Sin3a (SIN3 transcription regulator family member A) - Rat Genome Database

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Gene: Sin3a (SIN3 transcription regulator family member A) Rattus norvegicus
Analyze
Symbol: Sin3a
Name: SIN3 transcription regulator family member A
RGD ID: 1311598
Description: Enables RNA binding activity. Involved in cellular response to dopamine; cellular response to tert-butyl hydroperoxide; and regulation of hormone levels. Located in chromatin and nucleus. Part of protein-containing complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A); PARTICIPATES IN DNA modification pathway; Hedgehog signaling pathway; Huntington's disease pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363067; paired amphipathic helix protein Sin3a; SIN3 homolog A, transcription regulator; SIN3 homolog A, transcription regulator (yeast); SIN3 transcription regulator homolog A; SIN3 transcription regulator homolog A (yeast); transcriptional regulator, SIN3A; transcriptional regulator, SIN3A (yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,377,471 - 66,432,150 (+)NCBIGRCr8
mRatBN7.2857,481,539 - 57,536,195 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,481,573 - 57,536,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,009,384 - 63,059,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,288,238 - 61,338,757 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,152,689 - 59,203,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0861,748,590 - 61,803,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,762,768 - 61,803,099 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0860,323,131 - 60,373,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4860,832,595 - 60,884,764 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1860,851,648 - 60,904,028 (+)NCBI
Celera856,953,107 - 57,002,726 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chloride  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
Selamectin  (ISO)
tert-butyl hydroperoxide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. Boutell JM, etal., Hum Mol Genet. 1999 Sep;8(9):1647-55.
2. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
3. Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST. Dharap A, etal., ASN Neuro. 2013 Oct 23;5(4):283-9. doi: 10.1042/AN20130029.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. Geranton SM, etal., J Neurosci. 2007 Jun 6;27(23):6163-73.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Huang Y, etal., Nat Neurosci. 1999 Oct;2(10):867-72.
8. Epigenetic mechanisms in the dopamine D2 receptor-dependent inhibition of the prolactin gene. Liu JC, etal., Mol Endocrinol. 2005 Jul;19(7):1904-17. Epub 2005 Feb 24.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. Park JH, etal., J Clin Invest. 2008 Jun;118(6):2316-24.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Rodriguez JL, etal., Biochem J. 2006 Sep 15;398(3):431-7.
16. Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1. Shi L, etal., J Biol Chem. 2008 Dec 26;283(52):36474-85. Epub 2008 Oct 21.
17. In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes. Torres L, etal., Free Radic Biol Med. 2009 Mar 13.
Additional References at PubMed
PMID:7889570   PMID:8649810   PMID:10431247   PMID:10734093   PMID:12649481   PMID:14519686   PMID:14593184   PMID:14966270   PMID:15322089   PMID:15767674   PMID:15998811   PMID:17074803  
PMID:17182846   PMID:17670746   PMID:17827154   PMID:18212064   PMID:19235719   PMID:21680841   PMID:22783022   PMID:24029230   PMID:25931508   PMID:27399968  


Genomics

Comparative Map Data
Sin3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,377,471 - 66,432,150 (+)NCBIGRCr8
mRatBN7.2857,481,539 - 57,536,195 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,481,573 - 57,536,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,009,384 - 63,059,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,288,238 - 61,338,757 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,152,689 - 59,203,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0861,748,590 - 61,803,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,762,768 - 61,803,099 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0860,323,131 - 60,373,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4860,832,595 - 60,884,764 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1860,851,648 - 60,904,028 (+)NCBI
Celera856,953,107 - 57,002,726 (+)NCBICelera
Cytogenetic Map8q24NCBI
SIN3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381575,369,379 - 75,455,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1575,369,379 - 75,455,842 (-)EnsemblGRCh38hg38GRCh38
