_REF:0000033
CDCA5Humanmitotic cell cycle involved_inISORGD:16223139068941 PMID:15837422UniProtPMID:15837422
CDCA5Humanmitotic metaphase chromosome alignment involved_inIBAPANTHER:PTN002828026|UniProtKB:Q96FF9150520179 GO_CentralGO_REF:0000033
CDCA5Humanmitotic sister chromatid cohesion involved_inIPIUniProtKB:Q29RF7150520179 PMID:21111234UniProtPMID:21111234
CDCA5Humanmitotic sister chromatid cohesion involved_inIMP 150520179 PMID:15837422, PMID:17349791, PMID:21111234UniProtPMID:15837422|PMID:17349791|PMID:21111234
CDCA5Humanmitotic sister chromatid cohesion involved_inIBAMGI:1915099|PANTHER:PTN002828026|UniProtKB:A0A8J0V071|UniProtKB:Q96FF9150520179 GO_CentralGO_REF:0000033
CDCA5Humanmitotic sister chromatid cohesion involved_inIEAUniProtKB:Q9CPY3|ensembl:ENSMUSP00000025704150520179 EnsemblGO_REF:0000107
CDCA5Humanpositive regulation of exit from mitosis involved_inIBAPANTHER:PTN002828026|UniProtKB:Q96FF9150520179 GO_CentralGO_REF:0000033
1 to 10 of 10 rows

Cellular Component
1 to 18 of 18 rows

  
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Original Reference(s)
CDCA5Humanchromatin located_inISSUniProtKB:Q9CPY3150520179 UniProtGO_REF:0000024
CDCA5Humanchromatin located_inIEAUniProtKB:Q9CPY3|ensembl:ENSMUSP00000025704150520179 EnsemblGO_REF:0000107
CDCA5Humanchromosome located_inTAS 150520179 ReactomeReactome:R-HSA-2466068|Reactome:R-HSA-2467794|Reactome:R-HSA-2468041|Reactome:R-HSA-2468293
CDCA5Humanchromosome located_inIEAUniProtKB-KW:KW-0158150520179 UniProtGO_REF:0000043
CDCA5Humanchromosome located_inIEAUniProtKB-SubCell:SL-0468150520179 UniProtGO_REF:0000044
CDCA5Humanchromosome, centromeric region located_inTAS 150520179 ReactomeReactome:R-HSA-1638803|Reactome:R-HSA-1638821|Reactome:R-HSA-2467809|Reactome:R-HSA-2467811|Reactome:R-HSA-2468287|Reactome:R-HSA-2473151|Reactome:R-HSA-2484822
CDCA5Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
CDCA5Humancytoplasm located_inIEAUniProtKB:Q9CPY3|ensembl:ENSMUSP00000025704150520179 EnsemblGO_REF:0000107
CDCA5Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
CDCA5Humancytoplasm located_inISSUniProtKB:Q9CPY3150520179 UniProtGO_REF:0000024
CDCA5Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-2467794|Reactome:R-HSA-2467811
CDCA5Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
CDCA5Humannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-2468041|Reactome:R-HSA-2473151
CDCA5Humannucleus located_inIEAUniProtKB:Q9CPY3|ensembl:ENSMUSP00000025704150520179 EnsemblGO_REF:0000107
CDCA5Humannucleus is_active_inIBAMGI:1915099|PANTHER:PTN002828026|UniProtKB:Q96FF9150520179 GO_CentralGO_REF:0000033
CDCA5Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
CDCA5Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
CDCA5Humannucleus located_inISSUniProtKB:Q9CPY3150520179 UniProtGO_REF:0000024
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Molecular Function
1 to 9 of 9 rows

