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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:procainamide pharmacodynamics pathway
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Accession:PW:0001860 term browser browse the term
Definition:The pathway of procainamide-target interaction and of the biochemical or physiological responses to drug. The drug is a class Ia antiarrhythmic drug that can also elicit serious cytotoxic effects. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00324


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procainamide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00324 NCBI chr21:39,963,001...40,037,040
Ensembl chr21:39,962,947...40,036,981 		JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00324 NCBI chr27:25,199,580...25,352,637
Ensembl chr27:25,200,418...25,388,477 		JBrowse link
G ADRB1 adrenoceptor beta 1 ISO SMPDB SMP:00324 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO SMPDB SMP:00324 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00324 NCBI chr17:53,828,482...53,847,043
Ensembl chr17:53,813,976...53,847,167 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00324 NCBI chr 1:112,325,988...112,346,056
Ensembl chr 1:112,325,289...112,346,916 		JBrowse link
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00324 NCBI chr38:22,023,176...22,080,656
Ensembl chr38:22,023,221...22,080,604 		JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00324 NCBI chr 7:29,464,132...29,487,124
Ensembl chr 7:29,464,132...29,487,947 		JBrowse link
G ATP1B2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00324 NCBI chr 5:32,548,591...32,553,911
Ensembl chr 5:32,549,167...32,553,504 		JBrowse link
G ATP1B3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00324 NCBI chr23:37,684,507...37,727,535
Ensembl chr23:37,684,506...37,726,746 		JBrowse link
G ATP1B4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00324 NCBI chr  X:92,347,443...92,368,206
Ensembl chr  X:92,347,684...92,365,341 		JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00324 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00324 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00324 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00324 NCBI chr 6:39,510,129...39,533,129
Ensembl chr 6:39,510,121...39,533,753 		JBrowse link
G CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00324 NCBI chr20:38,859,047...38,995,239
Ensembl chr20:38,883,530...38,993,273 		JBrowse link
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00324 NCBI chr 9:23,182,407...23,197,035
Ensembl chr 9:23,180,554...23,195,673 		JBrowse link
G CALM1 calmodulin 1 ISO SMPDB SMP:00324 NCBI chr 8:61,398,231...61,408,874
Ensembl chr 8:61,398,244...61,406,195 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 ISO SMPDB SMP:00324 NCBI chr16:11,515,727...11,665,651
Ensembl chr16:11,515,426...11,664,977 		JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00324 NCBI chr33:30,016,323...30,253,180
Ensembl chr33:30,016,600...30,253,547 		JBrowse link
G FXYD2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00324 NCBI chr 5:15,812,335...15,824,552
Ensembl chr 5:15,815,969...15,823,057 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO SMPDB SMP:00324 NCBI chr30:36,637,492...36,656,194
Ensembl chr30:36,639,908...36,656,406 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO SMPDB SMP:00324 NCBI chr20:12,746,171...13,065,256
Ensembl chr20:12,747,315...13,064,198 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 ISO SMPDB SMP:00324 NCBI chr27:39,808,987...39,810,789
Ensembl chr27:39,756,363...39,811,035 		JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00324 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035 		JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00324 NCBI chr31:29,858,428...29,868,315 JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00324 NCBI chr31:29,777,154...29,777,839
Ensembl chr31:29,581,658...29,777,525 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00324 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504 		JBrowse link
G KCNIP2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00324 NCBI chr28:14,409,526...14,425,641
