Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1)

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Gene: Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1) Ictidomys tridecemlineatus

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Symbol:

Apex1

Name:

apurinic/apyrimidinic endodeoxyribonuclease 1

RGD ID:

12598472

Description:

ENCODES a protein that exhibits NF-kappaB binding (ortholog); protein-containing complex binding (ortholog); RNA endonuclease activity (ortholog); INVOLVED IN cell redox homeostasis (ortholog); cellular response to cAMP (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH Animal Disease Models (ortholog); Brain Injuries (ortholog); brain ischemia (ortholog); FOUND IN nucleus (ortholog); transcription regulator complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

apurinic/apyrimidinic endodeoxyribonuclease 1, transcript variant X1; apurinic/apyrimidinic endodeoxyribonuclease 1, transcript variant X2; DNA-(apurinic or apyrimidinic site) endonuclease; DNA-(apurinic or apyrimidinic site) lyase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	77,685,350 - 77,688,067 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936877	666,523 - 669,338 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936877	666,545 - 669,351 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

breast cancer (ISO)

breast carcinoma (ISO)

Cerebral Hemorrhage (ISO)

cervical cancer (ISO)

cervix carcinoma (ISO)

Disease Progression (ISO)

endometrial cancer (ISO)

Experimental Seizures (ISO)

Genetic Predisposition to Disease (ISO)

heart disease (ISO)

hepatocellular carcinoma (ISO)

lung adenocarcinoma (ISO)

lung disease (ISO)

melanoma (ISO)

Micronuclei, Chromosome-Defective (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

ovarian cancer (ISO)

prostate carcinoma in situ (ISO)

Prostatic Neoplasms (ISO)

purine nucleoside phosphorylase deficiency (ISO)

Reperfusion Injury (ISO)

severe pre-eclampsia (ISO)

spina bifida (ISO)

Spinal Cord Injuries (ISO)

status epilepticus (ISO)

Stomach Neoplasms (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (IEA)

cell redox homeostasis (IEA,ISO)

cellular response to cAMP (ISO)

cellular response to hydrogen peroxide (ISO)

cellular response to Thyroid stimulating hormone (ISO)

DNA catabolic process (IEA)

DNA recombination (IEA)

DNA repair (IEA)

negative regulation of smooth muscle cell migration (ISO)

positive regulation of G1/S transition of mitotic cell cycle (ISO)

positive regulation of gene expression via chromosomal CpG island demethylation (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of apoptotic process (IEA)

regulation of mRNA stability (IEA)

response to xenobiotic stimulus (ISO)

telomere maintenance (IEA)

telomere maintenance via base-excision repair (IEA)

Cellular Component

centrosome (IEA)

cytoplasm (IEA)

mitochondrion (IEA)

nuclear speck (IEA)

nucleolus (IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

perinuclear region of cytoplasm (IEA)

transcription regulator complex (ISO)

Molecular Function

3'-5' exonuclease activity (IEA)

3'-5'-DNA exonuclease activity (IEA)

chromatin DNA binding (IEA)

class II DNA-(apurinic or apyrimidinic site) endonuclease activity (IEA)

damaged DNA binding (IEA)

DNA binding (IEA)

DNA-(abasic site) binding (IEA)

DNA-(apurinic or apyrimidinic site) endonuclease activity (IEA)

double-stranded DNA 3'-5' DNA exonuclease activity (IEA)

double-stranded DNA exodeoxyribonuclease activity (IEA)

double-stranded telomeric DNA binding (IEA)

endonuclease activity (IEA)

exonuclease activity (IEA)

metal ion binding (IEA)

NF-kappaB binding (ISO)

oxidoreductase activity (IEA)

phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands (IEA)

phosphoric diester hydrolase activity (IEA)

protein binding (ISO)

protein-containing complex binding (ISO)