  
Object Symbol
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Original Reference(s)
CDCA5Humanchromatin binding enablesTAS 150520179 PMID:15837422UniProtPMID:15837422
CDCA5Humanprotein binding enablesIPIUniProtKB:P41227|UniProtKB:Q14683150520179 PMID:33961781IntActPMID:33961781
CDCA5Humanprotein binding enablesIPIUniProtKB:P41227|UniProtKB:Q9BSU3150520179 PMID:32296183IntActPMID:32296183
CDCA5Humanprotein binding enablesIPIUniProtKB:Q14683|UniProtKB:Q5FBB7150520179 PMID:23242214IntActPMID:23242214
CDCA5Humanprotein binding enablesIPIUniProtKB:Q29RF7150520179 PMID:21111234IntActPMID:21111234
CDCA5Humanprotein binding enablesIPIUniProtKB:Q29RF7|UniProtKB:Q9NTI5150520179 PMID:21111234UniProtPMID:21111234
CDCA5Humanprotein binding enablesIPIUniProtKB:Q14683|UniProtKB:Q29RF7150520179 PMID:26496610IntActPMID:26496610
CDCA5Humanprotein binding enablesIPIUniProtKB:Q14683150520179 PMID:22885700, PMID:35271311IntActPMID:22885700|PMID:35271311
CDCA5Humanprotein-containing complex binding enablesIDA 150520179 PMID:15837422UniProtPMID:15837422
1 to 9 of 9 rows

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Original Reference(s)
CDCA5HumanEpendymoma  IAGPRGD:146956198554872ClinVar Annotator: match by term: EpendymomaClinVar 
CDCA5HumanIntellectual disability  IAGPRGD:427234668554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
PMID:11111111   PMID:12188893   PMID:12477932   PMID:14702039   PMID:15146197   PMID:15489334   PMID:15837422   PMID:16169070   PMID:16964243   PMID:17081983   PMID:17349791   PMID:17361102  
PMID:18029348   PMID:20360068   PMID:20379614   PMID:20551060   PMID:21111234   PMID:21115494   PMID:21873635   PMID:21987589   PMID:21988832   PMID:22833568   PMID:22885700   PMID:22939629  
PMID:23242214   PMID:23455924   PMID:23548868   PMID:23901111   PMID:24098701   PMID:24999758   PMID:25092791   PMID:25257309   PMID:25281560   PMID:25608232   PMID:26177583   PMID:26186194  
PMID:26496610   PMID:26497678   PMID:26895426   PMID:26951638   PMID:28514442   PMID:29117863   PMID:29326043   PMID:29383807   PMID:29452217   PMID:29724914   PMID:30015982   PMID:30497429  
PMID:30657957   PMID:30804502   PMID:31010829   PMID:31068217   PMID:31180492   PMID:31586073   PMID:32203420   PMID:32296183   PMID:32694239   PMID:32759885   PMID:33639053   PMID:33650660  
PMID:33770322   PMID:33961781   PMID:34077004   PMID:34079125   PMID:34189442   PMID:34509929   PMID:34597346   PMID:35271311   PMID:35373420   PMID:35506437   PMID:35509067   PMID:35642672  
PMID:35973513   PMID:36004470   PMID:36373674   PMID:36424410   PMID:37247719   PMID:37689310   PMID:38539247   PMID:38978058  



