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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:parathyroid hormone signaling pathway
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Accession:PW:0001135 term browser browse the term
Definition:Parathyroid hormone (PTH) signaling is important for calcium and phosphate homeostasis in bone and kidney. It acts to increase the concentration of calcium in the blood, has both anabolic and catabolic effects in the bone and regulates calcium and phosphate reabsorption in the kidney. It also plays important roles in vitamin D metabolism.
Synonyms:related_synonym: PTH signaling pathway
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parathyroid hormone signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO RGD PMID:20703892 RGD:7207469 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:20703892 RGD:7207469 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Ezr ezrin ISO RGD PMID:21777186 RGD:7207465 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:19395963 RGD:7207470 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 ISO RGD PMID:21777186 RGD:7207465 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 ISO RGD PMID:21777186 RGD:7207465 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Pth parathyroid hormone IDA
ISO		 RGD PMID:9054374 PMID:21777186 PMID:19395963 RGD:7207455, RGD:7207465, RGD:7207470 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Pth1r parathyroid hormone 1 receptor IDA
ISO		 RGD PMID:9054374 PMID:21777186 PMID:20703892 PMID:19395963 RGD:7207455, RGD:7207465, RGD:7207469, RGD:7207470 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2635
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          parathyroid hormone family signaling pathway 8
            parathyroid hormone signaling pathway 8
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          metal homeostasis pathway 339
            calcium homeostasis pathway 277
              parathyroid hormone signaling pathway 8
paths to the root