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Gene: PRMT5 (protein arginine methyltransferase 5) Homo sapiens

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Symbol:

PRMT5

Name:

protein arginine methyltransferase 5

RGD ID:

1319178

HGNC Page

HGNC:10894

Description:

Enables several functions, including methyl-CpG binding activity; p53 binding activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including Golgi ribbon formation; RNA metabolic process; and positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway. Acts upstream of or within peptidyl-arginine N-methylation. Located in several cellular components, including Golgi apparatus; chromatin; and nucleoplasm. Part of histone methyltransferase complex and methylosome. Biomarker of Leydig cell tumor and seminoma.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

72 kDa ICln-binding protein; histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; HMT1 hnRNP methyltransferase-like 5 (S. cerevisiae); HRMT1L5; HSL7; IBP72; jak-binding protein 1; JBP1; protein arginine N-methyltransferase 5; shk1 kinase-binding protein 1 homolog; SKB1; SKB1 homolog; skb1 homolog (s. pombe); SKB1Hs

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Prmt5 (protein arginine N-methyltransferase 5)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Prmt5 (protein arginine methyltransferase 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Prmt5 (protein arginine methyltransferase 5)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	PRMT5 (protein arginine methyltransferase 5)	NCBI	Ortholog
Canis lupus familiaris (dog):	PRMT5 (protein arginine methyltransferase 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prmt5 (protein arginine methyltransferase 5)	NCBI	Ortholog
Sus scrofa (pig):	PRMT5 (protein arginine methyltransferase 5)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	PRMT5 (protein arginine methyltransferase 5)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Prmt5 (protein arginine methyltransferase 5)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Zfp474 (zinc finger protein 474)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Prmt5 (protein arginine methyltransferase 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prmt5 (protein arginine N-methyltransferase 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prmt5 (protein arginine methyltransferase 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	HSL7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	csul	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	prmt-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prmt5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	prmt5.L	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	prmt5.S	Alliance	DIOPT (Xenbase)

Related Pseudogenes:

PRMT5P1

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	22,920,525 - 22,929,408 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	23,389,738 - 23,398,585 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	22,459,573 - 22,468,501 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	22,459,578 - 22,468,501	NCBI
Celera	14	3,252,630 - 3,261,553 (-)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	3,506,765 - 3,515,687 (-)	NCBI		HuRef
CHM1_1	14	23,388,351 - 23,397,277 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	asthma		ISO	Prmt5 (Rattus norvegicus)	9491823	mRNA:increased expression:lung and spleen	RGD
PRMT5	Human	Leydig cell tumor		IEP		2299953	protein:altered localization	RGD
PRMT5	Human	seminoma		IEP		2299953	protein:altered localization	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	Brain-Lung-Thyroid Syndrome		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Brain-lung-thyroid syndrome	ClinVar	PMID:25741868
PRMT5	Human	lysinuric protein intolerance		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Lysinuric protein intolerance	ClinVar	PMID:28492532
PRMT5	Human	Specific Granule Deficiency		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Specific granule deficiency	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	diffuse large B-cell lymphoma		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:31123343
PRMT5	Human	medulloblastoma		EXP		11554173	CTD Direct Evidence: therapeutic	CTD	PMID:31694585
PRMT5	Human	multiple myeloma		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29158558
PRMT5	Human	Triple Negative Breast Neoplasms		EXP		11554173	CTD Direct Evidence: therapeutic	CTD	PMID:30957988

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	idiopathic scoliosis		ISS	Prmt5 (Mus musculus)	13592920		MouseDO

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	(1->4)-beta-D-glucan	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRMT5 mRNA	CTD	PMID:36331819
PRMT5	Human	1,2-dimethylhydrazine	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PRMT5 mRNA]	CTD	PMID:22206623
PRMT5	Human	1,2-dimethylhydrazine	increases expression	ISO	Prmt5 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in increased expression of PRMT5 mRNA	CTD	PMID:22206623
PRMT5	Human	2,2',4,4'-Tetrabromodiphenyl ether	affects expression	ISO	Prmt5 (Mus musculus)	6480464	2 more ...	CTD	PMID:30294300
PRMT5	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Prmt5 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of PRMT5 mRNA	CTD	PMID:21570461
PRMT5	Human	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in increased expression of PRMT5 mRNA	CTD	PMID:33387578
PRMT5	Human	2,4,6-tribromophenol	increases expression	EXP		6480464	2 more ...	CTD	PMID:31675489
PRMT5	Human	2,4-dinitrotoluene	affects expression	ISO	Prmt5 (Rattus norvegicus)	6480464	2 and 4-dinitrotoluene affects the expression of PRMT5 mRNA	CTD	PMID:21346803
PRMT5	Human	2,6-dimethoxyphenol	multiple interactions	EXP		6480464	[Furaldehyde co-treated with pyrogallol 1 more ...	CTD	PMID:38598786
PRMT5	Human	2,6-dinitrotoluene	affects expression	ISO	Prmt5 (Rattus norvegicus)	6480464	2 and 6-dinitrotoluene affects the expression of PRMT5 mRNA	CTD	PMID:21346803
PRMT5	Human	2-hydroxypropanoic acid	decreases expression	EXP		6480464	Lactic Acid results in decreased expression of PRMT5 mRNA	CTD	PMID:30851411
PRMT5	Human	2-methylcholine	affects expression	EXP		6480464	beta-methylcholine affects the expression of PRMT5 mRNA	CTD	PMID:21179406
PRMT5	Human	3,4-methylenedioxymethamphetamine	increases expression	ISO	Prmt5 (Mus musculus)	6480464	N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PRMT5 mRNA	CTD	PMID:20188158
PRMT5	Human	4,4'-diaminodiphenylmethane	increases expression	ISO	Prmt5 (Mus musculus)	6480464	4 and 4'-diaminodiphenylmethane results in increased expression of PRMT5 mRNA	CTD	PMID:18648102
PRMT5	Human	4-amino-2,6-dinitrotoluene	affects expression	ISO	Prmt5 (Rattus norvegicus)	6480464	4-amino-2 and 6-dinitrotoluene affects the expression of PRMT5 mRNA	CTD	PMID:21346803
PRMT5	Human	acrolein	multiple interactions	EXP		6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PRMT5 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PRMT5 mRNA	CTD	PMID:32699268
PRMT5	Human	acrylamide	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	Acrylamide results in increased expression of PRMT5 mRNA	CTD	PMID:28959563
PRMT5	Human	actinomycin D	multiple interactions	EXP		6480464	[Dactinomycin co-treated with nutlin 3] results in increased secretion of PRMT5 protein	CTD	PMID:38460933
PRMT5	Human	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of PRMT5 mRNA and Aflatoxin B1 results in increased expression of PRMT5 protein	CTD	PMID:27242039
PRMT5	Human	aflatoxin B1	decreases methylation	EXP		6480464	Aflatoxin B1 results in decreased methylation of PRMT5 gene	CTD	PMID:27153756
PRMT5	Human	all-trans-retinoic acid	decreases expression	EXP		6480464	Tretinoin results in decreased expression of PRMT5 mRNA	CTD	PMID:33167477
PRMT5	Human	alpha-pinene	multiple interactions	EXP		6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PRMT5 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PRMT5 mRNA	CTD	PMID:32699268
PRMT5	Human	aristolochic acid A	increases expression	EXP		6480464	aristolochic acid I results in increased expression of PRMT5 mRNA	CTD	PMID:33212167
PRMT5	Human	Aroclor 1254	increases expression	EXP		6480464	Chlorodiphenyl (54% Chlorine) results in increased expression of PRMT5 mRNA	CTD	PMID:16934159
PRMT5	Human	arsenite(3-)	decreases expression	ISO	Prmt5 (Mus musculus)	6480464	arsenite results in decreased expression of PRMT5 protein	CTD	PMID:37955338
PRMT5	Human	arsenous acid	multiple interactions	EXP		6480464	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PRMT5 protein]	CTD	PMID:26598702
PRMT5	Human	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of PRMT5 protein	CTD	PMID:33278487
PRMT5	Human	berberine	increases expression	EXP		6480464	Berberine results in increased expression of PRMT5 mRNA	CTD	PMID:27311644
PRMT5	Human	bisphenol A	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	bisphenol A results in increased expression of PRMT5 mRNA	CTD	PMID:25181051
PRMT5	Human	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of PRMT5 protein	CTD	PMID:31675489 and PMID:34186270
PRMT5	Human	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of PRMT5 mRNA	CTD	PMID:30903817
PRMT5	Human	bisphenol A	decreases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of PRMT5 mRNA	CTD	PMID:30816183 and PMID:32528016
PRMT5	Human	bisphenol A	increases methylation	ISO	Prmt5 (Rattus norvegicus)	6480464	bisphenol A results in increased methylation of PRMT5 gene	CTD	PMID:28505145
PRMT5	Human	bisphenol AF	increases expression	EXP		6480464	bisphenol AF results in increased expression of PRMT5 protein	CTD	PMID:34186270
PRMT5	Human	bisphenol F	increases expression	EXP		6480464	bisphenol F results in increased expression of PRMT5 protein	CTD	PMID:34186270
PRMT5	Human	carbamazepine	affects expression	EXP		6480464	Carbamazepine affects the expression of PRMT5 mRNA	CTD	PMID:25979313
PRMT5	Human	CGP 52608	multiple interactions	EXP		6480464	CGP 52608 promotes the reaction [RORA protein binds to PRMT5 gene]	CTD	PMID:28238834
PRMT5	Human	choline	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRMT5 gene	CTD	PMID:20938992
PRMT5	Human	chromium(6+)	affects expression	ISO	Prmt5 (Mus musculus)	6480464	chromium hexavalent ion affects the expression of PRMT5 mRNA	CTD	PMID:28472532
PRMT5	Human	clofibric acid	multiple interactions	ISO	Prmt5 (Rattus norvegicus)	6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRMT5 mRNA	CTD	PMID:17602206
PRMT5	Human	cocaine	decreases expression	ISO	Prmt5 (Mus musculus)	6480464	Cocaine results in decreased expression of PRMT5 mRNA	CTD	PMID:27506785
PRMT5	Human	copper(II) sulfate	decreases expression	EXP		6480464	Copper Sulfate results in decreased expression of PRMT5 mRNA	CTD	PMID:19549813
PRMT5	Human	coumestrol	increases expression	EXP		6480464	Coumestrol results in increased expression of PRMT5 mRNA	CTD	PMID:19167446
PRMT5	Human	cyclosporin A	increases expression	EXP		6480464	Cyclosporine results in increased expression of PRMT5 mRNA	CTD	PMID:20106945
PRMT5	Human	cylindrospermopsin	increases expression	EXP		6480464	cylindrospermopsin results in increased expression of PRMT5 mRNA	CTD	PMID:24921660
PRMT5	Human	deguelin	increases expression	EXP		6480464	deguelin results in increased expression of PRMT5 mRNA	CTD	PMID:33512557
PRMT5	Human	diarsenic trioxide	multiple interactions	EXP		6480464	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PRMT5 protein]	CTD	PMID:26598702
PRMT5	Human	dibutyl phthalate	decreases expression	ISO	Prmt5 (Mus musculus)	6480464	Dibutyl Phthalate results in decreased expression of PRMT5 mRNA	CTD	PMID:17361019
PRMT5	Human	dioxygen	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PRMT5 mRNA	CTD	PMID:30529165
PRMT5	Human	doxorubicin	decreases expression	EXP		6480464	Doxorubicin results in decreased expression of PRMT5 mRNA	CTD	PMID:29803840
PRMT5	Human	elemental selenium	increases expression	EXP		6480464	Selenium results in increased expression of PRMT5 mRNA	CTD	PMID:19244175
PRMT5	Human	endosulfan	increases expression	EXP		6480464	Endosulfan results in increased expression of PRMT5 mRNA	CTD	PMID:29054638
PRMT5	Human	endosulfan	multiple interactions	EXP		6480464	Endosulfan results in increased expression of and results in increased activity of PRMT5 protein	CTD	PMID:29054638
PRMT5	Human	enzyme inhibitor	multiple interactions	EXP		6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRMT5 protein	CTD	PMID:23301498
PRMT5	Human	epoxiconazole	decreases expression	ISO	Prmt5 (Mus musculus)	6480464	epoxiconazole results in decreased expression of PRMT5 mRNA	CTD	PMID:35436446
PRMT5	Human	fenthion	increases expression	ISO	Prmt5 (Mus musculus)	6480464	Fenthion results in increased expression of PRMT5 mRNA	CTD	PMID:34813904
PRMT5	Human	flutamide	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	Flutamide results in increased expression of PRMT5 mRNA	CTD	PMID:24136188
PRMT5	Human	flutamide	decreases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	Flutamide results in decreased expression of PRMT5 mRNA	CTD	PMID:24793618
PRMT5	Human	folic acid	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRMT5 gene more ...	CTD	PMID:20938992 and PMID:22206623
PRMT5	Human	furfural	multiple interactions	EXP		6480464	[Furaldehyde co-treated with pyrogallol 1 more ...	CTD	PMID:38598786
PRMT5	Human	gentamycin	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	Gentamicins results in increased expression of PRMT5 mRNA	CTD	PMID:22061828 and PMID:33387578
PRMT5	Human	ivermectin	decreases expression	EXP		6480464	Ivermectin results in decreased expression of PRMT5 protein	CTD	PMID:32959892
PRMT5	Human	L-methionine	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRMT5 gene	CTD	PMID:20938992
PRMT5	Human	leflunomide	decreases expression	EXP		6480464	leflunomide results in decreased expression of PRMT5 mRNA	CTD	PMID:28988120
PRMT5	Human	N-nitrosodiethylamine	multiple interactions	ISO	Prmt5 (Rattus norvegicus)	6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRMT5 mRNA	CTD	PMID:17602206
PRMT5	Human	nickel atom	decreases expression	EXP		6480464	Nickel results in decreased expression of PRMT5 mRNA	CTD	PMID:23195993
PRMT5	Human	nitrates	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of PRMT5 mRNA	CTD	PMID:35964746
PRMT5	Human	Nutlin-3	multiple interactions	EXP		6480464	[Dactinomycin co-treated with nutlin 3] results in increased secretion of PRMT5 protein	CTD	PMID:38460933
PRMT5	Human	ozone	multiple interactions	EXP		6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PRMT5 mRNA more ...	CTD	PMID:32699268
PRMT5	Human	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of PRMT5 mRNA	CTD	PMID:21420995
PRMT5	Human	perfluorononanoic acid	decreases expression	EXP		6480464	perfluoro-n-nonanoic acid results in decreased expression of PRMT5 mRNA	CTD	PMID:25812627
PRMT5	Human	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	Prmt5 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRMT5 mRNA	CTD	PMID:36331819
PRMT5	Human	perfluorooctane-1-sulfonic acid	decreases expression	EXP		6480464	perfluorooctane sulfonic acid results in decreased expression of PRMT5 mRNA	CTD	PMID:25812627
PRMT5	Human	perfluorooctanoic acid	decreases expression	EXP		6480464	perfluorooctanoic acid results in decreased expression of PRMT5 mRNA	CTD	PMID:25812627
PRMT5	Human	quercetin	decreases expression	EXP		6480464	Quercetin results in decreased expression of PRMT5 mRNA	CTD	PMID:21632981
PRMT5	Human	rac-lactic acid	decreases expression	EXP		6480464	Lactic Acid results in decreased expression of PRMT5 mRNA	CTD	PMID:30851411
PRMT5	Human	ribavirin	decreases expression	EXP		6480464	Ribavirin results in decreased expression of PRMT5 protein	CTD	PMID:33577917 and PMID:34919946
PRMT5	Human	ribavirin	decreases expression	ISO	Prmt5 (Mus musculus)	6480464	Ribavirin results in decreased expression of PRMT5 protein	CTD	PMID:33577917
PRMT5	Human	rotenone	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	Rotenone results in increased expression of PRMT5 mRNA	CTD	PMID:28374803
PRMT5	Human	S-adenosyl-L-homocysteine	decreases activity	EXP		6480464	S-Adenosylhomocysteine results in decreased activity of PRMT5 protein	CTD	PMID:33577917
PRMT5	Human	selenium atom	increases expression	EXP		6480464	Selenium results in increased expression of PRMT5 mRNA	CTD	PMID:19244175
PRMT5	Human	sirolimus	increases activity	EXP		6480464	Sirolimus results in increased activity of PRMT5 protein	CTD	PMID:31473880
PRMT5	Human	sodium arsenite	decreases expression	EXP		6480464	sodium arsenite results in decreased expression of PRMT5 mRNA	CTD	PMID:38568856
PRMT5	Human	sodium chloride	multiple interactions	EXP		6480464	[Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of PRMT5 protein	CTD	PMID:38598786
PRMT5	Human	sodium dichromate	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	sodium bichromate results in increased expression of PRMT5 mRNA	CTD	PMID:25993096
PRMT5	Human	T-2 toxin	increases expression	EXP		6480464	T-2 Toxin results in increased expression of PRMT5 mRNA	CTD	PMID:34581912
PRMT5	Human	tetrachloromethane	increases expression	ISO	Prmt5 (Mus musculus)	6480464	Carbon Tetrachloride results in increased expression of PRMT5 mRNA	CTD	PMID:31919559
PRMT5	Human	thioacetamide	increases expression	ISO	Prmt5 (Rattus norvegicus)	6480464	Thioacetamide results in increased expression of PRMT5 mRNA	CTD	PMID:23411599 and PMID:34492290
PRMT5	Human	thiram	decreases expression	EXP		6480464	Thiram results in decreased expression of PRMT5 mRNA	CTD	PMID:38568856
PRMT5	Human	titanium dioxide	decreases methylation	ISO	Prmt5 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of PRMT5 gene	CTD	PMID:35295148
PRMT5	Human	trimellitic anhydride	increases expression	ISO	Prmt5 (Mus musculus)	6480464	trimellitic anhydride results in increased expression of PRMT5 mRNA	CTD	PMID:19042947
PRMT5	Human	triphenyl phosphate	affects expression	EXP		6480464	triphenyl phosphate affects the expression of PRMT5 mRNA	CTD	PMID:37042841
PRMT5	Human	triptonide	increases expression	ISO	Prmt5 (Mus musculus)	6480464	triptonide results in increased expression of PRMT5 mRNA	CTD	PMID:33045310
PRMT5	Human	urethane	decreases expression	EXP		6480464	Urethane results in decreased expression of PRMT5 mRNA	CTD	PMID:28818685
PRMT5	Human	valproic acid	affects expression	ISO	Prmt5 (Mus musculus)	6480464	Valproic Acid affects the expression of PRMT5 mRNA	CTD	PMID:17292431
PRMT5	Human	valproic acid	increases expression	EXP		6480464	Valproic Acid results in increased expression of PRMT5 mRNA	CTD	PMID:23179753 and PMID:29154799