RNA endonuclease activity (ISO)

site-specific endodeoxyribonuclease activity, specific for altered base (IEA)

transcription coactivator activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Apex1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	77,685,350 - 77,688,067 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936877	666,523 - 669,338 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936877	666,545 - 669,351 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APEX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	20,455,226 - 20,457,767 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	20,455,191 - 20,457,772 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	20,923,385 - 20,925,926 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	19,993,130 - 19,995,766 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	784,440 - 787,076 (+)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	1,044,909 - 1,047,550 (+)	NCBI		HuRef
CHM1_1	14	20,924,670 - 20,927,311 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	14,652,129 - 14,654,670 (+)	NCBI		T2T-CHM13v2.0

Apex1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	51,162,406 - 51,164,645 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	51,162,425 - 51,164,596 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	50,924,949 - 50,927,188 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	50,924,968 - 50,927,139 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	51,544,696 - 51,546,813 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	49,846,972 - 49,849,089 (+)	NCBI		MGSCv36	mm8
Celera	14	47,224,610 - 47,226,746 (+)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	26.3	NCBI

Apex1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	26,618,146 - 26,620,330 (+)	NCBI		GRCr8
mRatBN7.2	15	24,144,595 - 24,146,785 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,144,362 - 24,146,785 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	26,915,867 - 26,917,967 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	27,874,571 - 27,876,673 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,124,410 - 26,126,510 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	27,849,943 - 27,852,083 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	27,849,979 - 27,852,082 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	31,682,368 - 31,684,508 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	26,904,124 - 26,906,224 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	26,919,823 - 26,921,924 (+)	NCBI
Celera	15	24,464,809 - 24,466,909 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

Apex1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955550	1,273,284 - 1,279,743 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955550	1,273,170 - 1,275,843 (+)	NCBI	ChiLan1.0	ChiLan1.0

APEX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	21,964,695 - 21,967,271 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	21,181,188 - 21,183,758 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	1,329,745 - 1,332,315 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	19,381,911 - 19,384,542 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	19,381,911 - 19,384,542 (+)	Ensembl	panpan1.1		panPan2

APEX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	17,786,808 - 17,789,422 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	17,786,357 - 17,789,422 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	18,269,795 - 18,272,409 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	18,043,890 - 18,046,511 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	18,042,845 - 18,046,514 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	17,726,748 - 17,729,354 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	17,781,386 - 17,784,004 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	17,910,565 - 17,913,179 (+)	NCBI		UU_Cfam_GSD_1.0

APEX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	78,451,851 - 78,454,938 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	78,451,845 - 78,454,938 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	83,479,687 - 83,481,839 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APEX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	20,978,878 - 20,981,393 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666059	25,448,880 - 25,451,389 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Apex1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	4,708,093 - 4,714,921 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624825	4,711,921 - 4,714,926 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005341405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013365744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040274581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000010106 ⟹ ENSSTOP00000009066

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936877	666,523 - 669,338 (+)	Ensembl

RefSeq Acc Id:

XM_005341405 ⟹ XP_005341462

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	77,685,360 - 77,688,067 (+)	NCBI
SpeTri2.0	NW_004936877	666,545 - 669,351 (+)	NCBI

Sequence:

