PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) - Rat Genome Database

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Gene: PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) Pan paniscus
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Symbol: PRKAR2A
Name: protein kinase cAMP-dependent type II regulatory subunit alpha
RGD ID: 11794236
Description: ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); cAMP binding (ortholog); cAMP-dependent protein kinase regulator activity (ortholog); INVOLVED IN modulation of chemical synaptic transmission (ortholog); negative regulation of cAMP-dependent protein kinase activity (ortholog); positive regulation of meiotic cell cycle process involved in oocyte maturation (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); congestive heart failure (ortholog); Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ortholog); FOUND IN cAMP-dependent protein kinase complex (ortholog); germinal vesicle (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP-dependent protein kinase type II-alpha regulatory subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,719,302 - 48,828,170 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,724,070 - 48,832,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,665,421 - 48,774,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,747,611 - 49,854,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,747,611 - 49,854,382 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRKAR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,719,302 - 48,828,170 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,724,070 - 48,832,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,665,421 - 48,774,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,747,611 - 49,854,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,747,611 - 49,854,382 (-)Ensemblpanpan1.1panPan2
PRKAR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,744,591 - 48,847,874 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,744,597 - 48,847,874 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,784,019 - 48,885,307 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,763,097 - 48,860,274 (-)NCBINCBI36Build 36hg18NCBI36
Build 34348,763,096 - 48,860,274NCBI
Celera348,744,318 - 48,841,506 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,846,714 - 48,943,468 (-)NCBIHuRef
CHM1_1348,740,185 - 48,837,372 (-)NCBICHM1_1
T2T-CHM13v2.0348,773,615 - 48,876,846 (-)NCBIT2T-CHM13v2.0
Prkar2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,569,342 - 108,627,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,566,513 - 108,627,635 (+)EnsemblGRCm39 Ensembl
GRCm389108,692,143 - 108,750,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,689,314 - 108,750,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,594,474 - 108,651,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,549,547 - 108,606,735 (+)NCBIMGSCv36mm8
Celera9108,299,573 - 108,356,490 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
Prkar2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,271,608 - 118,337,332 (+)NCBIGRCr8
mRatBN7.28109,393,189 - 109,458,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,395,833 - 109,455,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,013,927 - 115,072,982 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,213,100 - 113,272,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,055,904 - 111,114,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,486,085 - 117,548,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,486,083 - 117,546,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,830,841 - 116,893,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,746,384 - 113,805,476 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,765,838 - 113,824,931 (+)NCBI
Celera8108,691,132 - 108,750,351 (+)NCBICelera
RH 3.4 Map81114.1RGD
Cytogenetic Map8q32NCBI
Prkar2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532827,418 - 852,845 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955532827,112 - 896,487 (-)NCBIChiLan1.0ChiLan1.0
PRKAR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,277,655 - 40,388,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,277,906 - 40,384,633 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,194,965 - 40,305,481 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,762,529 - 40,873,645 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,633,410 - 40,873,638 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,000,705 - 40,111,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,404,451 - 40,515,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,685,401 - 40,796,977 (+)NCBIUU_Cfam_GSD_1.0
Prkar2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,767,658 - 63,840,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529528,114 - 601,122 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529528,138 - 601,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,426,213 - 31,517,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,427,786 - 31,517,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,688,004 - 34,770,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,153,951 - 10,251,438 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,150,378 - 10,251,397 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,838,051 - 156,931,070 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkar2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247302,743,921 - 2,807,270 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000040688   ⟹   ENSPPAP00000017967
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl349,747,611 - 49,854,382 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000040692   ⟹   ENSPPAP00000017971
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl349,752,598 - 49,853,870 (-)Ensembl
RefSeq Acc Id: XM_008971691   ⟹   XP_008969939
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2248,719,302 - 48,828,170 (-)NCBI
NHGRI_mPanPan1348,724,070 - 48,832,762 (-)NCBI
Mhudiblu_PPA_v0348,665,421 - 48,774,111 (-)NCBI
PanPan1.1349,747,611 - 49,854,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008971693   ⟹   XP_008969941
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2248,719,302 - 48,828,162 (-)NCBI
NHGRI_mPanPan1348,724,070 - 48,832,762 (-)NCBI
Mhudiblu_PPA_v0348,665,421 - 48,774,111 (-)NCBI
PanPan1.1349,747,611 - 49,854,382 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008969939 (Get FASTA)   NCBI Sequence Viewer  
  XP_008969941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000017967.1
  ENSPPAP00000017971.1
RefSeq Acc Id: XP_008969941   ⟸   XM_008971693
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008969939   ⟸   XM_008971691
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AKR7 (UniProtKB/TrEMBL),   A0A2R9AKT0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000017967   ⟸   ENSPPAT00000040688
Ensembl Acc Id: ENSPPAP00000017971   ⟸   ENSPPAT00000040692
Protein Domains
Cyclic nucleotide-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032093 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040688.1 UniProtKB/TrEMBL
  ENSPPAT00000040692.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
InterPro cAMP-dep_kinase_reg_chain UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
KEGG Report pps:100975668 UniProtKB/TrEMBL
NCBI Gene PRKAR2A ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  RIIa UniProtKB/TrEMBL
PIRSF PK_regulatory UniProtKB/TrEMBL
PRINTS CAMPKINASE UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  RIIa UniProtKB/TrEMBL
Superfamily-SCOP Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
UniProt A0A2R9AKR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AKT0 ENTREZGENE, UniProtKB/TrEMBL