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	chromatin organization	involved_in	IEA	UniProtKB-KW:KW-0156	150520179		UniProt	GO_REF:0000043
PRMT5	Human	chromatin remodeling	involved_in	IDA		150520179	PMID:18404153	UniProt	PMID:18404153
PRMT5	Human	circadian regulation of gene expression	involved_in	ISS	UniProtKB:Q8CIG8	150520179		UniProt	GO_REF:0000024
PRMT5	Human	DNA-templated transcription termination	involved_in	IMP		150520179	PMID:26700805	UniProt	PMID:26700805
PRMT5	Human	endothelial cell activation	involved_in	IMP		150520179	PMID:22269951	UniProt	PMID:22269951
PRMT5	Human	gene expression	involved_in	ISO	Prmt5 (Mus musculus)	9068941	PMID:16699504	MGI	PMID:16699504
PRMT5	Human	Golgi ribbon formation	involved_in	IMP		150520179	PMID:20421892	UniProt	PMID:20421892
PRMT5	Human	liver regeneration		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:15837430 and REF_RGD_ID:2299961
PRMT5	Human	liver regeneration	involved_in	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107
PRMT5	Human	methylation	involved_in	IEA	UniProtKB-KW:KW-0489	150520179		UniProt	GO_REF:0000043
PRMT5	Human	negative regulation of cell differentiation		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:21917714 and REF_RGD_ID:9491825
PRMT5	Human	negative regulation of cell differentiation	involved_in	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107
PRMT5	Human	negative regulation of DNA-templated transcription	involved_in	IEA	GO:0003714	150520179		GOC	GO_REF:0000108
PRMT5	Human	negative regulation of gene expression via chromosomal CpG island methylation		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:22041901 and REF_RGD_ID:9491827
PRMT5	Human	negative regulation of gene expression via chromosomal CpG island methylation	involved_in	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107
PRMT5	Human	negative regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	ISO	Prmt5 (Mus musculus)	9068941	PMID:18347060	MGI	PMID:18347060
PRMT5	Human	peptidyl-arginine methylation	involved_in	IMP		150520179	PMID:17709427	UniProt	PMID:17709427
PRMT5	Human	peptidyl-arginine N-methylation	acts_upstream_of_or_within	IDA		150520179	PMID:15369763	MGI	PMID:15369763
PRMT5	Human	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	involved_in	IGI	UniProtKB:P14416	150520179	PMID:26554819	WB	PMID:26554819
PRMT5	Human	positive regulation of mRNA splicing, via spliceosome	involved_in	NAS		150520179	PMID:11756452	ComplexPortal	PMID:11756452
PRMT5	Human	positive regulation of oligodendrocyte differentiation		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:22041901 and REF_RGD_ID:9491827
PRMT5	Human	positive regulation of oligodendrocyte differentiation	involved_in	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107
PRMT5	Human	protein methylation		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:21917714 and REF_RGD_ID:9491825
PRMT5	Human	regulation of DNA-templated transcription	involved_in	IBA	MGI:1351645 more ...	150520179		GO_Central	GO_REF:0000033
PRMT5	Human	regulation of ERK1 and ERK2 cascade		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:21917714 and REF_RGD_ID:9491825
PRMT5	Human	regulation of ERK1 and ERK2 cascade	involved_in	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107
PRMT5	Human	regulation of gene expression		ISO	Prmt5 (Rattus norvegicus)	9068941	Id2 more ...	RGD	PMID:22041901 and REF_RGD_ID:9491827
PRMT5	Human	regulation of gene expression	involved_in	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107
PRMT5	Human	regulation of mitotic nuclear division	involved_in	TAS		150520179	PMID:9843966	PINC	PMID:9843966
PRMT5	Human	regulation of signal transduction by p53 class mediator	involved_in	TAS		150520179		Reactome	Reactome:R-HSA-6804760
PRMT5	Human	rhythmic process	involved_in	IEA	UniProtKB-KW:KW-0090	150520179		UniProt	GO_REF:0000043
PRMT5	Human	spliceosomal snRNP assembly	involved_in	IMP		150520179	PMID:17709427	UniProt	PMID:17709427
PRMT5	Human	spliceosomal snRNP assembly	involved_in	NAS		150520179	PMID:11756452	ComplexPortal	PMID:11756452

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	chromatin	located_in	IDA		150520179	PMID:33376131	UniProt	PMID:33376131
PRMT5	Human	chromosome	located_in	IEA	UniProtKB-KW:KW-0158	150520179		UniProt	GO_REF:0000043
PRMT5	Human	chromosome	located_in	IEA	UniProtKB-SubCell:SL-0468	150520179		UniProt	GO_REF:0000044
PRMT5	Human	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	150520179		UniProt	GO_REF:0000043
PRMT5	Human	cytoplasm	part_of	IDA		150520179	PMID:22952863	CACAO	PMID:22952863
PRMT5	Human	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	150520179		UniProt	GO_REF:0000044
PRMT5	Human	cytosol	located_in	TAS		150520179		Reactome	Reactome:R-HSA-191790
PRMT5	Human	cytosol	located_in	IDA		150520179	PMID:18984161 and PMID:21081503	HPA	GO_REF:0000052 more ...
PRMT5	Human	cytosol	located_in	IEA	UniRule:UR000128653	150520179		UniProt	GO_REF:0000104
PRMT5	Human	cytosol	is_active_in	IBA	PANTHER:PTN000077429 and UniProtKB:O14744	150520179		GO_Central	GO_REF:0000033
PRMT5	Human	Golgi apparatus	located_in	IEA	UniProtKB-KW:KW-0333	150520179		UniProt	GO_REF:0000043
PRMT5	Human	Golgi apparatus	located_in	IEA	UniProtKB-SubCell:SL-0132	150520179		UniProt	GO_REF:0000044
PRMT5	Human	Golgi apparatus	located_in	IDA		150520179	PMID:20421892	UniProt	PMID:20421892
PRMT5	Human	histone methyltransferase complex	part_of	IDA		150520179	PMID:23048031	ParkinsonsUK-UCL	PMID:23048031
PRMT5	Human	male germ cell nucleus	located_in	ISO	Prmt5 (Mus musculus)	9068941	PMID:16787967	MGI	PMID:16787967
PRMT5	Human	methylosome	part_of	IDA		150520179	PMID:11756452 more ...	UniProt	PMID:11756452 more ...
PRMT5	Human	nucleoplasm	located_in	TAS		150520179		Reactome	Reactome:R-HSA-3215385 more ...
PRMT5	Human	nucleoplasm	located_in	IDA		150520179		HPA	GO_REF:0000052
PRMT5	Human	nucleus	located_in	IDA		150520179	PMID:21081503	UniProt	PMID:21081503
PRMT5	Human	nucleus	is_active_in	IBA	MGI:1351645 more ...	150520179		GO_Central	GO_REF:0000033
PRMT5	Human	nucleus	located_in	NAS		150520179	PMID:18404153	UniProt	PMID:18404153
PRMT5	Human	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
PRMT5	Human	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043
PRMT5	Human	nucleus	located_in	IEA	UniRule:UR000128653	150520179		UniProt	GO_REF:0000104
PRMT5	Human	protein-containing complex		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:12101096 more ...
PRMT5	Human	protein-containing complex	part_of	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	chromatin binding	enables	ISO	Prmt5 (Mus musculus)	9068941	PMID:18347060	MGI	PMID:18347060
PRMT5	Human	E-box binding	enables	ISS	UniProtKB:Q8CIG8	150520179		UniProt	GO_REF:0000024
PRMT5	Human	histone arginine N-methyltransferase activity	enables	IBA	PANTHER:PTN000077429 and WB:WBGene00016408	150520179		GO_Central	GO_REF:0000033
PRMT5	Human	histone H2AR3 methyltransferase activity	enables	ISO	Prmt5 (Mus musculus)	9068941	PMID:16699504	MGI	PMID:16699504
PRMT5	Human	histone H3 methyltransferase activity	enables	TAS		150520179		Reactome	Reactome:R-HSA-5205799 and Reactome:R-HSA-5661117
PRMT5	Human	histone H4R3 methyltransferase activity	enables	IDA		150520179	PMID:18404153 and PMID:22143770	UniProt	PMID:18404153 and PMID:22143770
PRMT5	Human	histone H4R3 methyltransferase activity	enables	ISS	UniProtKB:Q8CIG8	150520179		UniProt	GO_REF:0000024
PRMT5	Human	histone H4R3 methyltransferase activity	enables	IMP		150520179	PMID:25284789	UniProt	PMID:25284789
PRMT5	Human	histone methyltransferase activity	enables	TAS		150520179		Reactome	Reactome:R-HSA-5205861 and Reactome:R-HSA-5216234
PRMT5	Human	identical protein binding	enables	IPI	UniProtKB:O14744	150520179	PMID:11756452 more ...	IntAct	PMID:11756452 more ...
PRMT5	Human	methyl-CpG binding	enables	IDA		150520179	PMID:25284789	UniProt	PMID:25284789
PRMT5	Human	methyltransferase activity	enables	IEA	UniProtKB-KW:KW-0489	150520179		UniProt	GO_REF:0000043
PRMT5	Human	methyltransferase activity	enables	IEA	InterPro:IPR007857	150520179		InterPro	GO_REF:0000002
PRMT5	Human	methyltransferase activity	enables	IEA	ARBA:ARBA00028302	150520179		UniProt	GO_REF:0000117
PRMT5	Human	methyltransferase activity	enables	IDA		150520179	PMID:15369763 and PMID:19011621	MGI	PMID:15369763 and PMID:19011621
PRMT5	Human	p53 binding	enables	IPI	UniProtKB:P04637	150520179	PMID:19011621	UniProt	PMID:19011621
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P46783	150520179	PMID:20159986	UniProt	PMID:20159986
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q99LG4	150520179	PMID:19011621	UniProt	PMID:19011621
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q9BRS2	150520179	PMID:21081503 more ...	IntAct	PMID:21081503 more ...
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q6ZV65 and UniProtKB:Q6ZV65-2	150520179	PMID:33376131	IntAct	PMID:33376131
PRMT5	Human	protein binding	enables	IPI	UniProtKB:O15197-2 more ...	150520179	PMID:32296183	IntAct	PMID:32296183
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q9BQA1	150520179	PMID:26763441	IntAct	PMID:26763441
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P62993	150520179	PMID:12577067	IntAct	PMID:12577067
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q8BUV6	150520179	PMID:16087681	UniProt	PMID:16087681
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P54105	150520179	PMID:18984161	IntAct	PMID:18984161
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q16526	150520179	PMID:23133559	IntAct	PMID:23133559
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P24928	150520179	PMID:26700805	IntAct	PMID:26700805
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P63104 more ...	150520179	PMID:23455924	IntAct	PMID:23455924
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P24928 and UniProtKB:Q16637	150520179	PMID:26700805	UniProt	PMID:26700805
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P54105 more ...	150520179	PMID:22365833	IntAct	PMID:22365833
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q6ZV65	150520179	PMID:33376131	UniProt	PMID:33376131
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q91XC0	150520179	PMID:20133701	IntAct	PMID:20133701
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q01094	150520179	PMID:22327218	IntAct	PMID:22327218
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P01019 more ...	150520179	PMID:32814053	IntAct	PMID:32814053
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P31269	150520179	PMID:22269951	IntAct	PMID:22269951
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q08379	150520179	PMID:20421892	UniProt	PMID:20421892
PRMT5	Human	protein binding	enables	IPI	UniProtKB:O75044	150520179	PMID:20810653	IntAct	PMID:20810653
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P62805 and UniProtKB:Q9BQA1	150520179	PMID:20951943 more ...	IntAct	PMID:20951943 more ...
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P54105 and UniProtKB:Q9BQA1	150520179	PMID:11756452	IntAct	PMID:11756452
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P03418 and UniProtKB:Q9BQA1	150520179	PMID:23892143	AgBase	PMID:23892143
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q9Y3Y2	150520179	PMID:25284789	UniProt	PMID:25284789
PRMT5	Human	protein binding	enables	IPI	UniProtKB:P54105 and UniProtKB:Q9BRS2	150520179	PMID:35271311	IntAct	PMID:35271311
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q9NQ92	150520179	PMID:18404153 and PMID:33961781	UniProt	PMID:18404153 and PMID:33961781
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q9NX58	150520179	PMID:25092918	UniProt	PMID:25092918
PRMT5	Human	protein binding	enables	IPI	UniProtKB:Q86UQ8-1 and UniProtKB:Q9Y6K1	150520179	PMID:19234465	IntAct	PMID:19234465
PRMT5	Human	protein heterodimerization activity	enables	IDA		150520179	PMID:18495660	MGI	PMID:18495660
PRMT5	Human	protein-arginine N-methyltransferase activity	enables	IEA	UniRule:UR000128653	150520179		UniProt	GO_REF:0000104
PRMT5	Human	protein-arginine N-methyltransferase activity	enables	IEA	ARBA:ARBA00027362	150520179		UniProt	GO_REF:0000117
PRMT5	Human	protein-arginine N-methyltransferase activity	enables	IDA		150520179	PMID:20421892 and PMID:26554819	WB	PMID:20421892 and PMID:26554819
PRMT5	Human	protein-arginine N-methyltransferase activity	enables	IEA	InterPro:IPR025799	150520179		InterPro	GO_REF:0000002
PRMT5	Human	protein-arginine omega-N symmetric methyltransferase activity	enables	IMP		150520179	PMID:17709427	UniProt	PMID:17709427
PRMT5	Human	protein-arginine omega-N symmetric methyltransferase activity	enables	EXP		150520179	PMID:19011621	Reactome	PMID:19011621
PRMT5	Human	protein-arginine omega-N symmetric methyltransferase activity	enables	IEA	EC:2.1.1.320	150520179		UniProt	GO_REF:0000003
PRMT5	Human	protein-arginine omega-N symmetric methyltransferase activity	enables	IEA	RHEA:48108	150520179		RHEA	GO_REF:0000116
PRMT5	Human	protein-arginine omega-N symmetric methyltransferase activity	enables	IDA		150520179	PMID:22143770	WB	PMID:22143770
PRMT5	Human	protein-containing complex binding		ISO	Prmt5 (Rattus norvegicus)	9068941		RGD	PMID:15837430 and REF_RGD_ID:2299961
PRMT5	Human	protein-containing complex binding	enables	IEA	UniProtKB:D4A0E8 and ensembl:ENSRNOP00000016302	150520179		Ensembl	GO_REF:0000107
PRMT5	Human	ribonucleoprotein complex binding	enables	IPI	UniProtKB:P62318	150520179	PMID:17709427	UniProt	PMID:17709427
PRMT5	Human	transcription corepressor activity	enables	ISS	UniProtKB:Q8CIG8	150520179		UniProt	GO_REF:0000024
PRMT5	Human	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	150520179		UniProt	GO_REF:0000043