show sequence

TCAGTCACCCACGTGGGCGCAAAGCGTGCTCCATTCTTTGTGTTCGGGTAAGGAGGTGCCACGC
TCCGACCCAAGCAGGCAACACGGTAAAAGTACTGTTTCGGTGGGCGACGTGGTACTGGTTCCGA
AGGGCGTTCGTTACAGGGATGCCAAAGCGTGGGAAAAAGGGAGCGGCGGCAGAAGATGGGGAAG
AGCCCAAAACTGAGCCAGAGTCCAAGAAGAGTAAGGTAGGAGCAAAAAAAAAAGAAAAAGAGAC
AGCAGGAGAGGGCCCAGTCCTGTATGAAGACCCTCCAGATAAGAAAACCTCACCCAGTGGCAAA
TCTGCCACACTCAAGATCTGCTCTTGGAATGTTGATGGGCTTCGAGCCTGGATTAAGAAGAAAG
GTTTAGATTGGGTAAAGGAAGAAGCCCCAGATATCCTGTGCCTCCAAGAGACCAAATGTTCAGA
GAATAAACTACCACCTGAACTTCAAGAGCTGCCTGGATTATCCCATCAGTACTGGGCAGCTCCT
TCGGACAAGGAAGGATACAGTGGTGTGGGTCTACTTTCCCGCCAGTGCCCCATCAAAGTCTCTT
ATGGCATCGGTGAGGAGGAACATGATCAGGAAGGCCGGGTAATTGTGGCTGAATTTGACAAGTT
TGTGCTGGTAACAGCCTATGTACCTAATGCTGGCCGGGGTCTGGTAAGGCTGGAGTACCGCCAG
CGCTGGGATGAAGCCTTTCGCCAATTCCTGAAGGGCTTGGCTTCCCGCAAGCCCCTTGTGCTAT
GTGGGGACCTCAATGTGGCTCATGAAGAAATTGACCTTCGTAACCCCAAAGGAAACAAAAAAAA
TGCTGGCTTCACTCCACAGGAGCGCCAAGGCTTTGGAGAATTGCTGCAGGCTGTGCCACTGGCT
GACAGTTTCCGCCACTTGTACCCCAACACTGAATATGCCTATACCTTTTGGACTTACATGATGA
ATGCTCGGTCCAAGAACGTTGGTTGGCGCCTTGATTACTTTTTGTTGTCCCACTCTCTTTTACC
TGCATTGTGTGACAGCAAGATTCGCTCCAAGGCCCTTGGCAGTGATCACTGTCCCATCACCCTA
TACCTAGCACTGTGATACCCTCTTAGAATAATTTTGAGCCTTGGAAATAGCTTCCCTTACCCTC
AATGTTCCTTCTTTAGTACCTTGCTAGAGAAATCTGCATTTTATTTCTCTTCTGTAAGAATGAA
TCCTTAAATGAAGCTATTGTTACTAAGGTTTCTTTTAAGCCCAAGTTTTTTGTTGTGTGCACAC
ATGCCCCAGTTTTTTTTTTTTTTTTTAAAGACTTATCTGTAAAAATAAAAGGTCATAGTTTTGT
CTTTGCTGTGTTTTGTGTTTTACCCT

hide sequence

RefSeq Acc Id:

XM_013365744 ⟹ XP_013221198

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	77,685,350 - 77,688,067 (+)	NCBI
SpeTri2.0	NW_004936877	666,545 - 669,351 (+)	NCBI

Sequence:

show sequence

TCAGTCACCCACGTGGGCGCAAAGCGTGCTCCATTCTTTGTGTTCGGGCAACACGGTAAAAGTA
CTGTTTCGGTGGGCGACGTGGTACTGGTTCCGAAGGGCGTTCGTTACAGGGATGCCAAAGCGTG
GGAAAAAGGGAGCGGCGGCAGAAGATGGGGAAGAGCCCAAAACTGAGCCAGAGTCCAAGAAGAG
TAAGGTAGGAGCAAAAAAAAAAGAAAAAGAGACAGCAGGAGAGGGCCCAGTCCTGTATGAAGAC
CCTCCAGATAAGAAAACCTCACCCAGTGGCAAATCTGCCACACTCAAGATCTGCTCTTGGAATG
TTGATGGGCTTCGAGCCTGGATTAAGAAGAAAGGTTTAGATTGGGTAAAGGAAGAAGCCCCAGA
TATCCTGTGCCTCCAAGAGACCAAATGTTCAGAGAATAAACTACCACCTGAACTTCAAGAGCTG
CCTGGATTATCCCATCAGTACTGGGCAGCTCCTTCGGACAAGGAAGGATACAGTGGTGTGGGTC
TACTTTCCCGCCAGTGCCCCATCAAAGTCTCTTATGGCATCGGTGAGGAGGAACATGATCAGGA
AGGCCGGGTAATTGTGGCTGAATTTGACAAGTTTGTGCTGGTAACAGCCTATGTACCTAATGCT
GGCCGGGGTCTGGTAAGGCTGGAGTACCGCCAGCGCTGGGATGAAGCCTTTCGCCAATTCCTGA
AGGGCTTGGCTTCCCGCAAGCCCCTTGTGCTATGTGGGGACCTCAATGTGGCTCATGAAGAAAT
TGACCTTCGTAACCCCAAAGGAAACAAAAAAAATGCTGGCTTCACTCCACAGGAGCGCCAAGGC
TTTGGAGAATTGCTGCAGGCTGTGCCACTGGCTGACAGTTTCCGCCACTTGTACCCCAACACTG
AATATGCCTATACCTTTTGGACTTACATGATGAATGCTCGGTCCAAGAACGTTGGTTGGCGCCT
TGATTACTTTTTGTTGTCCCACTCTCTTTTACCTGCATTGTGTGACAGCAAGATTCGCTCCAAG
GCCCTTGGCAGTGATCACTGTCCCATCACCCTATACCTAGCACTGTGATACCCTCTTAGAATAA
TTTTGAGCCTTGGAAATAGCTTCCCTTACCCTCAATGTTCCTTCTTTAGTACCTTGCTAGAGAA
ATCTGCATTTTATTTCTCTTCTGTAAGAATGAATCCTTAAATGAAGCTATTGTTACTAAGGTTT
CTTTTAAGCCCAAGTTTTTTGTTGTGTGCACACATGCCCCAGTTTTTTTTTTTTTTTTTAAAGA
CTTATCTGTAAAAATAAAAGGTCATAGTTTTGTCTTTGCTGTGTTTTGTGTTTTACCCT

