MIR331 (microRNA 331) - Rat Genome Database
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Gene: MIR331 (microRNA 331) Homo sapiens
Analyze
Symbol: MIR331
Name: microRNA 331
RGD ID: 1349160
HGNC Page HGNC
Description: Predicted to be involved in several processes, including cellular response to cytokine stimulus; cellular response to forskolin; and sensory perception of sound. Predicted to localize to RISC complex.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-331; mir-331; MIRN331
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1295,308,420 - 95,308,513 (+)EnsemblGRCh38hg38GRCh38
GRCh381295,308,420 - 95,308,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371295,702,196 - 95,702,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,226,326 - 94,226,419 (+)NCBINCBI36hg18NCBI36
Celera1295,373,089 - 95,373,182 (+)NCBI
Cytogenetic Map12q22NCBI
HuRef1292,770,486 - 92,770,579 (+)NCBIHuRef
CHM1_11295,667,647 - 95,667,740 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15634332   PMID:16381832   PMID:17604727   PMID:17616659   PMID:19584056   PMID:20510161   PMID:20889907   PMID:21037258   PMID:21971048   PMID:23817697   PMID:24775712  
PMID:24825302   PMID:25750939   PMID:25903466   PMID:26002934   PMID:26259043   PMID:26497554   PMID:26646931   PMID:26718987   PMID:28641313   PMID:29367276   PMID:29850766   PMID:30029881  
PMID:30063890   PMID:30228315   PMID:30657584   PMID:31077182   PMID:31785262   PMID:31984860   PMID:32174262   PMID:32246100  


Genomics

Comparative Map Data
MIR331
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1295,308,420 - 95,308,513 (+)EnsemblGRCh38hg38GRCh38
GRCh381295,308,420 - 95,308,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371295,702,196 - 95,702,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,226,326 - 94,226,419 (+)NCBINCBI36hg18NCBI36
Celera1295,373,089 - 95,373,182 (+)NCBI
Cytogenetic Map12q22NCBI
HuRef1292,770,486 - 92,770,579 (+)NCBIHuRef
CHM1_11295,667,647 - 95,667,740 (+)NCBICHM1_1
Mir331
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,799,630 - 93,799,725 (-)NCBIGRCm39mm39
GRCm381093,963,768 - 93,963,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,963,768 - 93,963,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv371093,426,513 - 93,426,608 (-)NCBIGRCm37mm9NCBIm37
Celera1095,937,941 - 95,938,036 (-)NCBICelera
Cytogenetic Map10C2NCBI
Mir331
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0734,881,095 - 34,881,190 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,881,095 - 34,881,190 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,938,750 - 34,938,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera725,620,869 - 25,620,964 (-)NCBICelera
Cytogenetic Map7q13NCBI
MIR331
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1535,234,740 - 35,234,850 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11535,234,750 - 35,234,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR331
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl588,028,339 - 88,028,418 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1588,028,339 - 88,028,418 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2592,224,978 - 92,225,057 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
FHIThsa-miR-331-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21711110
ERBB2hsa-miR-331-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
E2F1hsa-miR-331-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20510161
DOHHhsa-miR-331-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22908221
DYNC2I1hsa-miR-331-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
ZC3H4hsa-miR-331-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
DCLRE1Bhsa-miR-331-3pTarbaseexternal_infoSequencingPOSITIVE
ERBB2hsa-miR-331-3pMirecordsexternal_info{changed}NA19584056
DOHHhsa-miR-331-3pOncomiRDBexternal_infoNANA22908221
ERBB2hsa-miR-331-3pOncomiRDBexternal_infoNANA20931396
E2F1hsa-miR-331-3pOncomiRDBexternal_infoNANA20510161
ERBB2hsa-miR-331-3pOncomiRDBexternal_infoNANA19584056
PKIGhsa-miR-331-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CDCA5hsa-miR-331-3pMirecordsexternal_info{changed}NA19996289

Predicted Targets
Summary Value
Count of predictions:45051
Count of gene targets:16898
Count of transcripts:38902
Interacting mature miRNAs:hsa-miR-331-3p, hsa-miR-331-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 11 13 6 98 6 8 15 28 13 41 77 3
Low 223 78 248 136 418 138 349 93 180 201 219 333 7 15 75 4
Below cutoff 137 66 79 16 24 10 187 168 144 19 41 61 6 46 144

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000362302
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1295,308,420 - 95,308,513 (+)Ensembl
RefSeq Acc Id: NR_029895
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381295,308,420 - 95,308,513 (+)NCBI
GRCh371295,702,196 - 95,702,289 (+)RGD
Celera1295,373,089 - 95,373,182 (+)RGD
HuRef1292,770,486 - 92,770,579 (+)ENTREZGENE
CHM1_11295,667,647 - 95,667,740 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31772 AgrOrtholog
COSMIC MIR331 COSMIC
Ensembl Genes ENSG00000199172 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362302 ENTREZGENE
GTEx ENSG00000199172 GTEx
HGNC ID HGNC:31772 ENTREZGENE
Human Proteome Map MIR331 Human Proteome Map
miRBase MI0000812 ENTREZGENE
NCBI Gene 442903 ENTREZGENE
PharmGKB PA164722664 PharmGKB
RNAcentral URS00001597DC RNACentral
  URS00003DDE27 RNACentral
  URS0000642F53 RNACentral