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Gene: RNASEL (ribonuclease L) Homo sapiens
Symbol: RNASEL
Name: ribonuclease L
Description: Exhibits RNA binding activity and identical protein binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytosol and mitochondrial matrix. Implicated in Lynch syndrome and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNase; DKFZp781D08126; hereditary prostate cancer 1; HPC1; interferon-induced 2-5A-dependent RNase; MGC104972; MGC133329; PRCA1; prostate cancer 1; ribonuclease 4; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L; RNS4
Mus musculus (house mouse) : Rnasel (ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent))  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnasel (ribonuclease L)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnasel (ribonuclease L)
Pan paniscus (bonobo/pygmy chimpanzee) : RNASEL (ribonuclease L)
Canis lupus familiaris (dog) : RNASEL (ribonuclease L)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnasel (ribonuclease L)
Sus scrofa (pig) : RNASEL (ribonuclease L)
Chlorocebus sabaeus (African green monkey) : RNASEL (ribonuclease L)
Heterocephalus glaber (naked mole-rat) : Rnasel (ribonuclease L)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1182,573,634 - 182,589,256 (-)EnsemblGRCh38hg38GRCh38
GRCh381182,573,634 - 182,589,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371182,542,769 - 182,558,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361180,809,395 - 180,822,731 (-)NCBINCBI36hg18NCBI36
Build 341179,274,428 - 179,287,765NCBI
Celera1155,654,005 - 155,667,341 (-)NCBI
Cytogenetic Map1q25.3NCBI
HuRef1153,779,235 - 153,794,860 (-)NCBIHuRef
CHM1_11183,966,207 - 183,981,832 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RNASEL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346643
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.