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	histone modification pathway		TAS		9479047		RGD
PRMT5	Human	homocysteine metabolic pathway		TAS		1359044		RGD
PRMT5	Human	methionine cycle/metabolic pathway		TAS		1359044		RGD
PRMT5	Human	methionine cycle/metabolic pathway		TAS		7242552		RGD

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRMT5	Human	p53 signaling pathway		EXP		6484113		PID	PID:200206

#	Reference Title	Reference Citation
1.	Arginine methylation an emerging regulator of protein function.	Bedford MT and Richard S, Mol Cell 2005 Apr 29;18(3):263-72.
2.	Histone arginine methylation.	Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
3.	Readers of histone methylarginine marks.	Gayatri S and Bedford MT, Biochim Biophys Acta. 2014 Aug;1839(8):702-710. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28.
4.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
5.	The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.	Liang JJ, etal., J Urol. 2007 May;177(5):1918-22.
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	[Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma].	Sun QZ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):716-9.

PMID:9556550	PMID:9843966	PMID:10531356	PMID:10734105	PMID:11152681	PMID:11713266	PMID:11720283	PMID:11747828	PMID:11756452	PMID:12101096	PMID:12358155	PMID:12477932
PMID:12577067	PMID:12665801	PMID:12718890	PMID:12972618	PMID:14559996	PMID:14583623	PMID:14702039	PMID:15130578	PMID:15324660	PMID:15369763	PMID:15485929	PMID:15489334
PMID:15654770	PMID:15670829	PMID:15701830	PMID:15737618	PMID:16087681	PMID:16169070	PMID:16300736	PMID:16428440	PMID:16699504	PMID:16712789	PMID:16969126	PMID:16980624
PMID:17409432	PMID:17573539	PMID:17620599	PMID:17627275	PMID:17643375	PMID:17707232	PMID:17709427	PMID:17925232	PMID:17974993	PMID:18029348	PMID:18347060	PMID:18404153
PMID:18495660	PMID:18562274	PMID:18694959	PMID:18984161	PMID:18992153	PMID:19011621	PMID:19032343	PMID:19086919	PMID:19167051	PMID:19188441	PMID:19234465	PMID:19380743
PMID:19520849	PMID:19738201	PMID:19741270	PMID:20133701	PMID:20159986	PMID:20195544	PMID:20360068	PMID:20421892	PMID:20473970	PMID:20495075	PMID:20810653	PMID:20811636
PMID:20951943	PMID:21081503	PMID:21081666	PMID:21118156	PMID:21145461	PMID:21159818	PMID:21262773	PMID:21316606	PMID:21385873	PMID:21592330	PMID:21700716	PMID:21873635
PMID:21907836	PMID:21917714	PMID:21951318	PMID:21975038	PMID:22143770	PMID:22169276	PMID:22179613	PMID:22193545	PMID:22199349	PMID:22231400	PMID:22266372	PMID:22268729
PMID:22269951	PMID:22327218	PMID:22354994	PMID:22365833	PMID:22586326	PMID:22689669	PMID:22708516	PMID:22726390	PMID:22733990	PMID:22863883	PMID:22939629	PMID:22952863
PMID:23048031	PMID:23071334	PMID:23084401	PMID:23133559	PMID:23184937	PMID:23246001	PMID:23261437	PMID:23292799	PMID:23398456	PMID:23455922	PMID:23455924	PMID:23569248
PMID:23671120	PMID:23686814	PMID:23749998	PMID:23892143	PMID:23904475	PMID:23912080	PMID:24098663	PMID:24121109	PMID:24163370	PMID:24169447	PMID:24189068	PMID:24292684
PMID:24326178	PMID:24366813	PMID:24453002	PMID:24477620	PMID:24550385	PMID:24664369	PMID:24705354	PMID:24711643	PMID:24753255	PMID:24981860	PMID:25012667	PMID:25071155
PMID:25092918	PMID:25144556	PMID:25220593	PMID:25234597	PMID:25281873	PMID:25284789	PMID:25324546	PMID:25347788	PMID:25457166	PMID:25475372	PMID:25485739	PMID:25582697
PMID:25704480	PMID:25713080	PMID:25721668	PMID:25742700	PMID:25756610	PMID:25852190	PMID:25864199	PMID:25870105	PMID:25921289	PMID:25927346	PMID:25944111	PMID:26069323
PMID:26078354	PMID:26086249	PMID:26147758	PMID:26151339	PMID:26186194	PMID:26248553	PMID:26300397	PMID:26344197	PMID:26460568	PMID:26482848	PMID:26496610	PMID:26527279
PMID:26536822	PMID:26541651	PMID:26554819	PMID:26563484	PMID:26597461	PMID:26658161	PMID:26693507	PMID:26700805	PMID:26708443	PMID:26729154	PMID:26735018	PMID:26759235
PMID:26763441	PMID:26777405	PMID:26831064	PMID:26864203	PMID:26912360	PMID:26912361	PMID:26912789	PMID:26972000	PMID:26990556	PMID:27025967	PMID:27068473	PMID:27158335
PMID:27183006	PMID:27247266	PMID:27292259	PMID:27315569	PMID:27342126	PMID:27465491	PMID:27480244	PMID:27546619	PMID:27591049	PMID:27634302	PMID:27643437	PMID:27684187
PMID:27708221	PMID:27860244	PMID:28031468	PMID:28061334	PMID:28074910	PMID:28087667	PMID:28101581	PMID:28107179	PMID:28115626	PMID:28238654	PMID:28302793	PMID:28381188
PMID:28416769	PMID:28514442	PMID:28515276	PMID:28533407	PMID:28581483	PMID:28591716	PMID:28685749	PMID:28718761	PMID:28854561	PMID:28874563	PMID:28945229	PMID:28977470
PMID:28986522	PMID:28987382	PMID:29053956	PMID:29106602	PMID:29154828	PMID:29185119	PMID:29227283	PMID:29229926	PMID:29262329	PMID:29263404	PMID:29331416	PMID:29384474
PMID:29395067	PMID:29441724	PMID:29449217	PMID:29501774	PMID:29507755	PMID:29509190	PMID:29518110	PMID:29540532	PMID:29547122	PMID:29559659	PMID:29603824	PMID:29676528
PMID:29679612	PMID:29718323	PMID:29721098	PMID:29749478	PMID:29764989	PMID:29802960	PMID:29844126	PMID:29845934	PMID:29846670	PMID:29884807	PMID:29911972	PMID:29920217
PMID:30021884	PMID:30033366	PMID:30054435	PMID:30057274	PMID:30082494	PMID:30179224	PMID:30189247	PMID:30196744	PMID:30209976	PMID:30257864	PMID:30258100	PMID:30282801
PMID:30289978	PMID:30305293	PMID:30320910	PMID:30392062	PMID:30429891	PMID:30442766	PMID:30446222	PMID:30461193	PMID:30463901	PMID:30472188	PMID:30542119	PMID:30575818
PMID:30635341	PMID:30675521	PMID:30704408	PMID:30736843	PMID:30745168	PMID:30773093	PMID:30800128	PMID:30833792	PMID:30884312	PMID:30922330	PMID:30940768	PMID:30948266
PMID:30988076	PMID:31010829	PMID:31091453	PMID:31123343	PMID:31160578	PMID:31239290	PMID:31253590	PMID:31267554	PMID:31300519	PMID:31312965	PMID:31391242	PMID:31439820
PMID:31473880	PMID:31498866	PMID:31527615	PMID:31527668	PMID:31533041	PMID:31570706	PMID:31611688	PMID:31620119	PMID:31665637	PMID:31665911	PMID:31694585	PMID:31765670
PMID:31822509	PMID:31839598	PMID:31851779	PMID:31868234	PMID:31938050	PMID:31980649	PMID:31992359	PMID:31995728	PMID:32023548	PMID:32041737	PMID:32089501	PMID:32129710
PMID:32152128	PMID:32176739	PMID:32191634	PMID:32269044	PMID:32292506	PMID:32296183	PMID:32301278	PMID:32322062	PMID:32392182	PMID:32416067	PMID:32456215	PMID:32460013
PMID:32552912	PMID:32555249	PMID:32623319	PMID:32665550	PMID:32698014	PMID:32707033	PMID:32709847	PMID:32711345	PMID:32747416	PMID:32759981	PMID:32807901	PMID:32808744
PMID:32814053	PMID:32868396	PMID:32887644	PMID:32999000	PMID:33020149	PMID:33045527	PMID:33090401	PMID:33097661	PMID:33220929	PMID:33274632	PMID:33277756	PMID:33296647
PMID:33306668	PMID:33376131	PMID:33416213	PMID:33450196	PMID:33462997	PMID:33495409	PMID:33579912	PMID:33624332	PMID:33658435	PMID:33664859	PMID:33675123	PMID:33729478
PMID:33731348	PMID:33766124	PMID:33782401	PMID:33795785	PMID:33829865	PMID:33849069	PMID:33896016	PMID:33961781	PMID:33972717	PMID:34017080	PMID:34026424	PMID:34026434
PMID:34033176	PMID:34103528	PMID:34326253	PMID:34358446	PMID:34373451	PMID:34445801	PMID:34476262	PMID:34476934	PMID:34522232	PMID:34531375	PMID:34581821	PMID:34728620
PMID:35046516	PMID:35111150	PMID:35149174	PMID:35256949	PMID:35271311	PMID:35305370	PMID:35333690	PMID:35339800	PMID:35365208	PMID:35391932	PMID:35446349	PMID:35509820
PMID:35563538	PMID:35622143	PMID:35652658	PMID:35676246	PMID:35696571	PMID:35705029	PMID:35819319	PMID:35831314	PMID:35896951	PMID:35944360	PMID:36041632	PMID:36042349
PMID:36057605	PMID:36114006	PMID:36114164	PMID:36114756	PMID:36154574	PMID:36167829	PMID:36168627	PMID:36180527	PMID:36180891	PMID:36215168	PMID:36232624	PMID:36261009
PMID:36282215	PMID:36400182	PMID:36411454	PMID:36526897	PMID:36574265	PMID:36597993	PMID:36609611	PMID:36864055	PMID:36878903	PMID:36897256	PMID:36913067	PMID:36927233
PMID:36931259	PMID:36980950	PMID:36991117	PMID:37047013	PMID:37140020	PMID:37173967	PMID:37201513	PMID:37223481	PMID:37267517	PMID:37314180	PMID:37314216	PMID:37317656
PMID:37399609	PMID:37400960	PMID:37438558	PMID:37448957	PMID:37450367	PMID:37486354	PMID:37528093	PMID:37536978	PMID:37827155	PMID:37830751	PMID:37861293	PMID:37905571
PMID:37963200	PMID:38105619	PMID:38113892	PMID:38129175	PMID:38156384	PMID:38177924	PMID:38252663	PMID:38272855	PMID:38438251	PMID:38474089	PMID:38626179	PMID:38663941
PMID:38760429	PMID:38803224	PMID:38827324	PMID:39147351