CDCA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,061,093 - 65,084,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,066,300 - 65,084,164 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,844,925 - 64,851,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,601,503 - 64,608,100 (-)NCBINCBI36Build 36hg18NCBI36
Build 341164,601,502 - 64,608,100NCBI
Celera1162,171,226 - 62,177,913 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,171,560 - 61,178,247 (-)NCBIHuRef
CHM1_11164,728,627 - 64,735,313 (-)NCBICHM1_1
T2T-CHM13v2.01165,054,375 - 65,077,318 (-)NCBIT2T-CHM13v2.0
Cdca5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,135,127 - 6,141,803 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,135,013 - 6,141,807 (+)EnsemblGRCm39 Ensembl
GRCm38196,085,097 - 6,091,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,084,983 - 6,091,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,085,097 - 6,091,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36196,085,097 - 6,091,773 (+)NCBIMGSCv36mm8
Celera195,957,560 - 5,964,236 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Cdca5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,807,863 - 212,821,313 (+)NCBIGRCr8
mRatBN7.21203,378,550 - 203,392,027 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,378,577 - 203,392,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,731,627 - 211,745,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,823,942 - 218,837,392 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,515,011 - 211,528,461 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,448,661 - 221,462,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,448,661 - 221,462,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,384,097 - 228,394,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41210,247,351 - 210,247,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1200,912,264 - 200,925,714 (+)NCBICelera
Cytogenetic Map1q43NCBI
Cdca5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542220,114,565 - 20,129,679 (+)NCBIChiLan1.0ChiLan1.0
CDCA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,115,081 - 52,129,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,115,203 - 52,120,817 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,723,160 - 50,736,970 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,156,720 - 53,170,506 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11852,251,940 - 52,258,937 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,825,978 - 51,839,752 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,620,789 - 52,634,766 (+)NCBIUU_Cfam_GSD_1.0
Cdca5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,842,550 - 7,856,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,284,958 - 4,291,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,285,007 - 4,291,875 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDCA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,103,673 - 7,113,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,103,648 - 7,112,772 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,235,704 - 6,251,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDCA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,151,503 - 9,157,412 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,151,712 - 9,157,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038106,533,173 - 106,538,620 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdca5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476721,321,286 - 21,327,780 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in CDCA5
21 total Variants

1 to 10 of 36 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_006782.3(ZFPL1):c.214+63C>T single nucleotide variant Malignant melanoma [RCV000069603] Chr11:65085289 [GRCh38]
Chr11:64852761 [GRCh37]
Chr11:64609337 [NCBI36]
Chr11:11q13.1
not provided
NM_006782.3(ZFPL1):c.439C>T (p.Pro147Ser) single nucleotide variant Malignant melanoma [RCV000069604] Chr11:65086750 [GRCh38]
Chr11:64854222 [GRCh37]
Chr11:64610798 [NCBI36]
Chr11:11q13.1
not provided
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_080668.4(CDCA5):c.667C>T (p.Pro223Ser) single nucleotide variant not specified [RCV004320221] Chr11:65079364 [GRCh38]
Chr11:64846836 [GRCh37]
Chr11:11q13.1
uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_080668.4(CDCA5):c.654G>A (p.Lys218=) single nucleotide variant not provided [RCV000881471] Chr11:65079377 [GRCh38]
Chr11:64846849 [GRCh37]
Chr11:11q13.1
likely benign
NM_080668.4(CDCA5):c.360T>A (p.Pro120=) single nucleotide variant not provided [RCV000903647] Chr11:65079671 [GRCh38]
Chr11:64847143 [GRCh37]
Chr11:11q13.1
benign
1 to 10 of 36 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR331hsa-miR-331-3pMirecordsexternal_info{changed}NA19996289

Predicted Target Of
Summary Value
Count of predictions:4239
Count of miRNA genes:1125
Interacting mature miRNAs:1403
Transcripts:ENST00000275517, ENST00000404147, ENST00000438878, ENST00000462902, ENST00000479032, ENST00000524733, ENST00000525464, ENST00000527430, ENST00000529290, ENST00000531401, ENST00000533015
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357380BW64_HBody weight QTL 64 (human)2.2Body weightpercent fat after exercise training116097893786978937Human
597368344GWAS1464418_Hmetabolic syndrome QTL GWAS1464418 (human)5e-10metabolic syndrome116506137065061371Human
597517131GWAS1613205_Hurate measurement QTL GWAS1613205 (human)5e-21urate measurementblood uric acid level (CMO:0000501)116507136165071362Human
597381027GWAS1477101_HRed cell distribution width QTL GWAS1477101 (human)4e-08Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)116507678765076788Human
597383617GWAS1479691_Hcardiovascular disease QTL GWAS1479691 (human)5e-08cardiovascular disease116506794365067944Human
596957817GWAS1077336_HRed cell distribution width QTL GWAS1077336 (human)4e-08Red cell distribution width116507678765076788Human
407382134GWAS1031110_Hobsolete_red blood cell distribution width QTL GWAS1031110 (human)4e-08obsolete_red blood cell distribution width116507678765076788Human
597486723GWAS1582797_Hgut microbiome measurement QTL GWAS1582797 (human)3e-08gut microbiome measurement116506581965065820Human