Ensembl chr28:14,409,526...14,425,641 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 ISO SMPDB SMP:00324 NCBI chr21:39,953,461...39,957,615
Ensembl chr21:39,955,551...39,956,723 		JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 ISO SMPDB SMP:00324 NCBI chr 9:16,468,938...16,475,722
Ensembl chr 9:16,468,938...16,475,722 		JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 ISO SMPDB SMP:00324 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766 		JBrowse link
G KCNJ4 potassium inwardly rectifying channel subfamily J member 4 ISO SMPDB SMP:00324 NCBI chr10:26,321,274...26,348,978
Ensembl chr10:26,347,140...26,348,486 		JBrowse link
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 ISO SMPDB SMP:00324 NCBI chr 5:5,736,544...5,760,705
Ensembl chr 5:5,740,176...5,760,866 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 ISO SMPDB SMP:00324 NCBI chr27:25,368,565...25,375,754
Ensembl chr27:25,368,810...25,375,009 		JBrowse link
G KCNK1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00324 NCBI chr 4:6,117,406...6,139,390
Ensembl chr 4:6,118,373...6,122,093 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00324 NCBI chr18:46,554,390...46,830,533
Ensembl chr18:46,518,908...46,830,043 		JBrowse link
G LOC477647 ALG10 alpha-1,2-glucosyltransferase ISO SMPDB SMP:00324 NCBI chr27:15,121,327...15,127,229 JBrowse link
G MYLK myosin light chain kinase ISO SMPDB SMP:00324 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181 		JBrowse link
G PLCB1 phospholipase C beta 1 ISO SMPDB SMP:00324 NCBI chr24:13,337,285...13,996,218
Ensembl chr24:13,322,296...13,995,539 		JBrowse link
G PLN phospholamban ISO SMPDB SMP:00324 NCBI chr 1:58,579,095...58,590,541
Ensembl chr 1:58,579,145...58,590,535 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00324 NCBI chr20:48,416,730...48,425,237
Ensembl chr20:48,409,045...48,426,669 		JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00324 NCBI chr 9:15,180,940...15,203,035
Ensembl chr 9:15,181,393...15,200,683 		JBrowse link
G RYR2 ryanodine receptor 2 ISO SMPDB SMP:00324 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00324 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO SMPDB SMP:00324 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
G SNTA1 syntrophin alpha 1 ISO SMPDB SMP:00324 NCBI chr24:22,636,716...22,665,828
Ensembl chr24:22,636,756...22,665,741 		JBrowse link
G SNTB1 syntrophin beta 1 ISO SMPDB SMP:00324 NCBI chr13:19,394,608...19,627,278
Ensembl chr13:19,397,509...19,627,403 		JBrowse link
G SNTB2 syntrophin beta 2 ISO SMPDB SMP:00324 NCBI chr 5:80,345,331...80,461,559
Ensembl chr 5:80,352,479...80,462,541 		JBrowse link
G TNNC1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00324 NCBI chr20:37,313,983...37,317,288
Ensembl chr20:37,311,966...37,317,321 		JBrowse link
G TNNC2 troponin C2, fast skeletal type ISO SMPDB SMP:00324 NCBI chr24:33,136,644...33,139,289
Ensembl chr24:33,128,290...33,163,050 		JBrowse link
G TNNI1 troponin I1, slow skeletal type ISO SMPDB SMP:00324 NCBI chr 7:1,647,138...1,658,648
Ensembl chr 7:1,647,377...1,658,724 		JBrowse link
G TNNI2 troponin I2, fast skeletal type ISO SMPDB SMP:00324 NCBI chr18:46,076,816...46,079,362
Ensembl chr18:46,077,581...46,079,361 		JBrowse link
G TNNI3 troponin I3, cardiac type ISO SMPDB SMP:00324 NCBI chr 1:102,475,146...102,478,319
Ensembl chr 1:102,475,146...102,478,318 		JBrowse link
G TNNT1 troponin T1, slow skeletal type ISO SMPDB SMP:00324 NCBI chr 1:102,479,617...102,490,776
Ensembl chr 1:102,366,801...102,491,147 		JBrowse link
G TNNT2 troponin T2, cardiac type ISO SMPDB SMP:00324 NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741 		JBrowse link
G TNNT3 troponin T3, fast skeletal type ISO SMPDB SMP:00324 NCBI chr18:46,131,925...46,148,577
Ensembl chr18:46,074,700...46,149,131 		JBrowse link
G TPM1 tropomyosin 1 ISO SMPDB SMP:00324 NCBI chr30:27,636,407...27,664,907
Ensembl chr30:27,636,283...27,664,442 		JBrowse link
G TPM2 tropomyosin 2 ISO SMPDB SMP:00324 NCBI chr11:52,212,372...52,219,947
Ensembl chr11:52,212,401...52,219,923 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    drug pathway 379
      cardiovascular system drug pathway 177
        antiarrhythmic drug pathway 95
          procainamide drug pathway 59
            procainamide pharmacodynamics pathway 59
paths to the root