PRMT5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	22,920,525 - 22,929,408 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	23,389,738 - 23,398,585 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	22,459,573 - 22,468,501 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	22,459,578 - 22,468,501	NCBI
Celera	14	3,252,630 - 3,261,553 (-)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	3,506,765 - 3,515,687 (-)	NCBI		HuRef
CHM1_1	14	23,388,351 - 23,397,277 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI		T2T-CHM13v2.0

Prmt5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	54,744,639 - 54,754,927 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	54,744,644 - 54,754,982 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	54,507,182 - 54,517,470 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	54,507,187 - 54,517,525 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	55,126,019 - 55,136,307 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	53,461,664 - 53,471,620 (-)	NCBI		MGSCv36	mm8
Celera	14	52,302,644 - 52,312,943 (-)	NCBI		Celera
Cytogenetic Map	14	C2	NCBI
cM Map	14	27.82	NCBI

Prmt5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	31,938,927 - 31,948,318 (-)	NCBI		GRCr8
mRatBN7.2	15	27,968,893 - 27,978,291 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	27,968,910 - 27,978,296 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	29,808,255 - 29,817,654 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	30,955,476 - 30,964,875 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	29,205,536 - 29,214,734 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	33,156,508 - 33,165,893 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	33,156,492 - 33,165,895 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	37,041,740 - 37,051,125 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	32,574,951 - 32,584,336 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	32,590,652 - 32,600,343 (-)	NCBI
Celera	15	27,551,512 - 27,560,897 (-)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

Prmt5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	37,369,234 - 37,378,093 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	37,369,507 - 37,378,034 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRMT5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	24,350,371 - 24,359,212 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	23,566,859 - 23,576,070 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	3,737,741 - 3,746,646 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	21,836,984 - 21,846,018 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	21,836,984 - 21,846,018 (-)	Ensembl	panpan1.1		panPan2

PRMT5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	3,248,349 - 3,257,567 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	3,248,404 - 3,257,456 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	3,196,693 - 3,205,933 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	3,356,162 - 3,365,422 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	3,356,165 - 3,365,310 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	3,047,415 - 3,056,657 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	3,108,945 - 3,118,202 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	3,371,200 - 3,380,454 (-)	NCBI		UU_Cfam_GSD_1.0

Prmt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	35,000,952 - 35,009,330 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936722	1,379,515 - 1,388,546 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936722	1,379,515 - 1,388,538 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRMT5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	76,110,951 - 76,124,989 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	76,110,956 - 76,119,619 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PRMT5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	23,288,458 - 23,297,746 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	23,288,835 - 23,297,518 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	23,123,104 - 23,132,411 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prmt5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	9,599,734 - 9,608,703 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	9,599,867 - 9,608,578 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in PRMT5
30 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3	copy number gain	See cases [RCV000050914]	Chr14:20151149..23442195 [GRCh38] Chr14:20619308..23911404 [GRCh37] Chr14:19689148..22981244 [NCBI36] Chr14:14q11.2	pathogenic
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1	copy number loss	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]\|See cases [RCV000051484]	Chr14:20151149..27723796 [GRCh38] Chr14:20619308..28193002 [GRCh37] Chr14:19689148..27262842 [NCBI36] Chr14:14q11.2-12	pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1	copy number loss	See cases [RCV000051485]	Chr14:20196945..45284802 [GRCh38] Chr14:20665104..45754005 [GRCh37] Chr14:19734944..44823755 [NCBI36] Chr14:14q11.2-21.2	pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3	copy number gain	See cases [RCV000053803]	Chr14:20000611..38984415 [GRCh38] Chr14:20468770..39453619 [GRCh37] Chr14:19538610..38523370 [NCBI36] Chr14:14q11.2-21.1	pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]\|See cases [RCV000053806]	Chr14:20150949..39746154 [GRCh38] Chr14:20619108..40215358 [GRCh37] Chr14:19688948..39285109 [NCBI36] Chr14:14q11.2-21.1	pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3	copy number gain	See cases [RCV000135543]	Chr14:20151149..106855263 [GRCh38] Chr14:20619308..107263478 [GRCh37] Chr14:19689148..106334523 [NCBI36] Chr14:14q11.2-32.33	pathogenic
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3	copy number gain	See cases [RCV000137725]	Chr14:20412587..25018120 [GRCh38] Chr14:20880746..25487326 [GRCh37] Chr14:19950586..24557166 [NCBI36] Chr14:14q11.2-12	likely pathogenic
GRCh38/hg38 14q11.2(chr14:21010790-22951814)x3	copy number gain	See cases [RCV000140829]	Chr14:21010790..22951814 [GRCh38] Chr14:21478949..23421023 [GRCh37] Chr14:20548789..22490863 [NCBI36] Chr14:14q11.2	uncertain significance
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3	copy number gain	See cases [RCV000143373]	Chr14:20043514..106877229 [GRCh38] Chr14:20511673..107285437 [GRCh37] Chr14:19581513..106356482 [NCBI36] Chr14:14q11.2-32.33	pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3	copy number gain	See cases [RCV000143186]	Chr14:20022693..44093672 [GRCh38] Chr14:20490852..44562875 [GRCh37] Chr14:19560692..43632625 [NCBI36] Chr14:14q11.2-21.2	pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3	copy number gain	See cases [RCV000143748]	Chr14:20043513..48642042 [GRCh38] Chr14:20511672..49111245 [GRCh37] Chr14:19581512..48180995 [NCBI36] Chr14:14q11.2-21.3	pathogenic
GRCh37/hg19 14q11.2-12(chr14:19100682-28730087)	copy number gain	not provided [RCV000767822]	Chr14:19100682..28730087 [GRCh37] Chr14:14q11.2-12	pathogenic
GRCh37/hg19 14q11.2-12(chr14:19794561-27768254)x3	copy number gain	See cases [RCV000240285]	Chr14:19794561..27768254 [GRCh37] Chr14:14q11.2-12	pathogenic
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3	copy number gain	See cases [RCV000447658]	Chr14:23164384..54733411 [GRCh37] Chr14:14q11.2-22.2	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3	copy number gain	See cases [RCV000446256]	Chr14:19794561..107234280 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q11.2-13.1(chr14:19794561-34049214)x3	copy number gain	See cases [RCV000448273]	Chr14:19794561..34049214 [GRCh37] Chr14:14q11.2-13.1	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437)	copy number gain	See cases [RCV000512041]	Chr14:20511673..107285437 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q11.2(chr14:23240787-23468899)x1	copy number loss	not provided [RCV000683591]	Chr14:23240787..23468899 [GRCh37] Chr14:14q11.2	uncertain significance
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3	copy number gain	not provided [RCV000738412]	Chr14:19000422..107289053 [GRCh37] Chr14:14q11.1-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3	copy number gain	not provided [RCV000738413]	Chr14:19280733..107287663 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3	copy number gain	not provided [RCV000738414]	Chr14:19327823..107287663 [GRCh37] Chr14:14q11.2-32.33	pathogenic
NM_006109.5(PRMT5):c.375C>T (p.Pro125=)	single nucleotide variant	not provided [RCV000973513]	Chr14:22927601 [GRCh38] Chr14:23396810 [GRCh37] Chr14:14q11.2	benign
GRCh37/hg19 14q11.2(chr14:21717093-24027220)x3	copy number gain	not provided [RCV000856644]	Chr14:21717093..24027220 [GRCh37] Chr14:14q11.2	likely pathogenic
NM_006109.5(PRMT5):c.241C>T (p.Leu81=)	single nucleotide variant	not provided [RCV000963989]	Chr14:22928200 [GRCh38] Chr14:23397409 [GRCh37] Chr14:14q11.2	benign
GRCh37/hg19 14q11.2-21.1(chr14:20511672-42881888)x3	copy number gain	not provided [RCV001249358]	Chr14:20511672..42881888 [GRCh37] Chr14:14q11.2-21.1	not provided
NM_006109.5(PRMT5):c.439C>T (p.His147Tyr)	single nucleotide variant	not specified [RCV004286297]	Chr14:22927537 [GRCh38] Chr14:23396746 [GRCh37] Chr14:14q11.2	uncertain significance
NC_000014.8:g.(?_23242819)_(25103366_?)dup	duplication	Lysinuric protein intolerance [RCV003105428]\|Specific granule deficiency [RCV003105427]	Chr14:23242819..25103366 [GRCh37] Chr14:14q11.2-12	uncertain significance
NM_006109.5(PRMT5):c.429C>T (p.His143=)	single nucleotide variant	not provided [RCV000963988]	Chr14:22927547 [GRCh38] Chr14:23396756 [GRCh37] Chr14:14q11.2	benign
GRCh37/hg19 14q11.2(chr14:20925965-23649548)x3	copy number gain	14q11.2 microduplication [RCV001786536]	Chr14:20925965..23649548 [GRCh37] Chr14:14q11.2	likely pathogenic
GRCh37/hg19 14q11.2-21.2(chr14:20511672-44829030)x3	copy number gain	not provided [RCV001006605]	Chr14:20511672..44829030 [GRCh37] Chr14:14q11.2-21.2	pathogenic
GRCh37/hg19 14q11.2-21.3(chr14:20511672-47481203)	copy number gain	Seizure [RCV002280625]	Chr14:20511672..47481203 [GRCh37] Chr14:14q11.2-21.3	pathogenic
NC_000014.8:g.(21162263_36986276)_(36987308_50713602)del	deletion	Brain-lung-thyroid syndrome [RCV002221171]	Chr14:36986276..36987308 [GRCh37] Chr14:14q11.2-21.3	pathogenic
NM_006109.5(PRMT5):c.20G>A (p.Gly7Glu)	single nucleotide variant	not specified [RCV004104994]	Chr14:22929342 [GRCh38] Chr14:23398551 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1475G>A (p.Arg492His)	single nucleotide variant	not specified [RCV004218910]	Chr14:22923061 [GRCh38] Chr14:23392270 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.659G>A (p.Arg220His)	single nucleotide variant	not specified [RCV004220358]	Chr14:22926251 [GRCh38] Chr14:23395460 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1823C>T (p.Ser608Phe)	single nucleotide variant	not specified [RCV004222724]	Chr14:22920995 [GRCh38] Chr14:23390204 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.529G>C (p.Glu177Gln)	single nucleotide variant	not specified [RCV004073509]	Chr14:22926736 [GRCh38] Chr14:23395945 [GRCh37] Chr14:14q11.2	likely benign
NM_006109.5(PRMT5):c.185G>C (p.Arg62Pro)	single nucleotide variant	not specified [RCV004120007]	Chr14:22928541 [GRCh38] Chr14:23397750 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1828A>C (p.Lys610Gln)	single nucleotide variant	not specified [RCV004173624]	Chr14:22920990 [GRCh38] Chr14:23390199 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.341G>T (p.Gly114Val)	single nucleotide variant	not specified [RCV004114738]	Chr14:22927635 [GRCh38] Chr14:23396844 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1130G>A (p.Arg377Gln)	single nucleotide variant	not specified [RCV004174026]	Chr14:22924339 [GRCh38] Chr14:23393548 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1654G>T (p.Ala552Ser)	single nucleotide variant	not specified [RCV004285009]	Chr14:22922485 [GRCh38] Chr14:23391694 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.640T>C (p.Ser214Pro)	single nucleotide variant	not specified [RCV004349713]	Chr14:22926270 [GRCh38] Chr14:23395479 [GRCh37] Chr14:14q11.2	uncertain significance
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3	copy number gain	not provided [RCV003485022]	Chr14:20511673..61826023 [GRCh37] Chr14:14q11.2-23.1	pathogenic
NM_006109.5(PRMT5):c.940-5A>G	single nucleotide variant	not provided [RCV003456863]	Chr14:22924714 [GRCh38] Chr14:23393923 [GRCh37] Chr14:14q11.2	likely benign
NM_006109.5(PRMT5):c.1579+6T>G	single nucleotide variant	not provided [RCV003456862]	Chr14:22922736 [GRCh38] Chr14:23391945 [GRCh37] Chr14:14q11.2	likely benign
NM_006109.5(PRMT5):c.26C>G (p.Ala9Gly)	single nucleotide variant	not specified [RCV004515305]	Chr14:22929336 [GRCh38] Chr14:23398545 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.608C>T (p.Ala203Val)	single nucleotide variant	not specified [RCV004515307]	Chr14:22926511 [GRCh38] Chr14:23395720 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.296T>C (p.Ile99Thr)	single nucleotide variant	not specified [RCV004515306]	Chr14:22928145 [GRCh38] Chr14:23397354 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1585A>G (p.Met529Val)	single nucleotide variant	not provided [RCV003886118]	Chr14:22922554 [GRCh38] Chr14:23391763 [GRCh37] Chr14:14q11.2	likely benign
NM_006109.5(PRMT5):c.28G>A (p.Gly10Ser)	single nucleotide variant	not specified [RCV004660317]	Chr14:22929334 [GRCh38] Chr14:23398543 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1041C>G (p.Asp347Glu)	single nucleotide variant	not specified [RCV004660318]	Chr14:22924514 [GRCh38] Chr14:23393723 [GRCh37] Chr14:14q11.2	uncertain significance
GRCh37/hg19 14q11.2(chr14:20875269-23659582)x3	copy number gain	not provided [RCV004819311]	Chr14:20875269..23659582 [GRCh37] Chr14:14q11.2	pathogenic
NM_006109.5(PRMT5):c.160T>G (p.Phe54Val)	single nucleotide variant	not specified [RCV004853581]	Chr14:22928566 [GRCh38] Chr14:23397775 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1444A>G (p.Asn482Asp)	single nucleotide variant	not specified [RCV004853582]	Chr14:22923092 [GRCh38] Chr14:23392301 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.538A>G (p.Ser180Gly)	single nucleotide variant	not specified [RCV004853583]	Chr14:22926727 [GRCh38] Chr14:23395936 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1154G>A (p.Arg385Gln)	single nucleotide variant	not specified [RCV004853585]	Chr14:22924315 [GRCh38] Chr14:23393524 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1021A>G (p.Ile341Val)	single nucleotide variant	not specified [RCV004853584]	Chr14:22924534 [GRCh38] Chr14:23393743 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1048C>T (p.Pro350Ser)	single nucleotide variant	not specified [RCV004853578]	Chr14:22924507 [GRCh38] Chr14:23393716 [GRCh37] Chr14:14q11.2	uncertain significance
NM_006109.5(PRMT5):c.1891C>T (p.Arg631Cys)	single nucleotide variant	not specified [RCV004853579]	Chr14:22920927 [GRCh38] Chr14:23390136 [GRCh37] Chr14:14q11.2	uncertain significance