GRCh371575,661,720 - 75,748,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361573,450,328 - 73,530,979 (-)NCBINCBI36Build 36hg18NCBI36
Build 341573,450,329 - 73,530,979NCBI
Celera1552,588,161 - 52,674,772 (-)NCBICelera
Cytogenetic Map15q24.2NCBI
HuRef1552,420,097 - 52,506,377 (-)NCBIHuRef
CHM1_11575,780,322 - 75,866,699 (-)NCBICHM1_1
T2T-CHM13v2.01573,239,476 - 73,331,180 (-)NCBIT2T-CHM13v2.0
Sin3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39956,979,271 - 57,035,652 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl956,979,324 - 57,035,650 (+)EnsemblGRCm39 Ensembl
GRCm38957,071,991 - 57,128,368 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,072,040 - 57,128,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv37956,919,847 - 56,976,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36956,874,519 - 56,926,290 (+)NCBIMGSCv36mm8
Celera954,295,792 - 54,352,077 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map930.89NCBI
Sin3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554502,808,130 - 2,870,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554502,804,551 - 2,870,450 (+)NCBIChiLan1.0ChiLan1.0
SIN3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,570,768 - 64,656,834 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,736,261 - 68,820,731 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01554,285,587 - 54,371,376 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,881,500 - 73,966,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,881,500 - 73,966,506 (-)Ensemblpanpan1.1panPan2
SIN3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13038,231,844 - 38,306,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3038,232,680 - 38,382,635 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3038,162,224 - 38,237,534 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,436,823 - 38,512,188 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,436,823 - 38,508,325 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,389,129 - 38,464,067 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,434,094 - 38,509,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,670,990 - 38,745,906 (-)NCBIUU_Cfam_GSD_1.0
Sin3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640116,357,106 - 116,416,720 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647134,204,524 - 34,260,564 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647134,206,084 - 34,260,538 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIN3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,176,167 - 58,245,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,171,821 - 58,246,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2762,861,102 - 62,934,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIN3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1267,971,208 - 8,060,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl267,975,484 - 8,058,278 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048133,632,174 - 133,722,014 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sin3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624894301,082 - 362,683 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624894300,027 - 388,397 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sin3a
163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:105
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000058685
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001395640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000058685   ⟹   ENSRNOP00000055480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,481,573 - 57,536,192 (+)Ensembl
Rnor_6.0 Ensembl861,762,768 - 61,803,099 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089557   ⟹   ENSRNOP00000072640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,481,573 - 57,536,192 (+)Ensembl
Rnor_6.0 Ensembl861,762,773 - 61,802,490 (+)Ensembl
RefSeq Acc Id: NM_001395640   ⟹   NP_001382569
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,381,783 - 66,432,150 (+)NCBI
mRatBN7.2857,485,823 - 57,536,192 (+)NCBI
RefSeq Acc Id: XM_006243129   ⟹   XP_006243191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,381,779 - 66,432,150 (+)NCBI
mRatBN7.2857,485,703 - 57,536,192 (+)NCBI
Rnor_6.0861,752,815 - 61,803,314 (+)NCBI
Rnor_5.0860,323,131 - 60,373,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766299   ⟹   XP_008764521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,377,774 - 66,432,150 (+)NCBI
mRatBN7.2857,482,878 - 57,536,195 (+)NCBI
