RGD Reference Report - APE/Ref-1 is controlled by both redox and cAMP-dependent mechanisms in rat thyroid cells. - Rat Genome Database

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APE/Ref-1 is controlled by both redox and cAMP-dependent mechanisms in rat thyroid cells.

Authors: Tell, G  Pines, A  Pandolfi, M  D'Elia, AV  Donnini, D  Lonigro, R  Manzini, G  Russo, D  Di Loreto, C  Damante, G 
Citation: Tell G, etal., Horm Metab Res 2002 Jun;34(6):303-10.
RGD ID: 634652
Pubmed: PMID:12173070   (View Abstract at PubMed)
DOI: DOI:10.1055/s-2002-33258   (Journal Full-text)

APE/Ref-1 is a multifunctional protein possessing both redox and DNA repair functions. Through its redox activity, APE/Ref-1 controls the DNA-binding function of several transcriptional regulators (AP1, NF-kappaB, p53, Pax proteins). We have previously shown that APE/Ref-1 upregulates the transcriptional activity of the thyroid-specific transcription factor Pax8. In thyroid cells, APE/Ref-1 can be detected both in the nuclear and cytoplasmatic compartments. In this study regulatory mechanisms acting on APE/Ref-1 were revealed using the FRTL-5 cell line. TSH induces both cytoplasm-to-nucleus translocation and neosynthesis of APE/Ref-1 protein. Interestingly, only neosynthesis is dependent on cAMP signalling. In contrast, the cytoplasm-to-nucleus translocation is dependent on redox-mediated mechanisms. Based upon the data shown in this study and in others, a bimodal control of APE/Ref-1 by TSH can be delineated.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Apex1Ratcellular response to cAMP  IEP  RGD 
Apex1Ratcellular response to hydrogen peroxide  IEP  RGD 
Apex1Ratcellular response to Thyroid stimulating hormone  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apex1  (apurinic/apyrimidinic endodeoxyribonuclease 1)


Additional Information