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
MIR19A	hsa-miR-19a-3p	Mirtarbase	external_info	Western blot	Functional MTI	18694959
MIR25	hsa-miR-25-3p	Mirtarbase	external_info	Western blot	Functional MTI	18694959
MIR18A	hsa-miR-18a-5p	Mirtarbase	external_info	immunohistochemistry//Microarray//qRT-PCR//Western	Functional MTI	19167416
MIR96	hsa-miR-96-5p	Mirtarbase	external_info	Western blot	Functional MTI	18694959
MIR32	hsa-miR-32-5p	Mirtarbase	external_info	Western blot	Functional MTI	18694959
MIR92B	hsa-miR-92b-3p	Mirtarbase	external_info	Western blot	Functional MTI	18694959

Predicted Target Of

	Summary Value
Count of predictions:	6592
Count of miRNA genes:	1210
Interacting mature miRNAs:	1562
Transcripts:	ENST00000216350, ENST00000324366, ENST00000397440, ENST00000397441, ENST00000421938, ENST00000454731, ENST00000476175, ENST00000538452, ENST00000553417, ENST00000553502, ENST00000553550, ENST00000553641, ENST00000553787, ENST00000553897, ENST00000553915, ENST00000554716, ENST00000554867, ENST00000554910, ENST00000555454, ENST00000555530, ENST00000556032, ENST00000556043, ENST00000556426, ENST00000556616, ENST00000557015, ENST00000557415, ENST00000557443, ENST00000557758
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
597368273	GWAS1464347_H	cup-to-disc ratio measurement QTL GWAS1464347 (human)		1e-13	cup-to-disc ratio measurement		14	22921877	22921878	Human

G21627

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	23,389,782 - 23,389,931	UniSTS	GRCh37
Build 36	14	22,459,622 - 22,459,771	RGD	NCBI36
Celera	14	3,252,679 - 3,252,828	RGD
Cytogenetic Map	14	q11.2	UniSTS
HuRef	14	3,506,814 - 3,506,963	UniSTS

A002Q41

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	23,389,740 - 23,389,954	UniSTS	GRCh37
Build 36	14	22,459,580 - 22,459,794	RGD	NCBI36
Celera	14	3,252,637 - 3,252,851	RGD
Cytogenetic Map	14	q11.2	UniSTS
HuRef	14	3,506,772 - 3,506,986	UniSTS
GeneMap99-GB4 RH Map	14	17.13	UniSTS
NCBI RH Map	14	31.0	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2253	4973	1726	2351	6	624	1951	465	2269	7306	6472	53	3734	1	852	1744	1617	175	1


RefSeq Transcripts	NM_001039619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001282953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001282954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001282955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001282956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_006109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047430881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054375270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001750113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008488813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008488814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_429287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA496357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB451246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB451370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF015913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF167572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK027737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK075251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK301812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK302240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK315500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL132780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL833612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC005820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CQ783364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR456741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DC395183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB789353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB789383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB811362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB811392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB824205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB824235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB827318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB827348	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB832629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB832659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB833178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB833208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB835923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB835953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB847656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB847686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB857233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB857263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB866093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB866123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB874522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB874552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB877659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB877689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB884959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB884989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB892816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB892846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB895939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB895969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB898146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB898176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB659412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB659442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB681421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB681451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB694264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB694294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB697377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB697407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB702688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB702718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB703237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB703267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB705982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB706012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB717715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB717745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB727292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB727322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB736152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB736182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB744581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB744611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB747718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB747748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB755018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB755048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB762875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB762905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB765998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB766028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB768205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB768235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB830570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB830600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000216350 ⟹ ENSP00000216350

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,530 - 22,929,391 (-)	Ensembl

Ensembl Acc Id:

ENST00000324366 ⟹ ENSP00000319169

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,529 - 22,929,376 (-)	Ensembl

Ensembl Acc Id:

ENST00000397440 ⟹ ENSP00000380582

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,529 - 22,929,356 (-)	Ensembl

Ensembl Acc Id:

ENST00000397441 ⟹ ENSP00000380583

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,525 - 22,929,401 (-)	Ensembl

Ensembl Acc Id:

ENST00000421938 ⟹ ENSP00000409482

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,926,737 - 22,929,368 (-)	Ensembl

Ensembl Acc Id:

ENST00000454731 ⟹ ENSP00000387663

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,825 - 22,923,162 (-)	Ensembl

Ensembl Acc Id:

ENST00000476175

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,529 - 22,922,821 (-)	Ensembl

Ensembl Acc Id:

ENST00000553417

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,926,481 - 22,927,596 (-)	Ensembl

Ensembl Acc Id:

ENST00000553502 ⟹ ENSP00000450956

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,924,162 - 22,925,046 (-)	Ensembl

Ensembl Acc Id:

ENST00000553550 ⟹ ENSP00000450737

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,924,638 - 22,929,392 (-)	Ensembl

Ensembl Acc Id:

ENST00000553641

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,926,133 - 22,929,351 (-)	Ensembl

Ensembl Acc Id:

ENST00000553787 ⟹ ENSP00000452102

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,925,000 - 22,929,373 (-)	Ensembl

Ensembl Acc Id:

ENST00000553897 ⟹ ENSP00000452555

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,876 - 22,929,408 (-)	Ensembl

Ensembl Acc Id:

ENST00000553915 ⟹ ENSP00000451127

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,857 - 22,929,365 (-)	Ensembl

Ensembl Acc Id:

ENST00000554716

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,924,663 - 22,929,365 (-)	Ensembl

Ensembl Acc Id:

ENST00000554867 ⟹ ENSP00000452218

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,926,235 - 22,929,376 (-)	Ensembl

Ensembl Acc Id:

ENST00000554910 ⟹ ENSP00000452411

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,926,275 - 22,929,081 (-)	Ensembl

Ensembl Acc Id:

ENST00000555454 ⟹ ENSP00000451245

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,810 - 22,924,179 (-)	Ensembl

Ensembl Acc Id:

ENST00000555530 ⟹ ENSP00000452409

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,924,317 - 22,928,143 (-)	Ensembl

Ensembl Acc Id:

ENST00000556032

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,927,526 - 22,929,351 (-)	Ensembl

Ensembl Acc Id:

ENST00000556043 ⟹ ENSP00000452509

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,924,499 - 22,926,456 (-)	Ensembl

Ensembl Acc Id:

ENST00000556426

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,928,263 - 22,929,376 (-)	Ensembl

Ensembl Acc Id:

ENST00000556616 ⟹ ENSP00000450919

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,926,240 - 22,929,376 (-)	Ensembl

Ensembl Acc Id:

ENST00000557015

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,928,131 - 22,929,394 (-)	Ensembl

Ensembl Acc Id:

ENST00000557415 ⟹ ENSP00000450633

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,926,238 - 22,929,392 (-)	Ensembl

Ensembl Acc Id:

ENST00000557443 ⟹ ENSP00000452501

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,920,529 - 22,922,240 (-)	Ensembl

Ensembl Acc Id:

ENST00000557758

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,922,132 - 22,922,910 (-)	Ensembl

Ensembl Acc Id:

ENST00000627278 ⟹ ENSP00000485787

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	22,927,596 - 22,929,361 (-)	Ensembl

RefSeq Acc Id:

NM_001039619 ⟹ NP_001034708

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI
GRCh37	14	23,389,733 - 23,398,789 (-)	NCBI
Build 36	14	22,459,573 - 22,468,501 (-)	NCBI Archive
HuRef	14	3,506,752 - 3,515,820 (-)	NCBI
CHM1_1	14	23,388,338 - 23,397,410 (-)	NCBI
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

Sequence:

show sequence

AGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGGAGCCGCGTGTCCAGCGGGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTG
AGGGCCGGACCTCCACGAGCGGAATGCGGGGTCCGAACTCGGGGACGGAGAAGGGCAGACTAGTCATCCCGGAGAAGCAGGGGTTTGATTTCCTCTGCATGCCTGTCTTCCATCCGCGTTTCAAGAGG
GAGTTCATTCAGGAACCTGCTAAGAATCGGCCCGGTCCCCAGACACGATCAGACCTACTGCTGTCAGGAAGGGACTGGAATACGCTAATTGTGGGAAAGCTTTCTCCATGGATTCGTCCAGACTCAAA
AGTGGAGAAGATTCGCAGGAACTCCGAGGCGGCCATGTTACAGGAGCTGAATTTTGGTGCATATTTGGGTCTTCCAGCTTTCCTGCTGCCCCTTAATCAGGAAGATAACACCAACCTGGCCAGAGTTT
TGACCAACCACATCCACACTGGCCATCACTCTTCCATGTTCTGGATGCGGGTACCCTTGGTGGCACCAGAGGACCTGAGAGATGATATAATTGAGAATGCACCAACTACACACACAGAGGAGTACAGT
GGGGAGGAGAAAACGTGGATGTGGTGGCACAACTTCCGGACTTTGTGTGACTATAGTAAGAGGATTGCAGTGGCTCTTGAAATTGGGGCTGACCTCCCATCTAATCATGTCATTGATCGCTGGCTTGG
GGAGCCCATCAAAGCAGCCATTCTCCCCACTAGCATTTTCCTGACCAATAAGAAGGGATTTCCTGTTCTTTCTAAGATGCACCAGAGGCTCATCTTCCGGCTCCTCAAGTTGGAGGTGCAGTTCATCA
TCACAGGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTTAAGCCAGAACCGTCCTCCACCTAATGCCTATGAACTCTTTGCCAAGGGCTATGAAGACTATCTG
CAGTCCCCGCTTCAGCCACTGATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGGACCCCATCAAATACTCTCAGTACCAGCAGGCCATCTATAAATGTCTGCTAGACCGAGTACCAGA
AGAGGAGAAGGATACCAATGTCCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTGAACGCTTCCCTGCGGGCAGCCAAGCAGGCCGACCGGCGGATAAAGCTGTATGCTGTGGAGAAAA
ACCCAAATGCCGTGGTGACGCTAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGTAGTCTCATCAGACATGAGGGAATGGGTGGCTCCAGAGAAAGCAGACATCATTGTCAGTGAGCTT
CTGGGCTCATTTGCTGACAATGAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGATGGTGTGAGCATCCCCGGGGAGTACACTTCCTTTCTGGCTCCCATCTCTTCCTCCAA
GCTGTACAATGAGGTCCGAGCCTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATGCCTTATGTGGTACGGCTGCACAACTTCCACCAGCTCTCTGCACCCCAGCCCTGTTTCACCTTCA
GCCATCCCAACAGAGATCCTATGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGAGGTGAACACAGTACTACATGGCTTTGCCGGCTACTTTGAGACTGTGCTTTATCAGGACATCACT
CTGAGTATCCGTCCAGAGACTCACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTATTAAGCAGCCCATAACGGTACGTGAAGGCCAAACCATCTGTGTGCGTTTCTGGCGATGCAGCAA
TTCCAAGAAGGTGTGGTATGAGTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCCACAGGCCGCTCATATACCATTGGCCTCTAGCCCTGCGTGCCAAGTGTCCAGAGCCTTGGAAGCA
GCTTCAGGTTCTGCTCCTGTAGTACAGAAGGTGCAGTACATCTATGGGCTGTGATTCCCCTTGCCCATCAGAGAGGAGCATTTCAATCTGCTTTCCTGCCTTACATCAAGGTGGGCAAGGGATTATAA
TTAATTGCAGGGCTCAAGCCACCAATCTATGAAGACCTCAGGCCAGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTACGCACTCAGCCTCAAGAACTCCCTGGAATATCCCTGAGAACATGGGGTTT
GAACGGATTTTCAGCCTTTTTCTGTTCTTGTTTTGATGGTTTTGTGTAAGAGGAAATACAAATAAAGTTATAGCCCTTTACTGCA

hide sequence

RefSeq Acc Id:

NM_001282953 ⟹ NP_001269882

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI
HuRef	14	3,506,752 - 3,515,820 (-)	NCBI
CHM1_1	14	23,388,338 - 23,397,410 (-)	NCBI
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

