PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) - Rat Genome Database

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Gene: PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) Sus scrofa
Analyze
Symbol: PRKAR2A
Name: protein kinase cAMP-dependent type II regulatory subunit alpha
RGD ID: 14184392
Description: ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); cAMP binding (ortholog); cAMP-dependent protein kinase regulator activity (ortholog); INVOLVED IN negative regulation of cAMP-dependent protein kinase activity; positive regulation of meiotic cell cycle process involved in oocyte maturation; regulation of meiotic cell cycle process involved in oocyte maturation; PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN cytoplasm; cytoplasm; germinal vesicle
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-dependent protein kinase type II-alpha regulatory subunit; cAMP-dependent protein kinase, regulatory subunit alpha 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,426,213 - 31,517,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,427,786 - 31,517,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,688,004 - 34,770,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:225318   PMID:2431926   PMID:22674394   PMID:23426434   PMID:24501172  


Genomics

Comparative Map Data
PRKAR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,426,213 - 31,517,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,427,786 - 31,517,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,688,004 - 34,770,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,744,591 - 48,847,874 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl348,744,597 - 48,847,874 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,784,019 - 48,885,307 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,763,097 - 48,860,274 (-)NCBINCBI36Build 36hg18NCBI36
Build 34348,763,096 - 48,860,274NCBI
Celera348,744,318 - 48,841,506 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,846,714 - 48,943,468 (-)NCBIHuRef
CHM1_1348,740,185 - 48,837,372 (-)NCBICHM1_1
T2T-CHM13v2.0348,775,598 - 48,876,846 (-)NCBIT2T-CHM13v2.0
Prkar2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,569,342 - 108,627,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,566,513 - 108,627,635 (+)EnsemblGRCm39 Ensembl
GRCm389108,692,143 - 108,750,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,689,314 - 108,750,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,594,474 - 108,651,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,549,547 - 108,606,735 (+)NCBIMGSCv36mm8
Celera9108,299,573 - 108,356,490 (+)NCBICelera
Cytogenetic Map9F2NCBI
Prkar2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,393,189 - 109,458,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,395,833 - 109,455,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,013,927 - 115,072,982 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08113,213,100 - 113,272,156 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08111,055,904 - 111,114,960 (+)NCBIRnor_WKY
Rnor_6.08117,486,085 - 117,548,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,486,083 - 117,546,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,830,841 - 116,893,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,746,384 - 113,805,476 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,765,838 - 113,824,931 (+)NCBI
Celera8108,691,132 - 108,750,351 (+)NCBICelera
RH 3.4 Map81114.1RGD
Cytogenetic Map8q32NCBI
Prkar2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532827,418 - 852,845 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955532827,112 - 896,487 (-)NCBIChiLan1.0ChiLan1.0
PRKAR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1349,747,611 - 49,854,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,747,611 - 49,854,382 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0348,665,421 - 48,774,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRKAR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,277,655 - 40,388,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,277,906 - 40,384,633 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,194,965 - 40,305,481 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,762,529 - 40,873,645 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,633,410 - 40,873,638 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,000,705 - 40,111,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,404,451 - 40,515,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,685,401 - 40,796,977 (+)NCBIUU_Cfam_GSD_1.0
Prkar2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,767,658 - 63,840,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529528,114 - 601,122 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936529528,138 - 601,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,153,951 - 10,251,438 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,150,378 - 10,251,397 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,838,051 - 156,931,070 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkar2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247302,743,921 - 2,807,270 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 15 2 3 3
Low 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000065573   ⟹   ENSSSCP00000042250
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,426,213 - 31,517,122 (-)Ensembl
RefSeq Acc Id: NM_214258   ⟹   NP_999423
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,427,786 - 31,517,005 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999423 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAH57697 (Get FASTA)   NCBI Sequence Viewer  
  CAA28414 (Get FASTA)   NCBI Sequence Viewer  
  P05207 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999423   ⟸   NM_214258
- UniProtKB: C1PIG4 (UniProtKB/TrEMBL),   A0A4X1T0V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000042250   ⟸   ENSSSCT00000065573
Protein Domains
Cyclic nucleotide-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011363 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015066913 UniProtKB/TrEMBL
  ENSSSCG00025054258 UniProtKB/TrEMBL
  ENSSSCG00030056318 UniProtKB/TrEMBL
  ENSSSCG00035071097 UniProtKB/TrEMBL
  ENSSSCG00040046185 UniProtKB/TrEMBL
  ENSSSCG00045034155 UniProtKB/TrEMBL
  ENSSSCG00050034132 UniProtKB/TrEMBL
  ENSSSCG00055016686 UniProtKB/TrEMBL
  ENSSSCG00060056564 UniProtKB/TrEMBL
  ENSSSCG00065032454 UniProtKB/TrEMBL
  ENSSSCG00070005298 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000042250 ENTREZGENE
  ENSSSCP00000042250.1 UniProtKB/TrEMBL
  ENSSSCP00015036802.1 UniProtKB/TrEMBL
  ENSSSCP00025032110.1 UniProtKB/TrEMBL
  ENSSSCP00030035882.1 UniProtKB/TrEMBL
  ENSSSCP00035040407.1 UniProtKB/TrEMBL
  ENSSSCP00040026142.1 UniProtKB/TrEMBL
  ENSSSCP00045041255.1 UniProtKB/TrEMBL
  ENSSSCP00050018819.1 UniProtKB/TrEMBL
  ENSSSCP00055026215.1 UniProtKB/TrEMBL
  ENSSSCP00060033296.1 UniProtKB/TrEMBL
  ENSSSCP00065018733.1 UniProtKB/TrEMBL
  ENSSSCP00070008286.1 UniProtKB/TrEMBL
  ENSSSCP00070008292.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000065573 ENTREZGENE
  ENSSSCT00000065573.2 UniProtKB/TrEMBL
  ENSSSCT00015090024.1 UniProtKB/TrEMBL
  ENSSSCT00025074188.1 UniProtKB/TrEMBL
  ENSSSCT00030078465.1 UniProtKB/TrEMBL
  ENSSSCT00035096063.1 UniProtKB/TrEMBL
  ENSSSCT00040062106.1 UniProtKB/TrEMBL
  ENSSSCT00045058942.1 UniProtKB/TrEMBL
  ENSSSCT00050045798.1 UniProtKB/TrEMBL
  ENSSSCT00055032907.1 UniProtKB/TrEMBL
  ENSSSCT00060077045.1 UniProtKB/TrEMBL
  ENSSSCT00065043982.1 UniProtKB/TrEMBL
  ENSSSCT00070010094.1 UniProtKB/TrEMBL
  ENSSSCT00070010100.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
InterPro cAMP_dep_PK_reg_su UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397493 UniProtKB/TrEMBL
NCBI Gene PRKAR2A ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  RIIa UniProtKB/TrEMBL
PIRSF PK_regulatory UniProtKB/TrEMBL
PRINTS CAMPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  RIIa UniProtKB/TrEMBL
Superfamily-SCOP Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit UniProtKB/TrEMBL
  SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AEK2_PIG UniProtKB/TrEMBL
  A0A4X1T087_PIG UniProtKB/TrEMBL
  A0A4X1T0V7 ENTREZGENE, UniProtKB/TrEMBL
  C1PIG4 ENTREZGENE, UniProtKB/TrEMBL
  KAP2_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:91804 ENTREZGENE