Rnasel (ribonuclease L) - Rat Genome Database

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Gene: Rnasel (ribonuclease L) Chinchilla lanigera
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Symbol: Rnasel
Name: ribonuclease L
RGD ID: 8910622
Description: ENCODES a protein that exhibits identical protein binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); negative regulation of viral genome replication (ortholog); positive regulation of D-glucose import (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); Animal Viral Hepatitis (ortholog); anthrax disease (ortholog); FOUND IN nuclear matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 2-5A-dependent ribonuclease; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,411,980 - 21,425,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540621,413,950 - 21,424,860 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rnasel
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,411,980 - 21,425,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540621,413,950 - 21,424,860 (-)NCBIChiLan1.0ChiLan1.0
RNASEL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,573,634 - 182,589,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,573,634 - 182,589,256 (-)EnsemblGRCh38hg38GRCh38
GRCh371182,542,769 - 182,558,391 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361180,809,395 - 180,822,731 (-)NCBINCBI36Build 36hg18NCBI36
Build 341179,274,428 - 179,287,765NCBI
Celera1155,654,005 - 155,667,341 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1153,779,235 - 153,794,860 (-)NCBIHuRef
CHM1_11183,966,207 - 183,981,832 (-)NCBICHM1_1
T2T-CHM13v2.01181,933,110 - 181,948,734 (-)NCBIT2T-CHM13v2.0
Rnasel
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,625,089 - 153,644,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,625,172 - 153,639,967 (+)EnsemblGRCm39 Ensembl
GRCm381153,749,344 - 153,768,690 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,749,426 - 153,764,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv371155,596,556 - 155,611,351 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,515,149 - 155,524,559 (+)NCBIMGSCv36mm8
Celera1156,181,252 - 156,196,205 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.43NCBI
Rnasel
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,446,641 - 68,460,804 (+)NCBIGRCr8
mRatBN7.21365,894,990 - 65,910,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,901,459 - 65,908,704 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1368,502,520 - 68,509,768 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,792,702 - 69,799,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01367,049,541 - 67,056,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,188,712 - 71,202,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,192,142 - 71,202,625 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01376,153,998 - 76,167,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41368,822,013 - 68,829,264 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11368,836,092 - 68,843,336 (+)NCBI
Celera1365,801,918 - 65,809,169 (+)NCBICelera
Cytogenetic Map13q21NCBI
RNASEL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2167,139,920 - 67,155,657 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,823,513 - 66,839,195 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,092,346 - 158,108,026 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,744,169 - 161,759,741 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,741,645 - 161,760,045 (-)Ensemblpanpan1.1panPan2
RNASEL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1715,978,055 - 16,001,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl715,856,151 - 16,001,569 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha715,566,511 - 15,588,072 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0715,706,990 - 15,731,063 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl715,584,822 - 15,731,112 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1715,621,143 - 15,642,651 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0715,729,189 - 15,750,983 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0715,858,335 - 15,880,030 (-)NCBIUU_Cfam_GSD_1.0
Rnasel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,316,525 - 89,330,595 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364817,165,353 - 7,177,538 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364817,165,400 - 7,177,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASEL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9123,893,294 - 123,910,398 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19123,895,045 - 123,910,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29136,210,085 - 136,224,410 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RNASEL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,779,221 - 46,795,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,779,700 - 46,795,842 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,997,591 - 48,013,734 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnasel
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481411,268,698 - 11,305,221 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481411,268,725 - 11,319,023 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000017559   ⟹   ENSCLAP00000017389
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540621,411,980 - 21,425,052 (-)Ensembl
RefSeq Acc Id: XM_005375004   ⟹   XP_005375061
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540621,413,950 - 21,424,860 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005375061 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017389
  ENSCLAP00000017389.1
RefSeq Acc Id: XP_005375061   ⟸   XM_005375004
- UniProtKB: A0A8C2VLE7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000017389   ⟸   ENSCLAT00000017559
Protein Domains
KEN   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011944 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017559 ENTREZGENE
  ENSCLAT00000017559.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.180 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  KEN_dom UniProtKB/TrEMBL
  KEN_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  RNase-L_RNase UniProtKB/TrEMBL
NCBI Gene Rnasel ENTREZGENE
PANTHER 2-5A-DEPENDENT RIBONUCLEASE UniProtKB/TrEMBL
  2-5A-DEPENDENT RIBONUCLEASE UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Ribonuc_2-5A UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  KEN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  PUG UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VLE7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Rnasel  ribonuclease L    ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)  Symbol and/or name change 5135510 APPROVED