hide sequence

RefSeq Acc Id:

XM_040274581 ⟹ XP_040130515

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	77,685,485 - 77,688,067 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005341462	(Get FASTA)	NCBI Sequence Viewer
	XP_013221198	(Get FASTA)	NCBI Sequence Viewer
	XP_040130515	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009066.2
GenBank Protein	KAG3261478	(Get FASTA)	NCBI Sequence Viewer
	KAG3261479	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013221198 ⟸ XM_013365744
- Peptide Label:	isoform X2
- UniProtKB:	I3MEU6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPKRGKKGAAAEDGEEPKTEPESKKSKVGAKKKEKETAGEGPVLYEDPPDKKTSPSGKSATLKI CSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPPELQELPGLSHQYWAAPSDKEGY SGVGLLSRQCPIKVSYGIGEEEHDQEGRVIVAEFDKFVLVTAYVPNAGRGLVRLEYRQRWDEAF RQFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHL YPNTEYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL hide sequence

RefSeq Acc Id:

XP_005341462 ⟸ XM_005341405

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPKRGKKGAAAEDGEEPKTEPESKKSKVGAKKKEKETAGEGPVLYEDPPDKKTSPSGKSATLKI
CSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPPELQELPGLSHQYWAAPSDKEGY
SGVGLLSRQCPIKVSYGIGEEEHDQEGRVIVAEFDKFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RQFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHL
YPNTEYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

hide sequence

RefSeq Acc Id:	XP_040130515 ⟸ XM_040274581
- Peptide Label:	isoform X2
- UniProtKB:	I3MEU6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000009066 ⟸ ENSSTOT00000010106

Protein Domains

Endonuclease/exonuclease/phosphatase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010096	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000010106.3	UniProtKB/TrEMBL
Gene3D-CATH	3.60.10.10	UniProtKB/TrEMBL
InterPro	AP_endonuc_1	UniProtKB/TrEMBL
	AP_endonuclease_F1_BS	UniProtKB/TrEMBL
	AP_endonuclease_F1_CS	UniProtKB/TrEMBL
	Endo/exonu/phosph_ase_sf	UniProtKB/TrEMBL
	Endo/exonuclease/phosphatase	UniProtKB/TrEMBL
NCBI Gene	Apex1	ENTREZGENE
PANTHER	DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE	UniProtKB/TrEMBL
	PTHR22748	UniProtKB/TrEMBL
Pfam	Exo_endo_phos	UniProtKB/TrEMBL
PROSITE	AP_NUCLEASE_F1_1	UniProtKB/TrEMBL
	AP_NUCLEASE_F1_2	UniProtKB/TrEMBL
	AP_NUCLEASE_F1_3	UniProtKB/TrEMBL
	AP_NUCLEASE_F1_4	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56219	UniProtKB/TrEMBL
UniProt	I3MEU6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)