ATP1B3 (ATPase Na+/K+ transporting subunit beta 3) - Rat Genome Database

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Pathways
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Gene: ATP1B3 (ATPase Na+/K+ transporting subunit beta 3) Canis lupus familiaris
Analyze
Symbol: ATP1B3
Name: ATPase Na+/K+ transporting subunit beta 3
RGD ID: 12236586
Description: ENCODES a protein that exhibits ATPase binding (ortholog); P-type sodium:potassium-exchanging transporter activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN membrane repolarization (ortholog); metal ion transport (ortholog); positive regulation of potassium ion import across plasma membrane (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN caveola (ortholog); cytoplasm (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium/potassium-transporting ATPase subunit beta-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12337,684,507 - 37,727,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2337,684,506 - 37,726,746 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2337,675,590 - 37,719,488 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02338,214,455 - 38,258,634 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2338,214,096 - 38,258,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12337,897,059 - 37,940,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02337,974,038 - 38,017,944 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02338,217,485 - 38,261,376 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ATP1B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12337,684,507 - 37,727,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2337,684,506 - 37,726,746 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2337,675,590 - 37,719,488 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02338,214,455 - 38,258,634 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2338,214,096 - 38,258,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12337,897,059 - 37,940,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02337,974,038 - 38,017,944 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02338,217,485 - 38,261,376 (+)NCBIUU_Cfam_GSD_1.0
ATP1B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383141,876,643 - 141,926,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3141,876,124 - 141,926,549 (+)EnsemblGRCh38hg38GRCh38
GRCh373141,595,485 - 141,645,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363143,078,160 - 143,128,072 (+)NCBINCBI36Build 36hg18NCBI36
Build 343143,078,167 - 143,128,080NCBI
Celera3140,019,481 - 140,069,148 (+)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3138,968,275 - 139,018,182 (+)NCBIHuRef
CHM1_13141,558,509 - 141,608,405 (+)NCBICHM1_1
T2T-CHM13v2.03144,623,941 - 144,673,839 (+)NCBIT2T-CHM13v2.0
Atp1b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39996,214,708 - 96,246,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl996,214,708 - 96,246,495 (-)EnsemblGRCm39 Ensembl
GRCm38996,332,655 - 96,364,431 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl996,332,655 - 96,364,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv37996,233,092 - 96,264,718 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36996,142,025 - 96,173,651 (-)NCBIMGSCv36mm8
Celera995,886,766 - 95,920,080 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map950.31NCBI
Atp1b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,789,824 - 105,821,151 (-)NCBIGRCr8
mRatBN7.2896,910,265 - 96,941,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,910,309 - 96,941,598 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8102,575,419 - 102,606,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08100,774,668 - 100,806,054 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0898,613,628 - 98,645,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08104,190,032 - 104,221,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8104,190,032 - 104,221,342 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,638,324 - 103,669,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48101,405,877 - 101,437,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18101,425,331 - 101,457,212 (-)NCBI
Celera896,353,742 - 96,384,785 (-)NCBICelera
Cytogenetic Map8q31NCBI
Atp1b3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555083,859,399 - 3,875,276 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555083,848,745 - 3,875,992 (-)NCBIChiLan1.0ChiLan1.0
ATP1B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,780,084 - 139,831,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13139,784,817 - 139,836,609 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03138,903,371 - 138,954,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13146,500,493 - 146,550,164 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3146,500,493 - 146,550,164 (+)Ensemblpanpan1.1panPan2