Sequence:

show sequence

AGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGGAGCCGCGTGTCCAGCGGGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTG
AGGGCCGGACCTCCACGAGCGGAATGCGGGGTCCGAACTCGGGGACGGAGAAGGGCAGACTAGTCATCCCGGAGAAGCAGGGGTTTGATTTCCTCTGCATGCCTGTCTTCCATCCGCGTTTCAAGAGG
GAGTTCATTCAGGAACCTGCTAAGAATCGGCCCGGTCCCCAGACACGATCAGACCTACTGCTGTCAGGAAGGGCTTTCCTGCTGCCCCTTAATCAGGAAGATAACACCAACCTGGCCAGAGTTTTGAC
CAACCACATCCACACTGGCCATCACTCTTCCATGTTCTGGATGCGGGTACCCTTGGTGGCACCAGAGGACCTGAGAGATGATATAATTGAGAATGCACCAACTACACACACAGAGGAGTACAGTGGGG
AGGAGAAAACGTGGATGTGGTGGCACAACTTCCGGACTTTGTGTGACTATAGTAAGAGGATTGCAGTGGCTCTTGAAATTGGGGCTGACCTCCCATCTAATCATGTCATTGATCGCTGGCTTGGGGAG
CCCATCAAAGCAGCCATTCTCCCCACTAGCATTTTCCTGACCAATAAGAAGGGATTTCCTGTTCTTTCTAAGATGCACCAGAGGCTCATCTTCCGGCTCCTCAAGTTGGAGGTGCAGTTCATCATCAC
AGGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTTAAGCCAGAACCGTCCTCCACCTAATGCCTATGAACTCTTTGCCAAGGGCTATGAAGACTATCTGCAGT
CCCCGCTTCAGCCACTGATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGGACCCCATCAAATACTCTCAGTACCAGCAGGCCATCTATAAATGTCTGCTAGACCGAGTACCAGAAGAG
GAGAAGGATACCAATGTCCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTGAACGCTTCCCTGCGGGCAGCCAAGCAGGCCGACCGGCGGATAAAGCTGTATGCTGTGGAGAAAAACCC
AAATGCCGTGGTGACGCTAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGTAGTCTCATCAGACATGAGGGAATGGGTGGCTCCAGAGAAAGCAGACATCATTGTCAGTGAGCTTCTGG
GCTCATTTGCTGACAATGAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGATGGTGTGAGCATCCCCGGGGAGTACACTTCCTTTCTGGCTCCCATCTCTTCCTCCAAGCTG
TACAATGAGGTCCGAGCCTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATGCCTTATGTGGTACGGCTGCACAACTTCCACCAGCTCTCTGCACCCCAGCCCTGTTTCACCTTCAGCCA
TCCCAACAGAGATCCTATGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGAGGTGAACACAGTACTACATGGCTTTGCCGGCTACTTTGAGACTGTGCTTTATCAGGACATCACTCTGA
GTATCCGTCCAGAGACTCACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTATTAAGCAGCCCATAACGGTACGTGAAGGCCAAACCATCTGTGTGCGTTTCTGGCGATGCAGCAATTCC
AAGAAGGTGTGGTATGAGTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCCACAGGCCGCTCATATACCATTGGCCTCTAGCCCTGCGTGCCAAGTGTCCAGAGCCTTGGAAGCAGCTT
CAGGTTCTGCTCCTGTAGTACAGAAGGTGCAGTACATCTATGGGCTGTGATTCCCCTTGCCCATCAGAGAGGAGCATTTCAATCTGCTTTCCTGCCTTACATCAAGGTGGGCAAGGGATTATAATTAA
TTGCAGGGCTCAAGCCACCAATCTATGAAGACCTCAGGCCAGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTACGCACTCAGCCTCAAGAACTCCCTGGAATATCCCTGAGAACATGGGGTTTGAAC
GGATTTTCAGCCTTTTTCTGTTCTTGTTTTGATGGTTTTGTGTAAGAGGAAATACAAATAAAGTTATAGCCCTTTACTGCA

hide sequence

RefSeq Acc Id:

NM_001282954 ⟹ NP_001269883

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI
HuRef	14	3,506,752 - 3,515,820 (-)	NCBI
CHM1_1	14	23,388,338 - 23,397,410 (-)	NCBI
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

Sequence:

show sequence

AGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGGAGCCGCGTGTCCAGCGGGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTG
AGGGCCGGACCTCCACGAGCGGAATGCGGGGTCCGAACTCGGGGACGGAGAAGGGCAGACTAGTCATCCCGGAGAAGCAGGGACTGGAATACGCTAATTGTGGGAAAGCTTTCTCCATGGATTCGTCC
AGACTCAAAAGTGGAGAAGATTCGCAGGAACTCCGAGGCGGCCATGTTACAGGAGCTGAATTTTGGTGCATATTTGGGTCTTCCAGCTTTCCTGCTGCCCCTTAATCAGGAAGATAACACCAACCTGG
CCAGAGTTTTGACCAACCACATCCACACTGGCCATCACTCTTCCATGTTCTGGATGCGGGTACCCTTGGTGGCACCAGAGGACCTGAGAGATGATATAATTGAGAATGCACCAACTACACACACAGAG
GAGTACAGTGGGGAGGAGAAAACGTGGATGTGGTGGCACAACTTCCGGACTTTGTGTGACTATAGTAAGAGGATTGCAGTGGCTCTTGAAATTGGGGCTGACCTCCCATCTAATCATGTCATTGATCG
CTGGCTTGGGGAGCCCATCAAAGCAGCCATTCTCCCCACTAGCATTTTCCTGACCAATAAGAAGGGATTTCCTGTTCTTTCTAAGATGCACCAGAGGCTCATCTTCCGGCTCCTCAAGTTGGAGGTGC
AGTTCATCATCACAGGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTTAAGCCAGAACCGTCCTCCACCTAATGCCTATGAACTCTTTGCCAAGGGCTATGAA
GACTATCTGCAGTCCCCGCTTCAGCCACTGATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGGACCCCATCAAATACTCTCAGTACCAGCAGGCCATCTATAAATGTCTGCTAGACCG
AGTACCAGAAGAGGAGAAGGATACCAATGTCCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTGAACGCTTCCCTGCGGGCAGCCAAGCAGGCCGACCGGCGGATAAAGCTGTATGCTG
TGGAGAAAAACCCAAATGCCGTGGTGACGCTAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGTAGTCTCATCAGACATGAGGGAATGGGTGGCTCCAGAGAAAGCAGACATCATTGTC
AGTGAGCTTCTGGGCTCATTTGCTGACAATGAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGATGGTGTGAGCATCCCCGGGGAGTACACTTCCTTTCTGGCTCCCATCTC
TTCCTCCAAGCTGTACAATGAGGTCCGAGCCTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATGCCTTATGTGGTACGGCTGCACAACTTCCACCAGCTCTCTGCACCCCAGCCCTGTT
TCACCTTCAGCCATCCCAACAGAGATCCTATGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGAGGTGAACACAGTACTACATGGCTTTGCCGGCTACTTTGAGACTGTGCTTTATCAG
GACATCACTCTGAGTATCCGTCCAGAGACTCACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTATTAAGCAGCCCATAACGGTACGTGAAGGCCAAACCATCTGTGTGCGTTTCTGGCG
ATGCAGCAATTCCAAGAAGGTGTGGTATGAGTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCCACAGGCCGCTCATATACCATTGGCCTCTAGCCCTGCGTGCCAAGTGTCCAGAGCC
TTGGAAGCAGCTTCAGGTTCTGCTCCTGTAGTACAGAAGGTGCAGTACATCTATGGGCTGTGATTCCCCTTGCCCATCAGAGAGGAGCATTTCAATCTGCTTTCCTGCCTTACATCAAGGTGGGCAAG
GGATTATAATTAATTGCAGGGCTCAAGCCACCAATCTATGAAGACCTCAGGCCAGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTACGCACTCAGCCTCAAGAACTCCCTGGAATATCCCTGAGAAC
ATGGGGTTTGAACGGATTTTCAGCCTTTTTCTGTTCTTGTTTTGATGGTTTTGTGTAAGAGGAAATACAAATAAAGTTATAGCCCTTTACTGCA

hide sequence

RefSeq Acc Id:

NM_001282955 ⟹ NP_001269884

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI
HuRef	14	3,506,752 - 3,515,820 (-)	NCBI
CHM1_1	14	23,388,338 - 23,397,410 (-)	NCBI
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

Sequence:

show sequence

AGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGGAGCCGCGTGTCCAGCGGGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTT
TGATTTCCTCTGCATGCCTGTCTTCCATCCGCGTTTCAAGAGGGAGTTCATTCAGGAACCTGCTAAGAATCGGCCCGGTCCCCAGACACGATCAGACCTACTGCTGTCAGGAAGGGCTTTCCTGCTGC
CCCTTAATCAGGAAGATAACACCAACCTGGCCAGAGTTTTGACCAACCACATCCACACTGGCCATCACTCTTCCATGTTCTGGATGCGGGTACCCTTGGTGGCACCAGAGGACCTGAGAGATGATATA
ATTGAGAATGCACCAACTACACACACAGAGGAGTACAGTGGGGAGGAGAAAACGTGGATGTGGTGGCACAACTTCCGGACTTTGTGTGACTATAGTAAGAGGATTGCAGTGGCTCTTGAAATTGGGGC
TGACCTCCCATCTAATCATGTCATTGATCGCTGGCTTGGGGAGCCCATCAAAGCAGCCATTCTCCCCACTAGCATTTTCCTGACCAATAAGAAGGGATTTCCTGTTCTTTCTAAGATGCACCAGAGGC
TCATCTTCCGGCTCCTCAAGTTGGAGGTGCAGTTCATCATCACAGGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTTAAGCCAGAACCGTCCTCCACCTAAT
GCCTATGAACTCTTTGCCAAGGGCTATGAAGACTATCTGCAGTCCCCGCTTCAGCCACTGATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGGACCCCATCAAATACTCTCAGTACCA
GCAGGCCATCTATAAATGTCTGCTAGACCGAGTACCAGAAGAGGAGAAGGATACCAATGTCCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTGAACGCTTCCCTGCGGGCAGCCAAGC
AGGCCGACCGGCGGATAAAGCTGTATGCTGTGGAGAAAAACCCAAATGCCGTGGTGACGCTAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGTAGTCTCATCAGACATGAGGGAATGG
GTGGCTCCAGAGAAAGCAGACATCATTGTCAGTGAGCTTCTGGGCTCATTTGCTGACAATGAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGATGGTGTGAGCATCCCCGG
GGAGTACACTTCCTTTCTGGCTCCCATCTCTTCCTCCAAGCTGTACAATGAGGTCCGAGCCTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATGCCTTATGTGGTACGGCTGCACAACT
TCCACCAGCTCTCTGCACCCCAGCCCTGTTTCACCTTCAGCCATCCCAACAGAGATCCTATGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGAGGTGAACACAGTACTACATGGCTTT
GCCGGCTACTTTGAGACTGTGCTTTATCAGGACATCACTCTGAGTATCCGTCCAGAGACTCACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTATTAAGCAGCCCATAACGGTACGTGA
AGGCCAAACCATCTGTGTGCGTTTCTGGCGATGCAGCAATTCCAAGAAGGTGTGGTATGAGTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCCACAGGCCGCTCATATACCATTGGCC
TCTAGCCCTGCGTGCCAAGTGTCCAGAGCCTTGGAAGCAGCTTCAGGTTCTGCTCCTGTAGTACAGAAGGTGCAGTACATCTATGGGCTGTGATTCCCCTTGCCCATCAGAGAGGAGCATTTCAATCT
GCTTTCCTGCCTTACATCAAGGTGGGCAAGGGATTATAATTAATTGCAGGGCTCAAGCCACCAATCTATGAAGACCTCAGGCCAGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTACGCACTCAGCC
TCAAGAACTCCCTGGAATATCCCTGAGAACATGGGGTTTGAACGGATTTTCAGCCTTTTTCTGTTCTTGTTTTGATGGTTTTGTGTAAGAGGAAATACAAATAAAGTTATAGCCCTTTACTGCA

hide sequence

RefSeq Acc Id:

NM_001282956 ⟹ NP_001269885

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI
HuRef	14	3,506,752 - 3,515,820 (-)	NCBI
CHM1_1	14	23,388,338 - 23,397,410 (-)	NCBI
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

Sequence:

show sequence

AGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGGAGCCGCGTGTCCAGCGGGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTG
AGGGCCGGACCTCCACGAGCGGAATGCGGGGTCCGAACTCGGGGACGGAGAAGGGCAGACTAGTCATCCCGGAGAAGCAGGGGTTTGATTTCCTCTGCATGCCTGTCTTCCATCCGCGTTTCAAGAGG
GAGTTCATTCAGGAACCTGCTAAGAATCGGCCCGGTCCCCAGACACGATCAGACCTACTGCTGTCAGGAAGGGACTGGAATACGCTAATTGTGGGAAAGCTTTCTCCATGGATTCGTCCAGACTCAAA
AGTGGAGAAGATTCGCAGGAACTCCGAGGCGTTGGAGGTGCAGTTCATCATCACAGGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTTAAGCCAGAACCGTC
CTCCACCTAATGCCTATGAACTCTTTGCCAAGGGCTATGAAGACTATCTGCAGTCCCCGCTTCAGCCACTGATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGGACCCCATCAAATAC
TCTCAGTACCAGCAGGCCATCTATAAATGTCTGCTAGACCGAGTACCAGAAGAGGAGAAGGATACCAATGTCCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTGAACGCTTCCCTGCG
GGCAGCCAAGCAGGCCGACCGGCGGATAAAGCTGTATGCTGTGGAGAAAAACCCAAATGCCGTGGTGACGCTAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGTAGTCTCATCAGACA
TGAGGGAATGGGTGGCTCCAGAGAAAGCAGACATCATTGTCAGTGAGCTTCTGGGCTCATTTGCTGACAATGAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGATGGTGTG
AGCATCCCCGGGGAGTACACTTCCTTTCTGGCTCCCATCTCTTCCTCCAAGCTGTACAATGAGGTCCGAGCCTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATGCCTTATGTGGTACG
GCTGCACAACTTCCACCAGCTCTCTGCACCCCAGCCCTGTTTCACCTTCAGCCATCCCAACAGAGATCCTATGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGAGGTGAACACAGTAC
TACATGGCTTTGCCGGCTACTTTGAGACTGTGCTTTATCAGGACATCACTCTGAGTATCCGTCCAGAGACTCACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTATTAAGCAGCCCATA
ACGGTACGTGAAGGCCAAACCATCTGTGTGCGTTTCTGGCGATGCAGCAATTCCAAGAAGGTGTGGTATGAGTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCCACAGGCCGCTCATA
TACCATTGGCCTCTAGCCCTGCGTGCCAAGTGTCCAGAGCCTTGGAAGCAGCTTCAGGTTCTGCTCCTGTAGTACAGAAGGTGCAGTACATCTATGGGCTGTGATTCCCCTTGCCCATCAGAGAGGAG
CATTTCAATCTGCTTTCCTGCCTTACATCAAGGTGGGCAAGGGATTATAATTAATTGCAGGGCTCAAGCCACCAATCTATGAAGACCTCAGGCCAGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTA
CGCACTCAGCCTCAAGAACTCCCTGGAATATCCCTGAGAACATGGGGTTTGAACGGATTTTCAGCCTTTTTCTGTTCTTGTTTTGATGGTTTTGTGTAAGAGGAAATACAAATAAAGTTATAGCCCTT
TACTGCA

hide sequence

RefSeq Acc Id:

