ADORA2A (adenosine A2a receptor) - Rat Genome Database

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Gene: ADORA2A (adenosine A2a receptor) Canis lupus familiaris
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Symbol: ADORA2A
Name: adenosine A2a receptor
RGD ID: 12228090
Description: ENCODES a protein that exhibits alpha-actinin binding (ortholog); G protein-coupled adenosine receptor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); astrocyte activation (ortholog); eating behavior (ortholog); PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH Agammaglobulinemia 2, Autosomal Recessive (ortholog); amphetamine abuse (ortholog); anxiety disorder (ortholog); FOUND IN asymmetric synapse (ortholog); axolemma (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adenosine receptor A2a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,141,076 - 28,150,600 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,141,076 - 28,150,598 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,207,866 - 27,225,894 (+)NCBI
ROS_Cfam_1.02629,536,347 - 29,554,384 (+)NCBI
UMICH_Zoey_3.12627,619,698 - 27,637,726 (+)NCBI
UNSW_CanFamBas_1.02627,237,300 - 27,255,320 (+)NCBI
UU_Cfam_GSD_1.02628,226,384 - 28,244,417 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
astrocyte activation  (ISO)
eating behavior  (IEA,ISO)
excitatory postsynaptic potential  (ISO)
G protein-coupled adenosine receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
inhibitory postsynaptic potential  (IEA,ISO)
locomotory behavior  (IEA,ISO)
membrane depolarization  (ISO)
negative regulation of alpha-beta T cell activation  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of locomotion  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of vascular permeability  (ISO)
neuron projection morphogenesis  (ISO)
positive regulation of acetylcholine secretion, neurotransmission  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of circadian sleep/wake cycle, sleep  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of urine volume  (ISO)
prepulse inhibition  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of calcium ion transport  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to alkaloid  (ISO)
response to amphetamine  (IEA,ISO)
response to caffeine  (ISO)
response to xenobiotic stimulus  (ISO)
synaptic transmission, cholinergic  (ISO)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic transmission, glutamatergic  (ISO)
vasodilation  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2125216   PMID:2159628   PMID:2541503   PMID:15784967   PMID:16390330   PMID:19833310   PMID:21044214  


Genomics

Comparative Map Data
ADORA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,141,076 - 28,150,600 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,141,076 - 28,150,598 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,207,866 - 27,225,894 (+)NCBI
ROS_Cfam_1.02629,536,347 - 29,554,384 (+)NCBI
UMICH_Zoey_3.12627,619,698 - 27,637,726 (+)NCBI
UNSW_CanFamBas_1.02627,237,300 - 27,255,320 (+)NCBI
UU_Cfam_GSD_1.02628,226,384 - 28,244,417 (+)NCBI
ADORA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2224,417,879 - 24,442,357 (+)EnsemblGRCh38hg38GRCh38
GRCh382224,423,597 - 24,442,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,819,565 - 24,838,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,153,530 - 23,168,325 (+)NCBINCBI36hg18NCBI36
Build 342223,153,645 - 23,162,878NCBI
Celera228,623,253 - 8,638,061 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,769,458 - 7,788,241 (+)NCBIHuRef
CHM1_12224,778,238 - 24,796,999 (+)NCBICHM1_1
Adora2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,152,711 - 75,170,626 (+)NCBIGRCm39mm39
GRCm39 Ensembl1075,152,711 - 75,170,618 (+)Ensembl
GRCm381075,316,877 - 75,334,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,316,877 - 75,334,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,779,688 - 74,797,533 (+)NCBIGRCm37mm9NCBIm37
MGSCv361074,769,745 - 74,777,652 (+)NCBImm8
Celera1076,364,032 - 76,382,114 (+)NCBICelera
Cytogenetic Map10C1NCBI
Adora2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22013,315,848 - 13,333,386 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2013,315,853 - 13,333,386 (-)Ensembl
Rnor_6.02014,265,251 - 14,282,873 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,449,385 - 16,466,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,815,719 - 13,834,131 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,815,944 - 13,825,845 (-)NCBI
Celera2014,801,379 - 14,818,841 (-)NCBICelera
Cytogenetic Map20p12NCBI
Adora2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,895,974 - 7,906,505 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,886,720 - 7,906,214 (+)NCBIChiLan1.0ChiLan1.0
ADORA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12222,099,404 - 22,114,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,104,253 - 22,114,189 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0225,233,876 - 5,248,622 (+)NCBIMhudiblu_PPA_v0panPan3
Adora2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,136,447 - 142,156,176 (-)NCBI
SpeTri2.0NW_004936619597,970 - 618,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,468,862 - 49,485,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,467,186 - 49,485,845 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,914,635 - 52,931,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADORA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,691,678 - 7,706,781 (-)NCBI
ChlSab1.1 Ensembl197,691,536 - 7,706,926 (-)Ensembl
Vero_WHO_p1.0NW_0236660854,894,557 - 4,913,637 (-)NCBI
Adora2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247479,846,254 - 9,860,938 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 5 22 6 6 6 2 1 12 8 10 6
Below cutoff 4 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000021939   ⟹   ENSCAFP00000020374
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2628,141,076 - 28,150,598 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000088536   ⟹   ENSCAFP00000043580
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2628,141,076 - 28,149,801 (+)Ensembl
RefSeq Acc Id: NM_001003278   ⟹   NP_001003278
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12628,141,076 - 28,150,600 (+)NCBI
Dog10K_Boxer_Tasha2627,207,866 - 27,225,894 (+)NCBI
ROS_Cfam_1.02629,536,347 - 29,554,384 (+)NCBI
UMICH_Zoey_3.12627,619,698 - 27,637,726 (+)NCBI
UNSW_CanFamBas_1.02627,237,300 - 27,255,320 (+)NCBI
UU_Cfam_GSD_1.02628,226,384 - 28,244,417 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA32210 (Get FASTA)   NCBI Sequence Viewer  
  P11617 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003278   ⟸   NM_001003278
- UniProtKB: P11617 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000043580   ⟸   ENSCAFT00000088536
RefSeq Acc Id: ENSCAFP00000020374   ⟸   ENSCAFT00000021939


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013828 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000020374 ENTREZGENE
Ensembl Transcript ENSCAFT00000021939 ENTREZGENE
NCBI Gene ADORA2A ENTREZGENE
UniProt P11617 ENTREZGENE
VGNC ID VGNC:37666 ENTREZGENE