RGD Reference Report - Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.

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Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.
Authors:	Shekari, M Sobti, RC Tamandani, DM Malekzadeh, K Kaur, P Suri, V
Citation:	Shekari M, etal., Cancer Biomark. 2008;4(2):63-71.
RGD ID:	2315662
Pubmed:	PMID:18503157 (View Abstract at PubMed)
Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined world wide incidence of almost half a million new cases. Reduced DNA repair capacity (DRC) can render a high risk of developing many types of cancer; including cervical cancer. Polymorphisms in DNA repair genes may contribute the genetic instability and carcinogenesis. Smoking experience and use of oral contraceptives have been confirmed to be risk factors for cervical cancer. The purpose of the present study was, therefore to investigate APE-1 genotypes (Asp/Asp, Asp/Glu, Glu/Glu) with different histological subtypes in cases compared with controls. It has been observed that Asp/Glu with Glu/Glu genotypes that combined we observed statistically significant with protective effect for developing of cervix cancer (OR-0.51, 95% CI 0.31-0.83, p-0.006). The combined Asp/Glu with Glu/Glu genotypes who were using oral contraceptives were shown to be statistically significant with reduced risk of cervical cancer (OR-0.22 95% CI- 0.11-0.47, p-0.0002). It has been suggested that significantly correlation between HPV 16 and users of oral contraceptives in certain APE-1 genotypes with reduced risk in developing cervix cancer. In conclusion we observed statistical significant association with reduced risk of cervix cancer in APE-1 with different genotypes, though, on the other hand, in association between HPV type 18 and those having SCC, highly increased risk of cervical cancer was observed.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
APEX1	Human	cervical cancer		IAGP		DNA:polymorphism: :p.D148E (human)	RGD
Apex1	Rat	cervical cancer		ISO	APEX1 (Homo sapiens)	DNA:polymorphism: :p.D148E (human)	RGD
Apex1	Mouse	cervical cancer		ISO	APEX1 (Homo sapiens)	DNA:polymorphism: :p.D148E (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1)

Genes (Mus musculus)

Apex1 (apurinic/apyrimidinic endonuclease 1)

Genes (Homo sapiens)

APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1)

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Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.