NM_006109 ⟹ NP_006100

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI
GRCh37	14	23,389,733 - 23,398,789 (-)	NCBI
Build 36	14	22,459,573 - 22,468,501 (-)	NCBI Archive
HuRef	14	3,506,752 - 3,515,820 (-)	NCBI
CHM1_1	14	23,388,338 - 23,397,410 (-)	NCBI
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

Sequence:

show sequence

AGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGGAGCCGCGTGTCCAGCG
GGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTTTGATTTCCTCTGCATGCCTGTCTTCCATCCGCGTTTCAAGAGGGAGTTCATTCAGGAACCTGCT
AAGAATCGGCCCGGTCCCCAGACACGATCAGACCTACTGCTGTCAGGAAGGGACTGGAATACGCTAATTGTGGGAAAGCTTTCTCCATGGATTCGTCCAGACTCAAAAGTGGAGAAGATTCGCAGGAA
CTCCGAGGCGGCCATGTTACAGGAGCTGAATTTTGGTGCATATTTGGGTCTTCCAGCTTTCCTGCTGCCCCTTAATCAGGAAGATAACACCAACCTGGCCAGAGTTTTGACCAACCACATCCACACTG
GCCATCACTCTTCCATGTTCTGGATGCGGGTACCCTTGGTGGCACCAGAGGACCTGAGAGATGATATAATTGAGAATGCACCAACTACACACACAGAGGAGTACAGTGGGGAGGAGAAAACGTGGATG
TGGTGGCACAACTTCCGGACTTTGTGTGACTATAGTAAGAGGATTGCAGTGGCTCTTGAAATTGGGGCTGACCTCCCATCTAATCATGTCATTGATCGCTGGCTTGGGGAGCCCATCAAAGCAGCCAT
TCTCCCCACTAGCATTTTCCTGACCAATAAGAAGGGATTTCCTGTTCTTTCTAAGATGCACCAGAGGCTCATCTTCCGGCTCCTCAAGTTGGAGGTGCAGTTCATCATCACAGGCACCAACCACCACT
CAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTTAAGCCAGAACCGTCCTCCACCTAATGCCTATGAACTCTTTGCCAAGGGCTATGAAGACTATCTGCAGTCCCCGCTTCAGCCACTG
ATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGGACCCCATCAAATACTCTCAGTACCAGCAGGCCATCTATAAATGTCTGCTAGACCGAGTACCAGAAGAGGAGAAGGATACCAATGT
CCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTGAACGCTTCCCTGCGGGCAGCCAAGCAGGCCGACCGGCGGATAAAGCTGTATGCTGTGGAGAAAAACCCAAATGCCGTGGTGACGC
TAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGTAGTCTCATCAGACATGAGGGAATGGGTGGCTCCAGAGAAAGCAGACATCATTGTCAGTGAGCTTCTGGGCTCATTTGCTGACAAT
GAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGATGGTGTGAGCATCCCCGGGGAGTACACTTCCTTTCTGGCTCCCATCTCTTCCTCCAAGCTGTACAATGAGGTCCGAGC
CTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATGCCTTATGTGGTACGGCTGCACAACTTCCACCAGCTCTCTGCACCCCAGCCCTGTTTCACCTTCAGCCATCCCAACAGAGATCCTA
TGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGAGGTGAACACAGTACTACATGGCTTTGCCGGCTACTTTGAGACTGTGCTTTATCAGGACATCACTCTGAGTATCCGTCCAGAGACT
CACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTATTAAGCAGCCCATAACGGTACGTGAAGGCCAAACCATCTGTGTGCGTTTCTGGCGATGCAGCAATTCCAAGAAGGTGTGGTATGA
GTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCCACAGGCCGCTCATATACCATTGGCCTCTAGCCCTGCGTGCCAAGTGTCCAGAGCCTTGGAAGCAGCTTCAGGTTCTGCTCCTGTA
GTACAGAAGGTGCAGTACATCTATGGGCTGTGATTCCCCTTGCCCATCAGAGAGGAGCATTTCAATCTGCTTTCCTGCCTTACATCAAGGTGGGCAAGGGATTATAATTAATTGCAGGGCTCAAGCCA
CCAATCTATGAAGACCTCAGGCCAGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTACGCACTCAGCCTCAAGAACTCCCTGGAATATCCCTGAGAACATGGGGTTTGAACGGATTTTCAGCCTTTTT
CTGTTCTTGTTTTGATGGTTTTGTGTAAGAGGAAATACAAATAAAGTTATAGCCCTTTACTGCA

hide sequence

RefSeq Acc Id:

XM_047430881 ⟹ XP_047286837

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI

RefSeq Acc Id:

XM_054375270 ⟹ XP_054231245

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

RefSeq Acc Id:

XR_001750113

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI

Sequence:

show sequence

AGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGGAGCCGCGTGTCCAGCG
GGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTGAGGGCCGGACCTCCACGAGCGGAATGCGGGGTCCGAACTCGGGGACGGAGAAGGGCAGACTAGT
CATCCCGGAGAAGCAGGGGTTTGATTTCCTCTGCATGCCTGTCTTCCATCCGCGTTTCAAGAGGGAGTTCATTCAGGAACCTGCTAAGAATCGGCCCGGTCCCCAGACACGATCAGACCTACTGCTGT
CAGGAAGGGACTGGAATACGCTAATTGTGGGAAAGCTTTCTCCATGGATTCGTCCAGACTCAAAAGTGGAGAAGATTCGCAGGAACTCCGAGGCGGCCATGTTACAGGAGCTGAATTTTGGTGCATAT
TTGGGTCTTCCAGCTTTCCTGCTGCCCCTTAATCAGGAAGATAACACCAACCTGGCCAGAGTTTTGACCAACCACATCCACACTGGCCATCACTCTTCCATGTTCTGGATGCGGGTACCCTTGGTGGC
ACCAGAGGACCTGAGAGATGATATAATTGAGAATGCACCAACTACACACACAGAGGAGTACAGTGGGGAGGAGAAAACGTGGATGTGGTGGCACAACTTCCGGACTTTGTGTGACTATAGTAAGAGGA
TTGCAGTGGCTCTTGAAATTGGGGCTGACCTCCCATCTAATCATGTCATTGATCGCTGGCTTGGGGAGCCCATCAAAGCAGCCATTCTCCCCACTAGCATTTTCCTGACCAATAAGAAGGGATTTCCT
GTTCTTTCTAAGATGCACCAGAGGCTCATCTTCCGGCTCCTCAAGTTGGAGGTGCAGTTCATCATCACAGGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTT
AAGCCAGAACCGTCCTCCACCTAATGCCTATGAACTCTTTGCCAAGGGCTATGAAGACTATCTGCAGTCCCCGCTTCAGCCACTGATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGG
ACCCCATCAAATACTCTCAGTACCAGCAGGCCATCTATAAATGTCTGCTAGACCGAGTACCAGAAGAGGAGAAGGATACCAATGTCCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTG
AACGCTTCCCTGCGGGCAGCCAAGCAGGCCGACCGGCGGATAAAGCTGTATGCTGTGGAGAAAAACCCAAATGCCGTGGTGACGCTAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGT
AGTCTCATCAGACATGAGGGAATGGGTGGCTCCAGAGAAAGCAGACATCATTGTCAGTGAGCTTCTGGGCTCATTTGCTGACAATGAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAA
AAGATGATGGTGTGAGCATCCCCGGGGAGTACACTTCCTTTCTGGCTCCCATCTCTTCCTCCAAGCTGTACAATGAGGTCCGAGCCTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATG
CCTTATGTGGTACGGCTGCACAACTTCCACCAGCTCTCTGCACCCCAGCCCTGTTTCACCTTCAGCCATCCCAACAGAGATCCTATGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGA
GGTGAACACAGTACTACATGGCTTTGCCGGCTACTTTGAGACTGTGCTTTATCAGGACATCACTCTGAGTATCCGTCCAGAGACTCACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTA
TTAAGCAGCCCATAACGGTACGTGAAGGCCAAACCATCTGTGTGCGTTTCTGGCGATGCAGCAATTCCAAGAAGGTGTGGTATGAGTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCC
ACAGGCCGCTCATATACCATTGGCCTCTAGCCCTGCGTGCCAAGTGTCCAGAGCCTTGGAAGCAGCTTCAGGTTCTGCTCCTGTAGTACAGAAGGGCTCAAGCCACCAATCTATGAAGACCTCAGGCC
AGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTACGCACTCAGCCTCAAGAACTCCCTGGAATATCCCTGAGAACATGGGGTTTGAACGGATTTTCAGCCTTTTTCTGTTCTTGTTTTGATGGTTTTG
TGTAAGAGGAAATACAAATAAAGTTATAGCCCTTTACTGCACGA

hide sequence

RefSeq Acc Id:

XR_008488813

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

RefSeq Acc Id:

XR_008488814

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	14	17,118,607 - 17,127,453 (-)	NCBI

RefSeq Acc Id:

XR_429287

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,920,529 - 22,929,376 (-)	NCBI

Sequence:

show sequence

GAATCCCGGCGTGGACAGCGCGAGGAGAAAGATGGCGGCGATGGCGGTCGGGGGTGCTGGTGGG
AGCCGCGTGTCCAGCGGGAGGGACCTGAATTGCGTCCCCGAAATAGCTGACACACTAGGGGCTGTGGCCAAGCAGGGGTTTGATTTCCTCTGCATGCCTGTCTTCCATCCGCGTTTCAAGAGGGAGTT
CATTCAGGAACCTGCTAAGAATCGGCCCGGTCCCCAGACACGATCAGACCTACTGCTGTCAGGAAGGGACTGGAATACGCTAATTGTGGGAAAGCTTTCTCCATGGATTCGTCCAGACTCAAAAGTGG
AGAAGATTCGCAGGAACTCCGAGGCGGCCATGTTACAGGAGCTGAATTTTGGTGCATATTTGGGTCTTCCAGCTTTCCTGCTGCCCCTTAATCAGGAAGATAACACCAACCTGGCCAGAGTTTTGACC
AACCACATCCACACTGGCCATCACTCTTCCATGTTCTGGATGCGGGTACCCTTGGTGGCACCAGAGGACCTGAGAGATGATATAATTGAGAATGCACCAACTACACACACAGAGGAGTACAGTGGGGA
GGAGAAAACGTGGATGTGGTGGCACAACTTCCGGACTTTGTGTGACTATAGTAAGAGGATTGCAGTGGCTCTTGAAATTGGGGCTGACCTCCCATCTAATCATGTCATTGATCGCTGGCTTGGGGAGC
CCATCAAAGCAGCCATTCTCCCCACTAGCATTTTCCTGACCAATAAGAAGGGATTTCCTGTTCTTTCTAAGATGCACCAGAGGCTCATCTTCCGGCTCCTCAAGTTGGAGGTGCAGTTCATCATCACA
GGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTACCTCCAATACCTGGAATACTTAAGCCAGAACCGTCCTCCACCTAATGCCTATGAACTCTTTGCCAAGGGCTATGAAGACTATCTGCAGTC
CCCGCTTCAGCCACTGATGGACAATCTGGAATCTCAGACATATGAAGTGTTTGAAAAGGACCCCATCAAATACTCTCAGTACCAGCAGGCCATCTATAAATGTCTGCTAGACCGAGTACCAGAAGAGG
AGAAGGATACCAATGTCCAGGTACTGATGGTGCTGGGAGCAGGACGGGGACCCCTGGTGAACGCTTCCCTGCGGGCAGCCAAGCAGGCCGACCGGCGGATAAAGCTGTATGCTGTGGAGAAAAACCCA
AATGCCGTGGTGACGCTAGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAAGTGACCGTAGTCTCATCAGACATGAGGGAATGGGTGGCTCCAGAGAAAGCAGACATCATTGTCAGTGAGCTTCTGGG
CTCATTTGCTGACAATGAATTGTCGCCTGAGTGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGATGGTGTGAGCATCCCCGGGGAGTACACTTCCTTTCTGGCTCCCATCTCTTCCTCCAAGCTGT
ACAATGAGGTCCGAGCCTGTAGGGAGAAGGACCGTGACCCTGAGGCCCAGTTTGAGATGCCTTATGTGGTACGGCTGCACAACTTCCACCAGCTCTCTGCACCCCAGCCCTGTTTCACCTTCAGCCAT
CCCAACAGAGATCCTATGATTGACAACAACCGCTATTGCACCTTGGAATTTCCTGTGGAGGTGAACACAGTACTACATGGCTTTGCCGGCTACTTTGAGACTGTGCTTTATCAGGACATCACTCTGAG
TATCCGTCCAGAGACTCACTCTCCTGGGATGTTCTCATGGTTTCCCATCCTCTTCCCTATTAAGCAGCCCATAACGGTACGTGAAGGCCAAACCATCTGTGTGCGTTTCTGGCGATGCAGCAATTCCA
AGAAGGTGTGGTATGAGTGGGCTGTGACAGCACCAGTCTGTTCTGCTATTCATAACCCCACAGGCCGCTCATATACCATTGGCCTCTAGCCCTGCGTGCCAAGTGTCCAGAGCCTTGGAAGCAGCTTC
AGGTTCTGCTCCTGTAGTACAGAAGGGCTCAAGCCACCAATCTATGAAGACCTCAGGCCAGGGGGTGAGGAATTAGTGCTGGATTTGAAGCTACGCACTCAGCCTCAAGAACTCCCTGGAATATCCCT
GAGAACATGGGGTTTGAACGGATTTTCAGCCTTTTTCTGTTCTTGTTTTGATGGTTTTGTGTAAGAGGAAATACAAATAAAGTTATAGCCCTTTACTGCACGA

