RGD Reference Report - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - Rat Genome Database

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Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Authors: Qing, Y  Wang, D  Lei, X  Xiang, DB  Li, MX  Li, ZP  Shan, JL 
Citation: Qing Y, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jan;40(1):125-8.
RGD ID: 2315657
Pubmed: PMID:19292061   (View Abstract at PubMed)

OBJECTIVE: To investigate the expression feature of the apurinic/apyrimidinic endonuclease (APE1) and its correlation with clinicopathology and prognostic significance after 252Cf radiotherapy in cervical cancer. METHODS: The expression of APE1 was detected by immunohistochemistry technique in 89 cases of cervical cancer (treated by 252Cf), 15 cases cervical intraepithelial neoplasia (CIN) and 10 cases of normal cervical tissue, and its association with clinicopathological data as well as prognosis were analyzed. RESULTS: The expression of APE1 in cervical cancer is higher significantly than that in normal cervical tissue and CIN (P < 0.01). In normal cervical tissue and CIN, the APE1 express was located in the nucleus. In cervical cancer, the APE1 express was located in the nucleus (59), cytoplasm (8) or nucleus and cytoplasm (22), the location of APE1 was related with FIGO stage and pathological grade (P < 0.01), and not related with lymph node metastasis. The level of APE1 express related with FIGO stage, pathological grade and lymph node metastasis (P < 0.05), and not related with age and pathological type. The Kaplan-Meier survival analysis demonstrated that the survival time of the group of APE1 nucleus expression (median survival time is 70.9 months) and the group of APE1 low expression (median survival time is 75.8 months) is longer significantly than that of the group of APE1 cytoplasm expression (median survival time is 57.8 months) and the group of APE1 high expression (median survival time is 56.5 months) (P = 0.025, 0.001). CONCLUSION: The dystopic express of APE1 might play a pivotal role in carcinogenesis and progression of cervical cancer, and the express of APE1 might estimate the prognosis after 252Cf radiotherapy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervical cancer  IEP 2315657 RGD 
cervical cancer  ISOAPEX1 (Homo sapiens)2315657; 2315657 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apex1  (apurinic/apyrimidinic endodeoxyribonuclease 1)

Genes (Mus musculus)
Apex1  (apurinic/apyrimidinic endonuclease 1)

Genes (Homo sapiens)
APEX1  (apurinic/apyrimidinic endodeoxyribonuclease 1)


Additional Information