A002B21  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,845,024 - 64,845,130UniSTSGRCh37
Build 361164,601,600 - 64,601,706RGDNCBI36
Celera1162,171,323 - 62,171,429RGD
Cytogenetic Map11q12.1UniSTS
HuRef1161,171,657 - 61,171,763UniSTS
GeneMap99-GB4 RH Map11237.91UniSTS
NCBI RH Map11573.2UniSTS
WI-21617  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,844,931 - 64,845,193UniSTSGRCh37
Build 361164,601,507 - 64,601,769RGDNCBI36
Celera1162,171,230 - 62,171,492RGD
Cytogenetic Map11q12.1UniSTS
HuRef1161,171,564 - 61,171,826UniSTS
GeneMap99-GB4 RH Map11238.01UniSTS
Whitehead-RH Map11316.9UniSTS
NCBI RH Map11573.2UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4947 1723 2345 4 622 1947 464 2268 7278 6452 52 3713 846 1732 1612 171


1 to 29 of 29 rows
RefSeq Transcripts NM_001433518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005273733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005273734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB231703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN332525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 29 of 29 rows

Ensembl Acc Id: ENST00000275517   ⟹   ENSP00000275517
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,077,453 - 65,084,040 (-)Ensembl
Ensembl Acc Id: ENST00000404147   ⟹   ENSP00000385711
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,079,088 - 65,084,047 (-)Ensembl
Ensembl Acc Id: ENST00000462902
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,083,250 - 65,083,896 (-)Ensembl
Ensembl Acc Id: ENST00000479032
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,079,132 - 65,084,039 (-)Ensembl
Ensembl Acc Id: ENST00000524733   ⟹   ENSP00000431888
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,078,633 - 65,083,531 (-)Ensembl
Ensembl Acc Id: ENST00000525464   ⟹   ENSP00000432342
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,066,365 - 65,079,415 (-)Ensembl
Ensembl Acc Id: ENST00000527430   ⟹   ENSP00000432621
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,079,166 - 65,083,977 (-)Ensembl
Ensembl Acc Id: ENST00000529290   ⟹   ENSP00000432183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,066,300 - 65,079,389 (-)Ensembl
Ensembl Acc Id: ENST00000531401
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,079,141 - 65,084,164 (-)Ensembl
Ensembl Acc Id: ENST00000533015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,068,044 - 65,083,900 (-)Ensembl
RefSeq Acc Id: NM_080668   ⟹   NP_542399
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,077,453 - 65,084,040 (-)NCBI
GRCh371164,833,772 - 64,851,635 (-)NCBI
Build 361164,601,503 - 64,608,100 (-)NCBI Archive
Celera1162,171,226 - 62,177,913 (-)RGD
HuRef1161,171,560 - 61,178,247 (-)ENTREZGENE
CHM1_11164,728,627 - 64,735,313 (-)NCBI
T2T-CHM13v2.01165,070,734 - 65,077,318 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005273733   ⟹   XP_005273790
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,300 - 65,084,040 (-)NCBI
GRCh371164,833,772 - 64,851,635 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005273734   ⟹   XP_005273791
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,300 - 65,084,040 (-)NCBI
GRCh371164,833,772 - 64,851,635 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544743   ⟹   XP_011543045
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,061,093 - 65,084,040 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544747   ⟹   XP_011543049
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,300 - 65,084,040 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544748   ⟹   XP_011543050
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,067,661 - 65,084,040 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544749   ⟹   XP_011543051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,066,572 - 65,084,040 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017158   ⟹   XP_016872647
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,065,035 - 65,084,040 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054367584   ⟹   XP_054223559
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,059,580 - 65,077,318 (-)NCBI
RefSeq Acc Id: XM_054367585   ⟹   XP_054223560
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,059,581 - 65,077,318 (-)NCBI
RefSeq Acc Id: XM_054367586   ⟹   XP_054223561
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,054,375 - 65,077,318 (-)NCBI
RefSeq Acc Id: XM_054367587   ⟹   XP_054223562
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,058,315 - 65,077,318 (-)NCBI
RefSeq Acc Id: XM_054367588   ⟹   XP_054223563
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,059,506 - 65,077,318 (-)NCBI
RefSeq Acc Id: XM_054367589   ⟹   XP_054223564
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,060,941 - 65,077,318 (-)NCBI
RefSeq Acc Id: XM_054367590   ⟹   XP_054223565
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,059,852 - 65,077,318 (-)NCBI
RefSeq Acc Id: XR_001747757
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,062,702 - 65,084,040 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001747758
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,062,702 - 65,084,040 (-)NCBI
Sequence:
RefSeq Acc Id: XR_008488336
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,055,983 - 65,077,318 (-)NCBI
RefSeq Acc Id: XR_008488337
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01165,055,983 - 65,077,318 (-)NCBI
1 to 5 of 21 rows
1 to 5 of 21 rows
RefSeq Acc Id: NP_542399   ⟸   NM_080668
- UniProtKB: Q96FF9 (UniProtKB/Swiss-Prot),   A8K625 (UniProtKB/Swiss-Prot),   B5MBX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005273790   ⟸   XM_005273733
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005273791   ⟸   XM_005273734
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011543045   ⟸   XM_011544743
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011543049   ⟸   XM_011544747
- Peptide Label: isoform X5
- Sequence:

Name Modeler Protein Id AA Range Protein Structure
AF-Q96FF9-F1-model_v2 AlphaFold Q96FF9 1-252 view protein structure

RGD ID:6788618
Promoter ID:HG_KWN:13299
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000404147,   NM_006782,   OTTHUMT00000318028,   OTTHUMT00000318029,   OTTHUMT00000318030,   UC009YQA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361164,607,421 - 64,608,312 (-)MPROMDB
RGD ID:7220969
Promoter ID:EPDNEW_H16230
Type:initiation region
Name:CDCA5_1
Description:cell division cycle associated 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16233  EPDNEW_H16231  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,084,040 - 65,084,100EPDNEW
RGD ID:7220975
Promoter ID:EPDNEW_H16231
Type:initiation region
Name:CDCA5_3
Description:cell division cycle associated 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16230  EPDNEW_H16233  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,084,174 - 65,084,234EPDNEW
RGD ID:7220973
Promoter ID:EPDNEW_H16233
Type:initiation region
Name:CDCA5_2
Description:cell division cycle associated 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16230  EPDNEW_H16231  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,084,413 - 65,084,473EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
COSMIC CDCA5 COSMIC
Ensembl Genes ENSG00000146670 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000275517 ENTREZGENE
  ENST00000275517.8 UniProtKB/Swiss-Prot
GTEx ENSG00000146670 GTEx
HGNC ID HGNC:14626 ENTREZGENE
Human Proteome Map CDCA5 Human Proteome Map
InterPro Sororin UniProtKB/Swiss-Prot
KEGG Report hsa:113130 UniProtKB/Swiss-Prot
NCBI Gene CDCA5 ENTREZGENE
OMIM 609374 OMIM
PANTHER PTHR31092 UniProtKB/Swiss-Prot
  SORORIN UniProtKB/Swiss-Prot
Pfam Sororin UniProtKB/Swiss-Prot
PharmGKB PA26278 PharmGKB
UniProt A8K625 ENTREZGENE
  B5MBX0 ENTREZGENE, UniProtKB/TrEMBL
  CDCA5_HUMAN UniProtKB/Swiss-Prot
  H0YCL8_HUMAN UniProtKB/TrEMBL
  H0YCR8_HUMAN UniProtKB/TrEMBL
  H0YCT9_HUMAN UniProtKB/TrEMBL
  H0YCZ9_HUMAN UniProtKB/TrEMBL
  Q96FF9 ENTREZGENE
UniProt Secondary A8K625 UniProtKB/Swiss-Prot
1 to 24 of 24 rows