hide sequence


Protein RefSeqs	NP_001034708	(Get FASTA)	NCBI Sequence Viewer
	NP_001269882	(Get FASTA)	NCBI Sequence Viewer
	NP_001269883	(Get FASTA)	NCBI Sequence Viewer
	NP_001269884	(Get FASTA)	NCBI Sequence Viewer
	NP_001269885	(Get FASTA)	NCBI Sequence Viewer
	NP_006100	(Get FASTA)	NCBI Sequence Viewer
	XP_047286837	(Get FASTA)	NCBI Sequence Viewer
	XP_054231245	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB66581	(Get FASTA)	NCBI Sequence Viewer
	AAF04502	(Get FASTA)	NCBI Sequence Viewer
	AAH25979	(Get FASTA)	NCBI Sequence Viewer
	BAG37884	(Get FASTA)	NCBI Sequence Viewer
	BAG52095	(Get FASTA)	NCBI Sequence Viewer
	BAG62512	(Get FASTA)	NCBI Sequence Viewer
	BAG63261	(Get FASTA)	NCBI Sequence Viewer
	BAG63592	(Get FASTA)	NCBI Sequence Viewer
	BAG70060	(Get FASTA)	NCBI Sequence Viewer
	BAG70184	(Get FASTA)	NCBI Sequence Viewer
	CAF86569	(Get FASTA)	NCBI Sequence Viewer
	CAG33022	(Get FASTA)	NCBI Sequence Viewer
	CAW36507	(Get FASTA)	NCBI Sequence Viewer
	CAW36522	(Get FASTA)	NCBI Sequence Viewer
	CAW47075	(Get FASTA)	NCBI Sequence Viewer
	CAW47090	(Get FASTA)	NCBI Sequence Viewer
	CAW52884	(Get FASTA)	NCBI Sequence Viewer
	CAW52899	(Get FASTA)	NCBI Sequence Viewer
	CAW54329	(Get FASTA)	NCBI Sequence Viewer
	CAW54344	(Get FASTA)	NCBI Sequence Viewer
	CAW56663	(Get FASTA)	NCBI Sequence Viewer
	CAW56678	(Get FASTA)	NCBI Sequence Viewer
	CAW56884	(Get FASTA)	NCBI Sequence Viewer
	CAW56899	(Get FASTA)	NCBI Sequence Viewer
	CAW58130	(Get FASTA)	NCBI Sequence Viewer
	CAW58145	(Get FASTA)	NCBI Sequence Viewer
	CAW63380	(Get FASTA)	NCBI Sequence Viewer
	CAW63395	(Get FASTA)	NCBI Sequence Viewer
	CAW67682	(Get FASTA)	NCBI Sequence Viewer
	CAW67697	(Get FASTA)	NCBI Sequence Viewer
	CAW71688	(Get FASTA)	NCBI Sequence Viewer
	CAW71703	(Get FASTA)	NCBI Sequence Viewer
	CAW75488	(Get FASTA)	NCBI Sequence Viewer
	CAW75503	(Get FASTA)	NCBI Sequence Viewer
	CAW76906	(Get FASTA)	NCBI Sequence Viewer
	CAW76921	(Get FASTA)	NCBI Sequence Viewer
	CAW80180	(Get FASTA)	NCBI Sequence Viewer
	CAW80195	(Get FASTA)	NCBI Sequence Viewer
	CAW83710	(Get FASTA)	NCBI Sequence Viewer
	CAW83725	(Get FASTA)	NCBI Sequence Viewer
	CAW85688	(Get FASTA)	NCBI Sequence Viewer
	CAW85725	(Get FASTA)	NCBI Sequence Viewer
	CAW88052	(Get FASTA)	NCBI Sequence Viewer
	CAW88087	(Get FASTA)	NCBI Sequence Viewer
	CBC02460	(Get FASTA)	NCBI Sequence Viewer
	CBC02475	(Get FASTA)	NCBI Sequence Viewer
	CBC12707	(Get FASTA)	NCBI Sequence Viewer
	CBC12736	(Get FASTA)	NCBI Sequence Viewer
	CBC24395	(Get FASTA)	NCBI Sequence Viewer
	CBC24426	(Get FASTA)	NCBI Sequence Viewer
	CBC27261	(Get FASTA)	NCBI Sequence Viewer
	CBC27290	(Get FASTA)	NCBI Sequence Viewer
	CBC31963	(Get FASTA)	NCBI Sequence Viewer
	CBC31992	(Get FASTA)	NCBI Sequence Viewer
	CBC32400	(Get FASTA)	NCBI Sequence Viewer
	CBC32427	(Get FASTA)	NCBI Sequence Viewer
	CBC34850	(Get FASTA)	NCBI Sequence Viewer
	CBC34879	(Get FASTA)	NCBI Sequence Viewer
	CBC45305	(Get FASTA)	NCBI Sequence Viewer
	CBC45335	(Get FASTA)	NCBI Sequence Viewer
	CBC53883	(Get FASTA)	NCBI Sequence Viewer
	CBC53913	(Get FASTA)	NCBI Sequence Viewer
	CBC61885	(Get FASTA)	NCBI Sequence Viewer
	CBC61915	(Get FASTA)	NCBI Sequence Viewer
	CBC69422	(Get FASTA)	NCBI Sequence Viewer
	CBC69455	(Get FASTA)	NCBI Sequence Viewer
	CBC72246	(Get FASTA)	NCBI Sequence Viewer
	CBC72276	(Get FASTA)	NCBI Sequence Viewer
	CBC78810	(Get FASTA)	NCBI Sequence Viewer
	CBC78840	(Get FASTA)	NCBI Sequence Viewer
	CBC85871	(Get FASTA)	NCBI Sequence Viewer
	CBC85900	(Get FASTA)	NCBI Sequence Viewer
	CBC88583	(Get FASTA)	NCBI Sequence Viewer
	CBC88615	(Get FASTA)	NCBI Sequence Viewer
	CBC90649	(Get FASTA)	NCBI Sequence Viewer
	CBC90681	(Get FASTA)	NCBI Sequence Viewer
	CBD29472	(Get FASTA)	NCBI Sequence Viewer
	CBD29487	(Get FASTA)	NCBI Sequence Viewer
	EAW66217	(Get FASTA)	NCBI Sequence Viewer
	EAW66218	(Get FASTA)	NCBI Sequence Viewer
	EAW66219	(Get FASTA)	NCBI Sequence Viewer
	EAW66220	(Get FASTA)	NCBI Sequence Viewer
	EAW66221	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000216350
	ENSP00000216350.8
	ENSP00000319169
	ENSP00000319169.8
	ENSP00000380582
	ENSP00000380582.4
	ENSP00000380583
	ENSP00000380583.2
	ENSP00000452555
	ENSP00000452555.1
GenBank Protein	O14744	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_006100 ⟸ NM_006109
- Peptide Label:	isoform a
- UniProtKB:	Q6IBR1 (UniProtKB/Swiss-Prot), E2QRE7 (UniProtKB/Swiss-Prot), D3DS33 (UniProtKB/Swiss-Prot), B5BU10 (UniProtKB/Swiss-Prot), B4DY30 (UniProtKB/Swiss-Prot), B4DX49 (UniProtKB/Swiss-Prot), A8MZ91 (UniProtKB/Swiss-Prot), A8MTP3 (UniProtKB/Swiss-Prot), Q9UKH1 (UniProtKB/Swiss-Prot), O14744 (UniProtKB/Swiss-Prot), B2RDD7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQ EDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFR LLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADR RIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQL SAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL hide sequence

RefSeq Acc Id:	NP_001034708 ⟸ NM_001039619
- Peptide Label:	isoform b
- UniProtKB:	B2RDD7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRGPNSGTEKGRLVIPEKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTG HHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHS EKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTL ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPM IDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL hide sequence

RefSeq Acc Id:	NP_001269884 ⟸ NM_001282955
- Peptide Label:	isoform e
- UniProtKB:	B2RDD7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAP TTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEK ADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFE TVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL hide sequence

RefSeq Acc Id:	NP_001269883 ⟸ NM_001282954
- Peptide Label:	isoform d
- UniProtKB:	B4DV00 (UniProtKB/TrEMBL), B2RDD7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTS IFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLM VLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREK DRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVT APVCSAIHNPTGRSYTIGL hide sequence

RefSeq Acc Id:	NP_001269882 ⟸ NM_001282953
- Peptide Label:	isoform c
- UniProtKB:	B2RDD7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRGPNSGTEKGRLVIPEKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRAFLLP LNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRL IFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQ ADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNF HQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL hide sequence

Protein Domains

PRMT5 arginine-N-methyltransferase PRMT5 oligomerisation PRMT5 TIM barrel SAM-dependent MTase PRMT-type

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O14744-F1-model_v2	AlphaFold	O14744	1-637	view protein structure

RGD ID:

6791903

Promoter ID:

HG_KWN:18976

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000216350, NM_001039619, OTTHUMT00000071674, OTTHUMT00000071677, UC001WHN.1, UC010AKD.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	14	22,468,346 - 22,469,502 (-)	MPROMDB

RGD ID:

6851288

Promoter ID:

EP73442

Type:

initiation region

Name:

HS_SKB1

Description:

SKB1 homolog (S. pombe).

SO ACC ID:

SO:0000170

Source:

EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

NEDO full length human cDNA sequencing project.; Oligo-capping

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	14	22,468,425 - 22,468,485	EPD

RGD ID:

7227071

Promoter ID:

EPDNEW_H19281

Type:

initiation region

Name:

PRMT5_1

Description:

protein arginine methyltransferase 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	22,929,376 - 22,929,436	EPDNEW

Database	Acc Id	Source(s)
COSMIC	PRMT5	COSMIC
Ensembl Genes	ENSG00000100462	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000216350	ENTREZGENE
	ENST00000216350.12	UniProtKB/Swiss-Prot
	ENST00000324366	ENTREZGENE
	ENST00000324366.13	UniProtKB/Swiss-Prot
	ENST00000397440	ENTREZGENE
	ENST00000397440.8	UniProtKB/Swiss-Prot
	ENST00000397441	ENTREZGENE
	ENST00000397441.6	UniProtKB/Swiss-Prot
	ENST00000553897	ENTREZGENE
	ENST00000553897.5	UniProtKB/Swiss-Prot
	ENST00000553915	ENTREZGENE
Gene3D-CATH	3.40.50.150	UniProtKB/Swiss-Prot
	Divalent-metal-dependent TIM barrel enzymes	UniProtKB/Swiss-Prot
	Hnrnp arginine n-methyltransferase1	UniProtKB/Swiss-Prot
GTEx	ENSG00000100462	GTEx
HGNC ID	HGNC:10894	ENTREZGENE
Human Proteome Map	PRMT5	Human Proteome Map
InterPro	Arg_MeTrfase	UniProtKB/Swiss-Prot
	Arg_MeTrfase_PRMT5	UniProtKB/Swiss-Prot
	PRMT5	UniProtKB/Swiss-Prot
	PRMT5_C	UniProtKB/Swiss-Prot
	PRMT5_TIM	UniProtKB/Swiss-Prot
	SAM-dependent_MTases	UniProtKB/Swiss-Prot
KEGG Report	hsa:10419	UniProtKB/Swiss-Prot
NCBI Gene	10419	ENTREZGENE
OMIM	604045	OMIM
PANTHER	PROTEIN ARGININE N-METHYLTRANSFERASE 5	UniProtKB/Swiss-Prot
	PTHR10738	UniProtKB/Swiss-Prot
Pfam	PRMT5	UniProtKB/Swiss-Prot
	PRMT5_C	UniProtKB/Swiss-Prot
	PRMT5_TIM	UniProtKB/Swiss-Prot
PharmGKB	PA35794	PharmGKB
PIRSF	Skb1_MeTrfase	UniProtKB/Swiss-Prot
PROSITE	SAM_MT_PRMT	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53335	UniProtKB/Swiss-Prot
UniProt	A8MTP3	ENTREZGENE
	A8MZ91	ENTREZGENE
	ANM5_HUMAN	UniProtKB/Swiss-Prot
	B2RDD7	ENTREZGENE, UniProtKB/TrEMBL
	B4DV00	ENTREZGENE, UniProtKB/TrEMBL
	B4DX49	ENTREZGENE
	B4DY30	ENTREZGENE
	B5BU10	ENTREZGENE
	C9JSX3_HUMAN	UniProtKB/TrEMBL
	D3DS33	ENTREZGENE
	E2QRE7	ENTREZGENE
	G3V2F5_HUMAN	UniProtKB/TrEMBL
	G3V2L6_HUMAN	UniProtKB/TrEMBL
	G3V2X6_HUMAN	UniProtKB/TrEMBL
	G3V3A3_HUMAN	UniProtKB/TrEMBL
	G3V507_HUMAN	UniProtKB/TrEMBL
	G3V580_HUMAN	UniProtKB/TrEMBL
	G3V5L5_HUMAN	UniProtKB/TrEMBL
	G3V5T6_HUMAN	UniProtKB/TrEMBL
	H0YJ77_HUMAN	UniProtKB/TrEMBL
	H0YJD3_HUMAN	UniProtKB/TrEMBL
	H0YJX6_HUMAN	UniProtKB/TrEMBL
	H0YJY6_HUMAN	UniProtKB/TrEMBL
	H7BZ44_HUMAN	UniProtKB/TrEMBL
	O14744	ENTREZGENE
	Q6IBR1	ENTREZGENE
	Q9UKH1	ENTREZGENE
UniProt Secondary	A8MTP3	UniProtKB/Swiss-Prot
	A8MZ91	UniProtKB/Swiss-Prot
	B4DX49	UniProtKB/Swiss-Prot
	B4DY30	UniProtKB/Swiss-Prot
	B5BU10	UniProtKB/Swiss-Prot
	D3DS33	UniProtKB/Swiss-Prot
	E2QRE7	UniProtKB/Swiss-Prot
	Q6IBR1	UniProtKB/Swiss-Prot
	Q9UKH1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-05	PRMT5	protein arginine methyltransferase 5	HRMT1L5	HMT1 hnRNP methyltransferase-like 5 (S. cerevisiae)	Data merged from RGD:1349514	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)