RGD Reference Report - Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection. - Rat Genome Database

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Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.

Authors: Li, Sam X  Barrett, Bradley S  Harper, Michael S  Heilman, Karl J  Halemano, Kalani  Steele, Amanda K  Guo, Kejun  Silverman, Robert H  Santiago, Mario L 
Citation: Li SX, etal., Virology. 2013 Aug 15;443(1):134-42. doi: 10.1016/j.virol.2013.05.009. Epub 2013 May 29.
RGD ID: 40902617
Pubmed: PMID:23725696   (View Abstract at PubMed)
PMCID: PMC3866974   (View Article at PubMed Central)
DOI: DOI:10.1016/j.virol.2013.05.009   (Journal Full-text)

Ribonuclease L (RNase L) is a type I interferon regulated factor that can significantly inhibit retroviruses in vitro and may activate cytoplasmic sensing pathways to augment adaptive immunity. However, the antiretroviral activity of RNase L remains to be validated in vivo. We investigated the role of RNaseL in counteracting Friend retrovirus (FV) infection relative to a well-described restriction factor, Apobec3. C57BL/6 wild-type (WT) and RNaseL knock-out (KO) mice exhibited similar acute FV infection levels despite significant transcriptional induction of oligoadenylate synthetase 1, which produces activators of RNase L. Apobec3 KO mice showed higher FV infection levels relative to WT mice, but deletion of RNaseL in Apobec3 KO mice did not augment FV infection. Moreover, RNaseL did not influence FV-specific IgG responses and recovery from viremia by 28 days post-infection. The results suggest that RNase L is not an evolutionarily-conserved host defense mechanism to counteract retroviruses in vivo.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APOBEC3HHumanMurine Acquired Immunodeficiency Syndrome disease_progressionISOApobec3 (Mus musculus)associated with Arterivirus InfectionsRGD 
Apobec3RatMurine Acquired Immunodeficiency Syndrome disease_progressionISOApobec3 (Mus musculus)associated with Arterivirus InfectionsRGD 
Apobec3MouseMurine Acquired Immunodeficiency Syndrome disease_progressionIMP associated with Arterivirus InfectionsRGD 
RNASELHumanMurine Acquired Immunodeficiency Syndrome  ISORnasel (Mus musculus)associated with Arterivirus InfectionsRGD 
RnaselRatMurine Acquired Immunodeficiency Syndrome  ISORnasel (Mus musculus)associated with Arterivirus InfectionsRGD 
RnaselMouseMurine Acquired Immunodeficiency Syndrome  IMP associated with Arterivirus InfectionsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apobec3  (apolipoprotein B mRNA editing enzyme catalytic subunit 3)
Rnasel  (ribonuclease L)

Genes (Mus musculus)
Apobec3  (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3)
Rnasel  (ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent))

Genes (Homo sapiens)
APOBEC3H  (apolipoprotein B mRNA editing enzyme catalytic subunit 3H)
RNASEL  (ribonuclease L)


Additional Information