Atp1b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560276,881,663 - 76,901,102 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365403,621,656 - 3,640,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11382,680,442 - 82,727,052 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21390,496,250 - 90,523,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11548,691,224 - 48,742,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1548,690,667 - 48,742,385 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604121,627,404 - 21,678,499 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1b3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473018,510,844 - 18,544,836 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473018,510,840 - 18,544,528 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ATP1B3
457 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 4 5 16 6 6 12 8 10 6
Low 6 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012366   ⟹   ENSCAFP00000011460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2337,684,506 - 37,726,746 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089499   ⟹   ENSCAFP00000049811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2337,684,506 - 37,726,746 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049899   ⟹   ENSCAFP00845039130
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2338,214,096 - 38,258,581 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049933   ⟹   ENSCAFP00845039157
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2338,214,096 - 38,258,581 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049961   ⟹   ENSCAFP00845039178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2338,214,096 - 38,258,581 (+)Ensembl
RefSeq Acc Id: XM_005634648   ⟹   XP_005634705
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12337,684,507 - 37,727,535 (+)NCBI
Dog10K_Boxer_Tasha2337,675,590 - 37,719,488 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038432550   ⟹   XP_038288478
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02338,214,455 - 38,258,634 (+)NCBI
RefSeq Acc Id: XM_038507855   ⟹   XP_038363783
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12337,897,059 - 37,940,955 (+)NCBI
RefSeq Acc Id: XM_038571095   ⟹   XP_038427023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02338,217,485 - 38,261,376 (+)NCBI
RefSeq Acc Id: XM_038635286   ⟹   XP_038491214
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02337,974,038 - 38,017,944 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005634705   ⟸   XM_005634648
- UniProtKB: A0A8C0M4W9 (UniProtKB/TrEMBL),   A0A8C0Q4A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000049811   ⟸   ENSCAFT00000089499
RefSeq Acc Id: ENSCAFP00000011460   ⟸   ENSCAFT00000012366
RefSeq Acc Id: XP_038363783   ⟸   XM_038507855
RefSeq Acc Id: XP_038491214   ⟸   XM_038635286
RefSeq Acc Id: XP_038288478   ⟸   XM_038432550
- UniProtKB: A0A8C0M4W9 (UniProtKB/TrEMBL),   A0A8C0Q4A5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038427023   ⟸   XM_038571095
- UniProtKB: A0A8C0K773 (UniProtKB/TrEMBL),   A0A8C0Q4A5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845039130   ⟸   ENSCAFT00845049899
RefSeq Acc Id: ENSCAFP00845039157   ⟸   ENSCAFT00845049933
RefSeq Acc Id: ENSCAFP00845039178   ⟸   ENSCAFT00845049961


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007731 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003892 UniProtKB/TrEMBL
  ENSCAFG00040005306 UniProtKB/TrEMBL
  ENSCAFG00845028285 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012366.5 UniProtKB/TrEMBL
  ENSCAFT00000089499.2 UniProtKB/TrEMBL
  ENSCAFT00000105679.1 UniProtKB/TrEMBL
  ENSCAFT00030007214.1 UniProtKB/TrEMBL
  ENSCAFT00030007275.1 UniProtKB/TrEMBL
  ENSCAFT00030007309.1 UniProtKB/TrEMBL
  ENSCAFT00040010033.1 UniProtKB/TrEMBL
  ENSCAFT00845049899.1 UniProtKB/TrEMBL
  ENSCAFT00845049933.1 UniProtKB/TrEMBL
  ENSCAFT00845049961.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  2.60.40.1660 UniProtKB/TrEMBL
InterPro Na/K_ATPase_sub_beta UniProtKB/TrEMBL
  Na/K_ATPase_sub_beta_sf UniProtKB/TrEMBL
NCBI Gene ATP1B3 ENTREZGENE
PANTHER PTHR11523 UniProtKB/TrEMBL
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-3 UniProtKB/TrEMBL
Pfam Na_K-ATPase UniProtKB/TrEMBL
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/TrEMBL
UniProt A0A8C0K773 ENTREZGENE
  A0A8C0M4V4_CANLF UniProtKB/TrEMBL
  A0A8C0M4W9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0M8B0_CANLF UniProtKB/TrEMBL
  A0A8C0Q4A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PX58_CANLF UniProtKB/TrEMBL
  A0A8I3SBE1_CANLF UniProtKB/TrEMBL
  A0A8I3SBE8_CANLF UniProtKB/TrEMBL
  A0A8P0PM05_CANLF UniProtKB/TrEMBL
  A0A8P0SCZ5_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0NZP4 UniProtKB/TrEMBL
VGNC ID VGNC:38250 ENTREZGENE