Rnor_6.0861,757,184 - 61,803,314 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766301   ⟹   XP_008764523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,377,471 - 66,432,150 (+)NCBI
mRatBN7.2857,481,539 - 57,536,195 (+)NCBI
Rnor_6.0861,748,590 - 61,803,314 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766302   ⟹   XP_008764524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,377,774 - 66,432,150 (+)NCBI
mRatBN7.2857,482,878 - 57,536,195 (+)NCBI
Rnor_6.0861,749,943 - 61,803,314 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081734   ⟹   XP_038937662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,381,779 - 66,432,150 (+)NCBI
mRatBN7.2857,485,821 - 57,536,192 (+)NCBI
RefSeq Acc Id: XM_039081735   ⟹   XP_038937663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,377,774 - 66,432,150 (+)NCBI
mRatBN7.2857,482,878 - 57,536,195 (+)NCBI
RefSeq Acc Id: XM_039081736   ⟹   XP_038937664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,377,558 - 66,432,150 (+)NCBI
mRatBN7.2857,481,690 - 57,536,195 (+)NCBI
RefSeq Acc Id: XM_039081737   ⟹   XP_038937665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,381,126 - 66,432,150 (+)NCBI
mRatBN7.2857,485,291 - 57,536,195 (+)NCBI
RefSeq Acc Id: XM_063265750   ⟹   XP_063121820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,381,781 - 66,432,150 (+)NCBI
RefSeq Acc Id: XM_063265751   ⟹   XP_063121821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,381,126 - 66,432,150 (+)NCBI
RefSeq Acc Id: XM_063265752   ⟹   XP_063121822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,381,781 - 66,432,150 (+)NCBI
RefSeq Acc Id: XM_063265753   ⟹   XP_063121823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,377,498 - 66,432,150 (+)NCBI
RefSeq Acc Id: XP_006243191   ⟸   XM_006243129
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764523   ⟸   XM_008766301
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764524   ⟸   XM_008766302
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764521   ⟸   XM_008766299
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072640   ⟸   ENSRNOT00000089557
Ensembl Acc Id: ENSRNOP00000055480   ⟸   ENSRNOT00000058685
RefSeq Acc Id: XP_038937664   ⟸   XM_039081736
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937663   ⟸   XM_039081735
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937665   ⟸   XM_039081737
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937662   ⟸   XM_039081734
- Peptide Label: isoform X1
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382569   ⟸   NM_001395640
- UniProtKB: D3ZBP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121823   ⟸   XM_063265753
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121821   ⟸   XM_063265751
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121822   ⟸   XM_063265752
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121820   ⟸   XM_063265750
- Peptide Label: isoform X1
Protein Domains
Histone deacetylase interacting

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3H5-F1-model_v2 AlphaFold A0A0G2K3H5 1-1274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311598 AgrOrtholog
BioCyc Gene G2FUF-30331 BioCyc
Ensembl Genes ENSRNOG00000032254 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058685.4 UniProtKB/TrEMBL
  ENSRNOT00000089557.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1160.11 UniProtKB/TrEMBL
InterPro HDAC_interact UniProtKB/TrEMBL
  PAH UniProtKB/TrEMBL
  PAH_sf UniProtKB/TrEMBL
  Sin3-like UniProtKB/TrEMBL
  Sin3_C UniProtKB/TrEMBL
NCBI Gene 363067 ENTREZGENE
PANTHER PTHR12346 UniProtKB/TrEMBL
  PTHR12346:SF2 UniProtKB/TrEMBL
Pfam HDAC_interact UniProtKB/TrEMBL
  PAH UniProtKB/TrEMBL
  Sin3a_C UniProtKB/TrEMBL
PhenoGen Sin3a PhenoGen
PROSITE PAH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032254 RatGTEx
SMART HDAC_interact UniProtKB/TrEMBL
Superfamily-SCOP PAH UniProtKB/TrEMBL
UniProt A0A0G2K3H5_RAT UniProtKB/TrEMBL
  D3ZBP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-18 Sin3a  SIN3 transcription regulator family member A  Sin3a  SIN3 transcription regulator homolog A (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Sin3a  SIN3 transcription regulator homolog A (yeast)  Sin3a  SIN3 homolog A, transcription regulator (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Sin3a  SIN3 homolog A, transcription regulator (yeast)  Sin3a  transcriptional regulator, SIN3A (yeast)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sin3a  transcriptional regulator, SIN3A (yeast)   Sin3a_predicted  transcriptional regulator, SIN3A (yeast) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sin3a_predicted  transcriptional regulator, SIN3A (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED